Search

The present study sought to characterise the gut microbiota of subjects with kidney transplantation and healthy control to identify the distinct gut microbiota and analyse their potential function. We found that gut microbiota abundance had significant differences in subjects between the two groups. Line Discriminant Analysis (LDA) Effect Size (LEfSe) analysis showed that the bacterial taxa were differentially represented between the two groups, and the potential biomarkers at different taxonomic levels in kidney transplant recipients were Streptococcus, Enterococcaceae, and Ruminococcus. Phylogenetic investigation of communities by reconstruction of unobserved states (PICRUSt) Functional Inference analyses suggested that the difference in gut microbiota between the two groups was correlated with bile acid metabolism. In conclusion, gut microbiota abundance is different between the two groups, which is related to bile acid metabolism, and may influence the metabolic homeostasis of allograft recipients. [ABSTRACT FROM AUTHOR]

In this paper, we first give some constructions of right (resp. left) Leibniz H-pseudoalgebras and explore the characterization of symmetric Leibniz H-pseudoalgebras. Furthermore, we introduce the notion of relative Rota-Baxter H-operator and show that a right (resp. left) Leibniz H-pseudoalgebra together with a relative Rota-Baxter H-operator gives rise to a representation of related right (resp. left) Leibniz H-pseudoalgebra. Finally, we describe the central extension and the formal deformation in terms of the corresponding second cohomology group. [ABSTRACT FROM AUTHOR]

To develop an alarm device for the mechanical compression device displacement (MCD), and further evaluate its effectiveness in clinical use. The alarm device is mainly composed of buzzer, indicator light, magnetic sheet. This is a prospective randomized and controlled study. Four hundred patients who met the inclusion/exclusion criteria were included and randomly assigned to two groups (MCD group vs alarm + MCD group). The primary outcome measures were the sensitivity and specificity of the alarm device to detect MCD displacement, time to hemostasis (TTH), time to ambulation (TTA), time to hospital discharge (TTHD), hospital costs (HC), complication rates, and patient satisfaction. The sensitivity and specificity of the alarm device in detecting MCD displacement were 94.44% and 88.46%, respectively. The study group achieved shorter TTH (p =.034), shorter TTA (p =.021), lower complication rates (p =.025), and better patients' satisfaction (p <.001) compared to the control group. However, no significant difference was observed in TTHD (p =.361) and HC (p =.583). The alarm device is highly sensitive in detecting MCD displacement, while achieving better clinical outcomes compared with artificial monitoring. [ABSTRACT FROM AUTHOR]

N6-methyladenosine (m6A) modification is an important regulatory factor affecting diseases, including multiple cancers and it is a developing direction for targeted disease therapy. Here, we present the M6ADD (m6A-diseases database) database, a public data resource containing manually curated data on potential m6A-disease associations for which some experimental evidence is available; the related high-throughput sequencing data are also provided and analysed by using different computational methods. To give researchers a tool to query the m6A modification data, the M6ADD was designed as a web-based comprehensive resource focusing on the collection, storage and online analysis of m6A modifications, aimed at exploring the associations between m6A modification and gene disorders and diseases. The M6ADD includes 222 experimentally confirmed m6A-disease associations, involving 59 diseases from a review of more than 2000 published papers. The M6ADD also includes 409,229 m6A-disease associations obtained by computational and statistical methods from 30 high-throughput sequencing datasets. In addition, we provide data on 5239 potential m6A regulatory proteins related to 24 cancers based on network analysis prediction methods. In addition, we have developed a tool to explore the function of m6A-modified genes through the protein–protein interaction networks. The M6ADD can be accessed at . [ABSTRACT FROM AUTHOR]

The article presents the discussion on FDA having responsibility for informing the public about the harms and benefits of e-cigarettes. Topics include contribution to public health by reducing combustible tobacco use, making such products less appealing while simultaneously making e-cigarette products safer; and e-cigarettes and related products subjecting to the same rules as tobacco products.

Let H be a triangular Hopf coquasigroup with bijective antipode and B a cotriangular Hopf coquasigroup with bijective antipode. Under some favorable conditions, the aim of this paper is to find some objects satisfying the double centralizer property for any Hopf coquasigroup A which can be written as a tensor product Hopf coquasigroup H ⊗ B. As a consequence of our theory, both Schur's double centralizer theorems for triangular and cotriangular Hopf algebras can be obtained. Our main result provides a new approach to construct more objects which have double centralizer property too. [ABSTRACT FROM AUTHOR]

The article presents the discussion on cases of family-assisted suicide in East Asia. Topics include preparing poisoned milk for helping the terminally-ill father committing suicide in line with father's request to spare him continued pain and suffering; and considering a more serious crime than ordinary homicide being punishable by capital punishment or life imprisonment.

The aim of this study is to fabricate and test a 3D-printed PCL scaffold incorporating IGF-1-releasing PLGA nanoparticles for cartilage tissue engineering. IGF-1 loaded PLGA nanoparticles were produced by the double-emulsion method, and were incorporated onto 3D printed PCL scaffolds via PDA. Particle size, loading effciency (LE) and encapsulation effciency (EE) of the nanoparticles were examined. SEM, pore size, porosity, compression testing, contact angle, IGF-1 release kinetics of the composite scaffolds were also determined. For cell culture studies, CCK-8, Live/dead, MTT, GAG content and expression level of chondrocytes specific proteins and genes and HIF-1α were also tested. There was no difference of the nanoparticle size. And the LE and EE of IGF-1 in PLGA nanoparticles was about 5.53 ± 0.12% and 61.26 ± 2.71%, respectively. There was a slower, sustained release for all drug-loaded nanoparticles PLGA/PDA/PCL scaffolds. There was no difference of pore size, porosity, compressive strength of each scaffold. The contact angles PCL scaffolds were significant decreased when coated with PDA and PLGA nanoparticales. (p <.05) Live/dead staining showed more cells attached to the IGF-1 PLGA/PDA/PCL scaffolds. The CCK-8 and MTT assay showed higher cell proliferation and better biocompatibility of the IGF-1 PLGA/PDA/PCL scaffolds. (p <.05) GAG content, chondrogenic protein and gene expression level of SOX-9, COL-II, ACAN, and HIF pathway related gene (HIF-1α) were significantly higher in IGF-1 PLGA/PDA/PCL scaffolds group compared to other groups. (p <.05) IGF-1 PLGA/PDA/PCL scaffolds may be a better method for sustained IGF-1 administration and a promising scaffold for cartilage tissue engineering. [ABSTRACT FROM AUTHOR]

Let H be a Hopf coquasigroup over a field k possessing an adjoint quasicoaction. We first show that if M is any right H-module and N is any right H-quasicomodule such that τ M , N ° τ N , M = i d N ⊗ M , where τ N , M : N ⊗ M → M ⊗ N is a favorable map, then we have H = k. As an application of this result, we get that symmetric category H H Y D Q of Yetter-Drinfeld quasicomodules over H is trivial, as a generalization of Pareigis' Theorem. Furthermore, let (H, R) be a quasitriangular Hopf coquasigroup and (B , σ) coquasitriangular Hopf coquasigroup. Then, we show that the category of generalized Long quasicomodules H B L Q is a braided monoidal subcategory of Yetter-Drinfeld category H ⊗ B H ⊗ B Y D Q . Finally, we give a new approach to a braided monoidal category by generalizing one of Schauenburg's main results in the setting of Hopf coquasigroups introduced by Klim and Majid. This yields new sources of braidings that provide solutions to the Yang-Baxter equation playing an important role in various areas of mathematics. [ABSTRACT FROM AUTHOR]

Aims: To report experience of perioperative nursing of tracheal silicon stent implantation in infants. Methods: Retrospective analysis on the cases of tracheal silicon stent implantation in infants in our hospital. Results and Conclusions: Since middle of 2014, totally four tracheal silicon stent implantation were performed in our center. Of them, one case was recurrent tracheoesophageal fistula and the other three cases were traheomalacia. Parent’s psychological support, infants’ nutrition support and airway care were key responsibility for a nurse before implantation. During the procedure of stent implantation, it was responsible for a nurse to closely monitor the infants and to support operator. After the implantation, airway care and prevention of intra-airway bacterial colonization were important to avoid complications. [ABSTRACT FROM AUTHOR]

The stability of a damaged ship is influenced especially by ship motions and floodwater behaviour with their interactions. The behaviour of floodwater is highly nonlinear so that a physical experiment is one of the best ways to obtain the assessment of damaged ship behaviour. The present study investigates experimentally on the performance of an intact and damaged combatant vessel DTMB-5415 in beam waves. Ship model is moored at the bow and stern during the tests in regular waves, and damaged opening is located at the starboard midships and two compartments are flooded. It is shown that ingress and egress of floodwater and the interaction between ship behaviour and water surface effect have a significant impact on ship motions and loads acting on the ship. [ABSTRACT FROM AUTHOR]

The calcium salt of hexahydrophthalic acid (Hyperform HPN-20E) is an effective nucleating agent for polyethylene which was developed by Milliken Chemical Co., (USA) in recent years. In this paper, the properties and crystallization behaviors of isotactic polypropylene (iPP) in the presence of Hyperform HPN-20E were investigated by using differential scanning calorimetry and polarized optical microscopy. Addition of Hyperform HPN-20E improved the tensile, flexural and optical properties of iPP significantly and increased the crystallization rate of iPP greatly. The nucleation effects were comparable to the nucleation efficiency of a highly effective commercial iPP nucleating agent Hyperform HPN-68. When the addition amount of Hyperform HPN-20E in iPP was 0.2 wt.%, the tensile strength, tensile modulus, flexural strength, and flexural modulus of iPP were increased by 10.81%, 8.65%, 16.67%, and 11.96%, respectively, compared to those of pure iPP; the haze value was decreased by 42.44% and the crystallization peak temperature was increased by 11.2°C. In addition, incorporation of Hyperform HPN-20E in iPP greatly reduced the spherulite size of iPP. [ABSTRACT FROM AUTHOR]

The article presents a case study of a 52-year-old male patient brought to the hospital with dermal petechiae and ecchymosis. The patient is positive for NPM1-MLF1 fusion complicated by a submicroscopic deletion of the 5' MLF1-3' NPM1 segment on the derivative chromosome 3. The adverse effect of haploinsufficiency of 3' NPM1 and other deleted genes on disease progression is also outlined.

This article presents an interview with actor Gu Yue, who presented a successful portrayal of Chinese revolutionary Mao Zedong on the screen. Gu Yue remarked that the craze for Mao Zedong has developed because, as the quality of material civilization has improved, people have a greater interest in spiritual civilization. People think fondly of the achievements of Mao Zedong. Ping-pong diplomacy and the establishment of diplomatic relations between China and the United States, as well as China and Japan, were all policies initiated by Mao Zedong and implemented by Premier Zhou Enlai. Mao Zedong's errors have been clearly explicated in the Communist Party Central documents. Yue is making films about the historical events everyone can agree on, like "Final Conflict" and "The Three Great Campaigns," and various periods before the Cultural Revolution. Gu Yue remarked that Chinese films are an advance on the style of filmmaking developed by Soviet directors from 1928. One can understand that some people hold fears for China becoming like the Soviet Union after Older Revolutionaries pass away. But the Soviet Union didn't change overnight and the Chinese people are presently taking precautions.

The article presents information on the points of consensus between the "Democrats" and the new authoritarians and their divergences. The new authoritarianism was born in 1986. The "relaxed" environment of the time brought up ripple after ripple of the clamor demanding democracy and yet the "bold wishes" of the "Democrats" were not requited to their satisfaction. Although the viewpoints of the "Democrats" and of the new authoritarians differ in terms of the roads they choose, there is still common ground between them. The new authoritarianism advocates that a powerful authority must be used, through the interference of politics in the economy and through the support and nurturing of the political power, in order to enable the market to grow to maturity under a protective umbrella and finally to become separated from politics. For a long time in China's traditional system, there has been a contradiction between the center and the localities (or regions). This is because in the traditional system, the question of "concentration of power" or "separation, (or delegation) of power" has been confined within the boundaries of the state's authoritative organization.