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Your search keyword '"Willems, A."' showing total 3 results
Start Over Author "Willems, A." Topic therapeutics Publication Year Range Last 50 years Publisher taylor & francis ltd
3 results on '"Willems, A."'

1. Our experience of solitary plasmacytoma of the bone: improved PFS with a short-course treatment by IMiDs or proteasome inhibitors combined with intensity-modulated radiotherapy.

Author

Le Ray, Emmanuelle, Belin, Lisa, Plancher, Corine, Anract, Philippe, Babinet, Antoine, Dumaine, Valérie, Tamburini, Jérôme, Deau Fischer, Bénédicte, Willems, Lise, Magro, Leonardo, Facon, Thierry, Leleu, Xavier, Bouscary, Didier, and Kirova, Youlia M.

Subjects
PLASMACYTOMA, IMIDES, PROTEASOME inhibitors, THERAPEUTICS
Published
2018
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2. Successful treatment of l-asparaginase-induced severe acute hepatotoxicity using mitochondrial cofactors.

Author

Al-Nawakil, Chadi, Willems, Lise, Mauprivez, Cedric, Laffy, Benjamin, Benm'rad, Mona, Tamburini, Jerome, Fontaine, Helene, Sogni, Philippe, Terris, Benoit, Bouscary, Didier, and Moachon, Laurence

Subjects
*ASPARAGINASE, *DRUG side effects, *MITOCHONDRIAL enzymes, *VITAMIN B complex, *CARNITINE, *COFACTORS (Biochemistry), *TREATMENT effectiveness, *VITAMIN therapy, *THERAPEUTICS
Abstract

The article presents three case studies involving patients with acute lymphoblastic leukemia (ALL) who developed L-asparaginase (L-ase)-induced severe acute hepatotoxicity with liver steatosis including a 60-year-old women, a 51-year-old man, and a 64-year-old woman. The article discusses the adverse effect of treatment with L-ase, treatment with the mitochondrial cofactors vitamin B complex and L-carnitine, and the effectiveness of the patients' treatment regimens.

Published
2014
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3. Pulsed dye laser versus treatment with calcipotriol/betamethasone dipropionate for localized refractory plaque psoriasis: Effects on T-cell infiltration, epidermal proliferation and keratinization.

Author

Bovenschen, Jorn H., Erceg, Angelina, Vlijmen‐Willems, Ivonne Van, Van De Kerkhof, Peter C. M., and Seyger, Marieke M. B.

Subjects
DYE lasers, SKIN diseases, PSORIASIS, KERATINIZATION, T cells, THERAPEUTICS
Abstract

Background: Selective photothermolysis of diseased capillaries by pulsed dye laser (PDL) treatment has been described as a mechanism for long-lasting clearance of psoriatic plaques. Aim: To evaluate PDL and a two-compound formulation of calcipotriol/betamethasone dipropionate ointment for the treatment of localized, recalcitrant plaque psoriasis. Methods: Eight psoriatic patients were treated for 4 weeks with both PDL and topical calcipotriol/betamethasone dipropionate in an open, intra-patient, left-right comparison. Biopsies were analyzed for T-cell subsets, cells expressing NK-receptors, epidermal proliferation, differentiation and epidermal thickness. Results: After active treatment, both treatments showed statistically significant but comparable improvements of T-cell subsets, epidermal proliferation, differentiation and epidermal thickness. In line with the clinical results, after an 8-week follow-up period statistically significant further reductions were observed for dermal CD3+, CD4+, CD45RO+, CD2+ T cells, epidermal CD3+, CD8+, CD45RO+, CD2+, CD25+ T cells and the epidermal parameters for the PDL-treated plaques, in contrast to the topically treated plaques. Conclusion: After 8 weeks of follow-up, PDL treatment for localized and recalcitrant plaque psoriasis resulted in persistent reductions of activated and memory effector T-helper cells in the dermis, cytotoxic T cells in the epidermis, and normalization of epidermal proliferation and keratinization, in contrast to treatment with calcipotriol/betamethasone dipropionate ointment. [ABSTRACT FROM AUTHOR]

Published
2007
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