1. Time to symptom improvement using elimination diets in non-Ig E-mediated gastrointestinal food allergies.
- Author
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Lozinsky, Adriana Chebar, Meyer, Rosan, De Koker, Claire, Dziubak, Robert, Godwin, Heather, Reeve, Kate, Dominguez Ortega, Gloria, and Shah, Neil
- Subjects
DIET therapy for food allergies ,IMMUNOLOGIC diseases ,IMMUNOGLOBULIN E ,GASTROINTESTINAL diseases ,IMMUNE response ,IMMUNOLOGICAL tolerance ,ELIMINATION diets - Abstract
Background The prevalence of food allergy has increased in recent decades, and there is paucity of data on time to symptom improvement using elimination diets in non-Immunoglobulin E (IgE)-mediated food allergies. We therefore aimed to assess the time required to improvement of symptoms using a symptom questionnaire for children with non-IgE-mediated food allergies on an elimination diet. Methods A prospective observational study was performed on patients with non-IgE-mediated gastrointestinal food allergies on an elimination diet, who completed a questionnaire that includes nine evidence-based food allergic symptoms before and after the exclusion diet. The questionnaire measured symptoms individually from 0 (no symptom) to 5 (most severe) and collectively from 0 to 45. Children were only enrolled in the study if collectively symptoms improved with the dietary elimination within 4 or 8 weeks. Results Data from 131 patients were analysed including 90 boys with a median age of 21 months [ IQR: 7 to 66]. Based on the symptom questionnaire, 129 patients (98.4%) improved after 4-week elimination diet and only two patients improved after 8 weeks. A statistically significant difference before and after commencing the elimination diet was seen in all nine recorded symptoms (all p < 0.001), and in the median of overall score (p < 0.001). Conclusion This is the first study attempting to establish time to improve after commencing the diet elimination. Almost all children in this study improved within 4 weeks of following the elimination diet, under dietary supervision. [ABSTRACT FROM AUTHOR]
- Published
- 2015
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