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223 results on '"Jia, Huixun"'

7. GENETIC FACTORS AND CHARACTERISTICS ON SPECTRAL-DOMAIN OPTICAL COHERENCE TOMOGRAPHY ARE ASSOCIATED WITH CHOROIDAL THICKNESS IN ABCA4-RELATED RETINOPATHY

Author

Wang, Yimin, Chen, Jieqiong, Zhang, Min, Yu, Suqin, Gong, Yuanyuan, Lin, Feng, Wu, Yidong, Liu, Wenjia, Sun, Junran, Li, Tong, Sun, Xiaodong, Sun, Xiaodong, Yu, Suqin, Gong, Yuanyuan, Chen, Jieqiong, Wang, Yimin, Liu, Wenjia, Wan, Xiaoling, Li, Tong, Yu, Yang, Jia, Huixun, Yuan, Fei, Shen, Xi, Wang, Zhiliang, Qiao, Tong, Wu, Qiang, Xu, Yu, Wang, Chaoyang, Yang, Chenhao, Qu, Jifang, and Chen, Jianjun

Published
2024
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9. Secondary cytoreduction followed by chemotherapy versus chemotherapy alone in platinum-sensitive relapsed ovarian cancer (SOC-1): A final overall survival analysis of a multicenter, open-label, randomized, phase 3 trial.

Author

Zang, Rongyu, primary, Zhu, Jianqing, additional, Liu, Jihong, additional, Jiang, Rong, additional, Cheng, Xi, additional, Chen, Yulian, additional, Jia, Huixun, additional, Shi, Tingyan, additional, Guo, Yi, additional, Feng, Yanling, additional, Tu, Dongsheng, additional, Zhang, Yuqin, additional, Huang, Xiao, additional, Jiang, Shiyang, additional, Gao, Wen, additional, Yang, Huijuan, additional, and Zhang, Ping, additional

Published
2024
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20. Brain-Derived Neurotrophic Factor Val66Met is Associated with Variation in Cortical Structure in Healthy Aging Subjects

Author

Shen, Ting, primary, Sheriff, Samran, primary, You, Yuyi, primary, Jiang, Jiyang, primary, Schulz, Angela, primary, Francis, Heather, primary, Mirzaei, Mehdi, primary, Saks, Danit, primary, Palanivel, Viswanthram, primary, Basavarajappa, Devaraj, primary, Chitranshi, Nitin, primary, Gupta, Veer, primary, Wen, Wei, primary, Sachdev, Perminder S., primary, Jia, Huixun, primary, Sun, Xiaodong, primary, Graham, Stuart L., primary, and Gupta, Vivek K., primary

Published
2024
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21. Involved-Field Irradiation in Definitive Chemoradiotherapy for Locoregional Esophageal Squamous Cell Carcinoma: Results From the ESO-Shanghai 1 Trial

Author

Zhu, Hongcheng, Rivin del Campo, Eleonor, Ye, Jinjun, Simone, Charles B., II, Zhu, Zhengfei, Zhao, Weixin, Amini, Arya, Zhou, Jialiang, Wu, Chaoyang, Tang, Huarong, Fan, Min, Li, Ling, Lin, Qin, Xia, Yi, Li, Yunhai, Li, Jiancheng, Mo, Miao, Jia, Huixun, Lu, Saiquan, Wang, Juanqi, Nie, Yongzhan, Chen, Junqiang, Wu, Shixiu, Hamaji, Masatsugu, Haque, Waqar, Jeong, Bae Kwon, Shridhar, Ravi, Zhang, Zhen, Chen, Yun, and Zhao, Kuaile

Published
2021
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26. Prevalence and optical coherence tomography analyses of outer retinal tubulations in Chinese population with inherited retinal diseases

Author

Chen, Yuhong, Chen, Jieqiong, Wang, Hong, Yu, Yang, Wang, Wenqiu, Liu, Wenjia, Yu, Suqin, Gong, Yuanyuan, Jia, Huixun, Li, Tong, and Sun, Xiaodong

Abstract

Background: To investigate the prevalence of outer retinal tubulation (ORT) and its correlations with optical coherence tomography (OCT) parameters in Chinese population with inherited retinal diseases (IRDs). Methods: This retrospective study enrolled consecutive patients identified with IRDs and referred for genetic testing between February 2016 and April 2021. Clinical characteristics from medical records and features of cross-sectional B-scans were reviewed and analysed. The associations of patient-specific and ocular features with the presence of ORT were evaluated using univariate and multivariate analyses. Results: Two hundred and three patients (401 eyes) with a mean age of 49.7 ± 16.7 years were enrolled. ORT was observed in 41 eyes (10.2%), including 26 of 28 eyes (92.9%) with Bietti crystalline corneoretinal dystrophy (BCD), 14 of 338 eyes (4.1%) with retinitis pigmentosa (RP), and 1 of 26 eyes (3.8%) in eyes with cone–rod dystrophy. Eyes with ORT showed significantly worse visual acuity than those without ORT (P= 0.002). Multivariate analysis indicated that the presence of ORT was positively correlated with choroidal atrophy and inner nuclear layer (INL) cysts (P< 0.01). ORTs were detected more frequently in eyes with BCD than RP (P= 0.024), most of which located exclusively within the extrafoveal area. Large choroidal vessels were detected underneath the corresponding ORTs in both patients with BCD and RP. Conclusions: The prevalence of ORT varies among different IRDs phenotypes, with the highest prevalence in BCD. The presence of choroidal atrophy and INL cysts may be associated with an increased risk of ORT formation in patients with IRD.

Published
2024
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29. A Novel Bispecific Fusion Protein Targeting C3b/C4b and VEGF in Patients With nAMD: A Randomized, Open-Label, Phase 1b Study

Author

Jia, Huixun, primary, Li, Tong, additional, Sun, Junran, additional, Gong, Yuanyuan, additional, Liu, Haiyun, additional, Wang, Hong, additional, Chen, Jieqiong, additional, Liu, Wenjia, additional, Lu, Shujie, additional, Feng, Liqi, additional, Wan, Qiuchen, additional, Qian, Lei, additional, Wang, Fenghua, additional, Liu, Xiaoling, additional, and Sun, Xiaodong, additional

Published
2023
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30. Progression of Polypoidal Lesions Associated with Exudative Recurrence in Polypoidal Choroidal Vasculopathy

Author

Bo, Qiyu, primary, Zhang, Min, additional, Chen, Jieqiong, additional, Jia, Huixun, additional, Shen, Mengxi, additional, Sun, Mengsha, additional, Xu, Mengqiao, additional, Feng, Jingyang, additional, Yan, Quan, additional, Yu, Yang, additional, Huang, Peirong, additional, Li, Tong, additional, Wang, Fenghua, additional, Rosenfeld, Philip J., additional, and Sun, Xiaodong, additional

Published
2023
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32. Surgery versus no surgery in platinum-sensitive relapsed ovarian cancer: final overall survival analysis of the SOC-1 randomized phase 3 trial

Author

Jiang, Rong, Feng, Yanling, Chen, Yulian, Cheng, Xi, Shi, Tingyan, Gao, Wen, Jia, Huixun, Jiang, Shiyang, Guo, Yi, Huang, Xiao, Tu, Dongsheng, Zhang, Yuqin, Yang, Huijuan, Zhang, Ping, Liu, Jihong, Zhu, Jianqing, and Zang, Rongyu

Abstract

Surgery for platinum-sensitive, relapsed ovarian cancer (PSROC) is widely practiced but had contradictory survival outcomes in previous studies. In this multicenter, open-label, phase 3 trial, women with PSROC, and having had one previous therapy and no platinum-based chemotherapy (platinum-free interval) of 6 months or more, were randomly assigned to either the surgery group (182 patients) or the no-surgery group (control) (175 patients). Patients with resectable diseases were eligible according to the international model (iMODEL), combined with a positron emission tomography-computed tomography imaging. Overall survival (OS) and progression-free survival were coprimary endpoints in hierarchical testing, and a significantly longer progression-free survival with surgery was previously reported. Final analysis of OS was planned at data maturity of 59%. Between 19 July 2012 and 3 June 2019, 357 patients were enrolled. Median follow-up was 82.5 months. Median OS was 58.1 months with surgery and 52.1 months for control (hazard ratio (HR) 0.80, 95% confidence interval (CI) 0.61–1.05, P= 0.11). The predefined threshold for statistical significance was not met, but prespecified sensitivity analysis was performed. Overall, 61 of 175 (35%) patients in control had crossed over to surgery following subsequent relapse, and adjusted HR for death in the surgery group compared with control was 0.76, 95% CI 0.58–0.99. In subgroup analysis of relapse sites by imaging, median survival was not estimable in the surgery group and was 69.5 months in control in patients with <20 sites (HR 0.69, 95% CI 0.46–1.03). Patients with a complete resection had the most favorable outcome, with a median OS of 73.0 months. Twenty-four of 182 (13.2%) patients remained relapse free and alive >60 months in the surgery group as compared with five of 175 (2.9%) patients in the control group. In patients with PSROC, surgery did not increase OS in the intention-to-treat population but resulted in a prolongation of survival following adjustment of crossover.

Published
2024
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43. Targeting C3b/C4b and VEGF with a bispecific fusion protein optimized for neovascular age-related macular degeneration therapy

Author

Yang, Shiqi, primary, Li, Tong, additional, Jia, Huixun, additional, Gao, Min, additional, Li, Yiming, additional, Wan, Xiaoling, additional, Huang, Zhen, additional, Li, Min, additional, Zhai, Yuanqi, additional, Li, Xiaomeng, additional, Yang, Xiaotong, additional, Wang, Tao, additional, Liang, Jian, additional, Gu, Qing, additional, Luo, Xueting, additional, Qian, Lei, additional, Lu, Shujie, additional, Liu, Junjian, additional, Song, Yanping, additional, Wang, Fenghua, additional, Sun, Xiaodong, additional, and Yu, Dechao, additional

Published
2022
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46. Long-Term Results of a Phase 2 Study of Definitive Chemoradiation Therapy Using S-1 for Esophageal Squamous Cell Carcinoma Patients Who Were Elderly or With Serious Comorbidities

Author

Chen, Yun, Zhu, Zhengfei, Zhao, Weixin, Liu, Qi, Zhang, Junhua, Deng, Jiaying, Ai, Dashan, Lu, Saiquan, Jiang, Liuqing, Tseng, Ihsuan, Jia, Huixun, and Zhao, Kuaile

Subjects
Cancer Research, Oncology
Abstract

BackgroundThe optimal evidence-based management for the subsets of locally advanced esophageal squamous cell carcinoma (ESCC) patients who rejected or were intolerant to intravenous chemotherapy due to old age or serious comorbidities is currently lacking. This study aimed to assess the safety and local control rate (LCR) of S-1 (tegafur–gimeracil–oteracil potassium) combined with radiotherapy in these subsets of ESCC patients.MethodsLocally advanced ESCC patients who rejected or were intolerant to intravenous chemotherapy due to age >75 years or serious comorbidities were enrolled in a prospective, single-arm, phase 2 trial. The patients were treated with definitive concurrent chemoradiotherapy with S-1, which was administered orally twice daily for 28 days. The radiotherapy dose was 61.2 Gy delivered in 34 fractions. The primary end-point was the 3-year LCR.ResultsOne hundred five ESCC patients were recruited between March 2013 and October 2015. At the median follow-up of 73.1 months (IQR 65.5–81.4 months), 3-year LCR was 61.1%, and 1, 3, and 5-year overall survival was 77.9, 42.3, and 24.8% respectively. For safety analysis, ≥grade 3 acute adverse events included thrombocytopenia (6.7%), leukopenia (2.9%), anemia (1.0%), anorexia (1.0%), fatigue (10.5%), hiccup (1.0%), pneumonitis (4.8%), and esophagitis (3.8%). Two patients (1.9%) died of late esophageal hemorrhage, and one patient (1.0%) died of late radiation-induced pneumonitis.ConclusionS-1 is a promising regimen in concurrent chemoradiotherapy with low toxicity and a favorable LCR in ESCC patients who rejected or were intolerant to intravenous chemotherapy due to old age or serious comorbidities.Clinical Trial RegistrationClinicalTrials.gov, NCT01831531.

Published
2022

48. Comparison of 3 Paclitaxel-Based Chemoradiotherapy Regimens for Patients With Locally Advanced Esophageal Squamous Cell Cancer

Author

Ai, Dashan, primary, Ye, Jinjun, additional, Wei, Shihong, additional, Li, Yunhai, additional, Luo, Hui, additional, Cao, Jianzhong, additional, Zhu, Zhengfei, additional, Zhao, Weixin, additional, Lin, Qin, additional, Yang, Huanjun, additional, Zheng, Xiangpeng, additional, Zhou, Jialiang, additional, Huang, Guang, additional, Li, Ling, additional, Li, Jiancheng, additional, Zhang, Zhi, additional, Zhou, Guoren, additional, Gu, Dayong, additional, Du, Mingyu, additional, Mo, Miao, additional, Jia, HuiXun, additional, Zhang, Zhen, additional, and Zhao, Kuaile, additional

Published
2022
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49. Status of Visual Impairment among Children with Special Needs in Rural China.

Author

Wu, Jiali, Chen, Jieqiong, Zhao, Ruyi, Zeng, Lan, Li, Tong, Wang, Wenqiu, Jia, Huixun, Wang, Fenghua, Zhu, Hong, Tan, Wei, and Sun, Xiaodong

Subjects
CHILDREN with disabilities, VISION disorders, POOR children, RURAL children, ELEMENTARY education, SPECIAL education teachers, SPECIAL education schools
Abstract

Introduction: Previous studies have reported a high prevalence of visual defects in children with special needs. However, routine ocular examinations for these children in rural areas of China are lacking. This study aimed to evaluate the status of visual impairment (VI) in children at special education schools in rural China. Methods: A total of 316 students from two special schools in Zunyi city, Guizhou province, were enrolled. Full ophthalmic examinations were performed, and gene-sequencing services were offered to potential patients. Results: The mean age of the 316 participants was 12.27 ± 3.49 years and 75 showed abnormal ophthalmic manifestations on slit-lamp examination. Visual acuity (VA) was assessed in 232 eyes, and the mean VA (logarithm of the minimum angle of resolution, logMAR) was 0.27 ± 0.34. Whole-exome sequencing identified 19 mutations in these children, which might explain their visual complaints. Children with Down syndrome had a significantly higher prevalence of ocular disorders than those without. Conclusion: VI is common among children at special education schools in rural areas; however, routine screening and effective interventions have not been consistently implemented. Efforts should be made to address this issue in these already disadvantaged children. [ABSTRACT FROM AUTHOR]

Published
2023
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