5 results on '"Toyama, Hirochika"'
Search Results
2. Association between tumor morphology and efficacy of atezolizumab plus bevacizumab for advanced hepatocellular carcinoma.
- Author
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Ishihara, Nobuaki, Komatsu, Shohei, Sofue, Keitaro, Ueshima, Eisuke, Yano, Yoshihiko, Fujishima, Yoshimi, Ishida, Jun, Kido, Masahiro, Gon, Hidetoshi, Fukushima, Kenji, Urade, Takeshi, Yanagimoto, Hiroaki, Toyama, Hirochika, Ueda, Yoshihide, Kodama, Yuzo, Murakami, Takamichi, and Fukumoto, Takumi
- Abstract
Aim Methods Results Conclusions The IMbrave150 trial revealed that atezolizumab plus bevacizumab (AtezoBv) showed a higher objective response rate (ORR) in patients with advanced hepatocellular carcinoma (HCC). Although conversion therapy after AtezoBv has been recently reported, markers predictive of its efficacy, particularly radiological imaging markers, have not yet been identified. The present study focused on tumor morphological appearance on radiological imaging and evaluated whether it could be associated with AtezoBv efficacy.Ninety‐five intrahepatic lesions in 74 patients who were given AtezoBv for advanced HCC were recruited for evaluation. The lesions were divided into two groups, simple nodular (SN group) and non‐simple nodular (non‐SN group), based on the gross morphology on pretreatment imaging, and retrospectively evaluated for treatment response and other relevant clinical outcomes.Assessing the size of individual tumors after treatment, waterfall plots showed that tumor shrinkage in the non‐SN group including 56 lesions was higher than that in the SN group comprising 39 lesions. The ORR was significantly higher in the non‐SN group (39.3% vs. 15.4%,
p = 0.012). Additionally, the median time to nodular progression was longer in the non‐SN group (21.0 months vs. 8.1 months,p = 0.119) compared to the SN group. Six patients with non‐SN lesions underwent sequential local therapy.Atezolizumab plus bevacizumab may show increased therapeutic efficacy in patients with tumors with a higher potential for aggressive oncological behavior, such as non‐SN lesions. Treatment strategies focusing on conversion therapy may be crucial in patients with non‐SN lesions. [ABSTRACT FROM AUTHOR]- Published
- 2024
- Full Text
- View/download PDF
3. Internal hernia through a transverse mesocolon defect after laparoscopic distal pancreatectomy: Report of a case.
- Author
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Nanno, Yoshihide, Goto, Tadahiro, Toyama, Hirochika, Asari, Sadaki, Terai, Sachio, Shirakawa, Sachiyo, Mizumoto, Takuya, Ueda, Yuki, Kido, Masahiro, Ajiki, Tetsuo, Fukumoto, Takumi, and Ku, Yonson
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HERNIA treatment , *PANCREATECTOMY , *LAPAROSCOPY , *OLDER patients - Abstract
We report a case of an internal hernia through a transverse mesocolon defect after laparoscopic distal pancreatectomy. The patient was a 58-year-old man with an intraductal papillary mucinous neoplasm of the pancreatic body who underwent laparoscopic distal pancreatectomy. During surgery, an approximately 5-cm defect in the transverse mesocolon was inadvertently made. The defect was not closed as it was thought to be large enough to preclude incarceration. However, the patient developed a bowel obstruction 2 months postoperatively. Laparotomy revealed that a loop of the proximal jejunum herniated through the defect and was adherent to the stapled pancreatic stump. An additional loop of the jejunum was herniated through the narrowed mesenteric defect. To our knowledge, this is the first case of an internal hernia through a transverse mesocolon defect after laparoscopic distal pancreatectomy. [ABSTRACT FROM AUTHOR]
- Published
- 2017
- Full Text
- View/download PDF
4. Lobularity rather than hyperechoic foci/stranding on endoscopic ultrasonography is associated with more severe histological features in chronic pancreatitis.
- Author
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Inomata, Noriko, Masuda, Atsuhiro, Yamakawa, Kohei, Takenaka, Mamoru, Tsujimae, Masahiro, Toyama, Hirochika, Sofue, Keitaro, Sakai, Arata, Kobayashi, Takashi, Tanaka, Takeshi, Yamada, Yasutaka, Ashina, Shigeto, Gonda, Masanori, Abe, Shohei, Masuda, Shigeto, Uemura, Hisahiro, Kohashi, Shinya, Nagao, Kae, Harada, Yoshiyuki, and Miki, Mika
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ENDOSCOPIC ultrasonography , *CYSTIC fibrosis , *PANCREATIC surgery , *PANCREATIC tumors , *CHRONIC pancreatitis , *MULTIVARIATE analysis , *ODDS ratio , *CONFIDENCE intervals - Abstract
Background and Aim: Endoscopic ultrasonography (EUS) findings of the pancreatic parenchyma, such as hyperechoic foci/stranding and lobularity, may be associated with the severity of chronic pancreatitis (CP). However, the correlation between parenchymal EUS findings and histology remains unclear. We designed a large‐scale retrospective study analyzing over 200 surgical specimens to elucidate the association between parenchymal EUS findings and histological features. Methods: Clinical data of 221 patients with pancreatobiliary tumors who underwent preoperative EUS and pancreatic surgery between January 2010 and November 2020 were reviewed to investigate the association between parenchymal EUS findings and histological features at the pancreatic body. None of these patients met the definition of CP. Results: Of the 221 patients, 87 (39.4%), 89 (40.2%), and 45 (20.4%) had normal EUS findings, hyperechoic foci/stranding without lobularity, and hyperechoic foci/stranding with lobularity, respectively. In the multivariate analyses, parenchymal EUS findings significantly correlated with histological CP findings of fibrosis, inflammation, and atrophy (hyperechoic foci/stranding without lobularity vs hyperechoic foci/stranding with lobularity, odds ratio [95% confidence interval]: 4.1 [2.2–7.9] vs 31.3 [9.3–105.6], Ptrend < 0.001; 3.9 [1.9–8.2] vs 21.8 [8.0–59.4], Ptrend < 0.001; and 4.0 [2.0–7.8] vs 22.9 [7.0–74.5], Ptrend < 0.001, respectively). Further, a trend toward higher histological grade was observed in the following order: normal findings, hyperechoic foci/stranding without lobularity, and hyperechoic foci/stranding with lobularity. Conclusions: Endoscopic ultrasonography findings of the pancreatic parenchyma may be associated with the histological conditions in CP, such as pancreatic fibrosis, inflammation, and atrophy. Lobularity reflects more severe histological conditions than does hyperechoic foci/stranding. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
5. Significance of pancreatic calcification on preoperative computed tomography of intraductal papillary mucinous neoplasms.
- Author
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Tsujimae, Masahiro, Masuda, Atsuhiro, Shiomi, Hideyuki, Toyama, Hirochika, Sofue, Keitaro, Ueshima, Eisuke, Yamakawa, Kohei, Ashina, Shigeto, Yamada, Yasutaka, Tanaka, Takeshi, Tanaka, Shunta, Nakano, Ryota, Sato, Yu, Ikegawa, Takuya, Kurosawa, Manabu, Fujigaki, Seiji, Kobayashi, Takashi, Sakai, Arata, Kutsumi, Hiromu, and Zen, Yoh
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CA 19-9 test , *COMPUTED tomography , *CALCIFICATION , *LOGISTIC regression analysis , *MUCINOUS adenocarcinoma , *CANCER - Abstract
Background and Aim: Chronic pancreatitis is a risk factor for pancreatic cancer. Pancreatic calcification is a characteristic of chronic pancreatitis; however, its significance for intraductal papillary mucinous neoplasm (IPMN) oncogenesis remains unknown. Therefore, we investigated the relationship between pancreatic calcification and invasive IPMN. Methods: This study included 157 patients who underwent resection for IPMN between April 2001 and October 2016 (intraductal papillary mucinous adenoma, n = 76; noninvasive intraductal papillary mucinous carcinoma [IPMC], n = 32; and invasive IPMC, n = 49). We divided the subjects on the basis of the presence/absence of pancreatic calcification on preoperative computed tomography (CT). The factors associated with pancreatic calcification were investigated in univariate analyses. Then, multivariate logistic regression analyses of the relationship between pancreatic calcification and invasive IPMC (after adjusting for clinical or imaging characteristics) were conducted. Results: Preoperative CT revealed pancreatic calcification in 17.2% (27/157) of the resected IPMN. In the univariate analyses, jaundice, high serum carbohydrate antigen 19‐9 levels, and invasive IPMC were significantly associated with pancreatic calcification (4/27 [14.8%] vs 4/130 [3.1%], 0.01; 12/27 [44.4%] vs 31/130 [23.8%], 0.03; and 15/27 [55.6%] vs 34/130 [26.2%], 0.001, respectively). Pancreatic calcification was significantly associated with invasive IPMC (multivariate odds ratio = 2.88, 95% confidence interval [95% CI] = 1.15–7.21, 0.03, adjusted for clinical characteristics; odds ratio = 5.50, 95% CI = 1.98–15.3, 0.001, adjusted for imaging characteristics). Conclusions: Pancreatic calcification on CT is associated with invasive IPMC. Pancreatic calcification might be a predictor of invasive IPMC. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF
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