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Information on some of the selected papers presented at the 2008 Southern Conference on Programmable Logic (SPL)held in Bariloche, Argentina on March 26-28 is presented. There were more than 95 papers submitted to the conference, wherein the 29 selected papers and the 23 short papers were authored by researchers from Argentina, Australia, France, Germany, Spain, Great Britain, the U.S., and other countries. It informs readers that articles presented in this issue are dedicated to the SPL 2008.

This paper presents the soil water deficit and soil water surplus obtained from soil water balance in three drainage areas of Buenos Aires province for the period from 1971 to 2010. The soil water balance had been performed using the evapotranspiration formula of Penman-Monteith and considering the soil water constants: field capacity, soil water moisture, and soil wilting point for all the different types of soils of the region. The obtained soil water deficit and surplus are considered as triggers of extreme hydrologic events. Annual threshold values of 200mm of soil water deficit and 300mm of soil water surplus were considered for drought and flood, respectively. It was found that almost the 25% of the floods are severe and extreme while the 50% of droughts were of these intensities. Mann-Kendall statistical test was performed, and significance trends at level 0.1 were found for drought and for two periods, one of twenty years (1991-2010) and the other of ten years (2001-2010). As a sample of the temporal evolution of both events and their trends, the results of one locality (Junin) were deeply analyzed. [ABSTRACT FROM AUTHOR]

This paper presents the application Ludwig designed to train operators of a CANDU Nuclear Power Plant (NPP) by means of a computer control panel that simulates the response of the evolution of the physical variables of the plant under normal transients. The model includes a close set of equations representing the principal components of a CANDU NPP plant, a nodalized primary circuit, core, pressurizer, and steam generators. The design of the application was performed using the object-oriented programming paradigm, incorporating an event-driven process to reflect the action of the human operators and the automatic control system. A comprehensive set of online graphical displays are provided giving an in-depth understanding of transient neutronic and thermal hydraulic response of the power plant. The model was validated against data froma real transient occurring in the Argentine NPP Embalse Río Tercero, showing good agreement. However, it should be stressed that the aim of the simulator is in the training of operators and engineering students. [ABSTRACT FROM AUTHOR]

INVAP, an Argentine company founded more than three decades ago, is today recognized as one of the leaders within the research reactor industry. INVAP has participated in several projects covering a wide range of facilities, designed in accordance with the requirements of our different clients. For complying with these requirements, INVAP developed special skills and capabilities to deal with different fuel assemblies, different core cooling systems, and different reactor layouts. This paper summarizes the general features and utilization of several INVAP research reactor designs, from subcritical and critical assemblies to high-power reactors. [ABSTRACT FROM AUTHOR]

The BaCo code ("Barra Combustible") was developed at the Atomic Energy National Commission of Argentina (CNEA) for the simulation of nuclear fuel rod behaviour under irradiation conditions.We present in this paper a brief description of the code and the strategy used for the development, improvement, enhancement, and validation of a BaCo during the last 30 years. "Extreme case analysis", parametric (or sensitivity), probabilistic (or statistic) analysis plus the analysis of the fuel performance (full core analysis) are the tools developed in the structure of BaCo in order to improve the understanding of the burnup extension in the Atucha I NPP, and the design of advanced fuel elements as CARA and CAREM. The 3D additional tools of BaCo can enhance the understanding of the fuel rod behaviour, the fuel design, and the safety margins. The modular structure of the BaCo code and its detailed coupling of thermo-mechanical and irradiation-induced phenomena make it a powerful tool for the prediction of the influence of material properties on the fuel rod performance and integrity. [ABSTRACT FROM AUTHOR]

FRAM-F/(Ph)otometric Robotic Atmospheric Monitor is one of the atmospheric monitoring instruments at the Pierre Auger Observatory in Argentina. FRAM is an optical telescope equipped with CCD cameras and photometer, and it automatically observes a set of selected standard stars. Primarily, FRAM observations are used to obtain the wavelength dependence of the light extinction. FRAM telescope is also able to observe secondary astronomical targets, and namely the detection of optical counterparts of gamma-ray bursts has already proven to be successful. Finally, a wide-field CCD camera of FRAM can be used for rapid monitoring of atmospheric conditions along the track of particularly interesting cosmic ray showers. The hardware setup of the telescope, its software system, data taking procedures, and results of analysis are described in this paper. [ABSTRACT FROM AUTHOR]

The ingestion of foreign bodies causing esophageal injuries is a common event, mostly in children’s population. The aim of the present paper is to present foreign body (FB) ingestion cases observed in a five-year period at the Children’s Hospital Gutierrez, Buenos Aires, Argentina and to compare the main findings with data coming from other well-known case series, already published in scientific literature. A prospective study on 320 of esophageal foreign body was carried out , with regard to age and sex distributions, type, dimensions and consistency, location, clinical presentation, removal and complications. In the majority of cases injuries happened while children were playing and in 85.3% adults were present. Children most frequently ingested coins (83.8% cases). Removal was performed in all cases under general anaesthesia, in 34 by esophageal forceps and in 286 cases by Magill hypopharyngeal forceps. Just one case showed complications, presenting esophageal perforation. The final results of this study show that injuries usually happen under adults’ supervision and highlight that FBs involved in the incident belong to classes of objects not conceived for children’s use and not suitable for their age. Therefore, educational strategies regarding safe behaviours have a key role in FB injuries prevention. [ABSTRACT FROM AUTHOR]

Porphyrias are a group of metabolic diseases that arise from deficiencies in the heme biosynthetic pathway. A partial deficiency in hydroxymethylbilane synthase (HMBS) produces a hepatic disorder named Acute Intermittent Porphyria (AIP); the acute porphyria is more frequent in Argentina. In this paper we review the results obtained for 101 Argentinean AIP families and 6 AIP families from foreign neighbour countries studied at molecular level at Centro de Investigaciones sobre Porfirinas y Porfirias (CIPYP). Thirty-five different mutations were found, of which 14 were described for the first time in our population. The most prevalent type of mutations was the missense mutations (43%) followed by splice defects (26%) and small deletions (20%). An odd case of a double heterozygous presentation of AIP in a foreign family from Paraguay is discussed. Moreover, it can be noted that 38 new families were found carrying the most frequent mutation in Argentina (p.G111R), increasing to 55.66% the prevalence of this genetic change in our population and adding further support to our previous hypothesis of a founder effect for this mutation in Argentina. Identification of patients with an overt AIP is important because treatment depends on an accurate diagnosis, but more critical is the identification of asymptomatic relatives to avoid acute attacks which may progress to death. [ABSTRACT FROM AUTHOR]

Background. Irrational use of antimicrobials (ATMs) triggers microbial resistance (AMR) which has severe consequences for human health. ATM consumption varies among countries and within each territory. These data should be known, in order to perform local policies towards AMR reduction. This work aimed to expose the association of the level of consumption of carbapenems and fluoroquinolones with their resistance rates in Pseudomonas aeruginosa in Argentina. Method. Consumption of antimicrobials was expressed by defined daily dose (DDD)/1000 inhabitants for each ATM during one year period, discriminating by each country region. Resistance of P. aeruginosa to carbapenems/fluoroquinolones groups was recorded. Consumption/resistance ratio "R" was calculated for each region of the country, comparing results with other countries. Results. P. aeruginosa resistance rate to fluoroquinolone (F) was 26.4% in blood samples and 29.7% in urine samples, whereas resistance rates to carbapenems (C) were 19.9 and 17.7% in blood and urine, respectively. Correlation between consumption and resistance was demonstrated for both antimicrobials (C : R = 0.58; p = 0.003 and F : R = 0.77; p = 0.0001). Great fluctuations of resistance levels were seen among regions within the country, always correlating resistance with areas in which a higher level of ATM consumption was detected. Conclusion. P. aeruginosa resistance to fluoroquinolone/carbapenems in Argentina directly correlated with antimicrobial consumption levels. A great heterogeneity in resistance profile was observed among areas where ATMs were widely used. Global data at the national level might mask local realities that require specific health policies in order to control the irrational use of ATMs. [ABSTRACT FROM AUTHOR]

The Chaco plain region in Argentina is located in the north of the country and east of Los Andes where the main activity is the agriculture. As such activity is highly affected by interannual rainfall variability, the influence of some of the principal atmospheric and oceanic forcing is investigated in this paper. Results show that the factors which affect precipitation highly depend on the season and the subregion. The position of the South Atlantic Height and the sea surface temperature in the coast of southern Brazil and Buenos Aires seem to be the factors that affect rainfall, all over the year. The El Niño-Southern Oscillation phenomenon affects summer and spring rainfall and the Southern Annular Mode involves spring precipitation but both only in the east of the study region. Furthermore, enhanced convection in Central Brazil, mainly influences autumn and spring rainfall. [ABSTRACT FROM AUTHOR]

The close contact between dogs and humans creates the best bridge for interspecies transmission of antimicrobial-resistant bacteria. The surveillance of its resistance including the detection of extended-spectrum beta-lactamases (ESBLs) in Escherichia coli as indicator bacteria is an important tool to control the use of antimicrobials. The aim of this research was to evaluate the E. coli resistance in strains by phenotypic methods, isolated from pet and stray dogs of La Plata city, Argentina. Faecal samples were collected using rectal swabs from 50 dogs with owners (home dogs = HD) and 50 homeless dogs (stray dogs = SD). They were cultured in 3 MacConkey agar plates, with and without antibiotics (ciprofloxacin and cefotaxime). 197 strains were isolated, of which only 95 strains were biochemically identified as E. coli, 46 strains were from HD, and 49 were from SD. Antimicrobial susceptibility was evaluated by the Kirby–Bauer disk diffusion method. The most prevalent resistance was for tetracycline, streptomycin, and ampicillin. In both groups, the level of resistance to 3rd generation cephalosporins was high, and there were multiresistant strains. There was a higher level of antimicrobial resistance in strains from SD compared to HD. There were 8% of strains suspected of being ESBLs among samples of HD and 36% of SD. One (2%) of the strains isolated from HD and 11 (22%) from SD were phenotypically confirmed as ESBL. Pets and stray dogs are a potential source of E. coli antibiotic resistance in Argentina; therefore, its surveillance must be guaranteed. [ABSTRACT FROM AUTHOR]

Tuberculosis (TB) is an infectious disease, caused by Mycobacterium tuberculosis, primarily affecting the lungs. The M. tuberculosis strain of the Haarlem family named M was responsible for a large multidrug-resistant TB (MDR-TB) outbreak in Buenos Aires. This outbreak started in the early 1990s and in the mid 2000s still accounted for 29% of all MDR-TB cases in Argentina. By contrast, a clonal variant of strain M, named 410, has caused a single tuberculosis case since the onset of the outbreak. The molecular bases of the high epidemiological fitness of the M strain remain unclear. To assess its unique molecular properties, herein, we performed a comparative protein and lipid analysis of a representative clone of the M strain (Mp) and the nonprosperous M variant 410. We also evaluated their growth in low pH. The variant 410 had higher levels of latency proteins under standard conditions and delayed growth at low pH, suggesting that it is more sensitive to stress stimuli than Mp. Moreover, Mp showed higher levels of mycolic acids covalently attached to the cell wall and lower accumulation of free mycolic acids in the outer layer than the 410 strain. The low expression of latency proteins together with the reduced content of surface mycolic acids may facilitate Mp to evade the host immune responses. [ABSTRACT FROM AUTHOR]

The osteoporotic hip fracture is associated with a high impact on morbidity, mortality, and health expenditure. The Chilean health system is made up of a mixed care system, with the public system called FONASA and the private system called ISAPRE. The people with lower incomes are listed on FONASA and correspond to 80.8% of the population. The aims of this study were to describe the incidence of hip fracture in the Chilean population from the age of 45 years and to estimate the direct medical cost of this disease. The records of the Department of the Health Statistics and Information of the Ministry of Health were used, from which the number of national hospital discharges due to hip fractures was obtained (codes S720, S721, and S722 of the ICD-10), in adults aged 45 years or older, by sex, from 2006 to 2017. The cost of osteoporotic hip fracture treatment in the public health system was obtained from the data of the surgical treatment according to the payment method associated with diagnosis (PAD bonus). A surgical intervention budget was used in a private clinic to calculate the direct cost of osteoporotic hip fracture in the private system. Between 2006 and 2017, the number of hospital discharges due to osteoporotic hip fracture in adults aged 45 years and older has increased progressively, registering 9.583 hospital discharges for this cause in 2017, which corresponds to 50% more than those recorded in 2006, with a 3 : 1 F/M ratio. The mean annual rate of hip fractures is 148.7 per 100,000 inhabitants aged above 45 years. The individual cost of managing an osteoporotic hip fracture in the public system was USD$ 3,919, and USD$ 9,092 in the private health system. The incidence of hip fracture was comparable with data from Southern European countries and from neighboring countries, such as Argentina and Uruguay. Hospitalization cost of hip fracture in Chile was 34 million USD per year. Hip fracture constitutes a serious healthcare problem in Chile, and efforts for the prevention and management of osteoporosis are needed. [ABSTRACT FROM AUTHOR]

Plants are a significant reservoir of cytotoxic agents, including compounds with the ability to interfere with multidrug-resistant (MDR) cells. With the aim of finding promising candidates for chemotherapy, 91 native and naturalized plants collected from the central region of Argentina were screened for their cytotoxic effect toward sensitive and MDR P-glycoprotein (P-gp) overexpressing human leukemia cells by means of MTT assays. The ethanol extracts obtained from Aldama tucumanensis, Ambrosia elatior, Baccharis artemisioides, Baccharis coridifolia, Dimerostemma aspilioides, Gaillardia megapotamica, and Vernonanthura nudiflora presented outstanding antiproliferative activity at 50 μg/mL, with inhibitory values from 93 to 100%, when tested on the acute lymphoblastic leukemia (ALL) cell line CCRF-CEM and the resistant derivative CEM-ADR5000, while 70–90% inhibition was observed against the chronic myelogenous leukemia (CML) cell K562 and its corresponding resistant subline, Lucena 1. Subsequent investigation showed these extracts to possess marked cytotoxicity with IC50 values ranging from 0.37 to 29.44 μg/mL, with most of them being below 7 μg/mL and with ALL cells, including the drug-resistant phenotype, being the most affected. G. megapotamica extract found to be one of the most effective and bioguided fractionation yielded helenalin (1). The sesquiterpene lactone displayed IC50 values of 0.63, 0.19, 0.74, and 0.16 μg/mL against K562, CCRF-CEM, Lucena 1, and CEM/ADR5000, respectively. These results support the potential of these extracts as a source of compounds for treating sensitive and multidrug-resistant leukemia cells and support compound 1 as a lead for developing effective anticancer agents. [ABSTRACT FROM AUTHOR]

The use of medicinal plants mixed with yerba mate (Ilex paraguariensis) has been poorly studied in the ethnopharmacological literature so far. The Paraguayan Mestizo people have the longest tradition of using the yerba mate beverage, apart from the indigenous Guarani people. This study analyses the role of yerba mate and medicinal plants in the treatment of illnesses within Paraguayan folk medicine. The research was conducted among 100 Paraguayan migrants living in Misiones, Argentina, in 2014 and 2015. Yerba mate is not considered to be amedicinal plant by its own virtues but is culturally a very important type ofmedicinal plant intake. Ninety-seven species are employed in hot and cold versions of the yerba mate beverage. The most important species are as follows:Allophylus edulis (highest number of citations),Aristolochia triangularis (highest relative importance value), and Achyrocline flaccida and Achyrocline tomentosa (highest score by Index of Agreement on Species). The plants are used in the treatment of 18 medicinal categories, which include illnesses traditionally treated with plants: digestive system, humoral medicine, and relatively new health conditions such as diabetes, hypertension, and high levels of cholesterol. Newly incorporated medicinal plants, such as Moringa oleifera, are ingested predominantly or exclusively with the mate beverage. [ABSTRACT FROM AUTHOR]

Chagas disease (CD) is a tropical parasitic disease largely underdiagnosed and mostly asymptomatic affecting marginalized rural populations. Argentina regularly reports acute cases of CD, mostly young individuals under 14 years old. There is a void of knowledge of health care seeking behavior in subjects experiencing a CD acute condition. Early treatment of the acute case is crucial to limit subsequent development of disease. The article explores how the health outcome of persons with acute CD may be conditioned by their health care seeking behavior. The study, with a qualitative approach, was carried out in rural areas of Santiago del Estero Province, a high risk endemic region for vector transmission of CD. Narratives of 25 in-depth interviews carried out in 2005 and 2006 are analyzed identifying patterns of health care seeking behavior followed by acute cases. Through the retrospective recall of paths for diagnoses, weaknesses of disease information, knowledge at the household level, and underperformance at the provincial health care system level are detected. The misdiagnoses were a major factor in delaying a health care response. The study results expose lost opportunities for the health care system to effectively record CD acute cases. [ABSTRACT FROM AUTHOR]

We evaluated results of temozolomide (TMZ) therapy in six patients, aged 34–78 years, presenting aggressive pituitary tumors. In all the patients tested O6-methylguanine-DNA methyltransferase (MGMT) immunoexpression in surgical specimens was absent. Patients received temozolomide 140–320 mg/day for 5 days monthly for at least 3 months. In two patients minimum time for evaluation could not be reached because of death in a 76-year-old man with a malignant prolactinoma and of severe neutro-thrombopenia in a 47-year-old woman with nonfunctioning pituitary adenoma. In two patients (a 34-year-old acromegalic woman and a 39-year-old woman with Nelson’s syndrome) no response was observed after 4 and 6 months, respectively, and the treatment was stopped. Conversely, two 52- and 42-year-old women with Cushing’s disease had long-term total clinical and radiological remissions which persisted after stopping temozolomide. We conclude that TMZ therapy may be of variable efficacy depending on—until now—incompletely understood factors. Cooperative work on a greater number of cases of aggressive pituitary tumors should be crucial to establish the indications, doses, and duration of temozolomide administration. [ABSTRACT FROM AUTHOR]

A description of the results for a Station Black-Out analysis for Atucha 2 Nuclear Power Plant is presented here. Calculations were performed with MELCOR 1.8.6 YV3165 Code. Atucha 2 is a pressurized heavy water reactor, cooled and moderated with heavy water, by two separate systems, presently under final construction in Argentina. The initiating event is loss of power, accompanied by the failure of four out of four diesel generators. All remaining plant safety systems are supposed to be available. It is assumed that during the Station Black-Out sequence the first pressurizer safety valve fails stuck open after 3 cycles of water release, respectively, 17 cycles in total. During the transient, the water in the fuel channels evaporates first while the moderator tank is still partially full. The moderator tank inventory acts as a temporary heat sink for the decay heat, which is evacuated through conduction and radiation heat transfer, delaying core degradation. This feature, together with the large volume of the steel filler pieces in the lower plenum and a high primary system volume to thermal power ratio, derives in a very slow transient in which RPV failure time is four to five times larger than that of other German PWRs. [ABSTRACT FROM AUTHOR]

In Argentina, oregano (Origanum spp.) is one of the most important aromatic species. Leaves and flowering tops are used as seasoning, targeting the retail consumer, industrial and less to export. Local production has low-average yields due to the variability of cultivated material, the vegetative propagation methods used, and the lack of knowledge and adaptive experimentation on advanced cultivation practices. Clones of oregano grown in the country were collected in order to characterize the germplasm used in Argentina. Twelve oregano clones, sanitized by meristems culture and micropropagated in vitro, were field evaluated in three different growing locations. Regardless of growing site, the quantitative variables with more discriminating value were essential oils yield, internode length, length of the longest branch, fresh weight, dry weight of leaf and stem, leaf/stem ratio, and leaf area. Based on the quantitative traits, oregano clones can be classified into four groups. From the observations based on botanical characteristics, it was determined that the evaluated clones belong to three different taxa: Origanum vulgare ssp. vulgare, Origanum vulgare ssp. hirtum, and Origanum x majoricum (hybrid).Within each group, the clones belong to the same taxon. [ABSTRACT FROM AUTHOR]

The ethical bases of Argentina's radiation safety approach are reviewed. The applied principles are those recommended and established internationally, namely: the principle of justification of decisions that alters the radiation exposure situation; the principle of optimization of protection and safety; the principle of individual protection for restricting possible inequitable outcomes of optimized safety; and the implicit principle of intergenerational prudence for protection future generations and the habitat. The principles are compared vis-à-vis the prevalent ethical doctrines: justification vis-à-vis teleology; optimization vis-à-vis utilitarianism; individual protection vis-à-vis deontology; and, intergenerational prudence vis-à-vis aretaicism (or virtuosity). The application of the principles and their ethics in Argentina is analysed. These principles are applied to ALL exposure to radiation harm; namely, to exposures to actual doses and to exposures to actual risk and potential doses, including those related to the safety of nuclear installations, and they are harmonized and applied in conjunction. It is concluded that building a bridge among all available ethical doctrines and applying it to radiation safety against actual doses and actual risk and potential doses is at the roots of the successful nuclear regulatory experience in Argentina. [ABSTRACT FROM AUTHOR]

The aim of this study was to evaluate fungi and contamination levels of aflatoxin B1, ochratoxin A, fumonisin B1, and zearalenone in raw materials and finished feed intended for sows at different reproductive stages. Total fungi, Aspergillus, Penicillium, and Fusarium species occurrence, were examined. Aspergillus flavus, A. niger aggregate spp., and F. verticillioides were the prevalent species. Fungal counts exceeded the levels proposed as feed hygienic quality limits (1×104 colony forming units) at all reproductive stages. Aflatoxin B1, ochratoxin A, fumonisin B1, and zearalenone were detected by high-pressure liquid chromatography. Aflatoxin levels in 80% samples of finished sow feeds were over the permitted levels of 0.02 μg g-1 (mean 228.2±95 μg Kg-1). Fumonisin B1 was detected in all tested raw materials at levels that varied from 50.3 to 1137.64 μg Kg-1 and finished feed samples at levels that ranged from 99.8 to 512.4 μg Kg-1. Aflatoxin B1, zearalenone, and ochratoxin A were not detected in raw materials. All finished feeds were negative for zearalenone contamination whereas all nonpregnant gilt samples were contaminated with low OTA levels (mean 0.259±0.123). This fact requires periodic monitoring to prevent the occurrence of mycotoxicosis in animal production, to reduce the economic losses, and to minimize hazards to human health. [ABSTRACT FROM AUTHOR]

The article focuses on the experiment which examines the primary mass inventory of natural circulation (NC) in the operation of ATUCHA-I PHWR nuclear power plant (NPP) in Argentina. The experiment applied heavy water to pressurize, cool and moderate heavy water reactors. NRC-RELAP5/MOD3.3 is the code used to perform the simulation analysis and the results are presented as natural circulation flow maps. The effect of pressurize size which showed the predicted evolution curve in the NC flow map (NCFM) is also discoursed.