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The sudden outbreak of the COVID-19 pandemic has changed people's long-standing group life, and "less gathering" has become a popular slogan during this period. People will probably feel lonely when they are physically, socially, or mentally distanced and isolated or excluded, and they usually perceive a deficiency in the quality or quantity of their social relationships. Although loneliness is easily conflated with solitude, loneliness as an emotion is generally regarded as negative while solitude can be positive. There are various causes and effects of loneliness during the COVID-19 pandemic, and loneliness has been found to have significant impacts on poorer physical and mental health. Religiosity and spirituality are specifically proven to have a great impact on handling loneliness during the COVID-19 pandemic. When regarding belongingness as the opposite of loneliness and social isolation, religious belonging means a feeling of being "at home" and "connected". In this paper, from a comparative approach, we attempt to investigate how the three most prominent traditions in East Asia, i.e., Confucianism, Daoism, and Buddhism, can help manage the feeling of loneliness. Due to different understandings of loneliness, their coping strategies for loneliness also vary. Through a preliminary study of "benevolence and rites," "wu-wei and freedom," and "mindfulness and spiritual realization," we can learn from the ancient wisdom about how to reduce loneliness and promote spiritual well-being during the COVID-19 pandemic. [ABSTRACT FROM AUTHOR]

Ganoderma lucidum has a long history of medicinal uses in the Far East countries of more than 2000 years due to its healing properties. Recently, G. lucidum has come under scientific scrutiny to evaluate its content of bioactive components that affect human physiology, and has been exploited for potent components in the pharmacology, nutraceuticals, and cosmetics industries. For instance, evidence is accumulating on the potential of this mushroom species as a promising antiviral medicine for treating many viral diseases, such as dengue virus, enterovirus 71, and recently coronavirus disease of 2019 (COVID-19). Still, more research studies on the biotherapeutic components of G. lucidum are needed to ensure the safety and efficiency of G. lucidum and promote the development of commercial functional foods. This paper provides an extensive overview of the nutraceutical value of Ganoderma lucidum and the development of commercial functional food. Moreover, the geo-origin tracing strategies of this mushroom and its products are discussed, a highly important parameter to ensure product quality and safety. The discussed features will open new avenues and reveal more secrets to widely utilizing this mushroom in many industrial fields; i.e., pharmaceutical and nutritional ones, which will positively reflect the global economy. [ABSTRACT FROM AUTHOR]

The literature reports that there was a significant difference in the medical impact of the coronavirus disease (COVID-19) pandemic between European and East Asian countries; specifically, the mortality rate of COVID-19 in Europe was significantly higher than that in East Asia. Considering such a difference, our narrative review aimed to compare the prevalence and characteristics of residual lung abnormalities at one-year follow-up computed tomography (CT) after severe or critical COVID-19 in survivors of European and East Asian countries. A literature search was performed to identify articles focusing on the prevalence and characteristics of CT lung abnormalities in survivors of severe or critical COVID-19. Database analysis identified 16 research articles, 9 from Europe and 7 from East Asia (all from China). Our analysis found a higher prevalence of CT lung abnormalities in European than in Chinese studies (82% vs. 52%). While the most prevalent lung abnormalities in Chinese studies were ground-glass opacities (35%), the most prevalent lung abnormalities in European studies were linear (59%) and reticular opacities (55%), followed by bronchiectasis (46%). Although our findings required confirmation, the higher prevalence and severity of lung abnormalities in European than in Chinese survivors of COVID-19 may reflect a greater architectural distortion due to a more severe lung damage. [ABSTRACT FROM AUTHOR]

Antimicrobials have allowed medical advancements over several decades. However, the continuous emergence of antimicrobial resistance restricts efficacy in treating infectious diseases. In this context, the drug repositioning of already known biological active compounds to antimicrobials could represent a useful strategy. In 2002 and 2003, the SARS-CoV pandemic immobilized the Far East regions. However, the drug discovery attempts to study the virus have stopped after the crisis declined. Today's COVID-19 pandemic could probably have been avoided if those efforts against SARS-CoV had continued. Recently, a new coronavirus variant was identified in the UK. Because of this, the search for safe and potent antimicrobials and antivirals is urgent. Apart from antiviral treatment for severe cases of COVID-19, many patients with mild disease without pneumonia or moderate disease with pneumonia have received different classes of antibiotics. Diarylureas are tyrosine kinase inhibitors well known in the art as anticancer agents, which might be useful tools for a reposition as antimicrobials. The first to come onto the market as anticancer was sorafenib, followed by some other active molecules. For this interesting class of organic compounds antimicrobial, antiviral, antithrombotic, antimalarial, and anti-inflammatory properties have been reported in the literature. These numerous properties make these compounds interesting for a new possible pandemic considering that, as well as for other viral infections also for CoVID-19, a multitarget therapeutic strategy could be favorable. This review is meant to be an overview on diarylureas, focusing on their biological activities, not dwelling on the already known antitumor activity. Quite a lot of papers present in the literature underline and highlight the importance of these molecules as versatile scaffolds for the development of new and promising antimicrobials and multitarget agents against new pandemic events. [ABSTRACT FROM AUTHOR]

The importance of host genetics and demography in coronavirus disease 2019 (COVID-19) is a crucial aspect of infection, prognosis and associated case fatality rate. Individual genetic landscapes can contribute to understand Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) burden and can give information on how to fight virus spreading and the associated severe acute respiratory distress syndrome (ARDS). The spread and pathogenicity of the virus have become pandemic on specific geographic areas and ethnicities. Interestingly, SARS-CoV-2 firstly emerged in East Asia and next in Europe, where it has caused higher morbidity and mortality. This is a peculiar feature of SARS-CoV-2, different from past global viral infections (i.e., SARS-1 or MERS); it shares with the previous pandemics strong age- and sex-dependent gaps in the disease outcome. The observation that the severest COVID-19 patients are more likely to have a history of hypertension, diabetes and/or cardiovascular disease and receive Renin-Angiotensin-System (RAS) inhibitor treatment raised the hypothesis that RAS-unbalancing may have a crucial role. Accordingly, we recently published a genetic hypothesis on the role of RAS-pathway genes (ACE1, rs4646994, rs1799752, rs4340, rs13447447; and ACE2, rs2285666, rs1978124, rs714205) and ABO-locus (rs495828, rs8176746) in COVID-19 prognosis, suspecting inherited genetic predispositions to be predictive of COVID-19 severity. In addition, recently, Genome-Wide Association Studies (GWAS) found COVID-19-association signals at locus 3p21.31 (rs11385942) comprising the solute carrier SLC6A20 (Na+ and Cl- coupled transporter family) and at locus 9q34.2 (rs657152) coincident with ABO-blood group (rs8176747, rs41302905, rs8176719), and interestingly, both loci are associated to RAS-pathway. Finally, ACE1 and ACE2 haplotypes seem to provide plausible explanations for why SARS-CoV-2 have affected more heavily some ethnic groups, namely people with European ancestry, than Asians. [ABSTRACT FROM AUTHOR]

Shortly after the outbreak of the novel infectious disease (COVID-19) started at the end of 2019, it turned into a global pandemic, which caused the lockdown of many countries across the world. Various strict measures were adopted to reduce anthropogenic activities in order to prevent further spread and infection of the disease. In this study, we utilized continental scale remotely sensed data along with city scale in situ air quality observations for 2020 as well as data from the baseline period (2015–2019) to provide an early insight on air pollution changes in response to the COVID-19 pandemic lockdown, by combining both continental and city scales. For the continental scale analysis, data of NO2, SO2, and O3 were acquired from the ozone monitoring instrument (OMI) and data of aerosol optical depth (AOD) were collected from the moderate resolution imaging spectroradiometer (MODIS). For city scale analysis, data of NO2, CO, PM2.5, O3, and SO2 were derived from ground-based air quality observations. Results from satellite observations at the continental scale showed that concentrations of NO2, SO2, and AOD substantially dropped in 2020 during the lockdown period compared to their averages for the baseline period over all continents, with a maximum reduction of ~33% for NO2 in East Asia, ~41% for SO2 in East Asia, and ~37% for AOD in South Asia. In the case of O3, the maximum overall reduction was observed as ~11% in Europe, followed by ~10% in North America, while a slight increase was found in other study regions. These findings align with ground-based air quality observations, which showed that pollutants such as NO2, CO, PM2.5, and SO2 during the 2020 lockdown period decreased significantly except that O3 had varying patterns in different cities. Specifically, a maximum reduction of ~49% in NO2 was found in London, ~43% in CO in Wuhan, ~38% in PM2.5 in Chennai, and ~48% in SO2 in Beijing. In the case of urban O3, a maximum reduction of ~43% was found in Wuhan, but a significant increase of ~47% was observed in Chennai. It is obvious that restricted human activities during the lockdown have reduced the anthropogenic emissions and subsequently improved air quality, especially across the metropolitan cities. [ABSTRACT FROM AUTHOR]