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The purpose of this study was to investigate effects of concurrent and independent administration of dietary nitrate (NO3−), administered as NO3–-rich beetroot juice (BR; ~12.4 mmol of NO3−), and N-acetylcysteine (NAC; 70 mg·kg−1) on physiological responses during prolonged exercise and subsequent high-intensity exercise tolerance. Sixteen recreationally active males supplemented with NO3–-depleted beetroot juice (PL) or BR for 6 days and ingested an acute dose of NAC or maltodextrin (MAL) 1 h prior to performing 1 h of heavy-intensity cycling exercise immediately followed by a severe-intensity time-to-exhaustion (TTE) test in four conditions: 1) PL+MAL, 2) PL+NAC, 3) BR+MAL and 4) BR+NAC. Pre-exercise plasma [NO3−] and nitrite ([NO2−]) were elevated following BR+NAC and BR+MAL (both P < 0.01) compared with PL+NAC and PL+MAL; plasma [cysteine] was increased in PL+NAC and BR+NAC (both P < 0.01) compared to PL+MAL. Muscle excitability declined over time during the prolonged cycling bout in all conditions but was better preserved in PL+NAC compared to BR+NAC (P < 0.01) and PL+MAL (P < 0.05). There was no effect of supplementation on subsequent TTE. These findings indicate that co-ingestion of BR and NAC does not appreciably alter physiological responses during prolonged heavy-intensity cycling or enhance subsequent exercise tolerance. [ABSTRACT FROM AUTHOR]

While previous research has compared outcomes between living donor liver transplantation (LDLT) and deceased donor liver transplantation, evidence is lacking regarding how donation after circulatory death (DCD) vs donation after brain death (DBD) affects this comparison. Using data from the Scientific Registry of Transplant Recipients for adults listed for liver transplant from 2012 to 2018, we compared 5-year patient and graft survival, readmissions, posttransplant chronic kidney disease (CKD), and return to work for 25,151 patients who underwent LDLT (1223 [4.9%]), DCD-LT (1431 [6.4%]), and DBD-LT (22,497 [89.4%]). LDLT recipients were significantly more likely to have a Model for End-Stage Liver Disease (MELD) score < 15 and to be working prior to transplant (P < 0.001 for both). At 5 years posttransplant, LDLT recipients had significantly more readmissions, but significantly less CKD and better survival than DBD-LT and DCD-LT recipients, as well as significantly better graft survival than DCD-LT recipients (P ≤ 0.01 for all). Significantly more LDLT recipients also returned to work for income (P < 0.01). This study shows a clear advantage of LDLT vs DCD-LT. This information should be weighed in transplantation decisions for patients such as those with low MELD scores who will realistically only be considered for DCD-LT. [ABSTRACT FROM AUTHOR]

Indigenous epistemologies view a person as a whole, interconnected to land, in relationship to others. Knowledge is subjective and collective. However, hegemonic western knowledge created dualism that are perpetuated through western schooling with detrimental effects on Indigenous knowledge systems and livelihood. The dualisms separate mind from body, body from nature, and spirit from matter which led to western schooling practices that support goals of settler colonialism including dispossession of Indigenous peoples from their lands. This article presents theoretical and conceptual discussions, personal reflections, and relationship-building the authors engaged while creating decolonizing and Indigenous syllabi in the fields of environmental studies, philosophy, and mathematics education at the university level. Engaging these processes disrupts the separation created through western dualisms and move toward reconnection as an initial step in creating decolonizing curricula, shifting dominant curricula organized through the logics of settler colonialism, to curricula that envision and support Indigenous nations and sovereignty. [ABSTRACT FROM AUTHOR]

Over the past decade, new techniques have been developed to entice and persuade advertisement viewers. One technique, which has grown in popularity, is the use of drones to capture images within an advertisement. While drones are particularly familiar to military use, new regulations have allowed businesses and amateurs to easily obtain and use drones to create images. With that in mind, this study aims to provide evidence that the verticality of images, i.e., those produced by the drone, can affect information processing of advertising, specifically, angles at which the images are being produced having a greater effect on the viewer than images produced at ground level. We propose a theoretical framework which suggests that mental simulation plays a mediating role between the advertisement watched and Attitude towards the Advertisement (Aad). By creating our own stimuli to eliminate outside discrepancies and focus on images, we were able to carry out an online experiment in which 67 university students participated. Results obtained show how drone images affect Aad as well as the mediating role of mental simulation. Implications for theory and practice are also discussed. [ABSTRACT FROM AUTHOR]

Purpose: To determine the accuracy of critical power (CP) and Wʹ (the curvature constant of the power-duration relationship) derived from self-paced time-trial (TT) prediction trials using mobile power meters to predict 16.1-km road cycling TT performance. This study also aimed to assess the agreement between functional threshold power (FTP) and CP. Methods: Twelve competitive male cyclists completed an incremental test to exhaustion, a FTP test and 4-5 self-paced TT bouts on a stationary bike within the lab, and a 16.1 km road TT, using mobile power meters. Results: CP and Wʹ derived from the power-duration relationship closely predicted TT performance. The 16.1-km road TT completion time (26.7 ± 2.2 min) was not significantly different from and was significantly correlated with the predicted time-to-completion (27.5 ± 3.3 min, r = 0.89, P < 0.01). CP and FTP were not significantly different (275 ± 40 W vs. 278 ± 42 W, P > 0.05); however, the limits of agreement between CP and FTP were 30 to -36 W. Discussion: The findings of this study indicate that CP and Wʹ determined using mobile power meters during maximal, self-paced TT prediction trials can be used to accurately predict 16.1-km cycling performance, supporting the application of the CP and Wʹ for performance prediction. However, the limits of agreement were too large to consider FTP and CP interchangeable. [ABSTRACT FROM AUTHOR]