1. Identification and characteristics of imipenem-resistant Acinetobacter baumannii in surgical wards in a Chinese university hospital.
- Author
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Wang D, Ma L, Wu Z, Li M, Li X, Zhang W, and Chen K
- Subjects
- Acinetobacter baumannii drug effects, Bacterial Proteins genetics, China epidemiology, Colistin pharmacology, Cross Infection epidemiology, Drug Resistance, Multiple, Bacterial, Hospital Units, Hospitals, University, Humans, Intensive Care Units, Microbial Sensitivity Tests, Molecular Typing, beta-Lactamases genetics, Acinetobacter Infections microbiology, Acinetobacter baumannii genetics, Acinetobacter baumannii isolation & purification, Cross Infection microbiology, Drug Resistance, Multiple, Imipenem pharmacology
- Abstract
The aim of this study was to investigate the prevalence and characteristics of imipenem-resistant Acinetobacter baumanni isolated from surgical wards in a university hospital, China. A total of 143 non-duplicate A. baumannii were isolated from 517 inpatients in surgery intensive care units (ICUs), burn wards, and general surgery wards. Of these, 102 isolates of A. baumannii (71.3%) were resistant to imipenem. Among imipenem-resistant isolates, all isolates were resistant to almost all antimicrobial agents except polymyxin E, all isolates were positive for blaOXA-23 and blaOXA-51 in addition to ISAba1, 52 (51%) were positive for blaOXA-58, 8 (7.8%) contained blaVIM-2, which co-harbored with blaOXA-58. Molecular typing revealed the presence of three clones among imipenem-resistant isolates. This study confirmed that A. baumannii strains harboring OXA or VIM type β-lactamases are widely distributed throughout the surgery wards. The data demonstrate that there was a high prevalence of imipenem-resistant A. baumannii infection in the region.
- Published
- 2015
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