Search

Neuromechanical studies investigate how the nervous system interacts with the musculoskeletal (MSK) system to generate volitional movements. Such studies have been supported by simulation models that provide insights into variables that cannot be measured experimentally and allow a large number of conditions to be tested before the experimental analysis. However, current simulation models of electromyography (EMG), a core physiological signal in neuromechanical analyses, remain either limited in accuracy and conditions or are computationally heavy to apply. Here, we provide a computational platform to enable future work to overcome these limitations by presenting NeuroMotion, an open-source simulator that can modularly test a variety of approaches to the full-spectrum synthesis of EMG signals during voluntary movements. We demonstrate NeuroMotion using three sample modules. The first module is an upper-limb MSK model with OpenSim API to estimate the muscle fibre lengths and muscle activations during movements. The second module is BioMime, a deep neural network-based EMG generator that receives nonstationary physiological parameter inputs, like the afore-estimated muscle fibre lengths, and efficiently outputs motor unit action potentials (MUAPs). The third module is a motor unit pool model that transforms the muscle activations into discharge timings of motor units. The discharge timings are convolved with the output of BioMime to simulate EMG signals during the movement. We first show how MUAP waveforms change during different levels of physiological parameter variations and different movements. We then show that the synthetic EMG signals during two-degree-of-freedom hand and wrist movements can be used to augment experimental data for regressing joint angles. Ridge regressors trained on the synthetic dataset were directly used to predict joint angles from experimental data. In this way, NeuroMotion was able to generate full-spectrum EMG for the first use-case of human forearm electrophysiology during voluntary hand, wrist, and forearm movements. All intermediate variables are available, which allows the user to study cause-effect relationships in the complex neuromechanical system, fast iterate algorithms before collecting experimental data, and validate algorithms that estimate non-measurable parameters in experiments. We expect this modular platform will enable validation of generative EMG models, complement experimental approaches and empower neuromechanical research., Competing Interests: • I have read the journal’s policy and the authors of this manuscript have the following competing interests: Kostiantyn Maksymenko and Samuel Deslauriers-Gauthier are the co-founders of the company Neurodec; all other authors have no competing interests., (Copyright: © 2024 Ma et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)

Objective: Mathematical modelling of surface electromyographic (EMG) signals has been proven a valuable tool to interpret experimental data and to validate signal processing techniques. Most analytical EMG models only consider muscle fibers with specific arrangements. However, the fiber orientation may change along the fiber paths and differ from fiber to fiber. Here we propose a subject-specific EMG model that simulates the fiber trajectories in muscles of the upper arm and analytically derives the action potentials assuming an approximate conductivity tensor. Methods: Magnetic Resonance (MR) images were acquired to generate muscle fiber paths and to build the volume conductor. While the action potentials propagated along the identified curvilinear fibers, the conductivity tensor was approximated to be cylindrically anisotropic. Single fiber action potentials (SFAPs) were computed by simulating the generation, propagation, and extinction of membrane current sources. To validate the assumption of the approximate conductivity tensor, two numerical models with approximate or exact conductivity tensors were implemented. Results: The motor unit action potentials generated by the proposed analytical model and the two numerical models were highly similar (cross-correlation $>$ 0.98, normalized root mean square error, nRMSE $\leq$ 0.04, relative error in the median frequency of the simulated waveforms of approximately 3%). The proposed analytical model was also evaluated by comparing simulated and experimentally recorded compound muscle action potentials (CMAPs). Finally, the proposed model was used to test the accuracy of an EMG decomposition algorithm, providing a realistic benchmark. Conclusions and Significance: The proposed analytical model generates action potentials that reflect the spatial distributions of muscle fibers with curvilinear paths. [ABSTRACT FROM AUTHOR]

Simultaneous and proportional control (SPC) using surface electromyography (sEMG) signals has become a prevailing solution for the intuitive control of prosthesis and human–robot interaction. However, only time and frequency domain features are generally involved in conventional SPC algorithms, ignoring the globally spatial information across channels. In this article, we presented an instantaneous sEMG-image-based model for continuous estimation on multiple degrees of freedom wrist torques. Specifically, a convolutional neural network was used to extract features from sEMG-images, and then to estimate wrist torques. The results demonstrated that the sEMG-image-based model outperformed three conventional regression methods and a deep-learning-based method with superior performance on estimation accuracy and smoothness. Furthermore, we found a strong linear correlation between the first two principal components of extracted features and the recorded wrist torques, validating the effectiveness of the proposed approach. The outcomes open up a new perspective for SPC and potentially enhance the performance of myoelectric control in practical application. [ABSTRACT FROM AUTHOR]