1. Fetuin-A promotes primary keratinocyte migration: independent of epidermal growth factor receptor signalling.
- Author
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Wang, Xue-Qing, Hung, Betsy S., Kempf, Margit, Liu, Pei-Yun, Dalley, Andrew J., Saunders, Nicholas A., and Kimble, Roy M.
- Subjects
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KERATINOCYTES , *WOUND healing , *EPIDERMAL growth factor , *CELL receptors , *CELL culture , *DERMATOLOGY - Abstract
Please cite this paper as: Fetuin-A promotes primary keratinocyte migration: independent of epidermal growth factor receptor signalling. Experimental Dermatology 2010; 19: e289-e292. Abstract: Previously, we reported that fetuin-A is a major component of ovine foetal skin and significantly enhances 'wound closure' in primary keratinocyte cultures. In this study, we found that in human newborn foreskin, a high level of fetuin-A protein is detected throughout the dermis. However, in adult skin a low level of fetuin-A is observed throughout the epidermal and dermal layers, except at regions surrounding hair follicles and at the epidermal-dermal junction where the level of fetuin-A is relatively high. Fetuin-A significantly induces actin-rich protrusions in human primary keratinocytes. Interestingly, blockade of epidermal growth factor (EGF) receptor signalling has a limited effect on fetuin-A promoted 'wound closure' on primary human keratinocytes, but significantly inhibits fetuin-A's effect on HaCaT cells. These results indicate that high levels of fetuin-A may partially contribute to less scar formation in newborn foreskin and that the effect of fetuin-A on primary keratinocyte migration is independent of EGF receptor signalling. [ABSTRACT FROM AUTHOR]
- Published
- 2010
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