1. Reduction in Serum High Mobility Group Box-1 Level by Polymyxin B-Immobilized Fiber Column in Patients with Idiopathic Pulmonary Fibrosis with Acute Exacerbation.
- Author
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Abe, Shinji, Hayashi, Hiroki, Seo, Yoshitsugu, Matsuda, Kuniko, Kamio, Koichiro, Saito, Yoshinobu, Usuki, Jiro, Azuma, Arata, Kudo, Shoji, and Gemma, Akihiko
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POLYMYXIN ,PULMONARY fibrosis ,LUNG diseases ,IDIOPATHIC pulmonary fibrosis ,INFLAMMATION - Abstract
Background/Aim: Recent reports suggest that polymyxin B (PMX)-immobilized fiber may have beneficial effects in idiopathic pulmonary fibrosis (IPF) with acute exacerbation (AE). High mobility group box-1 (HMGB-1) is an important pro-inflammatory mediator that contributes to acute lung inflammation. This study was aimed to investigate whether PMX treatment affects serum HMGB-1 levels and oxygenation in IPF patients with AE. Materials and Methods: Twenty IPF patients with AE were treated by PMX. PMX treatment was carried out once daily for 2 successive days. Serum HMGB-1 levels were measured before and after PMX treatment. We also monitored arterial oxygen tension (PaO
2 )/inspiratory oxygen fraction (FiO2 ) (P/F) ratio. PMX fiber columns were analyzed to examine whether HMGB-1 was absorbed by PMX. Results: PMX treatment significantly improved both the serum HMGB-1 level and P/F ratio. HMGB-1 was detected in washing medium from the PMX column. Conclusion: PMX treatment may reduce serum HMGB-1 and improve oxygenation in patients with IPF with AE. Copyright © 2011 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]- Published
- 2011
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