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Future changes in drought characteristics in Central Asia are projected at the regional scale using 21 climate models from phase 5 of the Coupled Model Intercomparison Project (CMIP5). Based on the standardized precipitation index (SPI) and standardized precipitation evapotranspiration index (SPEI), drought characteristics were characterized by drought frequency at 1-, 3-, and 12-month timescales. The drought duration was analyzed based on SPI1 and SPEI1. Drought indices were calculated by the multimodel ensemble (MME) from 21 CMIP5 models. The varimax rotation method was used to identify drought conditions for the entire area and seven drought subregions. In general, the projection results of future drought in Central Asia are related to the choice of drought index, and SPI and SPEI show different results. The drought frequency based on SPEI1, SPEI3, and SPEI12 showed an increasing trend in the future periods, that is, the drought frequency based on monthly, seasonal, and annual timescales will show an increase trend in the future periods. However, for SPI1, SPI3, and SPI12, the drought frequency will decrease in the future. SPI projected that the duration of drought will decrease in the future, while SPEI mainly showed an increasing trend. The results of the study should be of sufficient concern to policymakers to avoid land degradation, crop loss, water resource deficit, and economic loss. [ABSTRACT FROM AUTHOR]