1. pH-Responsive de-PEGylated nanoparticles based on triphenylphosphine-quercetin self-assemblies for mitochondria-targeted cancer therapy.
- Author
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Xing L, Lyu JY, Yang Y, Cui PF, Gu LQ, Qiao JB, He YJ, Zhang TQ, Sun M, Lu JJ, Xu X, Liu Y, and Jiang HL
- Subjects
- Animals, Antineoplastic Agents chemical synthesis, Antineoplastic Agents chemistry, Antineoplastic Agents pharmacology, Apoptosis drug effects, Caspase 3 metabolism, Caspase 9 metabolism, Cell Line, Tumor, Cytochromes c metabolism, Humans, Hydrogen-Ion Concentration, Male, Membrane Potential, Mitochondrial drug effects, Mice, Inbred ICR, Mitochondria metabolism, Nanoparticles chemistry, Particle Size, Phosphines chemical synthesis, Phosphines chemistry, Phosphines pharmacology, Polyethylene Glycols chemical synthesis, Polyethylene Glycols chemistry, Polyethylene Glycols pharmacology, Polyethylene Glycols therapeutic use, Quercetin chemical synthesis, Quercetin pharmacology, Reactive Oxygen Species metabolism, Antineoplastic Agents therapeutic use, Mitochondria drug effects, Nanoparticles therapeutic use, Phosphines therapeutic use, Quercetin analogs & derivatives, Quercetin therapeutic use
- Abstract
We have developed mitochondria-targeted self-assembled nanoparticles (NPs) based on amphiphilic triphenylphosphine-quercetin (TPP-Que) conjugates, which were further modified by poly(ethylene glycol) via a pH-responsive coordination bond to form TQ-PEG NPs. And it is revealed that the TQ-PEG NPs were more effective therapeutic agents compared with Que in vitro and in vivo.
- Published
- 2017
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