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Arsenic (As) is identified by the EPA as the third highest toxic inorganic contaminant. Almost every 9th or 10th human in more than 70 countries including mainland China is affected by As. Arsenic along with other toxins not only affects human life but also creates alarming situations such as the deterioration of farm lands and desertion of industrial/mining lands. Researchers and administrators have agreed to opt for phytoremediation of As over costly cleanups. Boehmeria nivea L. can soak up various heavy metals, such as Sb, Cd, Pb, and Zn. But the effect of As pollution on the biology and metabolism of B. nivea has been somewhat overlooked. This study attempts to evaluate the extent of As resistance, chlorophyll content, and metabolic changes in As-polluted (5, 10, 15, and 20 mg L−1 As) B. nivea in hydroponics. Toxic effects of As in the form of inhibited growth were apparent at the highest level of added As. The significant changes in the chlorophyll, electrolyte leakage, and H2O2, significant increases in As in plant parts, catalase (CAT), and malondialdehyde (MDA), with applied As revealed the potential of B. nivea for As decontamination. By employing the metabolic machinery of B. nivea, As was sustainably removed from the contaminated areas. [ABSTRACT FROM AUTHOR]

From the Global Agro-Ecological Zone (GAEZ) model, changes in the three climate factors (temperature, precipitation, and solar radiation) over the past five decades showed different trends and that production potential was impacted significantly by the geographic heterogeneity of climate change. An increase of approximately 1.58 million tons/decade in production potential correlated with climate change. Regions with increased production potential were located mainly in the Northeast China Plain, the northern arid and semiarid region, and the Huang-Huai-Hai Plain. Regions with decreased production potential were located mainly in the Middle-lower Yangtze Plain and southern China. The climate factors that impacted production potential varied by region. In the Northeast China Plain, increased temperature was the major cause of the increased production potential. In the northern arid and semiarid region, temperature and precipitation were the major factors affecting production potential, but their effects were in opposition to each other. In southern China, increased temperature and decreased solar radiation caused a decreased production potential. In the Middle-lower Yangtze Plain, a decrease in solar radiation was the major factor resulting in decreased production potential. In the Huang-Huai-Hai Plain, changes in temperature and solar radiation had large but opposite effects on production potential. [ABSTRACT FROM AUTHOR]

Many studies have demonstrated a compensatory amplification phenomenon during nerve regeneration. When a relatively fine nerve is used as a donor to connect to a distal nerve after transection, the donor nerve regenerates more collaterals than its own fibers, which extend to the distal stump, grow into distal endoneurial tubes, and finally reach and dominate the target organs. This is known as the amplification phenomenon. In this study, we investigated the amplification phenomenon in rats treated with Modified Formula Radix Hedysari (MFRH) as adjuvant therapy for 12 weeks. The rats were divided into three groups at random (six animals in each group). In the model group and the treatment group, the proximal common peroneal nerve was used as a donor nerve to connect to the distal tibial nerve. Rats in the normal group did not undergo surgery. After surgery, the treatment group was administered MFRH as systemic therapy, while the model group and the normal group were not given treatment. The results demonstrated that the nerve conduction velocity, the fiber diameter, the axon diameter, the number of regenerating nerve fibers, and the amplification ratio were better in the treatment group than in the model group, suggesting that MFRH promoted the nerve amplification effect. [ABSTRACT FROM AUTHOR]

We aim to investigate the therapeutic effects of QSYQ, a drug of heart failure (HF) in clinical practice in China, on a rat heart failure (HF) model. 3 groups were divided: HF model group (LAD ligation), QSYQ group (LAD ligation and treated with QSYQ), and sham-operated group. After 4 weeks, rats were sacrificed for cardiac injury measurements. Rats with HF showed obvious histological changes including necrosis and inflammation foci, elevated ventricular remodeling markers levels(matrix metallo proteinases-2, MMP-2), deregulated ejection fraction (EF) value, increased formation of oxidative stress (Malondialdehyde, MDA), and upregulated levels of apoptotic cells (caspase-3,p53 and tunnel) in my ocardial tissue. Treatment of QSYQ improved cardiac remodeling through counter-acting those events. The improvement of QSYQ was accompanied with a restoration of NADPH oxidase 4 (NOX4) and NADPH oxidase 2 (NOX2) pathways in different patterns. Administration of QSYQ could attenuate LAD-induced HF, and AngII-NOX2-ROS-MMPs pathway seemed to be the critical potential targets for QSYQ to reduce the remodeling. Moreover, NOX4 was another key targets to inhibit the p53 and Caspase 3, thus to reduce the hypertrophy and apoptosis, and eventually provide a synergetic cardiac protective effect. [ABSTRACT FROM AUTHOR]