13 results on '"Poffe, Alessandro"'
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2. Vasopressin 1A (V1A) Receptor Antagonists Reduce Anxiety in Marmosets
3. Characterisation of the selective 5-HT1B receptor antagonist SB-616234-A (1-[6-(cis-3,5-dimethylpiperazin-1-yl)-2,3-dihydro-5-methoxyindol-1-yl]-1-[2′-methyl-4′-(5-methyl-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methanone hydrochloride): In vivo neurochemical and behavioural evidence of anxiolytic/antidepressant activity
4. In vitro hippocampal slices and in vivo video–tEEG model in rat to assess convulsion/seizure risk of novel compounds
5. Validation of video-tEEG model in rat to assess convulsion/seizure risk of novel compounds
6. Discovery process and pharmacological characterization of a novel dual orexin 1 and orexin 2 receptor antagonist useful for treatment of sleep disorders
7. GSK356278, a Potent, Selective, Brain-Penetrant Phosphodiesterase 4 Inhibitor That Demonstrates Anxiolytic and Cognition-Enhancing Effects without Inducing Side Effects in Preclinical Species
8. Optimisation of an integrated strategy to assess convulsion/seizure risk of novel compounds
9. Behavioural effects of Compound X and picrotoxin dose–response following ICV administration in the rat
10. Validation of video-tEEG model in rat to assess convulsion/seizure risk of novel compounds
11. Optimisation of an integrated strategy to assess convulsion/seizure risk of novel compounds
12. Identification, biological characterization and pharmacophoric analysis of a new potent and selective NK1 receptor antagonist clinical candidate.
13. Characterisation of the selective 5-HT1B receptor antagonist SB-616234-A (1-[6-(cis-3,5-dimethylpiperazin-1-yl)-2,3-dihydro-5-methoxyindol-1-yl]-1-[2′-methyl-4′-(5-methyl-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methanone hydrochloride): In vivo neurochemical and behavioural evidence of anxiolytic/antidepressant activity
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