1. Synthesis and crystal structure of peptide dimethyl biphenyl hybrid C52H60N6O10·0.25H2O
- Author
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Xuan Tu Nguyen, Thuy Quynh Le, Tra My Bui Thi, Dinh Hung Mac, and Thai Thanh Thu Bui
- Subjects
crystal structure ,hydrogen bonding ,peptide dimethyl biphenyl hybrids ,pro-phe-ala ,Crystallography ,QD901-999 - Abstract
The synthesis and crystal structure of peptide 6,6′-dimethyl biphenyl hybrid are described. The title compound was synthesized by reaction between 6,6′-dimethyl-[1,1′-biphenyl]-2,2′-dicarbonyl dichloride in CH2Cl2, amine HN–proline–phenylalanine–alanine–COOMe and Et3N at 273 K under N2 atmosphere and characterized by single-crystal X-ray diffraction. The asymmetric unit contains one peptide molecule and a quarter of a water molecule. A disorder of a methyl and methoxycarbonyl group of one alanine residue is observed with occupancy ratio 0.502 (6):0.498 (6). The structure is consolidated by intra- and intermolecular hydrogen bonds.
- Published
- 2020
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