1. The Role of Macrophage Colony-Stimulating Factor in Patients With Acute Myocardial Infarction: A Pilot Study.
- Author
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Novo, Giuseppina, Rizzo, Manfredi, Carruba, Salvatore La, Caruso, Marco, Amoroso, Gisella Rita, Balistreri, Carmela Rita, Coppola, Giuseppe, Evola, Giovanna, Caruso, Calogero, Assennato, Pasquale, Novo, Salvatore, and Mancuso, Dario
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ACADEMIC medical centers , *HEART ventricle diseases , *BIOMARKERS , *CARDIAC output , *CARDIOVASCULAR diseases risk factors , *COLONY-stimulating factors (Physiology) , *CONFIDENCE intervals , *EPIDEMIOLOGY , *LEFT heart ventricle , *HEART beat , *MACROPHAGES , *MULTIVARIATE analysis , *MYOCARDIAL infarction , *STATISTICS , *T-test (Statistics) , *LOGISTIC regression analysis , *PILOT projects , *DATA analysis , *DATA analysis software , *DESCRIPTIVE statistics - Abstract
We assessed whether macrophage colony-stimulating factor (M-CSF) levels are associated with left ventricular systolic dysfunction (LVSD) in patients with acute myocardial infarction (AMI). We studied 56 patients with AMI (mean age: 67 ± 12 years) and identified those with clinical (Killip class >II) or echocardiographic signs (ejection fraction ≤45%) of LVSD. We evaluated the established cardiovascular risk factors and measured several cardiovascular biomarkers, including M-CSF. Serum M-CSF concentrations (pg/mL) were significantly increased in patients with both clinical and echocardiographic signs of LVSD (460 ± 265 vs 290 ± 210, P = .0103 and 493 ± 299 vs 287 ± 174, P = .0028, respectively). We found a significant inverse association between M-CSF and ejection fraction (r = −.351, P = .0079). Logistic regression analysis revealed that, among all evaluated clinical and biochemical parameters, the stronger predictor of LVSD was M-CSF (odds ratios 2.1, 95% confidence interval 1.1-2.9, P = .0168). This is the first study reporting plasma M-CSF levels as independent determinants of low LV ejection fraction and clinical LV dysfunction in patients with AMI. [ABSTRACT FROM PUBLISHER]
- Published
- 2012
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