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Designability is an attractive feature for metal–organic frameworks (MOFs) and essential for reticular chemistry, and many ideas are significantly useful in the carboxylate system. Bi‐, tri‐, and tetra‐topic phosphonate ligands are used to achieve framework structures. However, an efficient method for designing phosphonate MOFs is still on the way, especially for uranyl phosphonates, owing to the complicated coordination modes of the phosphonate group. Uranyl phosphonates prefer layer or pillar‐layered structures as the topology extension for uranyl units occurs in the plane perpendicular to the linear uranium‐oxo bonds and phosphonate ligands favor the formation of compact structures. Therefore, an approach that can construct three‐dimensional (3D) uranyl phosphonate MOFs is desired. In this paper, a sterically hindered phosphonate ligand method (SHPL) is described and is successfully used to achieve 3D framework structures of uranyl phosphonates. Four MOF compounds ([AMIM]2(UO2)(TppmH4)⋅H2O (UPF‐101), [BMMIM]2(UO2)3(TppmH4)2⋅H2O (UPF‐102), [Py14]2(UO2)3(TppmH4)2⋅3 H2O (UPF‐103), and [BMIM](UO2)3(TppmH3)F2⋅2 H2O (UPF‐104); [AMIM]=1‐allyl‐3‐methylimidazolium, [BMMIM]=1‐butyl‐2,3‐dimethylimidazolium, [Py14]=N‐butyl‐N‐methylpyrrolidinium, and [BMIM]=1‐butyl‐3‐methylimidazolium) are obtained by ionothermal synthesis, with zero‐dimensional nodes of uranyl phosphonates linked by steric tetra‐topic ligands, namely tetrakis[4‐(dihyroxyphosphoryl)phenyl]methane (TppmH8), to give 3D framework structures. Characterization by PXRD, UV/Vis, IR, Raman spectroscopy, and thermogravimetry (TG) were also performed. [ABSTRACT FROM AUTHOR]

DNA has emerged as an appealing material for information storage due to its great storage density and durability. Random reading and rewriting are essential tasks for practical large‐scale data storage. However, they are currently difficult to implement simultaneously in a single DNA‐based storage system, strongly limiting their practicability. Here, a "Cell Disk" storage system is presented, achieving high‐density in vivo DNA data storage that enables both random reading and rewriting. In this system, each yeast cell is used as a chamber to store information, similar to a "disk block" but with the ability to self‐replicate. Specifically, each genome of yeast cell has a customized CRISPR/Cas9‐based "lock‐and‐key" module inserted, which allows selective retrieval, erasure, or rewriting of the targeted cell "block" from a pool of cells ("disk"). Additionally, a codec algorithm with lossless compression ability is developed to improve the information density of each cell "block". As a proof of concept, target‐specific reading and rewriting of the compressed data from a mimic cell "disk" comprising up to 105 "blocks" are demonstrated and achieve high specificity and reliability. The "Cell Disk" system described here concurrently supports random reading and rewriting, and it should have great scalability for practical data storage use. [ABSTRACT FROM AUTHOR]

Ultrahigh‐capacity silicon (Si) anodes are essential for the escalating energy demands driven by the booming e‐transportation and energy storage field. However, their practical applications are strictly hampered by their intrinsically low electroconductivity, sluggish Li‐ion diffusion, and undesirably large volume change. Herein, a high‐performance Si anode, comprised of a modulated soft/hard coating of polyethylene glycol (PEG) (as Li‐ion conductor) and polyaniline (PANI) (as electron conductor) on the surface of Si nanoparticles (NPs) through H‐bonding network, is introduced. In this design, the abundant ─OH groups of soft PEG allow it to uniformly cover Si NPs while the hard PANI binds to PEG through its ─N─H group, thus constructing a tight connectin between Si and PEG‐PANI (PP). Consequently, the elastic PP allows Si@PP to accommodate the huge volume expansion while possessing fine electronic/ionic conductivity. Therefore, the Si@PP anode exhibits a high initial Coulombic efficiency of 90.5% and a stable capacity of 1871 mAh g−1 after 100 cycles at 1 A g−1 with a retention of 85.7%. Additionally, the Si@PP anode also demonstrates a high areal capacity of 3.01 mAh cm−2 after 100 cycles at 0.5 A g−1. This work reveals a scalable interface design of multi‐layer multifunctional coatings for high‐performance electrode materials in next‐generation Li‐ion batteries. [ABSTRACT FROM AUTHOR]

This paper proposes a new dual horizontal squash capsule network (DHS‐CapsNet) to classify the lung and colon cancers on histopathological images. DHS‐CapsNet is made up of encoder feature fusion (EFF) and a novel horizontal squash (HSquash) function. The EFF aggregates the extracted feature from the 2‐lane convolutional layers, which provides rich information for better accuracy. HSquash is proposed as a squash function to ensure that vectors are effectively squashed and produces sparsity for a high discriminative capsule to extract important information from images with varied backgrounds. To present the effectiveness of DHS‐CapsNet empirically, we applied this method on histopathological images (LC25000 dataset). We achieved better results of 99.23% compared to traditional CapsNet (85.55%). The DHS‐CapsNet provides the top‐1 classification error of 0.77% compared to 14.45% of the traditional CapsNet. Our results illustrate that our method improves CapsNet and can be adopted as a computer‐aided diagnostic method to support doctors in lung and colon cancer diagnostics. [ABSTRACT FROM AUTHOR]

Summary: The biofilm formation by Pseudomonas aeruginosa highly increases the bacterial resistance to antimicrobial agents and host immune clearance. The biofilm formation is positively regulated by two small RNAs, RsmY and RsmZ. Previously, we reported that mutation in the polynucleotide phosphorylase (PNPase) coding gene pnp increases the levels of RsmY/Z. However, in this study, we found that the biofilm formation is decreased in the pnp mutant, which is due to a defect in rhamnolipids production. The rhamnolipids production is regulated by the RhlI‐RhlR quorum sensing system. We found that PNPase influences the translation of RhlI through its 5′‐untranslated region (UTR) and identified that the sRNA P27 is responsible for the translational repression. In vitro translation experiments demonstrated that P27 directly represses the translation of the rhlI mRNA through its 5′UTR in an Hfq‐dependent manner. Point mutations in the rhlI 5′UTR or P27, which abolish the pairing between the two RNAs restore the rhlI expression and rhamnolipids production as well as the biofilm formation in the pnp mutant. Overall, our results reveal a novel layer of regulation of the Rhl quorum sensing system by the sRNA P27. [ABSTRACT FROM AUTHOR]