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3,457 results on '"Ikeda, Hiroshi"'

125. Intra-Articular Injections of the Adipose-Derived Mesenchymal Stem Cells Suppress Progression of a Mouse Traumatic Knee Osteoarthritis Model

Author

Wakayama, Takanori, primary, Saita, Yoshitomo, additional, Nagao, Masashi, additional, Uchino, Sayuri, additional, Yoshihara, Sei-ichi, additional, Tsuji, Kunikazu, additional, Koga, Hideyuki, additional, Kobayashi, Yohei, additional, Nishio, Hirofumi, additional, Momoi, Yasumasa, additional, Ikeda, Hiroshi, additional, Kaneko, Kazuo, additional, and Ishijima, Muneaki, additional

Published
2022
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131. Quality comparison between two different types of platelet-rich plasma for knee osteoarthritis

Author

Wakayama Takanori, Saita Yoshitomo, Kobayashi Yohei, Nishio Hirofumi, Uchino Sayuri, Fukusato Shin, Ikeda Hiroshi, and Kaneko Kazuo

Subjects
autologous protein solution, platelet-rich plasma, leukocyte, platelet, anti-inflammatory cytokine, growth factor, Medicine
Abstract

Introduction: Knee osteoarthritis (KOA), the most common form of osteoarthritis (OA) is a considerable health concern worldwide. Platelet-rich plasma (PRP) is a common therapeutic option for KOA. Different types of PRPs have varying efficacies. However, a comparative analysis of the qualities of these PRPs is lacking. Methods: Two types of PRPs, including autologous protein solution (APS), and leukocyte-poor PRP (LP-PRP) along with whole blood (WB) and platelet-poor plasma (PPP) were characterized for platelet content, leukocyte content, and composition in 10 healthy volunteers (HV) (the controlled laboratory study) and 16 KOA patients (a retrospective observational study). Additionally, the levels of the platelet-derived growth factor (PDGF)-BB, and different cytokines were estimated in HV. Results: In HV, the concentrations of platelets and leukocytes, levels of different cytokines, including interleukin 1 receptor antagonist (IL-1Ra), soluble TNF receptor type II (sTNF-RII), and IL-1β, and the ratio of IL-1Ra/IL-1β were significantly higher in APS, whereas the PDGF-BB was higher in LP-PRP than APS. In KOA patients, a higher concentration of platelets was observed in LP-PRP, and a higher concentration of leukocytes was observed in APS than LP-PRP. Following the PAW classification system, LP-PRP was classified as P2-B type in HV (51.3 × 104/μl) and KOA (53.4 × 104/μl), whereas APS was classified as P3-A type in HV (110.1 × 104/μl) and P2-A type in KOA (29.0 × 104/μl). In a retrospective observational study, the KOA patients who underwent APS injection had a higher incidence of arthralgia, and this arthralgia lasted for a longer time than LP-PRP injection in the same individual. Discussion: The quality of the two PRPs differed distinctively depending on their preparation methods, which might affect their clinical efficacies and adverse events. Therefore, the characterization of these parameters should be prioritized while choosing PRP.

Published
2020
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138. Selection of the candidate compound at an early stage of new drug development: retrospective pharmacokinetic and metabolic evaluations of valsartan using common marmosets

Author

Matsumoto, Shogo, primary, Uehara, Shotaro, additional, Kamimura, Hidetaka, additional, Cho, Naoki, additional, Ikeda, Hiroshi, additional, Maeda, Satoshi, additional, Kagiyama, Kensuke, additional, Miyata, Atsunori, additional, Suemizu, Hiroshi, additional, and Fukasawa, Kazumasa, additional

Published
2022
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145. Fulminant myocarditis with COVID‐19 infection having normal C‐reactive protein and serial magnetic resonance follow‐up.

Author

Usui, Eisuke, Nagaoka, Eiki, Ikeda, Hiroshi, Ohmori, Mari, Tao, Susumu, Yonetsu, Taishi, Maejima, Yasuhiro, Arai, Hirokuni, Amemiya, Kisaki, Ikeda, Yoshihiko, and Sasano, Tetsuo

Subjects
C-reactive protein, COVID-19, CARDIAC magnetic resonance imaging, MAGNETIC resonance, ARTIFICIAL blood circulation, CHEST pain
Abstract

A 44‐year‐old woman who was quarantined for 5 days after the diagnosis of coronavirus disease of 2019 (COVID‐19) was transferred to our hospital with the complaint of chest pain. The patient was unvaccinated. Electrocardiography revealed ST elevation in the lateral leads. Echocardiographic biventricular dysfunction with oedematous wall thickening was identified. Cardiac enzyme levels were elevated; however, C‐reactive protein (CRP) levels, and the coronary angiogram were normal. The patient required mechanical circulatory support to stabilize haemodynamics and was treated with remdesivir, baricitinib, and intravenous methylprednisolone. She recovered after 13 days of mechanical support. Serial cardiac magnetic resonance imaging revealed acute myocardial oedema and subsequent fibrosis. An endomyocardial biopsy on admission showed mild interstitial inflammatory infiltrates with endomyocardial fibrous thickening and mild interstitial fibrosis of the myocardium. Normal CRP levels suggested minor involvement of interleukin (IL)‐6, supporting the efficacy of baricitinib. [ABSTRACT FROM AUTHOR]

Published
2023
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149. Osteoarthritis as a Cause of Locomotive Syndrome: Its Influence on Functional Mobility and Activities of Daily Living

Author

Ishijima, Muneaki, Kaneko, Haruka, Hada, Shinnosuke, Kinoshita, Mayuko, Sadatsuki, Ryo, Liu, Lizu, Shimura, Yukio, Arita, Hitoshi, Shiozawa, Jun, Yusup, Anwarjan, Futami, Ippei, Sakamoto, Yuko, Ishibashi, Masayoshi, Machida, Syuichi, Naito, Hisashi, Arikawa-Hirasawa, Eri, Hamada, Chieko, Saita, Yoshitomo, Takazawa, Yuji, Ikeda, Hiroshi, Okada, Yasunori, and Kaneko, Kazuo

Published
2016
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