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Your search keyword '"Ma, Mingwei"' showing total 6 results
6 results on '"Ma, Mingwei"'

4. Synovitis, acne, pustulosis, hyperostosis and osteitis syndrome with mandibular involvement: Would surgical operation help?

Author

Liu Y, Wu X, Cao Y, Liu S, Ma M, and Li C

Subjects
Humans, Osteitis, Acquired Hyperostosis Syndrome diagnosis, Hyperostosis pathology, Osteomyelitis drug therapy, Synovitis pathology, Acne Vulgaris pathology
Abstract

Background: Synovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO) syndrome is a rare autoinflammatory disease; its primary manifestation includes osteoarthropathy with skin involvement. Janus kinase (JAK) inhibitors, such as tofacitinib, were used for rheumatoid arthritis; however, due to its downregulation of immune cytokines including interleukin (IL)-6 and IL-8, it might be effective for SAPHO patients., Case Summary: We report the 1st case of mandibular-related SAPHO syndrome treated with tofacitinib. The patient underwent mandibular resection surgery twice and postoperative pathology showed "osteomyelitis". The patient developed sclerosing osteomyelitis in the left wrist 9 months after surgery and SAPHO syndrome was diagnosed. The patient was administered nonsteroidal anti-inflammatory drugs and corticosteroids therapy without much remission. A 3-month tofacitinib therapy provided remission from both systemic inflammation status and peripheral osteoarticular symptoms and no significant recurrence was observed during follow-up in this case., Conclusion: Mandibular involvement in SAPHO syndrome is easily misdiagnosed due to its rarity. Mandibular resection surgery should be applied carefully; after systemic treatment with tofacitinib, the patient had remission. We provide a successful experience for the treatment of mandibular-related SAPHO syndrome., (© 2022 Asia Pacific League of Associations for Rheumatology and John Wiley & Sons Australia, Ltd.)

Published
2023
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6. Tumor necrosis factor inhibitors for pediatric patients with SAPHO syndrome associated with acne conglobata.

Author

Liu S, Wu X, Cao Y, Li Z, Liu Y, Ma M, and Li C

Subjects
Adolescent, Child, Humans, Tumor Necrosis Factor Inhibitors, Acne Conglobata complications, Acne Vulgaris complications, Acne Vulgaris drug therapy, Acne Vulgaris pathology, Acquired Hyperostosis Syndrome complications, Acquired Hyperostosis Syndrome drug therapy, Osteitis
Abstract

Synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome is a rare chronic inflammatory disease with osteoarticular and cutaneous involvements as its main manifestations. Acne conglobata as a severe acne form may affect adolescent patients. Tumor necrosis factor inhibitors are usually used as a second-line therapy for refractory SAPHO syndrome and has been reported to treat acne conglobata successfully. We herein report three cases of adolescent patients with SAPHO syndrome associated with acne conglobata who were successfully treated with TNFi therapy., (© 2022. The Author(s).)

Published
2022
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