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Additional file 7. Within group evolution in memory outcomes, executive function and attention according to plasma MCP-1 status (excluding ApoE ��4 genotype). Mixed-effect linear regression analysis for variation in memory outcomes over time according to plasma MCP-1 status among community-dwelling older adults (excluding ApoE ��4 genotype).

Additional file 6. Within group evolution in overall cognitive outcomes, executive function and attention according to plasma MCP-1 status (excluding ApoE ��4 genotype). Within group evolution in memory outcomes over time according to plasma MCP-1 status among community-dwelling older adults (excluding ApoE ��4 genotype).

Additional file 1. Description of features of ELLA System for plasma MCP-1 determination.

Additional file 5. Evolution in overall memory outcomes according to plasma MCP-1 status (excluding ApoE ��4 genotype). Mixed-effect linear regression analysis for variation in memory outcomes over time according to plasma MCP-1 status among community-dwelling older adults (excluding ApoE ��4 genotype).

Additional file 4. Evolution in overall cognitive outcomes, executive function and attention according to plasma MCP-1 status (excluding ApoE ��4 genotype). Mixed-effect linear regression analysis for variation in overall cognitive outcomes, executive function and attention over time according to plasma MCP-1 status among community-dwelling older adults (excluding ApoE ��4 genotype).

Additional file 2. Neuroimaging procedures. Description of neuroimaging techniques used in the present study.

Additional file 3. Differences between included and excluded participants. Differences in baseline characteristics between MAPT study participants included and excluded in the present study.

The Transparency and Accountability Learning of the Spanish Municipalities This article studies the instrumental development of transparency in the Spanish municipalities’ websites between 2011-2017, under two different regulations on transparency and good governance. The research method consists of the study of 41 indicators, later expanded to 52 to adjust it to the reform of the legislation on transparency and access to public information, approved in 2013. The general objective is the investigation of the resources, the traits and the practices of public communication that the municipalities carry out through the web. The particular goal is the identification of these resources on the websites, as well as the possible structural and message deficiencies. The indicators are published and updated in successive waves into the Map Infoparticip@ platform (http://www.mapainfoparticipa.com). The research work has a universe of 2,930 municipalities, although the sample used for this article is reduced to 400 cities that have more than 20,001 registered inhabitants. This sample allows a qualitative analysis that include what variations have been observed, what type of treatment is offered or what citizen services have appeared in the period. The result of this paper announces that the regulation on transparency, access to public information and good governance does not ensure better results in the publication of information on municipal websites. The indicators analyzed offer worse results, regardless the size of the municipality or the change in ownership and political orientation of the mayor's office It advocates, on the other hand, for a culture of broader transparency that involves civil society and encourages citizen participation. The legal approach to transparency issues reduces its positive effect on the public management of municipalities. El aprendizaje de la transparencia y la rendición de cuentas de los ayuntamientos españoles Este artículo estudia el desarrollo instrumental de la transparencia de las webs de los Ayuntamientos españoles en el periodo comprendido entre 2011 y 2017, bajo dos regulaciones distintas acerca de la transparencia y buen gobierno. El método de investigación consiste en el estudio de 41 indicadores, posteriormente ampliado a 52 para ajustarlo a la reforma de la legislación sobre transparencia y acceso a la información pública, aprobada en 2013. El objetivo general es la investigación de los recursos, los rasgos y las prácticas de comunicación pública que realizan los ayuntamientos a través de la web. En particular se busca identificar dichos recursos y las posibles deficiencias estructurales y de mensaje en las webs. Los indicadores se publican y actualizan en sucesivas oleadas en la plataforma Mapa Infoparticip@ (http://www.mapainfoparticipa.com). El trabajo de investigación cuenta con un universo de 2.930 municipios, si bien la muestra que se emplea para este artículo se reduce a 400 municipios que tienen más de 20.001 habitantes empadronados. La muestra permite un análisis cualitativo que incluye: qué variaciones se han observado, qué tipo de tratamiento se ofrece o qué servicios ciudadanos han aparecido en el periodo. El resultado del trabajo anuncia que la regulación sobre transparencia, acceso a la información pública y buen gobierno no asegura mejores resultados en la publicación de información en las webs municipales. Los indicadores analizados ofrecen peores resultados, independientemente del tamaño del municipio o del cambio de titularidad y orientación política de la alcaldía. Se aboga, en cambio, por una cultura de transparencia más amplia que implique a la sociedad civil y anime a la participación ciudadana. El enfoque jurídico de las cuestiones de transparencia reduce su efecto positivo en la gestión pública de los municipios.