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Global climate model simulations project that the tropical Andes Mountains of South America, which are particularly vulnerable to climate change because of a reliance on snow and glacial melt for freshwater resources, will experience enhanced warming in the near future, with both higher rates of warming at higher elevations within the mountain range itself and localized enhancement of warming exceeding surrounding areas of the globe. Yet recent surface temperature changes in the tropical Andes do not show evidence for either elevation-dependent warming or regional enhancement of warming on average. However, it remains a possibility that the expected warming trends in this region have begun to manifest in other ways (e.g., in the free atmosphere or at intermediate mountain elevations). This paper proposes evidence from several reanalysis products that there has indeed been a regional enhancement of midtropospheric warming around the central Andes over the past few decades that makes this region stand out as a hot spot within the broader pantropics. This trend is generally not reproduced by historical AMIP climate model simulations, which suggests that the mechanisms through which the atmosphere is warming over the central Andes are not adequately captured by climate models. Possible explanations for localized enhancement of warming in this region are considered. On the other hand, reanalysis products do not consistently exhibit enhanced warming at intermediate mountain elevations in the central Andes as evidenced by the generally moderate rates of change in the freezing-level height, except perhaps in the highest-resolution reanalysis product. [ABSTRACT FROM AUTHOR]