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Summary.Bone resorption inhibitors,such as bisphosphonates and denosumab,are widely used to treat bone lesions caused by disorders of bone metabolism,multiple myeloma,and bone metastases from solid tumors,and the occurrence of antiresorptive agentrelated osteonecrosis of the jaw (ARONJ) is increasing.Currently,surgical treatment is recommended;however,case reports are sparse and there is no established global consensus on treatment.We report the case of a 75–year–old female patient with osteonecrosis of the mandible following bisphosphonate administration for the treatment of multiple myeloma,who was cured by conservative treatment alone.The patient had multiple myeloma and,therefore,had been receiving bisphosphonates for about 24 months prior to her first visit to Matsumoto Dental University Hospital.During periodontal treatment,the patient underwent extraction of the left mandibular wisdom tooth.About 6 months later,bone exposure was observed in the same area,and coexisting osteomyelitis of the jaw was diagnosed.Conservative treatment involving oral hygiene instructions,several doses of antibacterial agents,and frequent rinses was chosen for the bone exposure.About 6 months after the start of such treatment,the decayed bone had disappeared,and after 7 months,the mucosa had completely sealed.Disappearance of the findings of osteomyelitis was assessed by MRI.The infection tended to spread during the clinical course of the disease,but improved with conservative treatment alone,and the exposed area of bone has since epithelialized.We reaffirmed the importance of collaboration and sharing information on the medical history and medications between physicians and dentists while treating patients with primary diseases indicated for bisphosphonates.

Frailty is a cause of a nursing care status for the elderly people. Generally, elderly people get aged by various diseases such as Non–Communicable Diseases, stress, and lifestyle diseases overlap, and go through a period of frailty to necessary support, state of longterm care required stages. Therefore, efforts to stop weakness during the frailty period which can return to a healthy state, that is, to extend healthy life span is very important in future medical care.Social capital is characterized as a capital of a social organization that leads cooperative action to achieve the objectives of “social connection: network”, “norm”, “trust”, and has been reported a deep relationship with healthy life.Therefore, by examining the relationship between the health condition of the periodontal tissue, and the frailty and social capital, we focused on the influence on the healthy life from the health condition of the periodontal tissue. In other words, in this study, through the hypothesis that the health condition of periodontal tissue correlates with the frailty, and that individualsʼ social capital deteriorates due to frailty, it was aimed to elucidate whether the health condition of the periodontal tissue affects the healthy life span or not. A correlation tendency between the pre frailty state and the number of present teeth and the feeling of oral health of social capital was observed. When the pre frailty state worsened, the number of present teeth increased, and if the oral health condition at the questionnaire was bad, pre frailty state worsened. Further studies are needed to increase the number of cases in the future to determine whether oral condition due to periodontal disease is associated with frailty.

The incidence of mandibular fractures is the highest among facial bone fractures. Addi-tionally, most of mandibular fractures occur in the mandibular angle and condylar process. On the other hand, the incidence of fracture of coronoid process is extremely low. We experienced a case of mandibular fractures involving mandibular body, condylar process as well as the coronoid process in a man aged 3₉–years–old who had received strong direct external force to the mandible. Mandibular fractures usually occur in the condylar process and mandibular angle because direct external force is more likely to transmit to these re-gions. Based on the classification of mandibular fractures, the incidence of mandibularfractures involving coronoid process increases with an increased number of fractures lines that means complicated fracture. At the viewpoint of anatomical portion, direct external force dose not transmit to coronoid process; however, it is possible that direct external force may transmit coronoid process in the case of complicated fracture. In this case report, we considered the potential mechanism of fracture of coronoid process by using a three–dimensional finite element model of a human mandible stress distribution analysis.

Objective: Glioblastoma (GBM) and Primary Central Nervous System Lymphoma (PCNSL) are common intracranial malignant tumors. The treatment of these tumors is quite different, accurate preoperative differentiation is the essential of clinical relevance.However, they sometimes present similar radiological[for full text, please go to the a.m. URL], 71. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 9. Joint Meeting mit der Japanischen Gesellschaft für Neurochirurgie

Relationships between environmental factors and fluctuations in landing of North Pacific giant octopus(Enteroctopus dofleini Wulker, 1910) at Minamikayabe town, Hakodate city, Japan, during 1985-2016 were analyzed using regression analysis. Annual landings ranged between 165 and 403 tons, with an average of 273 tons. The relationship between landings and temperature was significant in 9 of the 24 months examined; 7 of the 9 occurred in catches 3-4 years after the temperature was measured. Rainfall showed no significant relationship with catch amounts. The results of the regression analyses suggest that landings of E. dofleini were related to ocean temperature, especially to temperatures 3-4 years before the landings occurred, presumably during the early part of the life cycle of the landed octopuses.

We report a case of intramuscular lipoma of the left buccal region, along with a review of the relevant literature. Magnetic resonance imaging showed a spindle–shaped mass extending from the canine region to the anterior portion of the masseter muscle in the buccal–alveolar portion of the left mandible. The inner part was visualized as homogeneous high–signal intensity on both T1– and T2–weighted images, and a partial linear region with the same signal intensity as muscle was also observed. The removed tumor measured 35×40×15mm in size, and histopathological findings showed an intramuscular lipoma composed of adipose, muscle and connective tissues. Intramuscular lipomas account for 1.7%–2% of all lipomas, and they very rarely occur in the oral and maxillofacial region. Twenty–three cases with intramuscular lipomas in the oral and maxillofacial region, including our case, have been reported in Japan. The postoperative healing process is generally good. We followed–up our patient after explaining to him the importance of careful, long–term follow–up. It has been only 2 months, to date, since surgery but the outcome appears to be good.

Odontogenic keratocysts show a marked tendency toward proliferation or biological activity compared with jawbone cysts, being a disease highly recurrent after extirpation, which has been characterized as a cystic tumor. The WHO tissue classification of odontogenic cysts revised in 2005 states that, of previous odontogenic keratocysts, those whose epithelium histologically becomes parakeratotic are keratocystic odontogenic tumors. We encountered a keratocystic odontogenic tumor that had extensively progressed in the right maxillary sinus of a 17–year–old boy. In diagnostic imaging, an opaque image containing an impacted tooth was detected, which seemed to invade the right maxillary sinus. Then, the tumor in the right maxillary sinus was resected with a radical operation under systemic anesthesia. Histopathological tests showed that the tumor was coated with stratified squamous epithelium presenting with parakeratosis, with no inflammation found in the fibrous connective tissues under the epithelium. Consequently, a keratocystic odontogenic tumor was diagnosed. The postoperative course was favorable, with no recurrence as of 1 year and 8 months after the operation.