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To study the representative dose coefficients near nuclear facilities in the arid regions of Northwest China, a simplified anatomical model of Sphingonotus insects using computed tomography (CT) scanning is proposed. In addition, a voxel model created by using Photoshop and Python is used to assess the results of the simplified anatomical model. The dose coefficients of internal and external 90Sr and 137Cs irradiation on different organs of Sphingonotus insects in the environmental medium are calculated. To verify the feasibility of the proposed model, the results are compared with the dose coefficients reported in the International Commission on Radiological Protection (ICRP) Publication 108. Based on the simplified model adopted by ICRP to arrive at the results reported in Publication 108, the average value of dose coefficients of each organ of the insect is used to calculate the results presented in this paper. The dose coefficients of internal and external 90Sr irradiation for the simplified anatomical model of Sphingonotus were found to be 6.59×10-4 μGyh-1/Bqkg-1 and 6.74×10-4 μGyh-1/Bqkg-1, respectively. Meanwhile, the dose coefficients of internal and external 137Cs irradiation for the simplified anatomical model were 1.34×10-4 μGyh-1/Bqkg-1 and 4.40×10-3 μGyh-1/Bqkg-1, respectively. The dose coefficients were 7.87×10-4μGyh-1/Bqkg-1 and 6.74×10-4μGyh-1/Bqkg-1, respectively. The dose coefficients were 1.33×10-4μGyh-1/Bqkg-1 and 3.51×10-3μGyh-1/Bqkg-1, respectively. The dose coefficients of internal and external 90Sr radiation for reference insects as reported in the ICRP Publication 108 were 1.00×10-2 μGyh-1/Bqkg-1 and 3.90×10-10 μGyh-1/Bqkg-1, respectively. Moreover, the dose coefficients of internal and external 137Cs radiation in the ICRP Publication 108 were 3.20×10-3 μGyh-1/Bqkg-1 and 2.80×10-3 μGyh-1/Bqkg-1, respectively. The above data indicate that the dose coefficients of internal irradiation reported in the ICRP Publication 108 are larger than those calculated using the proposed dosiological model, whereas those of external irradiation in ICRP Publication 108 are smaller. This trend is probably related to the size of the organism, decay rate, and energy of radionuclides. The adoption of a simplified anatomical model, morphologically similar to the organism, and a voxel model, highly overlapping with the organism, in this study allows a visualization of the real exposure situation for the organism considered with high accuracy, proving the feasibility of the insect dosimetry model established in this study.

Objective To analyze the effect of Traditional Chinese Medicine(TCM) directional drug penetration therapy combined with elastic bandage compression dressing on relief of TCM syndrome in patients with ecthyma. Methods A total of 80 hospitalized patients with ecthyma were divided into two groups according their hospital admission sequence. In the control group(n=40), the ulcer wound was treated with elastic bandage after conventional dressing change. In the observation group(n=40), the ulcer wound was treated with directional drug penetration therapy for 15-20 minutes before dressing change, and then the ulcer wound was treated with elastic bandage after conventional dressing change. The improvement rate of ecthyma-related syndromes was measured and compared between the two groups. Results The total effective rate of syndromes relief was 97. 50%(39/40)in the observation group, which was significantly higher than 80. 00%(32/40)in the control group (P＜0. 05). Conclusion TCM directional drug penetration therapy combined with elastic bandage compression dressing has significant effect on relief of ecthyma-related clinical syndromes, and it is an easy-to-use, safe and painless TCM technique, which is worthy for clinical application. (目的 分析中医定向透药联合弹力绷带加压包扎对促进臁疮患者中医证候改善的效果。方法 根据入院时间顺序, 将住院治疗的80例臁疮患者分为两组。对照组40例患者溃疡创面采用常规换药后用弹力绷带加压包扎; 观察组40例患者在换药前进行定向透药治疗15~20 min, 溃疡创面采用常规换药后用弹力绷带加压包扎。比较两组患者臁疮相关中医证候的改善情况。结果 观察组中医证候改善总有效率97. 50%(39/40), 高于对照组的80. 00%(32/40), 差异有统计学意义(P＜0. 05)。结论 中医定向透药联合弹力绷带加压包扎能够促进臁疮患者中医证候改善, 且操作简便、安全、无痛苦, 适合临床推广使用。)

Objective To investigate the intervention effect of nursing based on shared decision making (SDM) in maintenance period of comprehensive detumescence therapy (CDT)for lower-extremity lymphedema, and to investigate its influence on patient self-management skills. Methods Totally 27 patients were randomly divided into two groups on even or odd numbers according to the order of hospitalization: control group (n=14) included the patients with odd numbers and observation group (n=13) included the patients with even numbers. In the control group, lymphedema therapist implemented CDT for lower-extremity lymphedema, 10 days as a course of treatment, two consecutive courses. Self-identification of symptoms and signs of lymphedema and basic routine nursing measures were carried out during hospitalization. Before discharge, patients were educated with knowledge about skin care, lymphatic drainage, use of pressure gradient socks and functional exercise during the maintenance period of CDT treatment. In addition to routine care, nursing interventions based on a five-step process of shared decision making were carried out in the observation group during hospitalization and within 3 months after discharge. The patient self-management skills and satisfaction with nursing service were evaluated at discharge time, 1 month and 3 months after discharge. Results Scores of Self-management Behavior Assessment Scale and Newcastle Satisfaction with Nursing Scale (NSNS) decreased at 1 month and 3 months after discharge, and scores of the observation group were significantly higher than those of the control group(P＜0. 01). Conclusion The application of SDM-based nursing interventions in maintenance period of CDT for lower-extremity lymphedema is effective to improve patient satisfaction, enhance the ability of home self-management and compliance, reduce the occurrence of recurrence and complications, and improve the quality of life of patients. (目的 探讨共享决策模护理模式在下肢淋巴水肿患者综合消肿治疗(CDT)维持期中的干预效果, 以及对患者自我管理能力的影响。方法 根据患者入院时间顺序单双号, 单号14例患者纳入对照组, 由淋巴水肿治疗师实施下肢淋巴水肿CDT治疗, 10 d为1个疗程, 连续2个疗程。住院期间落实患者自我识别淋巴水肿的症状、体征和基本的常规护理措施, 出院前对患者进行CDT治疗维持期的皮肤护理、淋巴引流和压力梯度袜使用及功能锻炼的指导。双号13例患者纳入观察组, 观察组实在对照组常规护理的基础上, 采用共享决策护理模式进行干预, 实施基于共享决策5步骤的护理干预过程至出院后3个月。分别在出院时、出院后1个月和3个月, 对患者进行自我管理行为和护理满意度进行评估。结果 出院1个月和3个月后, 两组自我管理行为量表评分和纽卡斯尔护理满意度量表(NSNS)评分均较出院时升高, 且观察组得分优于对照组, 差异有统计学意义(P＜0. 01)。结论 共享决策护理模式应用于下肢淋巴水肿患者CDT治疗维持期中, 能提高护理满意度, 增强患者居家自我管理的能力和依从性, 降低复发和并发症的发生风险, 从而提高患者的生活质量。)

Urban fringe areas, characterized by relatively larger community sizes and lower population densities compared to central areas, may lead to variations in walkability as well as gender differences, such as safety perception. While objective measurements have received considerable attention, further research is needed to comprehensively assess subjective perceptions of walking in the urban periphery. As a case study, we evaluated survey responses of community perceptions of "Imageability", "Enclosure", "Human scale", "Complexity" and "Safety" of Shanghai's five new towns, comparing these with responses from the central area in terms of gender difference, and analyzed influencing factors and prediction performance of machine learning (ML) models. We developed a TrueSkill-based rating system to dynamically collect audits of street view images (SVIs) from professional students and used the result to integrate with Geographic Information Systems (GIS), Computer Vision (CV), Clustering analysis, and ML algorithm for further investigation. Results show that most of the new towns' communities are perceived as moderately walkable or higher, with the city center's community exhibiting the best walkability perceptions in general. Male and female perceptions of the "Human scale" and the factors that affect it differ little, but there are significant disparities in the other four perceptions. The best-performing ML models were effective at variable explanations and generalizations, with Random Forest Regression (RFR) performing better on more perception predictions. Responses also suggest that certain street design factors, such as street openness, can positively influence walkability perceptions of women and could be prioritized in new town development and urban renewal for more inclusive and walkable cities. [ABSTRACT FROM AUTHOR]

Objective: To compare the effect of different techniques on serum immunoglobulin A and interleukin-10 in patients with high simple anal fistula., Methods: .The cross-sectional study was conducted at Dongyang People's Hospital, Weishan, China, from January 2019 to April 2021, and comprised patients with high simple anal fistula who were randomly and equally divided into Group A getting treatment with modified ligation of intersphincteric fistula tract, and Group B getting treatment with incision-thread-drawing method. Serum immunoglobulin A and interleukin-10 as well as the Wexner score were compared between the groups. Data was analysed using SPSS 25., Results: Of the 140 patients, there were 70(50%) in each of the two groups. There were 125(89.2%) male subjects overall. The mean age in Group A was 38.91±8.91 years, while in Group B it was 38.20±8.51. Mean hospital stay in Group A was shorter than that in Group B (p<0.001). Mean serum immunoglobulin A and interleukin-10 values were not significantly different at baseline, but on day 7 post-surgery, the difference was significant between the groups (p<0.05). Likewise, Wexner score was significantly different at 3 months post-surgery (p<0.05). There was no significant difference in the incidence of postoperative complications between the groups (p=0.730)., Conclusions: The modified ligation of intersphincteric fistula tract method was found to be a better option in the management of patients with high simple anal fistula.

Anaesthetics have been implicated to influence cancer cells and progression. Similarly, crosstalk between cancer cells and stromal components within the microenvironment is also an important factor driving progression. Stromal cell-derived factor-1 (SDF-1) and hepatocyte growth factor (HGF) are key chemokines/cytokines produced by fibroblasts which have been established as influential factors in cancer progression. The present study explored the capacity of anaesthetics to influence the expression of these key molecules in fibroblasts. The anaesthetics rocuronium bromide (RB), vecuronium bromide (VB), suxamethonium chloride CRS (SCC), dexmedetomidine hydrochloride (DH) and lidocaine were used to treat MRC-5 fibroblasts over a range of concentrations. Following treatment, transcript expression of SDF-1 and HGF was quantified using quantitative PCR. Treatment of MRC-5 cells with RB brought about a reduction of SDF-1 expression which was found to be significant in the 45 µg/ml treatment group. Treatment with the other anaesthetics brought about some alterations in SDF-1 expression but these were not found to be statistically significant. Treatment with the tested anaesthetics did not have any significant effect on HGF transcript expression within MRC-5 cells, although again some alterations were observed. The results indicated that anaesthetics may have an impact on the fibroblast component of the tumour microenvironment, potentially influencing SDF-1 and HGF expression which in turn could influence tumour progression., (Copyright: © Gong et al.)

Aim: To investigate the efficacy and safety of nanoparticle albumin-bound paclitaxel (nab-paclitaxel) for locally advanced or metastatic non-small cell lung cancer (NSCLC) as second-line chemotherapy., Patients and Methods: We retrospectively reviewed the treatment of 34 patients with advanced NSCLC whose first-line treatment had failed. These patients received nab-paclitaxel 260 mg/m 2 on day 1 and day 8 of a 21-day cycle from July 2014 to February 2016. One cycle of treatment lasted 3 weeks and all patients completed more than two cycles. All patients were assessed for adverse events related to treatment., Results: No patient achieved complete response (CR); 12 patients reached partial response (PR), 12 patients achieved stable disease (SD) and 10 patients progressive disease (PD). The overall response rate (ORR) was 35.3% and the disease control rate (DCR) 70.6 %. There was no significant difference in either ORR or DCR within the subgroups. The median progression-free survival (PFS) was 5.7 months (95% confidence interval (CI)=3.8-7.6) and the median overall survival (OS) was 9 months (95% CI=8.3-9.7). There was no statistical difference in OS (p=0.066), but subgroup analysis showed that patients with squamous carcinoma benefited more in PFS (the median PFS of squamous carcinoma vs. adenocarcinoma was 7.3 months vs. 5 months, p=0.001). Major adverse events included myelosuppression, gastrointestinal response, baldness, myalgia and neurotoxicity. Hypersensitivity reactions were not reported., Conclusion: Nab-paclitaxel is an effective chemotherapy for locally advanced and metastatic NSCLC as treatment and has a superior application prospect for squamous NSCLC. Toxicity is generally mild and manageable., (Copyright© 2017, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.)