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In the context of its 40th anniversary, this article analyses how the Association of Southeast Asian Nations (ASEAN) has sought to deal with the problem of drug production, trafficking and consumption in Southeast Asia. Reviewing more than three decades of cooperation, it asks whether an international regime against the illicit trafficking and abuse of drugs has been established in the region under the auspices of ASEAN. In particular, the paper discusses the ASEAN and China Cooperative Operations in Response to Dangerous Drugs (ACCORD) as an attempt to create a framework of multilateral cooperation. It argues however that it is still premature today to characterise existing regional consultations as a working anti-drug regime. The existing cooperative structure has remained a loose forum for information sharing despite the strong Chinese involvement that has deepened consultations since the late 1990s. [ABSTRACT FROM AUTHOR]