282 results on '"Colombo, Francesca"'
Search Results
2. Finance and health dialogue needed to build resilient health systems
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James, Chris, Colombo, Francesca, Morgan, David, and Vammalle, Camila
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Epidemics -- Economic aspects -- France ,Public finance -- Management ,Medical economics -- Methods ,Company business management ,Health - Abstract
The coronavirus disease 2019 (COVID-19) pandemic has demonstrated that high-performing, resilient health systems are essential to the health of populations as well as to resilient economies and societies. (1) Yet [...]
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- 2024
3. Dosimetric Comparison Between Proton and Photon Radiation Therapies for Pediatric Neuroblastoma
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Mirandola, Alfredo, Colombo, Francesca, Cavagnetto, Francesca, Cavallo, Anna, Gusinu, Marco, Molinelli, Silvia, Pignoli, Emanuele, Ciocca, Mario, Barra, Salvina, Giannelli, Flavio, Pecori, Emilia, Jereczek-Fossa, Barbara A., Orlandi, Ester, and Vennarini, Sabina
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- 2024
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4. Addressing barriers and identifying facilitators to support informed consent and recruitment in the Cavernous malformations A Randomised Effectiveness (CARE) pilot phase trial: insights from the integrated QuinteT recruitment intervention (QRI)
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Mallucci, Conor, White, Philip M., Eriksson, Madeleine, Hayat, Raza, Kinsella, Elaine, Lewis, Katherine, Neilson, Aileen R., White, David C.S., Boyd, Julia, Bullen, Alastair, Maclean, Morag, Stoddart, Andrew, Phair, Sandra, Evans, Helen, Noakes, Jo, Alexander, Debra, Keerie, Catriona, Linsley, Christopher, Milne, Garry, Norrie, John, Bunch, Janet, Douthwaite, Kathryn, Temple, Simon, Hogg, James, Scott, David, Spallone, Pat, Stuart, Ian, Wardlaw, Joanna M., Palmer, Jeb, Sakka, Eleni, Mukerji, Nitin, Cirstea, Emanuel, Davies, Susan, Giannakaki, Venetia, Kadhim, Ammar, Kennion, Oliver, Islam, Moidul, Ferguson, Lucie, Prasad, Manjunath, Bacon, Andrew, Richards, Emma, Howe, Jo, Kamara, Christine, Gardner, Jonathan, Roman, Madalina, Sikaonga, Mary, Cahill, Julian, Rossdeutsch, Alex, Cahill, Varduhi, Hamina, Imron, Chaudhari, Kishor, Danciut, Mihai, Clarkson, Emma, Bjornson, Anna, Bulters, Diederik, Digpal, Ronneil, Ruiz, Winnington, Taylor, Mirriam, Anyog, Divina, Tluchowska, Katarzyna, Nolasco, Jackson, Brooks, Daniel, Angelopoulou, Kleopatra, Welch, Bethany, Broomes, Nicole, Fouyas, Ioannis, MacRaild, Allan, Kaliaperumal, Chandru, Teasdale, Jessica, Coakley, Michelle, Brennan, Paul, Sokol, Drahoslav, Wiggins, Anthony, MacDonald, Mairi, Risbridger, Sarah, Bhatt, Pragnesh, Irvine, Janice, Majeed, Sohail, Williams, Sandra, Reid, John, Walch, Annika, Muir, Farah, van Beijnum, Janneke, Leach, Paul, Hughes, Tom, Makwana, Milan, Hamandi, Khalid, McAleer, Dympna, Gunning, Belinda, Walsh, Daniel, Wright, Oliver Wroe, Patel, Sabina, Gurusinghe, Nihal, Raza-Knight, Saba, Cromie, Terri-Louise, Brown, Allan, Raj, Sonia, Pennington, Ruth, Campbell, Charlene, Patel, Shakeelah, Colombo, Francesca, Teo, Mario, Wildman, Jack, Smith, Kerry, Goff, Elizabeth, Stephens, Deanna, Borislavova, Borislava, Worner, Ruth, Buddha, Sandeep, Clatworthy, Philip, Edwards, Richard, Clayton, Evangeline, Coy, Karen, Tucker, Lisa, Dymond, Sandra, Mallick, Andrew, Hodnett, Rebecca, Spickett-Jones, Francesca, Grover, Patrick, Banaras, Azra, Tshuma, Sifelani, Muirhead, William, Hill, Ciaran Scott, Shah, Rupal, Doke, Thomas, Hall, Rebecca, Coskuner, Sonny, Aslett, Laura, Vindlacheruvu, Raghu, Ghosh, Anthony, Fitzpatrick, Teresa, Harris, Lauren, Hayton, Tom, Whitehouse, Arlo, McDarby, Andrew, Hancox, Rebecca, Auyeung, Claudia Kate, Nair, Ramesh, Thomas, Rhys, McLachlan, Heather, Kountourgioti, Athanasia, Orjales, Guillelme, Kruczynski, Jan, Hunter, Sophie, Bohnacker, Niamh, Marimon, Rosette, Parker, Lydia, Raha, Oishik, Sharma, Puneet, Uff, Christopher, Boyapati, Geetha, Papadopoulos, Marios, Kearney, Siobhan, Visagan, Ravindran, Bosetta, Ellaine, Asif, Hasan, Helmy, Adel, Chapas, Liliana, Tarantino, Silvia, Caldwell, Karen, Guilfoyle, Mathew, Agarwal, Smriti, Brown, Daniel, Holland, Sarah, Tajsic, Tamara, Fletcher, Clare, Sebyatki, Aisha, Ushewokunze, Shungu, Ali, Sarah, Preston, John, Chambers, Carole, Patel, Mohammed, Holsgrove, Daniel, McLaughlan, Danielle, Marsden, Tracey, Cawley, Kathryn, Raffalli, Hellen, Lee, Stephanie, Israni, Anil, Dore, Rachael, Anderson, Taya, Hennigan, Dawn, Mayor, Shelley, Glover, Samantha, Chavredakis, Emmanuel, Brown, Debbie, Sokratous, Giannis, Williamson, John, Stoneley, Cathy, Brodbelt, Andrew, Farah, Jibril Osman, Illingworth, Sarah, Konteas, Anastasios Benjamin, Davies, Deborah, Owen, Carol, Kerr, Loretta, Wade, Julia, Farrar, Nicola, Realpe, Alba X., Donovan, Jenny L., Forsyth, Laura, Harkness, Kirsty A., Hutchinson, Peter J.A., Kitchen, Neil, Lewis, Steff C., Loan, James J.M., Stephen, Jacqueline, and Al-Shahi Salman, Rustam
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- 2024
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5. Challenges and opportunities for incentivising antibiotic research and development in Europe
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Anderson, Michael, Panteli, Dimitra, van Kessel, Robin, Ljungqvist, Gunnar, Colombo, Francesca, and Mossialos, Elias
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- 2023
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6. Personalized Setup Optimization Strategies to Improve Clinical Workflow in Image-Guided Pediatric Particle Therapy
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Pepa, Matteo, primary, Pella, Andrea, additional, Sellaro, Giulia, additional, Galante, Federica, additional, Mirandola, Alfredo, additional, Ghirelli, Angelica, additional, Vennarini, Sabina, additional, Colombo, Francesca, additional, Imparato, Sara, additional, Iannalfi, Alberto, additional, Ciocca, Mario, additional, Paganelli, Chiara, additional, Orlandi, Ester, additional, and Baroni, Guido, additional
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- 2024
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7. Chestnut extracts decrease the in-vitro digestibility and polyphenol bioavailability of soy-based nutrients but protect the epithelial barrier function of pig jejunum segments after digestion
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Tretola, Marco, Silacci, Paolo, Sousa, Raquel, Colombo, Francesca, Panseri, Sara, Ottoboni, Matteo, Pinotti, Luciano, and Bee, Giuseppe
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- 2022
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8. Proton Therapy in Non-Rhabdomyosarcoma Soft Tissue Sarcomas of Children and Adolescents
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Vennarini, Sabina, primary, Colombo, Francesca, additional, Mirandola, Alfredo, additional, Orlandi, Ester, additional, Pecori, Emilia, additional, Chiaravalli, Stefano, additional, Massimino, Maura, additional, Casanova, Michela, additional, and Ferrari, Andrea, additional
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- 2024
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9. COVID-19 mortality in Italy varies by patient age, sex and pandemic wave
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Minnai, Francesca, De Bellis, Gianluca, Dragani, Tommaso A., and Colombo, Francesca
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- 2022
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10. Gut microbiota composition in colorectal cancer patients is genetically regulated
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Colombo, Francesca, Illescas, Oscar, Noci, Sara, Minnai, Francesca, Pintarelli, Giulia, Pettinicchio, Angela, Vannelli, Alberto, Sorrentino, Luca, Battaglia, Luigi, Cosimelli, Maurizio, Dragani, Tommaso A., and Gariboldi, Manuela
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- 2022
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11. An explainable model of host genetic interactions linked to COVID-19 severity
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Onoja, Anthony, Picchiotti, Nicola, Fallerini, Chiara, Baldassarri, Margherita, Fava, Francesca, Colombo, Francesca, Chiaromonte, Francesca, Renieri, Alessandra, Furini, Simone, and Raimondi, Francesco
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- 2022
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12. Common, low-frequency, rare, and ultra-rare coding variants contribute to COVID-19 severity
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Fallerini, Chiara, Picchiotti, Nicola, Baldassarri, Margherita, Zguro, Kristina, Daga, Sergio, Fava, Francesca, Benetti, Elisa, Amitrano, Sara, Bruttini, Mirella, Palmieri, Maria, Croci, Susanna, Lista, Mirjam, Beligni, Giada, Valentino, Floriana, Meloni, Ilaria, Tanfoni, Marco, Minnai, Francesca, Colombo, Francesca, Cabri, Enrico, Fratelli, Maddalena, Gabbi, Chiara, Mantovani, Stefania, Frullanti, Elisa, Gori, Marco, Crawley, Francis P., Butler-Laporte, Guillaume, Richards, Brent, Zeberg, Hugo, Lipcsey, Miklos, Hultström, Michael, Ludwig, Kerstin U., Schulte, Eva C., Pairo-Castineira, Erola, Baillie, John Kenneth, Schmidt, Axel, Frithiof, Robert, Mari, Francesca, Renieri, Alessandra, and Furini, Simone
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- 2022
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13. Editorial: Pharmacogenetic landscape in human solid cancers
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Lastraioli, Elena, primary, Colombo, Francesca, additional, and Frullanti, Elisa, additional
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- 2024
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14. Lung expression of genes putatively involved in SARS-CoV-2 infection is modulated in cis by germline variants
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Cotroneo, Chiara E., Mangano, Nunzia, Dragani, Tommaso A., and Colombo, Francesca
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- 2021
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15. Winemaking by-products as a sustainable source of antioxidant and functional compounds
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Di Lorenzo Chiara, Colombo Francesca, Bani Corinne, Mercogliano Francesca, Biella Simone, Bosso Antonella, and Restani Patrizia
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Microbiology ,QR1-502 ,Physiology ,QP1-981 ,Zoology ,QL1-991 - Abstract
In the last years, the international guidelines encourage the reduction of food waste or processing by-products to promote a circular economy approach. Winemaking represents one of the sectors with the highest by-products generation, with several potential negative impact on the environment. Winemaking by-products are mainly used to produce distillates or fertilizers, but the interest in grape pomaceas a potential source of phenolic compounds has considerably increased. The aim of this study was the application of in vitro methods for the characterization of the phenolic fraction of winemaking by-products from different red grape varieties, and, in parallel, the evaluation of their antioxidant activity. The methods were: 1) Folin-Cocalteau's assay for the quantification of total polyphenol content; 2) the vanillin assay for the assessment of total flavan-3-ols (proanthocyanidins) content; 3) the pH differential method for the quantification of total anthocyanin content; 4) DPPH assay for the measurement of total antioxidant activity; 5) High Performance Thin Layer Chromatography for separation of phenolic substances and assessment of their antioxidant activity. Although a significant differences among varieties, grape pomace, particularly when containing seeds, are generally a good source of polyphenols with a significant antioxidant activity supporting itsuse in formulating healthy products.
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- 2023
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16. Adverse effects to food supplements containing botanical ingredients
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Colombo, Francesca, Di Lorenzo, Chiara, Biella, Simone, Vecchio, Sarah, Frigerio, Gianfranco, and Restani, Patrizia
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- 2020
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17. SELP Asp603Asn and severe thrombosis in COVID-19 males
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Fallerini, Chiara, Daga, Sergio, Benetti, Elisa, Picchiotti, Nicola, Zguro, Kristina, Catapano, Francesca, Baroni, Virginia, Lanini, Simone, Bucalossi, Alessandro, Marotta, Giuseppe, Colombo, Francesca, Baldassarri, Margherita, Fava, Francesca, Beligni, Giada, Di Sarno, Laura, Alaverdian, Diana, Palmieri, Maria, Croci, Susanna, Isidori, Andrea M., Furini, Simone, Frullanti, Elisa, Renieri, Alessandra, and Mari, Francesca
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- 2021
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18. Skin Anti-Aging Effect of Oral Vitamin A Supplementation in Combination with Topical Retinoic Acid Treatment in Comparison with Topical Treatment Alone: A Randomized, Prospective, Assessor-Blinded, Parallel Trial
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Milani, Massimo, primary and Colombo, Francesca, additional
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- 2023
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19. Clinical Insight on Proton Therapy for Paediatric Rhabdomyosarcoma
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Vennarini, Sabina, primary, Colombo, Francesca, additional, Mirandola, Alfredo, additional, Chiaravalli, Stefano, additional, Orlandi, Ester, additional, Massimino, Maura, additional, Casanova, Michela, additional, and Ferrari, Andrea, additional
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- 2023
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20. Perioperative Means to Prevent Surgical Site Infections following Elective Craniotomies: A Single-Center Experience
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Colombo, Francesca, additional, Maye, Helen, additional, Bourama, Eva, additional, Waqar, Mueez, additional, Karabatsou, Konstantina, additional, Coope, David, additional, Bailey, Matthew, additional, Heal, Calvin, additional, Patel, Hiren C., additional, and D'Urso, Pietro I., additional
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- 2023
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21. Feasibility of comparing medical management and surgery (with neurosurgery or stereotactic radiosurgery) with medical management alone in people with symptomatic brain cavernoma – protocol for the Cavernomas: A Randomised Effectiveness (CARE) pilot trial
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Loan, James J M, primary, Bacon, Andrew, additional, van Beijnum, Janneke, additional, Bhatt, Pragnesh, additional, Bjornson, Anna, additional, Broomes, Nicole, additional, Bullen, Alistair, additional, Bulters, Diederik, additional, Cahill, Julian, additional, Chavredakis, Emmanuel, additional, Colombo, Francesca, additional, Danciut, Mihai, additional, Digpal, Ronneil, additional, Edwards, Richard J, additional, Ferguson, Lucie, additional, Forsyth, Laura, additional, Fouyas, Ioannis, additional, Ganesan, Vijeya, additional, Grover, Patrick, additional, Gurusinghe, Nihal, additional, Hall, Peter S, additional, Harkness, Kirsty, additional, Harris, Lauren S, additional, Hayton, Tom, additional, Helmy, Adel, additional, Holsgrove, Daniel, additional, Hutchinson, Peter J, additional, Israni, Anil, additional, Kinsella, Elaine, additional, Lewis, Steff, additional, Majeed, Sohail, additional, Mallucci, Conor, additional, Mukerji, Nitin, additional, Nair, Ramesh, additional, Neilson, Aileen R, additional, Papadopoulos, Marios C, additional, Radatz, Matthias, additional, Rossdeutsch, Alex, additional, Raza-Knight, Saba, additional, Stephen, Jacqueline, additional, Stoddart, Andrew, additional, Teo, Mario, additional, Turner, Carole, additional, Wade, Julia, additional, Walsh, Daniel, additional, White, David, additional, White, Phil, additional, Wildman, Jack, additional, Wroe Wright, Oliver, additional, Uff, Christopher, additional, Ushewokunze, Shungu, additional, Vindlacheruvu, Raghu, additional, Kitchen, Neil, additional, and Al-Shahi Salman, Rustam, additional
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- 2023
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22. Surgery vs radiosurgery for vestibular schwannoma: shared decision making in a multi-disciplinary clinic
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Colombo, Francesca, primary, Maye, Helen, additional, Rutherford, Scott, additional, King, Andrew, additional, Hammerbeck-Ward, Charlotte, additional, Whitfield, Gillian A, additional, McBain, Catherine, additional, Colaco, Rovel, additional, Entwistle, Helen, additional, Wadeson, Andrea, additional, Lloyd, Simon, additional, Freeman, Simon, additional, and Pathmanaban, Omar N, additional
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- 2023
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23. Funtional analyses of genetic elements associated with lung cancer
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Colombo, Francesca
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616.994 - Published
- 2011
24. Human functioning: realizing the value of health
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Colombo, Francesca
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- 2023
25. Lung Adenocarcinoma Diagnosed at a Younger Age Is Associated with Advanced Stage, Female Sex, and Ever-Smoker Status, in Patients Treated with Lung Resection
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Dragani, Tommaso A., primary, Muley, Thomas, additional, Schneider, Marc A., additional, Kobinger, Sonja, additional, Eichhorn, Martin, additional, Winter, Hauke, additional, Hoffmann, Hans, additional, Kriegsmann, Mark, additional, Noci, Sara, additional, Incarbone, Matteo, additional, Tosi, Davide, additional, Franzi, Sara, additional, and Colombo, Francesca, additional
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- 2023
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26. Blood- and Imaging-Derived Biomarkers for Oncological Outcome Modelling in Oropharyngeal Cancer: Exploring the Low-Hanging Fruit
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Volpe, Stefania, primary, Gaeta, Aurora, additional, Colombo, Francesca, additional, Zaffaroni, Mattia, additional, Mastroleo, Federico, additional, Vincini, Maria Giulia, additional, Pepa, Matteo, additional, Isaksson, Lars Johannes, additional, Turturici, Irene, additional, Marvaso, Giulia, additional, Ferrari, Annamaria, additional, Cammarata, Giulio, additional, Santamaria, Riccardo, additional, Franzetti, Jessica, additional, Raimondi, Sara, additional, Botta, Francesca, additional, Ansarin, Mohssen, additional, Gandini, Sara, additional, Cremonesi, Marta, additional, Orecchia, Roberto, additional, Alterio, Daniela, additional, and Jereczek-Fossa, Barbara Alicja, additional
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- 2023
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27. Identification of genetic polymorphisms modulating nausea and vomiting in two series of opioid-treated cancer patients
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Colombo, Francesca, Pintarelli, Giulia, Galvan, Antonella, Noci, Sara, Corli, Oscar, Skorpen, Frank, Klepstad, Pål, Kaasa, Stein, Pigni, Alessandra, Brunelli, Cinzia, Roberto, Anna, Piazza, Rocco, Pirola, Alessandra, Gambacorti-Passerini, Carlo, and Caraceni, Augusto Tommaso
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- 2020
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28. Cigarette smoke alters the transcriptome of non-involved lung tissue in lung adenocarcinoma patients
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Pintarelli, Giulia, Noci, Sara, Maspero, Davide, Pettinicchio, Angela, Dugo, Matteo, De Cecco, Loris, Incarbone, Matteo, Tosi, Davide, Santambrogio, Luigi, Dragani, Tommaso A., and Colombo, Francesca
- Published
- 2019
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29. Phenolic Profile and In Vitro Antioxidant Activity of Different Corn and Rice Varieties
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Bani, Corinne, primary, Di Lorenzo, Chiara, additional, Restani, Patrizia, additional, Mercogliano, Francesca, additional, and Colombo, Francesca, additional
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- 2023
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30. Evaluation of the Potential Anti-Inflammatory Activity of Black Rice in the Framework of Celiac Disease
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Piazza, Stefano, primary, Colombo, Francesca, additional, Bani, Corinne, additional, Fumagalli, Marco, additional, Vincentini, Olimpia, additional, Sangiovanni, Enrico, additional, Martinelli, Giulia, additional, Biella, Simone, additional, Silano, Marco, additional, Restani, Patrizia, additional, Dell’Agli, Mario, additional, and Di Lorenzo, Chiara, additional
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- 2022
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31. Next-Generation Sequencing of a Large Gene Panel for Outcome Prediction of Bariatric Surgery in Patients with Severe Obesity
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Bonetti, Gabriele, primary, Dhuli, Kristjana, additional, Ceccarini, Maria Rachele, additional, Kaftalli, Jurgen, additional, Samaja, Michele, additional, Precone, Vincenza, additional, Cecchin, Stefano, additional, Maltese, Paolo Enrico, additional, Guerri, Giulia, additional, Marceddu, Giuseppe, additional, Beccari, Tommaso, additional, Aquilanti, Barbara, additional, Velluti, Valeria, additional, Matera, Giuseppina, additional, Perrone, Marco, additional, Iaconelli, Amerigo, additional, Colombo, Francesca, additional, Greco, Francesco, additional, Raffaelli, Marco, additional, Ergoren, Mahmut Cerkez, additional, and Bertelli, Matteo, additional
- Published
- 2022
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32. Salvage Stereotactic Reirradiation for Local Recurrence in the Prostatic Bed After Prostatectomy: A Retrospective Multicenter Study
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Archer, Paul, Marvaso, Giulia, Detti, Beatrice, Colombo, Francesca, Francolini, Giulio, Vandendorpe, Benjamin, Thananayagam, Marie Albert, Baty, Manon, De Crevoisier, Renaud, Alongi, Filippo, Nicosia, Luca, Scher, Nathaniel, Toledano, Alain, Di Muzio, Nadia, Fodor, Andrei, Zilli, Thomas, Franzese, Ciro, Scorsetti, Marta, Shelan, Mohamed, Triggiani, Luca, Aymes, Estelle, Le Deley, Marie-Cécile, Alicja Jereczek-Fossa, Barbara, and Pasquier, David
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Prostate cancer ,Salvage stereotactic radiation therapy ,Oncology ,Recurrence ,Urology ,Prostatic bed ,Radical prostatectomy ,Reirradiation ,Radiology, Nuclear Medicine and imaging ,Surgery ,610 Medicine & health - Abstract
BACKGROUND Management of local recurrence of prostate cancer (PCa) in the prostatic bed after radical prostatectomy (RP) and radiotherapy remains challenging. OBJECTIVE To assess the efficacy and safety of salvage stereotactic body radiotherapy (SBRT) reirradiation in this setting and evaluate prognostic factors. DESIGN, SETTING, AND PARTICIPANTS We conducted a large multicenter retrospective series that included 117 patients who were treated with salvage SBRT for local recurrence in the prostatic bed after RP and radiotherapy in 11 centers across three countries. OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS Progression-free survival (PFS; biochemical, clinical, or both) was estimated using the Kaplan-Meier method. Biochemical recurrence was defined as prostate-specific antigen nadir +0.2 ng/ml, confirmed by a second increasing measure. The cumulative incidence of late toxicities was estimated using the Kalbfleisch-Prentice method by considering recurrence or death as a competing event. RESULTS AND LIMITATIONS The median follow-up was 19.5 mo. The median SBRT dose was 35 Gy. The median PFS was 23.5 mo (95% confidence interval [95% CI], 17.6-33.2). In the multivariable models, the volume of the recurrence and its contact with the urethrovesical anastomosis were significantly associated with PFS (hazard ratio [HR]/10 cm3 = 1.46; 95% CI, 1.08-1.96; p = 0.01 and HR = 3.35; 95% CI, 1.38-8.16; p = 0.008, respectively). The 3-yr cumulative incidence of grade ≥2 late GU or GI toxicity was 18% (95% CI, 10-26). In the multivariable analysis, a recurrence in contact with the urethrovesical anastomosis and D2% of the bladder were significantly associated with late toxicities of any grade (HR = 3.65; 95% CI, 1.61-8.24; p = 0.002 and HR/10 Gy = 1.88; 95% CI, 1.12-3.16; p = 0.02, respectively). CONCLUSIONS Salvage SBRT for local recurrence in the prostate bed may offer encouraging control and acceptable toxicity. Therefore, further prospective studies are warranted. PATIENT SUMMARY We found that salvage stereotactic body radiotherapy after surgery and radiotherapy allows for encouraging control and acceptable toxicity in locally relapsed prostate cancer.
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- 2023
33. Efficacy and tolerability of an oral supplement containing amino acids, iron, selenium, and marine hydrolyzed collagen in subjects with hair loss (androgenetic alopecia, AGA or FAGA or telogen effluvium). A prospective, randomized, 3‐month, controlled, assessor‐blinded study
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Milani, Massimo and Colombo, Francesca
- Subjects
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BALDNESS , *AMINO acids , *IRON , *DIETARY supplements , *COLLAGEN , *SELENIUM , *HAIR growth , *DEFEROXAMINE , *METHIONINE - Abstract
Background: Oral supplementation with some amino acids (like methionine, taurine, and cysteine) could be useful in subjects with hair loss conditions such as androgenic alopecia (AGA or FAGA) or telogen effluvium (TE). Hydrolysed collagen (HC) oral supplementation has demonstrated to have beneficial effects on nail and skin health and could improve hair growth. A food supplement in tablet formulation containing hydrolysed fish‐origin collagen (300 mg/dose), taurine, cysteine, methionine, iron, and selenium has been recently available. To date no controlled data are available regarding the clinical efficacy of this product as adjuvant to hair loss specific treatments in these clinical conditions. Study aims: To evaluate and compare the efficacy and tolerability of an oral supplementation based on HC and amino acids in subjects with hair loss due to AGA/FAGA or chronic TE in combination with drug treatments in comparison with drug treatments alone. Methods and subjects: In a prospective, 12‐week, randomized, assessor‐blinded controlled trial 83 subjects (mean age 41 ± 16 years; 26 men and 57 women) were enrolled in the study. Fifty‐nine subjects suffered from AGA/FAGA (Hamilton I‐VA, Ludwig I‐1, II‐2) and 24 from chronic TE. Subjects were randomized to oral supplementation (1 tablet day) in combination with the specify drug treatment decided by the investigator according to the type of hair loss (AGA/FAGA or TE) (Group A; N = 48) or to specific drugs treatment only (Group B; N = 35). The main outcome of the trial was the clinical efficacy evaluation using a 7‐point global assessment score (GAS) (from +3: Much Improved to ‐3 Much worsened; with score 0 representing no modification). The GAS score was evaluated using standardized photographs by an investigator unaware of the treatment groups at week 6 and at week 12. A secondary outcome was the evaluation of acceptability of the treatment regimen using a 10‐point evaluation score. Results: Seventy‐six participants (91.6%) completed the 12‐week study period. The GAS score at week 6 was 0.5 ± 0.2 in group A and 0.0 ± 0.1 in Group B (p < 0.05; Mann‐Whitney). At week 12 the GAS score in Group A was statistically significant higher in comparison with Group B (1.67 ± 0.16 and 0.66 ± 0.20, p < 0.001; Mann–Whitney test). A higher percentage of Group A subjects achieved a GAS score of ≥2 in comparison with group B (50% vs. 23%). The oral supplement was generally well tolerated. Conclusion: An oral supplement containing hydrolysed fish‐origin collagen, taurine, cysteine, methionine, iron, and selenium has demonstrated to improve the clinical efficacy of specific anti‐hair loss treatments in subjects with AGA/FAGA or chronic TE. [ABSTRACT FROM AUTHOR]
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- 2023
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34. Genetic predisposition to lung adenocarcinoma outcome is a feature already present in patients' noninvolved lung tissue
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Minnai, Francesca, primary, Noci, Sara, additional, Chierici, Marco, additional, Cotroneo, Chiara Elisabetta, additional, Bartolini, Barbara, additional, Incarbone, Matteo, additional, Tosi, Davide, additional, Mattioni, Giovanni, additional, Jurman, Giuseppe, additional, Dragani, Tommaso A., additional, and Colombo, Francesca, additional
- Published
- 2022
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35. Environmental Factors in Northern Italy and Sickle Cell Disease Acute Complications: A Multicentric Study
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Guerzoni, Maria Elena, primary, Marchesi, Stefano, additional, Palazzi, Giovanni, additional, Lodi, Mariachiara, additional, Pinelli, Margherita, additional, Venturelli, Donatella, additional, Bigi, Elena, additional, Quaglia, Nadia, additional, Corti, Paola, additional, Serra, Roberta, additional, Colombatti, Raffaella, additional, Sainati, Laura, additional, Masera, Nicoletta, additional, Colombo, Francesca, additional, Barone, Angelica, additional, and Iughetti, Lorenzo, additional
- Published
- 2022
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36. Decompressive Craniectomy for the Treatment of Severe Diffuse Traumatic Brain Injury: A Randomized Controlled Trial
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Hashmi, Syed Muhammad Maroof, additional, Nazir, Sadaf, additional, Colombo, Francesca, additional, Jamil, Akmal, additional, and Ahmed, Shahid, additional
- Published
- 2022
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37. Diet, Polyphenols, and Human Evolution
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Restani, Patrizia, primary, Colombo, Francesca, additional, Biella, Simone, additional, Bani, Corinne, additional, Mercogliano, Francesca, additional, and Di Lorenzo, Chiara, additional
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- 2022
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38. Upfront transoral robotic surgery (TORS) versus intensity-modulated radiation therapy (IMRT) in HPV-positive oropharyngeal cancer: real-world data from a tertiary comprehensive cancer centre
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Zorzi, Stefano Filippo, primary, Agostini, Giovanni, additional, Chu, Francesco, additional, Tagliabue, Marta, additional, Pietrobon, Giacomo, additional, Corrao, Giulia, additional, Volpe, Stefania, additional, Marvaso, Giulia, additional, Colombo, Francesca, additional, Cossu Rocca, Maria, additional, Gandini, Sara, additional, Gaeta, Aurora, additional, Ruju, Francesca, additional, Alterio, Daniela, additional, and Ansarin, Mohssen, additional
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- 2022
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39. Pycard and BC017158 Candidate Genes of Irm1 Locus Modulate Inflammasome Activation for IL-1β Production
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Borrego, Andrea, primary, Colombo, Francesca, additional, de Souza, Jean Gabriel, additional, Jensen, José Ricardo, additional, Dassano, Alice, additional, Piazza, Rocco, additional, Rodrigues dos Santos, Barbara Anaís, additional, Ribeiro, Orlando Garcia, additional, De Franco, Marcelo, additional, Cabrera, Wafa Hanna Koury, additional, Icimoto, Marcelo Yudi, additional, Starobinas, Nancy, additional, Magalhães, Geraldo, additional, Monteleone, Leticia Figueiredo, additional, Eto, Silas Fernandes, additional, DeOcesano-Pereira, Carlos, additional, Goldfeder, Mauricio Barbugiani, additional, Pasqualoto, Kerly Fernanda Mesquita, additional, Dragani, Tommaso A., additional, and Ibañez, Olga Célia Martinez, additional
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- 2022
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40. Evaluation of the Potential Anti-Inflammatory Activity of Black Rice in the Framework of Celiac Disease.
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Piazza, Stefano, Colombo, Francesca, Bani, Corinne, Fumagalli, Marco, Vincentini, Olimpia, Sangiovanni, Enrico, Martinelli, Giulia, Biella, Simone, Silano, Marco, Restani, Patrizia, Dell'Agli, Mario, and Di Lorenzo, Chiara
- Subjects
GLIADINS ,CELIAC disease ,ANTI-inflammatory agents ,RICE ,REACTIVE oxygen species ,AGGLUTINATION tests ,GLUTEN-free foods - Abstract
Inflammation and oxidative stress are two mechanisms involved in the pathogenesis of celiac disease (CD). Since the direct effect of gliadin on the intestinal epithelia is less studied, the aims of this study were the development of a specific cellular model based on the use of gliadin as a pro-inflammatory stimulus and the evaluation of the potential antioxidant and anti-inflammatory properties of extracts from different black rice in the framework of CD. The rice extracts were in vitro digested, characterized in terms of phenolic compounds and antioxidant capacity, and tested on Caco-2 cells to investigate their inhibitory effect on Reactive Oxygen Species, the NF-κB transcription and the CXC chemokines (sICAM-1, IL-8, and CXCL-10). In addition, the role of the extracts in modulating the activation of epithelial cells in CD was confirmed by applying the K562(S) agglutination test. The black rice extracts showed inhibitory effects on the production of the oxidative and the inflammatory mediators considered, with particular reference to lymphocyte-attracting CXCL-10 both before and after digestion. The presence of anthocyanins and their digestion metabolites may account for the observed anti-inflammatory activity after in vitro digestion. This work provided preliminary data supporting the use of black rice as a healthy food or ingredient of food supplements for celiacs. [ABSTRACT FROM AUTHOR]
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- 2023
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41. Genetic predisposition to lung adenocarcinoma outcome is a feature already present in patients' noninvolved lung tissue.
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Minnai, Francesca, Noci, Sara, Chierici, Marco, Cotroneo, Chiara Elisabetta, Bartolini, Barbara, Incarbone, Matteo, Tosi, Davide, Mattioni, Giovanni, Jurman, Giuseppe, Dragani, Tommaso A., and Colombo, Francesca
- Abstract
Emerging evidence suggests that the prognosis of patients with lung adenocarcinoma can be determined from germline variants and transcript levels in nontumoral lung tissue. Gene expression data from noninvolved lung tissue of 483 lung adenocarcinoma patients were tested for correlation with overall survival using multivariable Cox proportional hazard and multivariate machine learning models. For genes whose transcript levels are associated with survival, we used genotype data from 414 patients to identify germline variants acting as cis‐expression quantitative trait loci (eQTLs). Associations of eQTL variant genotypes with gene expression and survival were tested. Levels of four transcripts were inversely associated with survival by Cox analysis (CLCF1, hazard ratio [HR] = 1.53; CNTNAP1, HR = 2.17; DUSP14, HR = 1.78; and MT1F: HR = 1.40). Machine learning analysis identified a signature of transcripts associated with lung adenocarcinoma outcome that was largely overlapping with the transcripts identified by Cox analysis, including the three most significant genes (CLCF1, CNTNAP1, and DUSP14). Pathway analysis indicated that the signature is enriched for ECM components. We identified 32 cis‐eQTLs for CNTNAP1, including 6 with an inverse correlation and 26 with a direct correlation between the number of minor alleles and transcript levels. Of these, all but one were prognostic: the six with an inverse correlation were associated with better prognosis (HR < 1) while the others were associated with worse prognosis. Our findings provide supportive evidence that genetic predisposition to lung adenocarcinoma outcome is a feature already present in patients' noninvolved lung tissue. [ABSTRACT FROM AUTHOR]
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- 2023
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42. Common, low-frequency, rare, and ultra-rare coding variants contribute to COVID-19 severity
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Fallerini, Chiara, Picchiotti, Nicola, Baldassarri, Margherita, Zguro, Kristina, Daga, Sergio, Fava, Francesca, Benetti, Elisa, Amitrano, Sara, Bruttini, Mirella, Palmieri, Maria, Croci, Susanna, Lista, Mirjam, Beligni, Giada, Valentino, Floriana, Meloni, Ilaria, Tanfoni, Marco, Minnai, Francesca, Colombo, Francesca, Cabri, Enrico, Fratelli, Maddalena, Gabbi, Chiara, Mantovani, Stefania, Frullanti, Elisa, Gori, Marco, Crawley, Francis P, Butler-Laporte, Guillaume, Richards, Brent, Zeberg, Hugo, Lipcsey, Miklos, Hultström, Michael, Ludwig, Kerstin U, Schulte, Eva C, Pairo-Castineira, Erola, Baillie, John Kenneth, Schmidt, Axel, Frithiof, Robert, Mari, Francesca, Renieri, Alessandra, Furini, Simone Simone Furini, Francesca, Montagnani, Mario, Tumbarello, Ilaria, Rancan, Massimiliano, Fabbiani, Barbara, Rossetti, Laura, Bergantini, Miriana, D'Alessandro, Paolo, Cameli, David, Bennett, Federico, Anedda, Simona, Marcantonio, Sabino, Scolletta, Federico, Franchi, Maria Antonietta Mazzei, Susanna, Guerrini, Edoardo, Conticini, Luca, Cantarini, Bruno, Frediani, Danilo, Tacconi, Chiara Spertilli Raffaelli, Marco, Feri, Alice, Donati, Raffaele, Scala, Luca, Guidelli, Genni, Spargi, Marta, Corridi, Cesira, Nencioni, Leonardo, Croci, Gian Piero Caldarelli, Maurizio, Spagnesi, Davide, Romani, Paolo, Piacentini, Maria, Bandini, Elena, Desanctis, Silvia, Cappelli, Anna, Canaccini, Agnese, Verzuri, Valentina, Anemoli, Manola, Pisani, Agostino, Ognibene, Alessandro, Pancrazzi, Maria, Lorubbio, Massimo, Vaghi, Antonella, D 'Arminio Monforte, Federica Gaia Miraglia, Mario, U Mondelli, Massimo, Girardis, Sophie, Venturelli, Stefano, Busani, Andrea, Cossarizza, Andrea, Antinori, Alessandra, Vergori, Arianna, Emiliozzi, Stefano, Rusconi, Matteo, Siano, Arianna, Gabrieli, Agostino, Riva, Daniela, Francisci, Elisabetta, Schiaroli, Francesco, Paciosi, Andrea, Tommasi, Pier Giorgio Scotton, Francesca, Andretta, Sandro, Panese, Stefano, Baratti, Renzo, Scaggiante, Francesca, Gatti, Saverio Giuseppe Parisi, Francesco, Castelli, Eugenia, Quiros-Roldan, Melania Degli Antoni, Isabella, Zanella, Matteo Della Monica, Carmelo, Piscopo, Mario, Capasso, Roberta, Russo, Immacolata, Andolfo, Achille, Iolascon, Giuseppe, Fiorentino, Massimo, Carella, Marco, Castori, Filippo, Aucella, Pamela, Raggi, Rita, Perna, Matteo, Bassetti, Antonio Di Biagio, Maurizio, Sanguinetti, Luca, Masucci, Alessandra, Guarnaccia, Serafina, Valente, Oreste De Vivo, Gabriella, Doddato, Rossella, Tita, Annarita, Giliberti, Maria Antonietta Mencarelli, Caterina Lo Rizzo, Anna Maria Pinto, Valentina, Perticaroli, Francesca, Ariani, Miriam Lucia Carriero, Laura Di Sarno, Diana, Alaverdian, Elena, Bargagli, Marco, Mandalà, Alessia, Giorli, Lorenzo, Salerni, Patrizia, Zucchi, Pierpaolo, Parravicini, Elisabetta, Menatti, Tullio, Trotta, Ferdinando, Giannattasio, Gabriella, Coiro, Fabio, Lena, Leonardo Gianluca Lacerenza, Domenico, A Coviello, Cristina, Mussini, Enrico, Martinelli, Sandro, Mancarella, Luisa, Tavecchia, Mary Ann Belli, Lia, Crotti, Gianfranco, Parati, Maurizio, Sanarico, Francesco, Raimondi, Filippo, Biscarini, Alessandra, Stella, Marco, Rizzi, Franco, Maggiolo, Diego, Ripamonti, Claudia, Suardi, Tiziana, Bachetti, Maria Teresa La Rovere, Simona, Sarzi-Braga, Maurizio, Bussotti, Katia, Capitani, Simona, Dei, Sabrina, Ravaglia, Rosangela, Artuso, Elena, Andreucci, Giulia, Gori, Angelica, Pagliazzi, Erika, Fiorentini, Antonio, Perrella, Francesco, Bianchi, Paola, Bergomi, Emanuele, Catena, Riccardo, Colombo, Sauro, Luchi, Giovanna, Morelli, Paola, Petrocelli, Sarah, Iacopini, Sara, Modica, Silvia, Baroni, Francesco Vladimiro Segala, Francesco, Menichetti, Marco, Falcone, Giusy, Tiseo, Chiara, Barbieri, Tommaso, Matucci, Grassi, Davide, Ferri, Claudio, Marinangeli, Franco, Brancati, Francesco, Antonella, Vincenti, Valentina, Borgo, Lombardi, Stefania, Mirco, Lenzi, Massimo Antonio Di Pietro, Francesca, Vichi, Benedetta, Romanin, Letizia, Attala, Cecilia, Costa, Andrea, Gabbuti, Menè, Roberto, Umberto, Zuccon, Lucia, Vietri, Stefano, Ceri, Pietro, Pinoli, Patrizia, Casprini, Giuseppe, Merla, Gabriella Maria Squeo, Marcello, Maffezzoni, Raffaele, Bruno, Marco, Vecchia, Marta, Colaneri, Serena, Ludovisi, Yanara, Marincevic-Zuniga, Jessica, Nordlund, Tomas, Luther, Anders, Larsson, Katja Hanslin Anna Gradin, Sarah, Galien, Sara Bulow Anderberg, Jacob, Rosén, Sten, Rubertsson, Hugo, Zeberg, Robert, Frithiof, Miklós, Lipcsey, Michael, Hultström, Sara Clohisey Peter Horby, Johnny, Millar, Julian, Knight, Hugh, Montgomery, David, Maslove, Lowell, Ling, Alistair, Nichol, Charlotte, Summers, Tim, Walsh, Charles, Hinds, Malcolm, G Semple, Peter J, M Openshaw, Manu, Shankar-Hari, Antonia, Ho, Danny, Mcauley, Chris, Ponting, Kathy, Rowan, J Kenneth Baillie, Fiona, Griffiths, Wilna, Oosthuyzen, Jen, Meikle, Paul, Finernan, James, Furniss, Ellie, Mcmaster, Andy, Law, Sara, Clohisey, Trevor, Paterson, Tony, Wackett, Ruth, Armstrong, Lee, Murphy, Angie, Fawkes, Richard, Clark, Audrey, Coutts, Lorna, Donnelly, Tammy, Gilchrist, Katarzyna, Hafezi, Louise, Macgillivray, Alan, Maclean, Sarah, Mccafferty, Kirstie, Morrice, Jane, Weaver, Ceilia, Boz, Ailsa, Golightly, Mari, Ward, Hanning, Mal, Helen, Szoor-McElhinney, Adam, Brown, Ross, Hendry, Andrew, Stenhouse, Louise, Cullum, Dawn, Law, Sarah, Law, Rachel, Law, Max Head Fourman, Maaike, Swets, Nicky, Day, Filip, Taneski, Esther, Duncan, Marie, Zechner, Nicholas, Parkinson, Erola, Pairo-Castineira, Lucija, Klaric, Andrew, D Bretherick, Konrad, Rawlik, Dorota, Pasko, Susan, Walker, Nick, Parkinson, Clark, D Russell, Anne, Richmond, Elvina, Gountouna, David, Harrison, Wang, Bo, Yang, Wu, Alison, Meynert, Athanasios, Kousathanas, Loukas, Moutsianas, Zhijian, Yang, Ranran, Zhai, Chenqing, Zheng, Graeme, Grimes, Jonathan, Millar, Barbara, Shih, Jian, Yang, Xia, Shen, Chris, P Ponting, Albert, Tenesa, Andrew, Law, Veronique, Vitart, James, F Wilson, Collier, D, Wood, S, Zak, A, Borra, C, Matharu, M, May, P, Alldis, Z, Mitchelmore, O, Bowles, R, Easthorpe, A, Bibi, F, Lancoma-Malcolm, I, Gurasashvili, J, Pheby, J, Shiel, J, Bolton, M, Patel, M, Taylor, M, Zongo, O, Ebano, P, Harding, P, Astin-Chamberlain, R, Choudhury, Y, Cox, A, Kallon, D, Burton, M, Hall, R, Blowes, S, Prime, Z, Biddle, J, Prysyazhna, O, Newman, T, Tierney, C, Kassam, J, Shankar-Hari, M, Ostermann, M, Campos, S, Bociek, A, Lim, R, Grau, N, O Jones, T, Whitton, C, Marotti, M, Arbane, G, Bonner, S, Hugill, K, Reid, J, Welters, I, Waugh, V, Williams, K, Shaw, D, J Fernandez Roman, M Lopez Martinez, Johnson, E, Waite, A, Johnson, B, Hamilton, O, Mulla, S, Mcphail, M, Smith, J, K Baillie, J, Barclay, L, Hope, D, Mcculloch, C, Mcquillan, L, Clark, S, Singleton, J, Priestley, K, Rea, N, Callaghan, M, Campbell, R, Andrew, G, Marshall, L, Mckechnie, S, Hutton, P, Bashyal, A, Davidson, N, Summers, C, Polgarova, P, Stroud, K, Pathan, N, Elston, K, Agrawal, S, Battle, C, Newey, L, Rees, T, Harford, R, Brinkworth, E, Williams, M, Murphy, C, White, I, Croft, M, Bandla, N, Gellamucho, M, Tomlinson, J, Turner, H, Davies, M, Quinn, A, Hussain, I, Thompson, C, Parker, H, Bradley, R, Griffiths, R, Scriven, J, Gill, J, Puxty, A, Cathcart, S, Salutous, D, Turner, L, Duffy, K, Puxty, K, Joseph, A, Herdman-Grant, R, Simms, R, Swain, A, Naranjo, A, Crowe, R, Sollesta, K, Loveridge, A, Baptista, D, Morino, E, Davey, M, Golden, D, Jones, J, J Moreno Cuesta, Haldeos, A, Bakthavatsalam, D, Vincent, R, Elhassan, M, Xavier, K, Ganesan, A, Purohit, D, Abdelrazik, M, Morgan, J, Akeroyd, L, Bano, S, Warren, D, Bromley, M, Sellick, K, Gurr, L, Wilkinson, B, Nagarajan, V, Szedlak, P, Cupitt, J, Stoddard, E, Benham, L, Preston, S, Slawson, N, Bradshaw, Z, Brown, J, Caswell, M, Smelling, Bamford, P, Faulkner, M, Cawley, K, Jeffrey, H, London, E, Sainsbury, H, Nagra, I, Nasir, F, Dunmore, Ce, Jones, R, Abraheem, A, Al-Moasseb, M, Girach, R, Brantwood, C, Alexander, P, Bradley-Potts, J, Allen, S, Felton, T, Manna, S, Farnell-Ward, S, Leaver, S, Queiroz, J, Maccacari, E, Dawson, D, C Castro Delgado, R Pepermans Saluzzio, Ezeobu, O, Ding, L, Sicat, C, Kanu, R, Durrant, G, Texeira, J, Harrison, A, Samakomva, T, Willis, H, Hopkins, B, Thrasyvoulou, L, Jackson, M, Zaki, A, Tibke, C, Bennett, S, Woodyatt, W, Kent, A, Goodwin, E, Brandwood, C, Clark, R, Smith, L, Rooney, K, Thomson, N, Rodden, N, Hughes, E, Mcglynn, D, Clark, C, Clark, P, Abel, L, Sundaram, R, Gemmell, L, Brett, M, Hornsby, J, Macgoey, P, Price, R, Digby, B, O'Neil, P, Mcconnell, P, Henderson, P, Henderson, S, Sim, M, Kennedy-Hay, S, Mcparland, C, Rooney, L, Baxter, N, Pogson, D, Rose, S, Daly, Z, Brimfield, L, K Phull, M, Hussain, M, Pogreban, T, Rosaroso, L, E Salciute, L Grauslyte, Brealey, D, Wraith, E, Maccallum, N, Bercades, G, Hass, I, Smyth, D, Reyes, A, Martir, G, D Clement, I, Webster, K, Hays, C, Gulati, A, Hodgson, L, Margarson, M, Gomez, R, Baird, Y, Thirlwall, Y, Folkes, L, Butler, A, Meadows, E, Moore, S, Raynard, D, Fox, H, Riddles, L, King, K, Kimber, S, Hobden, G, Mccarthy, A, Cannons, V, Balagosa, I, Chadbourn, I, Gardner, A, Horner, D, Mclaughlanv, D, Charles, B, Proudfoot, N, Marsden, T, L Mc Morrow, Blackledge, B, Pendlebury, J, Harvey, A, Apetri, E, Basikolo, C, Catlow, L, Doonan, R, Knowles, K, Lee, S, Lomas, D, Lyons, C, Perez, J, Poulaka, M, Slaughter, M, Slevin, K, Thomas, V, Walker, D, Harris, J, Drummond, A, Tully, R, Dearden, J, Philbin, J, Munt, S, Rishton, C, O'Connor, G, Mulcahy, M, Dobson, E, Cuttler, J, Edward, M, Rose, A, Sloan, B, Buckley, S, Brooke, H, Smithson, E, Charlesworth, R, Sandu, R, Thirumaran, M, Wagstaff, V, J Cebrian Suarez, Kaliappan, A, Vertue, M, Nicholson, A, Riches, J, Solesbury, A, Kittridge, L, Forsey, M, Maloney, G, Cole, J, Davies, R, Hill, H, Thomas, E, Williams, A, Duffin, D, Player, B, Radhakrishnan, J, Gibson, S, Lyle, A, Mcneela, F, Patel, B, Gummadi, M, Sloane, G, Dormand, N, Salmi, S, Farzad, Z, Cristiano, D, Liyanage, K, Thwaites, V, Varghese, M, 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Almaden-Boyle, C, Pattison, N, Cruz, C, Vochin, A, Kent, H, Thomas, A, Murdoch, S, David, B, Penacerrada, M, Lubimbi, G, Bastion, V, Wulandari, R, Valentine, J, Clarke, D, Serrano-Ruiz, A, Hierons, S, Ramos, L, Demetriou, C, Mitchard, S, White, K, White, N, Pitts, S, Branney, D, Frankham, J, Watters, M, Langton, H, Prout, R, Page, V, Varghes, T, Cowton, A, Kay, A, Potts, K, Birt, M, Kent, M, Wilkinson, A, Jude, E, Turner, V, Savill, H, Mccormick, J, Coulding, M, Siddiqui, S, Mercer, O, Rehman, H, Potla, D, Capps, N, Donaldson, D, Button, H, Martin, T, Hard, K, Agasou, A, Tonks, L, Arden, T, Boyle, P, Carnahan, M, Strickley, J, Adams, C, Childs, D, Rikunenko, R, Leigh, M, Breekes, M, Wilcox, R, Bowes, A, Tiveran, H, Hurford, F, Summers, J, Carter, A, Hussain, Y, Ting, L, Javaid, A, Motherwell, N, Moore, H, Millward, H, Jose, S, Schunki, N, Noakes, A, Clulow, C, Sadera, G, Jacob, R, Jones, C, Blunt, M, Coton, Z, Curgenven, H, S Mohamed Ally, Beaumont, K, Elsaadany, M, Fernandes, K, I Ali Mohamed Ali, Rangarajan, H, Sarathy, V, Selvanayagam, S, Vedage, D, White, M, Smith, M, Truman, N, Chukkambotla, S, Keith, S, Cockerill-Taylor, J, Ryan-Smith, J, Bolton, R, Springle, P, Dykes, J, Thomas, J, Khan, M, T Hijazi, M, Massey, E, Croston, G, Reschreiter, H, Camsooksai, J, Patch, S, Jenkins, S, Humphrey, C, Wadams, B, Bhatia, N, Msiska, M, Adanini, O, Attwood, B, Parsons, P, Tatham, K, Jhanji, S, Black, E, A Dela Rosa, Howle, R, Thomas, B, Bemand, T, Raobaikady, R, Saha, R, Staines, N, Daniel, A, Finn, J, Hutter, J, Doble, P, Shovelton, C, Pawley, C, Kannan, T, Hill, M, Combes, E, Monnery, S, Joefield, T, Popescu, M, Thankachen, M, Oblak, M, Little, J, Mcivor, S, Brady, A, Whittle, H, Prady, H, Chan, R, Ahmed, A, Morris, A, Gibson, C, Gordon, E, Keenan, S, Quinn, H, Benyon, S, Marriott, S, Zitter, L, Park, L, Baines, K, Lyons, M, Holland, M, Keenan, N, Young, M, Garrioch, S, Dawson, J, Tolson, M, Scholefield, B, R, Bi, Richardson, N, Schumacher, N, Cosier, T, Millen, G, Higham, A, Turki, S, Allen, L, Crisp, N, Hazleton, T, Knight, A, Deery, J, Price, C, Turney, S, Tilbey, S, Beranova, E, Wright, D, Georg, L, Twiss, S, Wadd, S, Postlethwaite, K, Gondo, P, Masunda, B, Kayani, A, Hadebe, B, Whiteside, J, Clarke, N, Donnison, P, Trim, F, Leadbitter, I, Butcher, D, O'Sullivan, S, Purewal, B, Bell, S, Rivers', V, O'Leary, R, Birch, J, Collins, E, Anderson, S, Hammerton, K, Andrews, E, Burns, K, Edmond, I, Todd, A, Donnachie, J, Turner, P, Prentice, L, Symon, L, Runciman, N, Auld, F, Halkes, M, Mercer, P, Thornton, L, Debreceni, G, Wilkins, J, Brown, A, Crickmore, V, Subramanian, G, Marshall, R, Jennings, C, Latif, M, Bunni, L, Spivey, M, Bean, S, Burt, K, Linnett, V, Ritzema, J, Sanderson, A, Mccormick, W, Bokhari, M, Kapoor, R, Loader, D, Ayers, A, Harrison, W, North, J, Belagodu, Z, Parasomthy, R, Olufuwa, O, Gherman, A, Fuller, B, Stuart, C, Kelsall, O, Davis, C, Wild, L, Wood, H, Thrush, J, Durie, A, Austin', K, Archer, K, Anderson, P, Vigurs, C, Thorpe, C, Knights, E, Boyle, N, Price, A, Kubisz-Pudelko, A, Wood, D, Lewis, A, Board, S, Pippard, L, Perry, J, Beesley, K, Rattray, A, Lee, E, Lennon, L, Douglas, K, Bell, D, Boyle, R, Glass, L, M Nauman Akhtar, Dent, K, Potoczna, D, Pearson, S, Horsley, E, Spencer, S, Mullan, D, Skinner, D, Gaylard, J, Ortiz-Ruizdegordoa, L, Barber, R, Hewitt, C, Hilldrith, A, Shepardson, S, Wills, M, Jackson-Lawrence, K, Gupta, A, Easthope, A, Timlick, E, Gorman, C, Otaha, I, Gales, A, Coetzee, S, Raj, M, Peiu, M, Quaid, S, Watson, E, Elliott, K, Mallinson, J, Chandler, B, Turnbull, A, Finch, C, Holl, C, Cooper, J, Evans, A, Khaliq, W, Collins, A, E Treus Gude, Love, N, L van Koutrik, Hunt, J, Kaye, D, Fisher, E, Brayne, A, Tuckey, V, Jackson, P, Parkin, J, Raith, E, Tariq, A, Houlden, H, Tucci, A, Hardy, J, Moncur, E, Highgate, J, Cowley, A, Mitra, A, Stead, R, Behan, T, Burnett, C, Newton, M, Heeney, E, Pollard, R, Hatton, J, Patel, A, Kasipandian, V, Allibone, S, M Genetu, R, Otahal, I, O'Brien, L, Omar, Z, Perkins, E, Davies, K, Tetla, D, Shelley, B, Irvine, V, Williams, S, Williams, P, Goodsell, J, Tutton, R, Bough, L, Winter-Goodwin, B, Kitson, R, Pinnell, J, Wilson, A, Nortcliffe, T, Wood, T, Home, M, Holdroyd, K, Robinson, M, Shaw, R, Greig, J, Brady, M, Haigh, A, Matupe, L, Usher, M, Mellor, S, Dale, S, Gledhill, L, Shaw, L, Turner, G, Kelly, D, Anwar, B, Riley, H, Sturgeon, H, Ali, A, Thomis, L, Melia, D, Dance, A, Hanson, K, Humphreys, S, Frost, I, Gopal, V, Godden, J, Holden, A, Swann, S, Smith, T, Clapham, M, Poultney, U, Harper, R, Rice, P, Reece-Anthony, R, Gurung, B, Moultrie, S, Odam, M, Mayer, A, Bellini, A, Pickard, A, Bryant, J, Roe, N, Sowter, J, Lang, K, Taylor, J, Barry, P, Hobrok, M, Tench, H, Wolf-Roberts, R, Mcguinness, H, Loosley, R, Hawcutt, D, Rad, L, O'Malley, L, Saunderson, P, Seddon, G, Anderson, T, Rogers, N, Ruddy, J, Harkins, M, Beith, C, Mcalpine, A, Ferguson, L, Grant, P, Macfadyen, S, Mclaughlin, M, Baird, T, Rundell, S, Welsh, B, Hamill, R, Fisher, F, Gregory, J, Axel, Schmidt, Kerstin, U Ludwig, Selina, Rolker, Markus, M Nöthen, Julia, Fazaal, Verena, Keitel, Björn, Jensen, Torsten, Feldt, Lisa, Knopp, Julia, Schröder, Carlo, Maj, Fabian, Brand, Marc, M Berger, Thorsten, Brenner, Anke, Hinney, Oliver, Witzke, Robert, Bals, Christian, Herr, Nicole, Ludwig, Jörn, Walter, Jochen, Schneider, Johanna, Erber, Christoph, D Spinner, Clemens, M Wendtner, Christof, Winter, Ulrike, Protzer, Nicolas, Casadei, Stephan, Ossowski, Olaf, H Riess, Eva, C Schulte, J Brent Richards, Guillaume, Butler-Laporte, Mirosław, Kwasniewski, Urszula, Korotko, Karolina, Chwialkowska, Magdalena, Niemira, Jerzy, Jaroszewicz, Barbara, Sobala-Szczygiel, Beata, Puzanowska, Anna, Parfieniuk-Kowerda, Diana, Martonik, Anna, Moniuszko-Malinowska, Sławomir, Pancewicz, Dorota, Zarębska-Michaluk, Krzysztof, Simon, Monika, Pazgan-Simon, Iwona, Mozer-Lisewska, Maciej, Bura, Agnieszka, Adamek, Krzysztof Tomasiewicz Małgorzata Pawłowska, Anna, Piekarska, Aleksandra, Berkan-Kawinska, Andrzej, Horban, Justyna, Kowalska, Regina, Podlasin, Piotr, Wasilewski, Arsalin, Azzadin, Miroslaw, Czuczwar, Slawomir, Czaban, Paweł, Olszewski, Jacek, Bogocz, Magdalena, Ochab, Anna, Kruk, Sandra, Uszok, Agnieszka, Bielska, Anna, Szałkowska, Justyna, Raczkowska, Gabriela, Sokołowska, Joanna, Chorostowska-Wynimko, Aleksandra, Jezela-Stanek, Adriana, Roży, Urszula, Lechowicz, Urszula, Polowianiuk, Kamil, Grubczak, Aleksandra, Starosz, Andrzej, Eljaszewicz, Wiktoria, Izdebska, Adam, Krętowski, Robert, Flisiak, Marcin Moniuszko Malak Abedalthagafi Manal Alaamery, Salam, Massadeh, Mohamed, Fawzy, Hadeel, Albardis, Nora, Aljawini, Moneera, Alsuwailm, Faisal, Almalki, Serghei, Mangul, Junghyun, Jung, Hamdi, Mbarek, Chadi, Saad, Yaser, Al-Sarraj, Wadha, Al-Muftah, Radja, Badji, Asma Al Thani, Said, I Ismail, HGI, WES/WGS Working Group Within the, Consortium, GenOMICC, Study, GEN-COVID Multicenter, Renieri, Alessandra [0000-0002-0846-9220], Apollo - University of Cambridge Repository, NIHR, Fallerini, C, Picchiotti, N, Baldassarri, M, Zguro, K, Daga, S, Fava, F, Benetti, E, Amitrano, S, Bruttini, M, Palmieri, M, Croci, S, Lista, M, Beligni, G, Valentino, F, Meloni, I, Tanfoni, M, Minnai, F, Colombo, F, Cabri, E, Fratelli, M, Gabbi, C, Mantovani, S, Frullanti, E, Gori, M, Crawley, F, Butler-Laporte, G, Richards, B, Zeberg, H, Lipcsey, M, Hultström, M, Ludwig, K, Schulte, E, Pairo-Castineira, E, Baillie, J, Schmidt, A, Frithiof, R, Mari, F, Renieri, A, Furini, S, and Crotti, L
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Male ,Medicin och hälsovetenskap ,Linkage disequilibrium ,Medizin ,severity ,Genome-wide association study ,Disease ,WES/WGS Working Group Within the HGI ,Logistic regression ,Severity of Illness Index ,Medical and Health Sciences ,Whole Exome Sequencing ,Cohort Studies ,0302 clinical medicine ,Lasso (statistics) ,GEN-COVID Multicenter Study ,Germany ,80 and over ,Genetics (clinical) ,Exome sequencing ,Original Investigation ,Genetics & Heredity ,Aged, 80 and over ,0303 health sciences ,Adult ,Aged ,COVID-19 ,Female ,Humans ,Italy ,Middle Aged ,Polymorphism, Single Nucleotide ,Quebec ,SARS-CoV-2 ,Sweden ,United Kingdom ,Genetic Predisposition to Disease ,Phenotype ,Single Nucleotide ,covid-19 ,1104 Complementary and Alternative Medicine ,GenOMICC Consortium ,Human ,coding variants ,Computational biology ,Biology ,03 medical and health sciences ,Exome Sequencing ,Genetics ,Polymorphism ,Gene ,030304 developmental biology ,0604 Genetics ,1114 Paediatrics and Reproductive Medicine ,Cohort Studie ,030217 neurology & neurosurgery ,Coding (social sciences) - Abstract
The combined impact of common and rare exonic variants in COVID-19 host genetics is currently insufficiently understood. Here, common and rare variants from whole-exome sequencing data of about 4000 SARS-CoV-2-positive individuals were used to define an interpretable machine-learning model for predicting COVID-19 severity. First, variants were converted into separate sets of Boolean features, depending on the absence or the presence of variants in each gene. An ensemble of LASSO logistic regression models was used to identify the most informative Boolean features with respect to the genetic bases of severity. The Boolean features selected by these logistic models were combined into an Integrated PolyGenic Score that offers a synthetic and interpretable index for describing the contribution of host genetics in COVID-19 severity, as demonstrated through testing in several independent cohorts. Selected features belong to ultra-rare, rare, low-frequency, and common variants, including those in linkage disequilibrium with known GWAS loci. Noteworthily, around one quarter of the selected genes are sex-specific. Pathway analysis of the selected genes associated with COVID-19 severity reflected the multi-organ nature of the disease. The proposed model might provide useful information for developing diagnostics and therapeutics, while also being able to guide bedside disease management. Supplementary Information The online version contains supplementary material available at 10.1007/s00439-021-02397-7.
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- 2021
43. L’ASSURANCE MALADIE DANS L’OCDE
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COLOMBO, Francesca
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- 2004
44. Ancient and Modern Cereals as Ingredients of the Gluten-Free Diet: Are They Safe Enough for Celiac Consumers?
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Colombo, Francesca, Di Lorenzo, Chiara, Biella, Simone, Bani, Corinne, and Restani, Patrizia
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Triticum monococcum ,Avena sativa ,Chemical technology ,nutritional and metabolic diseases ,food and beverages ,Triticum aestivum ssp. spelta ,Review ,TP1-1185 ,Triticum turgidum ,digestive system diseases ,gluten-free diet ,celiac disease - Abstract
Celiac disease is an autoimmune disorder that occurs in genetically predisposed individuals after consuming prolamins from some cereals. Although the products available for celiac subjects have increased significantly in quality and quantity over the last few decades, research still focuses on identifying new ingredients to improve the nutritional, sensorial and functional qualities of gluten-free products. In terms of toxicity for people with celiac disease, there is a wide variability between ancient and modern grains. The most contradictory results are related to the role of oats in the gluten-free diet. In order to clarify the role of minor cereals (such as oat) and ancient grains in the diets of celiac patients, this review discusses recent in vitro and in vivo studies performed on those cereals for which the toxicity for celiac subjects is still controversial. According to in vivo studies, selected oat varieties could be tolerated by celiac patients. On the other hands, although some wheat-ancient grains (Triticum monococcum, Triticum aestivum ssp. spelta and Kamut®) showed a reduced in vitro toxicity, to date, these grains are still considered toxic for celiac patients. Contradictory results underline the importance of studying the safety of “unusual” cereals in more detail.
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- 2021
45. Pigmented Corn Varieties as Functional Ingredients for Gluten-Free Products
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Colombo, Francesca, primary, Di Lorenzo, Chiara, additional, Petroni, Katia, additional, Silano, Marco, additional, Pilu, Roberto, additional, Falletta, Ermelinda, additional, Biella, Simone, additional, and Restani, Patrizia, additional
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- 2021
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46. Antioxidant activity of wine assessed by different in vitro methods
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Di Lorenzo Chiara, Badea Mihaela, Colombo Francesca, Orgiu Francesca, Frigerio Gianfranco, Pastor Raul F., and Restani Patrizia
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Microbiology ,QR1-502 ,Physiology ,QP1-981 ,Zoology ,QL1-991 - Abstract
Epidemiological studies have suggested that a diet rich in antioxidant compounds could help in counteracting the effects of reactive oxygen species, reducing the risk factors for chronic diseases. The moderate consumption of wine, especially red wine, has been associated with the reduction in mortalities from cardiovascular diseases. One of the possible reasons for the protective effect of wine can be identified in the high content of polyphenols (mainly flavonoids), which have significant antioxidant activity. Even though several in vitro tests have been developed for the measure of the antioxidant property, no method has showed a satisfactory correlation with the in vivo situation. On these bases, the aim of this study was the application and comparison of different in vitro methods to assess the antioxidant activity of red, rosé and white wines. The methods were: 1) Folin-Cocalteau's assay for the quantification of total polyphenol content; 2) the DPPH (1,1-diphenyl-2-picrylhydrazyl) spectrophotometric assay and the Trolox Equivalent Antioxidant Capacity (TEAC) spectrophotometric assay for measuring the antioxidant activity of samples; 3) High Performance Thin Layer Chromatography for separation of phenolic substances and assessment of the associated antioxidant activity; 4) electrochemical detection by using a biosensor. Although all the approaches show some limitations, this battery of tests offers a more reliable body of data on the antioxidant activity of vine derivatives.
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- 2017
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47. Adverse effects of plant food supplements and botanical preparations: a systematic review with critical evaluation of causality
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Di Lorenzo, Chiara, Ceschi, Alessandro, Kupferschmidt, Hugo, Lüde, Saskia, De Souza Nascimento, Elizabeth, Dos Santos, Ariana, Colombo, Francesca, Frigerio, Gianfranco, Nrby, Karin, Plumb, Jenny, Finglas, Paul, and Restani, Patrizia
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- 2015
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48. CovidNeuroOnc: A UK multicenter, prospective cohort study of the impact of the COVID-19 pandemic on the neuro-oncology service
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Fountain, Daniel M, Piper, Rory J, Poon, Michael T C, Solomou, Georgios, Brennan, Paul M, Chowdhury, Yasir A, Colombo, Francesca, Elmoslemany, Tarek, Ewbank, Frederick G, Grundy, Paul L, Hasan, Md T, Hilling, Molly, Hutchinson, Peter J, Karabatsou, Konstantina, Kolias, Angelos G, McSorley, Nathan J, Millward, Christopher P, Phang, Isaac, Plaha, Puneet, Price, Stephen J, Rominiyi, Ola, Sage, William, Shumon, Syed, Silva, Ines L, Smith, Stuart J, Surash, Surash, Thomson, Simon, Lau, Jun Y, Watts, Colin, Jenkinson, Michael D, Al-Tamimi, Yahia, Alalade, Andrew F, Albanese, Erminia, Bailey, Matthew, Brodbelt, Andrew R, Chalmers, Anthony, Chan, Huan Wee, Coope, David J, Cundliffe, Sarah, DUrso, Pietro I, Entwistle, Helen, Evans, Rhiannon M, Fielding, Rebecca, Gkolemis, Christos, Hammerbeck-Ward, Charlotte, Jeyaretna, D Sanjeeva, King, Andrew T, Laurente, Raphael M, Leggate, James, Lewis, Rachel, Maclean, Jillian, McBain, Catherine, McKenna, Grainne S, Molloy, Elizabeth, Pathmanaban, Omar N, Patkar, Pradnya, Powell, James, Rutherford, Scott A, Santarius, Thomas, Sinha, Saurabh, Sitaraman, Murugan, Solth, Anna, Thakur, Bhaskar, Wadeson, Andrea, Wykes, Victoria, Zafar, Muhammed R, Hutchinson, Peter [0000-0002-2796-1835], Kolias, Angelos [0000-0003-3992-0587], Price, Stephen [0000-0002-7535-3009], and Apollo - University of Cambridge Repository
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Pediatrics ,medicine.medical_specialty ,intracranial tumour ,medicine.medical_treatment ,SARS-CoV-2 ,Clinical Investigations ,Brain tumor ,03 medical and health sciences ,0302 clinical medicine ,Glioma ,Pandemic ,AcademicSubjects/MED00300 ,Medicine ,brain tumour ,Neuro-Oncology ,Prospective cohort study ,Chemotherapy ,Neurologic Oncology ,business.industry ,neurooncology ,Cancer ,COVID-19 ,intracranial tumor ,General Medicine ,medicine.disease ,Chemotherapy regimen ,030220 oncology & carcinogenesis ,AcademicSubjects/MED00310 ,business ,030217 neurology & neurosurgery ,brain tumor - Abstract
Background The COVID-19 pandemic has profoundly affected cancer services. Our objective was to determine the effect of the COVID-19 pandemic on decision making and the resulting outcomes for patients with newly diagnosed or recurrent intracranial tumors. Methods We performed a multicenter prospective study of all adult patients discussed in weekly neuro-oncology and skull base multidisciplinary team meetings who had a newly diagnosed or recurrent intracranial (excluding pituitary) tumor between 01 April and 31 May 2020. All patients had at least 30-day follow-up data. Descriptive statistical reporting was used. Results There were 1357 referrals for newly diagnosed or recurrent intracranial tumors across 15 neuro-oncology centers. Of centers with all intracranial tumors, a change in initial management was reported in 8.6% of cases (n = 104/1210). Decisions to change the management plan reduced over time from a peak of 19% referrals at the start of the study to 0% by the end of the study period. Changes in management were reported in 16% (n = 75/466) of cases previously recommended for surgery and 28% of cases previously recommended for chemotherapy (n = 20/72). The reported SARS-CoV-2 infection rate was similar in surgical and non-surgical patients (2.6% vs. 2.4%, P > .9). Conclusions Disruption to neuro-oncology services in the UK caused by the COVID-19 pandemic was most marked in the first month, affecting all diagnoses. Patients considered for chemotherapy were most affected. In those recommended surgical treatment this was successfully completed. Longer-term outcome data will evaluate oncological treatments received by these patients and overall survival.
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- 2021
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49. Additional file 1 of SELP Asp603Asn and severe thrombosis in COVID-19 males
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Fallerini, Chiara, Daga, Sergio, Benetti, Elisa, Picchiotti, Nicola, Zguro, Kristina, Catapano, Francesca, Baroni, Virginia, Lanini, Simone, Bucalossi, Alessandro, Marotta, Giuseppe, Colombo, Francesca, Baldassarri, Margherita, Fava, Francesca, Beligni, Giada, Di Sarno, Laura, Alaverdian, Diana, Palmieri, Maria, Croci, Susanna, Isidori, Andrea M., Furini, Simone, Frullanti, Elisa, Renieri, Alessandra, and Mari, Francesca
- Abstract
Additional file 1. Material and Methods plus study group appendix.
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- 2021
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50. Polyphenols and Human Health: The Role of Bioavailability
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Di Lorenzo, Chiara, primary, Colombo, Francesca, additional, Biella, Simone, additional, Stockley, Creina, additional, and Restani, Patrizia, additional
- Published
- 2021
- Full Text
- View/download PDF
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