1. MiR-30a-5p frequently downregulated in prostate cancer inhibits cell proliferation via targeting PCLAF.
- Author
-
Zhao, Hu, Zhang, Wei, Lai, Xiaofeng, Zhu, Hehuan, Zhang, Shenhang, Wu, Weizhen, Wang, Shuiliang, Tang, Minying, Deng, Zhen, and Tan, Jianming
- Subjects
CANCER cell proliferation ,PROSTATE cancer ,CELL proliferation ,CELL lines - Abstract
MicroRNAs (miRNAs) have vastly expanded our view of RNA world in intracellular signal regulating networks. Here, we functionally characterized a normally highly expressed miRNA, miR-30a-5p (MIMAT0000087), which exhibits downregulated expression profiles in prostate cancer samples. MiR-30a-5p knockdown and overexpression in PC-3 cell line alters cell proliferation supporting a tumour suppressor role. We also discovered that PCLAF is the direct target of miR-30a-5p. Notably, PC-3 cell proliferation is inhibited by miR-30a-5p/PCLAF axis. miR-30a-5p represents a novel molecule of functionally important miRNAs which may shed light on the novel therapeutic targets for prostate cancer. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF