1. Association of NLRP1 and NLRP3 Polymorphisms with Psoriasis Vulgaris Risk in the Chinese Han Population.
- Author
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Yu, Pei, Hao, Siyu, Zheng, Hewei, Zhao, Xueying, and Li, Yuzhen
- Subjects
PSORIASIS ,DISEASE risk factors ,CHI-squared test ,CHINESE people ,CONFIDENCE intervals ,GENETIC polymorphisms ,CASE-control method ,DATA analysis software ,DESCRIPTIVE statistics ,ODDS ratio ,GENOTYPES - Abstract
Aim . To clarify the association between the single nucleotide polymorphisms (SNPs) in theNLRP1 andNLRP3 and Psoriasis Vulgaris (PsV) in the Chinese Han population.Methods . We genotyped eight SNPs, four fromNLRP1 (rs8079034, rs11651270, rs11657747, and rs878329) andNLRP3 (rs7512998, rs3806265, rs10754557, and rs10733113) each in 540 patients with PsV and 612 healthy controls in the Chinese Han population using an improved multiplexed ligation detection reaction (iMLDR) method. The genotype and haplotype frequencies were analyzed using a case-control study design.Results . We identified two SNPs, rs3806265 and rs10754557, inNLRP3 that were significantly associated with PsV. The genotype distribution of the rs3806265 SNP was significantly different between cases and controls (p=0.0451; OR = 0.791; 95% CI = 0.627–0.998). In the recessive model, the genotype distribution of the rs10754557 SNP was significantly different between cases and controls (p=0.0344; OR = 1.277; 95% CI = 0.987–1.652). The haplotype analysis of rs3806265 and rs10754557 also presented a significant association of TA haplotype with PsV (χ2 =4.529; p=0.033).Conclusion . NLRP3 may play a role in PsV susceptibility in the Chinese Han population. [ABSTRACT FROM AUTHOR]- Published
- 2018
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