1. Mucosal responses to infection with Trichinella spiralis in mice
- Author
-
Derek Wakelin, M Kamal, and Yashwant R. Mahida
- Subjects
Cellular immunity ,Paneth Cells ,goblet cells ,Veterinary (miscellaneous) ,T-Lymphocytes ,Trichinella spiralis ,T cells ,Inflammation ,mast cells ,Mice, SCID ,Trichinosis ,Biology ,lcsh:Infectious and parasitic diseases ,Mice ,Immune system ,Immunity ,medicine ,Animals ,lcsh:RC109-216 ,Intestinal Mucosa ,intestine ,mucosa ,Immunity, Mucosal ,Mice, Knockout ,Mice, Inbred BALB C ,T-cell receptor ,Trichinella spiral ,Trichinellosis ,medicine.disease ,biology.organism_classification ,cytokines ,Mice, Inbred C57BL ,Infectious Diseases ,medicine.anatomical_structure ,Jejunum ,inflammation ,Insect Science ,worm expulsio ,Paneth cell ,Immunology ,Genes, T-Cell Receptor beta ,Animal Science and Zoology ,Parasitology ,medicine.symptom ,epithelium ,Genes, T-Cell Receptor delta - Abstract
Infections with T. spiralis in mice elicit strong inflammatory responses. The nature and control of these responses, and their relationship to the process of worm expulsion, have been debated for many years. Many components of inflammation are, like worm expulsion, T cell-dependent, but some are not. The paper describes novel observations on Paneth cell responses to infection in immunologically normal mice and in a variety of T cell-deficient mice. Responses occurred normally in nu/nu and scid/scid mice but not in beta/delta knock out mice incapable of generating cells with functional TCR. However all of these mice failed to expel worms in the pattern seen in immunologically normal controls. These data are incorporated into a discussion of the causal relevance of intestinal inflammatory changes to the process of worm expulsion.
- Published
- 2001