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Replantation of multilevel amputation of the hand requires considerable hospital resources, and the surgical outcomes in older adults have not been described in detail. Thus, replantation for this injury was mostly confined to young patients. Here, we describe the case of a 63-year-old patient with multilevel amputation of the hand in whom replantation surgery was successful with grasp and pinch functions by the last follow-up. We report the clinical, functional, and patient-reported outcomes and discuss the indications. As the patient transfer system and communication technology develops, more patients will arrive at hospitals in a critical time for replantation. Accordingly, hand surgeons should consider offering replantation option for multilevel amputation after evaluating the indications. [ABSTRACT FROM AUTHOR]