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156 results on '"Rathinam, Sivakumar R."'

1. Quality-of-Life Outcomes From a Randomized Clinical Trial Comparing Antimetabolites for Intermediate, Posterior, and Panuveitis.

Author

Niemeyer, Katherine M, Gonzales, John A, Rathinam, Sivakumar R, Babu, Manohar, Thundikandy, Radhika, Kanakath, Anuradha, Porco, Travis C, Browne, Erica N, Rao, Maya M, and Acharya, Nisha R

Subjects
Humans, Panuveitis, Uveitis, Posterior, Antimetabolites, Treatment Outcome, Administration, Oral, Follow-Up Studies, Health Status, Visual Acuity, Dose-Response Relationship, Drug, Quality of Life, Adult, Female, Male, Surveys and Questionnaires, Clinical Trials and Supportive Activities, Patient Safety, Clinical Research, Eye Disease and Disorders of Vision, Evaluation of treatments and therapeutic interventions, 6.1 Pharmaceuticals, Eye, Good Health and Well Being, Clinical Sciences, Opthalmology and Optometry, Public Health and Health Services, Ophthalmology & Optometry
Abstract

PurposeTo evaluate the changes in quality of life in noninfectious uveitis patients treated with 2 of the most commonly prescribed antimetabolite treatments.DesignSecondary analysis of a multicenter, block-randomized clinical trial.MethodsEighty patients at Aravind Eye Hospitals in Madurai and Coimbatore, India, with noninfectious intermediate, posterior, or panuveitis were randomized to receive oral methotrexate, 25 mg weekly, or oral mycophenolate mofetil, 1 g twice daily, and were followed up monthly for 6 months. Best-corrected visual acuity, Indian Vision Function Questionnaire (IND-VFQ), and Medical Outcomes Study 36-item Short Form Survey (SF-36) were obtained at enrollment and at 6 months (or prior, in the event of early treatment failure).ResultsIND-VFQ scores, on average, increased by 9.2 points from trial enrollment to 6 months (95% confidence interval [CI]: 4.9, 13.5, P = .0001). Although the SF-36 physical component summary score did not significantly differ over the course of the trial, the mental component summary score decreased by 2.3 points (95% CI: -4.4, -0.1, P = .04) and the vitality subscale decreased by 3.5 points (95% CI: -5.6, -1.4, P = .001). Quality-of-life scores did not differ between treatment arms. Linear regression modeling showed a 3.2-point improvement in IND-VFQ score for every 5-letter improvement in visual acuity (95% CI: 1.9, 4.3; P < .001).ConclusionsAlthough uveitis treatment was associated with increased vision and vision-related quality of life, patient-reported physical health did not change after 6 months of treatment, and mental health decreased. Despite improved visual outcomes, uveitis patients receiving systemic immunosuppressive therapy may experience a deterioration in mental health-related quality of life.

Published
2017

2. A Bayesian Analysis of a Randomized Clinical Trial Comparing Antimetabolite Therapies for Non-Infectious Uveitis

Author

Browne, Erica N, Rathinam, Sivakumar R, Kanakath, Anuradha, Thundikandy, Radhika, Babu, Manohar, Lietman, Thomas M, and Acharya, Nisha R

Subjects
Biomedical and Clinical Sciences, Ophthalmology and Optometry, Clinical Trials and Supportive Activities, Clinical Research, Good Health and Well Being, Adolescent, Adult, Anti-Inflammatory Agents, Antimetabolites, Bayes Theorem, Female, Humans, Immunosuppressive Agents, Male, Methotrexate, Mycophenolic Acid, Uveitis, Young Adult, Antimetabolite, Bayesian, clinical trial, non-infectious uveitis, statistics, Clinical Sciences, Opthalmology and Optometry, Public Health and Health Services, Epidemiology, Ophthalmology and optometry, Public health
Abstract

PurposeTo conduct a Bayesian analysis of a randomized clinical trial (RCT) for non-infectious uveitis using expert opinion as a subjective prior belief.MethodsA RCT was conducted to determine which antimetabolite, methotrexate or mycophenolate mofetil, is more effective as an initial corticosteroid-sparing agent for the treatment of intermediate, posterior, and pan-uveitis. Before the release of trial results, expert opinion on the relative effectiveness of these two medications was collected via online survey. Members of the American Uveitis Society executive committee were invited to provide an estimate for the relative decrease in efficacy with a 95% credible interval (CrI). A prior probability distribution was created from experts' estimates. A Bayesian analysis was performed using the constructed expert prior probability distribution and the trial's primary outcome.ResultsA total of 11 of the 12 invited uveitis specialists provided estimates. Eight of 11 experts (73%) believed mycophenolate mofetil is more effective. The group prior belief was that the odds of treatment success for patients taking mycophenolate mofetil were 1.4-fold the odds of those taking methotrexate (95% CrI 0.03-45.0). The odds of treatment success with mycophenolate mofetil compared to methotrexate was 0.4 from the RCT (95% confidence interval 0.1-1.2) and 0.7 (95% CrI 0.2-1.7) from the Bayesian analysis.ConclusionsA Bayesian analysis combining expert belief with the trial's result did not indicate preference for one drug. However, the wide credible interval leaves open the possibility of a substantial treatment effect. This suggests clinical equipoise necessary to allow a larger, more definitive RCT.

Published
2017

4. Outcomes of Vogt-Koyanagi-Harada Disease: A Subanalysis From a Randomized Clinical Trial of Antimetabolite Therapies.

Author

Shen, Elizabeth, Rathinam, Sivakumar R, Babu, Manohar, Kanakath, Anuradha, Thundikandy, Radhika, Lee, Salena M, Browne, Erica N, Porco, Travis C, and Acharya, Nisha R

Subjects
Humans, Uveomeningoencephalitic Syndrome, Panuveitis, Mycophenolic Acid, Methotrexate, Immunosuppressive Agents, Enzyme Inhibitors, Drug Administration Schedule, Visual Acuity, Adult, Middle Aged, Female, Male, Clinical Trials and Supportive Activities, Clinical Research, Patient Safety, Eye Disease and Disorders of Vision, 6.1 Pharmaceuticals, Evaluation of treatments and therapeutic interventions, Eye, Clinical Sciences, Opthalmology and Optometry, Public Health and Health Services, Ophthalmology & Optometry
Abstract

PurposeTo report outcomes of Vogt-Koyanagi-Harada (VKH) disease from a clinical trial of antimetabolite therapies.DesignSubanalysis from an observer-masked randomized clinical trial for noninfectious intermediate, posterior, and panuveitis.Methodssetting: Clinical practice at Aravind Eye Hospitals, India.Patient populationForty-three of 80 patients enrolled (54%) diagnosed with VKH.InterventionPatients were randomized to either 25 mg oral methotrexate weekly or 1 g mycophenolate mofetil twice daily, with a corticosteroid taper.Main outcome measuresPrimary outcome was corticosteroid-sparing control of inflammation at 5 and 6 months. Secondary outcomes included visual acuity, central subfield thickness, and adverse events. Patients were categorized as acute (diagnosis ≤3 months prior to enrollment) or chronic (diagnosis >3 months prior to enrollment).ResultsTwenty-seven patients were randomized to methotrexate and 16 to mycophenolate mofetil; 30 had acute VKH. The odds of achieving corticosteroid-sparing control of inflammation with methotrexate were 2.5 times (95% CI: 0.6, 9.8; P = .20) the odds with mycophenolate mofetil, a difference that was not statistically significant. The average improvement in visual acuity was 12.5 Early Treatment Diabetic Retinopathy Study (ETDRS) letters. On average, visual acuity for patients with acute VKH improved by 14 more ETDRS letters than those with chronic VKH (P < .001), but there was no difference in corticosteroid-sparing control of inflammation (P = .99). All 26 eyes with a serous retinal detachment at baseline resolved, and 88% achieved corticosteroid-sparing control of inflammation.ConclusionsThe majority of patients treated with antimetabolites and corticosteroids were able to achieve corticosteroid-sparing control of inflammation by 6 months. Although patients with acute VKH gained more visual improvement than those with chronic VKH, this did not correspond with a higher rate of controlled inflammation.

Published
2016

6. List of Contributors

Author

Aleman, Tomas S., primary, Arepalli, Sruthi, additional, Belfort, Rubens, additional, Blodi, Frederick R., additional, Bodaghi, Bahram, additional, Chan, Weilin, additional, Chang, Peter Yuwei, additional, Chorfi, Sarah, additional, Conrady, Christopher, additional, Eliott, Dean, additional, Foster, C. Stephen, additional, Trief, Danielle, additional, Hassan, Muhammad, additional, Kaliki, Swathi, additional, Kaplan, Henry J., additional, Karadzic, Jelena, additional, Kerley, Madison E., additional, Levison, Ashleigh L., additional, Lindeke-Myers, Aaron, additional, Magrath, George, additional, Maguire, Albert M., additional, Minkus, Caroline L., additional, Modjtahedi, Bobeck S., additional, Mohay, Judith, additional, Moussa, Kareem, additional, Munk, Marion Ronit, additional, Nguyen, Quan Dong, additional, Onghanseng, Neil, additional, Papaliodis, George N., additional, Pepple, Kathryn, additional, Radosavljevic, Aleksandra, additional, Ramasubramanian, Aparna, additional, Rathinam, Sivakumar R., additional, Sadiq, Mohammad Ali, additional, Sandhu, Harpal S., additional, Shantha, Jessica G., additional, Shields, Ryan A., additional, Sobrin, Lucia, additional, Stanescu, Dinu, additional, Strässle, Kim Anne, additional, Suhler, Eric, additional, Thanos, Aristomenis, additional, Touhami, Sara, additional, Toutee, Adelaide, additional, Uchiyama, Eduardo, additional, Gelder, Russell Neil Van, additional, Ventura, Camila V., additional, Ventura, Liana O., additional, Vitale, Albert, additional, Yeh, Steven, additional, and Zierhut, Manfred, additional

Published
2021
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11. A Randomized Clinical Trial Comparing Methotrexate and Mycophenolate Mofetil for Noninfectious Uveitis

Author

Rathinam, Sivakumar R, Babu, Manohar, Thundikandy, Radhika, Kanakath, Anuradha, Nardone, Natalie, Esterberg, Elizabeth, Lee, Salena M, Enanoria, Wayne TA, Porco, Travis C, Browne, Erica N, Weinrib, Rachel, and Acharya, Nisha R

Subjects
Clinical Research, Clinical Trials and Supportive Activities, Patient Safety, Comparative Effectiveness Research, Eye Disease and Disorders of Vision, Evaluation of treatments and therapeutic interventions, 6.1 Pharmaceuticals, Eye, Administration, Oral, Adult, Female, Humans, Immunosuppressive Agents, Macular Edema, Male, Methotrexate, Middle Aged, Mycophenolic Acid, Uveitis, Visual Acuity, Young Adult, Clinical Sciences, Opthalmology and Optometry, Public Health and Health Services, Ophthalmology & Optometry
Abstract

ObjectiveTo compare the relative effectiveness of methotrexate and mycophenolate mofetil for noninfectious intermediate uveitis, posterior uveitis, or panuveitis.DesignMulticenter, block-randomized, observer-masked clinical trial.ParticipantsEighty patients with noninfectious intermediate, posterior, or panuveitis requiring corticosteroid-sparing therapy at Aravind Eye Hospitals in Madurai and Coimbatore, India.InterventionPatients were randomized to receive 25 mg weekly oral methotrexate or 1 g twice daily oral mycophenolate mofetil and were monitored monthly for 6 months. Oral prednisone and topical corticosteroids were tapered.Main outcome measuresMasked examiners assessed the primary outcome of treatment success, defined by achieving the following at 5 and 6 months: (1) ≤0.5+ anterior chamber cells, ≤0.5+ vitreous cells, ≤0.5+ vitreous haze and no active retinal/choroidal lesions in both eyes, (2) ≤10 mg of prednisone and ≤2 drops of prednisolone acetate 1% a day, and (3) no declaration of treatment failure because of intolerability or safety. Additional outcomes included time to sustained corticosteroid-sparing control of inflammation, change in best spectacle-corrected visual acuity, resolution of macular edema, adverse events, subgroup analysis by anatomic location, and medication adherence.ResultsForty-one patients were randomized to methotrexate and 39 to mycophenolate mofetil. A total of 67 patients (35 methotrexate, 32 mycophenolate mofetil) contributed to the primary outcome. Sixty-nine percent of patients achieved treatment success with methotrexate and 47% with mycophenolate mofetil (P = 0.09). Treatment failure from adverse events or tolerability was not different by treatment arm (P = 0.99). There were no differences between treatment groups in time to corticosteroid-sparing control of inflammation (P = 0.44), change in best spectacle-corrected visual acuity (P = 0.68), or resolution of macular edema (P = 0.31).ConclusionsThere was no statistically significant difference in corticosteroid-sparing control of inflammation between patients receiving methotrexate or mycophenolate mofetil. However, there was a 22% difference in treatment success favoring methotrexate.

Published
2014

12. Leptospirosis

Author

Rathinam, Sivakumar R., Zierhut, Manfred, editor, Pavesio, Carlos, editor, Ohno, Shigeaki, editor, Orefice, Fernando, editor, and Rao, Narsing A., editor

Published
2016
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13. Outcomes of Uveitic Macular Edema in the First-line Antimetabolites as Steroid-Sparing Treatment Uveitis Trial

Author

Tsui, Edmund, primary, Rathinam, Sivakumar R., additional, Gonzales, John A., additional, Thundikandy, Radhika, additional, Kanakath, Anuradha, additional, Balamurugan, S., additional, Vedhanayaki, R., additional, Lim, Lyndell L., additional, Suhler, Eric B., additional, Al-Dhibi, Hassan A., additional, Doan, Thuy, additional, Keenan, Jeremy, additional, Ebert, Caleb D., additional, Kim, Eric, additional, Madow, Brian, additional, Porco, Travis C., additional, and Acharya, Nisha R., additional

Published
2022
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14. Trematode fluke Procerovum varium as cause of ocular inflammation in children, South India

Author

Arya, Lalan Kumar, Rathinam, Sivakumar R., Lalitha, Prajna, Kim, Usha R., Ghatani, Sudeep, and Tandon, Veena

Subjects
Hostages -- Health aspects, Ponds -- Health aspects, Health
Abstract

Diseases caused by helminths (e.g., nematodes, cestodes, and trematodes) are a major public health concern worldwide, particularly in developing countries because of poor hygiene, lack of public health education, and [...]

Published
2016
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19. Clinical spectrum of tuberculous optic neuropathy

Author

Davis, Ellen J., Rathinam, Sivakumar R., Okada, Annabelle A., Tow, Sharon L., Petrushkin, Harry, Graham, Elizabeth M., Chee, Soon-Phaik, Guex-Crosier, Yan, Jakob, Eva, Tugal-Tutkun, Ilknur, Cunningham, Jr., Emmett T., Leavitt, Jacqueline A., Mansour, Ahmad M., Winthrop, Kevin L., Hills, William L., and Smith, Justine R.

Published
2012
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23. Contributors

Author

Abràmoff, Michael, primary, Abrams, Gary W., additional, Agarwal, Anita, additional, Ai, Everett, additional, Aiello, Lloyd M., additional, Aiello, Lloyd Paul, additional, Albert, Daniel M., additional, Aschbrenner, Mathew W., additional, Ávila, Marcos, additional, Aylward, G. William, additional, Bedell, Matthew, additional, Belfort, Rubens, additional, Bennett, Jean, additional, Bergstrom, Chris, additional, Besirli, Cagri G., additional, Bhende, Pramod S., additional, Binder, Susanne, additional, Bird, Alan C., additional, Blodi, Barbara A., additional, Blumenkranz, Mark S., additional, Boldt, H. Culver, additional, Bornfeld, Norbert, additional, Bottoni, Ferdinando, additional, Boulton, Michael E., additional, Bowne, Sara J., additional, Brantley, Milam A., additional, Bressler, Neil M., additional, Bressler, Susan B., additional, Bringmann, Andreas, additional, Brinton, Daniel A., additional, Brown, Gary C., additional, Brown, Justin C., additional, Brunner, Simon, additional, Bush, Ronald A., additional, Cao, Dingcai, additional, Capone, Antonio, additional, Carruthers, David, additional, Cavallerano, Jerry D., additional, Chakravarthy, Usha, additional, Chan, Chi-Chao, additional, Chan, Waiman, additional, Charles, Steven, additional, Charteris, David G., additional, Chen, Dong Feng, additional, Chen, Jeannie, additional, Chen, Youxin, additional, Cheung, Carol Yim Lui, additional, Chew, Emily Y., additional, Chiang, Allen, additional, Chiang, Michael F., additional, Constable, Ian J., additional, Coscas, Gabriel, additional, Cruess, Alan F., additional, Cunningham, Emmett T., additional, Curcio, Christine A., additional, Daiger, Stephen P., additional, Damato, Bertil E., additional, Davis, Janet L., additional, Davis, Matthew D., additional, Day, Shelley, additional, De Potter, Patrick, additional, de Smet, Marc D., additional, Denniston, Alastair K., additional, Dhaliwal, Ranjit S., additional, Ding, Xiaoyan, additional, Do, Diana V., additional, Dou, Guorui, additional, Dunn, William A., additional, Ehlers, Justis P., additional, Engelbert, Michael, additional, Faia, Lisa J., additional, Falsini, Benedetto, additional, Fawzi, Amani A., additional, Fekrat, Sharon, additional, Feldon, Steven E., additional, Fernandes, Rodrigo A. Brant, additional, Ferreyra, Henry A., additional, Ferrington, Deborah A., additional, Ferris, Frederick L., additional, Finger, Paul T., additional, Fisher, Steven K., additional, Fishman, Gerald A., additional, Fleckenstein, Monika, additional, Flynn, Harry W., additional, Fok, Andrew C., additional, Foulds, Wallace S., additional, Freeman, William R., additional, Freton, Aurélien, additional, Friedlander, Martin, additional, Frishman, Laura J., additional, Fu, Arthur D., additional, Garcia Filho, Carlos Alexandre de Amorim, additional, Garcia-Valenzuela, Enrique, additional, Gaudric, Alain, additional, Gayed, Mary, additional, Genead, Mohamed A., additional, Gerding, Heinrich, additional, Giani, Andrea, additional, Goldberg, Morton F., additional, Gombos, Dan S., additional, Gopal, Lingam, additional, Gordon, Caroline, additional, Goto, Hiroshi, additional, Gragoudas, Evangelos S., additional, Grant, Maria B., additional, Green, W. Richard, additional, Gregg, Ronald G., additional, Gregor, Zdenek, additional, Gregori, Giovanni, additional, Gregory-Evans, Kevin, additional, Grob, Seanna, additional, Groenewald, Carl, additional, Grossniklaus, Hans E., additional, Grover, Sandeep, additional, Gullapalli, Vamsi K., additional, Gupta, Aditi, additional, Guthoff, Rudolf F., additional, Hahn, Paul, additional, Haller, Julia A., additional, Harbour, J. William, additional, Haritoglou, Christos, additional, Hartnett, Mary E., additional, Hawkins, Barbara S., additional, He, Shikun, additional, Herwig, Martina C., additional, Heussen, Florian M.A., additional, Hinton, David R., additional, Holz, Frank G., additional, Houston, Samuel K., additional, Hui, Yan-Nian, additional, Humayun, Mark S., additional, Ikuno, Yasushi, additional, Isaac, David, additional, Ishibashi, Tatsuro, additional, Jabs, Douglas A., additional, Jaffe, Glenn J., additional, Jampol, Lee M., additional, Joffe, Leonard, additional, Johnson, Mark, additional, Johnson, Mark W., additional, Johnson, Robert N., additional, Joussen, Antonia M., additional, Julian, Karina, additional, Jumper, J. Michael, additional, Kaiser, Peter K., additional, Kampik, Anselm, additional, Katamay, Robert, additional, Kay, Christine N., additional, Keane, Pearse A., additional, Kenney, M. Cristina, additional, Khaderi, Khizer R., additional, Khodair, Mohamad A., additional, Kim, Ivana K., additional, Kim, Tae Wan, additional, Kirchhof, Bernd, additional, Klein, Barbara E.K., additional, Klein, Ronald, additional, Konstantinidis, Lazaros, additional, Kozak, Igor, additional, Kuppermann, Baruch D., additional, Labriola, Leanne T., additional, Lai, Timothy Y., additional, Lam, Dennis S., additional, Lam, Linda A., additional, Landers, Maurice B., additional, Lane, Anne Marie, additional, Lavik, Erin B., additional, Leary, James F., additional, Lee, Sun Young, additional, Lee, Thomas C., additional, Leung, Loh-Shan B., additional, Lewis, David A., additional, Lewis, Geoffrey P., additional, Leys, Anita, additional, Li, Xiaoxin, additional, Liakopoulos, Sandra, additional, Lin, Chang-Ping, additional, Lin, Phoebe, additional, Liu, David T., additional, London, Nikolas J.S., additional, Lujan, Brandon J., additional, Luo, Yan, additional, Lutty, Gerard A., additional, MacLaren, Robert, additional, Madreperla, Steven, additional, Maguire, Albert M., additional, Mainster, Martin A., additional, Mansfield, Nancy C., additional, Markoe, Arnold M., additional, Marmor, Michael F., additional, Martin, Daniel F., additional, Massey, Stephen C., additional, McCall, Maureen A., additional, McCannel, Tara A., additional, McCutchan, J. Allen, additional, McDonald, H. Richard, additional, Mehta, Milap P., additional, Meier, Petra, additional, Merbs, Shannath, additional, Meredith, Travis A., additional, Meyer, Carsten H., additional, Mieler, William F., additional, Miller, Joan W., additional, Mirza, Rukhsana G., additional, Mitter, Sayak K., additional, Mittra, Robert A., additional, Miyake, Yozo, additional, Montemagno, Carlo, additional, Moshiri, Ala, additional, Mruthyunjaya, Prithvi, additional, Muccioli, Cristina, additional, Mullins, Robert F., additional, Murata, Toshinori, additional, Murphree, A. Linn, additional, Murphy, Robert P., additional, Murray, Philip I., additional, Murray, Timothy G., additional, Nagpal, Manish, additional, Namperumalsamy, Perumalsamy, additional, Nanda, Sumit K., additional, Nguyen, Quan Dong, additional, Nussenblatt, Robert B., additional, Oh, Kean T., additional, Ohji, Masahito, additional, Ohno-Matsui, Kyoko, additional, Palanker, Daniel, additional, Patel, Purnima S., additional, Pavlick, Anna C., additional, Peereboom, David M., additional, Pennesi, Mark E., additional, Pepose, Jay S., additional, Perry, Julian D., additional, Puliafito, Carmen A., additional, Quiram, Polly A., additional, Raman, Rajiv, additional, Ramchandran, Rajeev S., additional, Rao, Haripriya Vittal, additional, Rao, Narsing A., additional, Rao, P. Kumar, additional, Rathinam, Sivakumar R., additional, Recchia, Franco M., additional, Redmond, Kristin J., additional, Reh, Thomas A., additional, Reichenbach, Andreas, additional, Ritch, Robert, additional, Rosenfeld, Philip J., additional, Rubin, Gary S., additional, Ruiz-Garcia, Humberto, additional, Ryan, Stephen J., additional, Sadda, SriniVas R., additional, Sadun, Alfredo A., additional, Sakamoto, Taiji, additional, Sampath, Alapakkam P., additional, Schachat, Andrew P., additional, Schmitz-Valckenberg, Steffen, additional, Schwartz, Stephen G., additional, Scott, Adrienne W., additional, Sebag, Jerry, additional, Seddon, Johanna M., additional, Sen, H. Nida, additional, Sepah, Yasir Jamal, additional, Sharma, Sanjay, additional, Sharma, Tarun, additional, Sheu, Shwu-Jiuan, additional, Shields, Carol L., additional, Shields, Jerry A., additional, Shinoda, Kei, additional, Shukla, Dhananjay, additional, Sieving, Paul A., additional, Silva, Paolo A.S., additional, Silveira, Claudio, additional, Singh, Arun D., additional, Smith, Sylvia B., additional, Smith, Wendy M., additional, Sobrin, Lucia, additional, Sodhi, Akrit, additional, Sohn, Elliott H., additional, Soubrane, Gisèle, additional, Spielberg, Leigh, additional, Srivastava, Sunil K., additional, Stachs, Oliver, additional, Staurenghi, Giovanni, additional, Sternberg, Paul, additional, Stone, Edwin M., additional, Sugino, Ilene K., additional, Sullivan, Lori S., additional, Sullivan, Paul, additional, Sun, Jennifer K., additional, Sunness, Janet S., additional, Tadayoni, Ramin, additional, Tang, Shibo, additional, Terasaki, Hiroko, additional, Thomas, Matthew A., additional, Thompson, John T., additional, Thumann, Gabriele, additional, Toth, Cynthia A., additional, Trese, Michael T., additional, Tsai, Julie H., additional, Turell, Mary E., additional, Turner, Patricia L., additional, Udar, Nitin, additional, Ulrich, J. Niklas, additional, Van Gelder, Russell N., additional, van Meurs, Jan C., additional, Vasconcelos-Santos, Daniel Vítor, additional, Vavvas, Demetrios G., additional, Vemulakonda, G. Atma, additional, Wang, Hao, additional, Wang, Yusheng, additional, Weiland, James D., additional, Weleber, Richard G., additional, Wharam, Moody D., additional, Wickham, Louisa, additional, Wiedemann, Peter, additional, Wiley, Henry E., additional, Wilkinson, C.P., additional, Wilson, David J., additional, Wolfensberger, Thomas J., additional, Wong, David, additional, Wong, Ian Y., additional, Wong, Tien Yin, additional, Wu, David M., additional, Yandiev, Yanors, additional, Yang, Chang-Hao, additional, Yang, Chung-May, additional, Yannuzzi, Lawrence A., additional, Yasuda, Miho, additional, Yeh, Po-Ting, additional, Yehoshua, Zohar, additional, Yiu, Glenn, additional, Yoon, Young Hee, additional, Yu, Hyeong Gon, additional, Yuan, Alex, additional, Zarbin, Marco A., additional, Zhang, Jun Jun, additional, Zhang, Kang, additional, Zhao, Mingwei, additional, and Zhou, Peng, additional

Published
2013
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27. An Algorithm for the Diagnosis of Behçet Disease Uveitis in Adults

Author

Tugal-Tutkun, Ilknur, primary, Onal, Sumru, additional, Stanford, Miles, additional, Akman, Mehmet, additional, Twisk, Jos W.R., additional, Boers, Maarten, additional, Oray, Merih, additional, Özdal, P., additional, Kadayifcilar, Sibel, additional, Amer, Radgonde, additional, Rathinam, Sivakumar R., additional, Vedhanayaki, Rajesh, additional, Khairallah, Moncef, additional, Akova, Yonca, additional, Yalcindag, F., additional, Kardes, Esra, additional, Basarir, Berna, additional, Altan, Çigdem, additional, Özyazgan, Yilmaz, additional, and Gül, Ahmet, additional

Published
2020
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29. An Algorithm for the Diagnosis of Behçet Disease Uveitis in Adults.

Author

Tugal-Tutkun, Ilknur, Onal, Sumru, Stanford, Miles, Akman, Mehmet, Twisk, Jos W.R., Boers, Maarten, Oray, Merih, Özdal, P., Kadayifcilar, Sibel, Amer, Radgonde, Rathinam, Sivakumar R., Vedhanayaki, Rajesh, Khairallah, Moncef, Akova, Yonca, Yalcindag, F., Kardes, Esra, Basarir, Berna, Altan, Çigdem, Özyazgan, Yilmaz, and Gül, Ahmet

Subjects
IRIDOCYCLITIS, BEHCET'S disease, CART algorithms, UVEITIS, DIAGNOSIS, ADULTS
Abstract

Purpose: To develop an algorithm for the diagnosis of Behçet's disease (BD) uveitis based on ocular findings. Methods: Following an initial survey among uveitis experts, we collected multi-center retrospective data on 211 patients with BD uveitis and 207 patients with other uveitides, and identified ocular findings with a high diagnostic odds ratio (DOR). Subsequently, we collected multi-center prospective data on 127 patients with BD uveitis and 322 controls and developed a diagnostic algorithm using Classification and Regression Tree (CART) analysis and expert opinion. Results: We identified 10 items with DOR >5. The items that provided the highest accuracy in CART analysis included superficial retinal infiltrate, signs of occlusive retinal vasculitis, and diffuse retinal capillary leakage as well as the absence of granulomatous anterior uveitis or choroiditis in patients with vitritis. Conclusion: This study provides a diagnostic tree for BD uveitis that needs to be validated in future studies. [ABSTRACT FROM AUTHOR]

Published
2021
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31. Mosquito-Borne Uveitis

Author

Cunningham, Emmett T., primary, Khairallah, Moncef, additional, Rathinam, Sivakumar R., additional, Belfort, Rubens, additional, and Zierhut, Manfred, additional

Published
2018
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34. Intravitreal Sirolimus for Noninfectious Uveitis: A Phase III Sirolimus Study Assessing Double-masKed Uveitis TReAtment (SAKURA)

Author

Nguyen, Quan Dong, primary, Merrill, Pauline T., additional, Clark, W. Lloyd, additional, Banker, Alay S., additional, Fardeau, Christine, additional, Franco, Pablo, additional, LeHoang, Phuc, additional, Ohno, Shigeaki, additional, Rathinam, Sivakumar R., additional, Thurau, Stephan, additional, Abraham, Abu, additional, Wilson, Laura, additional, Yang, Yang, additional, and Shams, Naveed, additional

Published
2016
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38. Contributors

Author

Abràmoff, Michael D., Abrams, Gary W., Afshar, Armin R., Agarwal, Aniruddha, Agarwal, Anita, Aiello, Lloyd M., Aiello, Lloyd Paul, Albert, Daniel M., Andreoli, Michael T., Armbrust, Karen R., Aronow, Mary E., Aschbrenner, Mathew W., Ávila, Marcos, Aylward, G.W., Baldwin, Andrew J., Baldwin, Angela N., Belfort, Rubens, Jr., Bennett, Jean, Bergstrom, Chris, Besirli, Cagri G., Bessette, Angela, Bhende, Muna, Bhende, Pramod S., Binder, Susanne, Bird, Alan, Blodi, Barbara A., Blumenkranz, Mark S., Boldt, H. Culver, Borkar, Durga S., Bornfeld, Norbert, Bottoni, Ferdinando, Boulton, Michael E., Bowne, Sara J., Brady, Christopher J., Brantley, Milam A., Jr., Bressler, Neil M., Bressler, Susan B., Bringmann, Andreas, Brinton, Daniel A., Brown, Gary C., Brown, Melissa M., Brunner, Simon, Burris, Christopher K.H., Bush, Ronald A., Cao, Dingcai, Capone, Antonio, Jr., Carruthers, David, Cavallerano, Jerry D., Chakravarthy, Usha, Chan, Helen, Charles, Steve, Charteris, David G., Chen, Jeannie, Cheung, Carol Yim-lui, Chew, Emily Y., Chiang, Allen, Chiang, Michael F., Chundury, Rao V., Clegg, Dennis O., Constable, Ian J., Coscas, Gabriel, Cruess, Alan F., Cunningham, Emmett T., Jr., Curcio, Christine A., Daiger, Stephen P., Damato, Bertil E., Das, Sudipta, Davis, Janet L., Davis, Matthew D., Day, Shelley, de Amorim, Carlos Alexandre, De Potter, Patrick, de Smet, Marc D., Denniston, Alastair K., Dhaliwal, Ranjit S., Dick, Andrew D., Ding, Xiaoyan, Do, Diana V., Duker, Jay S., Duncan, Jacque L., Ehlers, Justis P., Eliott, Dean, Faia, Lisa J., Falsini, Benedetto, Fekrat, Sharon, Feldon, Steven E., Ferreyra, Henry A., Ferrington, Deborah A., Ferris, Frederick L., III, Finger, Paul T., Fisher, Steven K., Fishman, Gerald A., Fleckenstein, Monika, Flynn, Harry W., Jr., Foulds, Wallace S., Fox, Austin R., Freeman, William R., Friedlander, Martin, Frishman, Laura J., Fu, Arthur D., Gamm, David M., Garcia-Valenzuela, Enrique, Garg, Sunir J., Gaudric, Alain, Gayed, Mary, Gerding, Heinrich, Giani, Andrea, Goldberg, Morton F., Gopal, Lingam, Gordon, Caroline, Goto, Hiroshi, Gragoudas, Evangelos S., Grant, Maria B., Gregg, Ronald G., Gregory-Evans, Kevin, Groenewald, Carl, Grossniklaus, Hans E., Grover, Sandeep, Gullapalli, Vamsi K., Guthoff, Rudolf F., Gutkind, J. Silvio, Hahn, Paul, Haller, Julia A., Handa, James T., Haritoglou, Christos, Haug, Sara, Hawkins, Barbara S., He, Shikun, Herwig-Carl, Martina C., Heussen, Florian M.A., Hinton, David R., Hodgson, Nickisa M., Holz, Frank G., Houston, Samuel K., Hui, Yan-Nian, Humayun, Mark S., Ikuno, Yasushi, Isaac, David, Ishibashi, Tatsuro, Jabs, Douglas A., Jaffe, Glenn J., Jampol, Lee M., Joffe, Leonard, Johnson, Mark, Johnson, Mark W., Johnson, Robert N., Joussen, Antonia M., Julian, Karina, Jumper, J. Michael, Kaiser, Peter K., Kamermans, Maarten, Kampik, Anselm, Karanjia, Rustum, Kashani, Amir H., Keane, Pearse A., Kenney, M. Cristina, Khaderi, S. Khizer R., Khodair, Mohamad A., Kim, Ivana K., Kim, Jonathan W., Kim, Tae Wan, Kirchhof, Bernd, Kiss, Szilard, Klein, Barbara E.K., Klein, Ronald, Klufas, Michael A., Kolomeyer, Anton M., Konstantinidis, Lazaros, Kowluru, Renu, Kozak, Igor, Kuppermann, Baruch D., Kuriyan, Ajay E., Labriola, Leanne T., Lam, Dennis, Lam, Linda A., Lane, Anne Marie, Lavik, Erin B., Leary, James F., Lee, Richard W.J., Lee, Sun Young, Lee, Thomas C., Lee, Vincent, Leung, Loh-Shan B., Lewis, Geoffrey P., Leys, Anita, Li, Xiaoxin, Liakopoulos, Sandra, Lin, Chang-Ping, Lin, Phoebe, Liu, Enchun M., Liu, Shirley, Lois, Noemi, London, Nikolas J.S., Lu, Lin, Lujan, Brandon J., Luo, Yan, Lutty, Gerard A., MacLaren, Robert, Madreperla, Steven, Maguire, Albert M., Mainster, Martin A., Mansfield, Nancy C., Markoe, Arnold M., Marmor, Michael F., Martin, Daniel F., Massey, Stephen C., McCall, Maureen A., McCannel, Tara A., McCutchan, J. Allen, McDonald, H. Richard, Meier, Petra, Meredith, Travis A., Meyer, Carsten H., Mieler, William F., Miller, Joan W., Mirza, Rukhsana G., Mitter, Sayak K., Mittra, Robert A., Miyake, Yozo, Montemagno, Carlo, Moore, Anthony T., Mruthyunjaya, Prithvi, Muccioli, Cristina, Mullins, Robert F., Murphree, A. Linn, Murphy, Robert P., Murray, Philip I., Murray, Timothy G., Nagpal, Manish, Namperumalsamy, Perumalsamy, Nanda, Sumit K., Nazari, Hossein, Nguyen, Quan Dong, Nussenblatt, Robert B., Oellers, Patrick, Ohji, Masahito, Ohno-Matsui, Kyoko, Palanker, Daniel, Papakostas, Thanos D., Patel, Avni V., Patel, Purnima S., Pavlick, Anna C., Pay, S. Louise, Peereboom, David M., Pennesi, Mark E., Pepose, Jay S., Perry, Julian D., Quiram, Polly A., Raman, Rajiv, Ramchandran, Rajeev S., Rao, P. Kumar, Rao, Narsing A., Rathinam, Sivakumar R., Recchia, Franco M., Redmond, Kristin J., Reed, David, Reh, Thomas A., Reichenbach, Andreas, Rezaei, Kourous A., Rhoades, William R., Rhodes, Benjamin, Ritch, Robert, Robson, Anthony G., Rosenfeld, Philip J., Rowland, Teisha J., Rubin, Gary S., Sadda, SriniVas R., Sadun, Alfredo A., Sampath, Alapakkam P., Sangave, Amit A., Schachat, Andrew P., Schechet, Sid, Schmitz-Valckenberg, Steffen, Schwartz, Stephen G., Scott, Adrienne W., Sebag, J., Seddon, Johanna M., Seider, Michael I., Sen, H. Nida, Sepah, Yasir Jamal, Sharma, Sanjay, Sharma, Tarun, Sheu, Shwu-Jiuan, Shields, Carol L., Shields, Jerry A., Shinoda, Kei, Shukla, Dhananjay, Sieving, Paul A., Silva, Paolo S., Silveira, Claudio, Singer, Joshua, Singh, Arun D., Skalet, Alison, Skugor, Mario, Smith, Sylvia B., Sobrin, Lucia, Sodhi, Akrit, Sohn, Elliott H., Soubrane-Daguet, Gisèle, Spielberg, Leigh, Srivastava, Sunil K., Stachs, Oliver, Staurenghi, Giovanni, Sternberg, Paul, Jr., Stewart, Jay M., Stitt, Alan, Stone, Edwin M., Sugino, Ilene K., Sullivan, Lori S., Sullivan, Paul, Sun, Jennifer K., Sunness, Janet S., Symons, R.C. Andrew, Tadayoni, Ramin, Tang, Shibo, Terasaki, Hiroko, Thanos, Aristomenis, Thomas, Matthew A., Thompson, John T., Toth, Cynthia A., Toy, Brian, Trese, Michael T., Tsai, Julie H., Udar, Nitin, Ulrich, J. Niklas, Umfress, Allison C., Van Gelder, Russell N., van Meurs, Jan C., Vasconcelos-Santos, Daniel Vítor, Vavvas, Demetrios G., Vemulakonda, G. Atma, Waheed, Nadia K., Weiland, James, Weleber, Richard G., Wenick, Adam S., Wharam, Moody D., Jr., Wickham, Louisa, Wiedemann, Peter, Wiley, Henry E., Wilkinson, C.P., Wilson, David, Wolf, Sebastian, Wolfensberger, Thomas J., Wong, David, Wong, Ian Y., Wong, Tien Y., Wu, Frances, Yandiev, Yanors, Yang, Chang-Hao, Yang, Chung-May, Yannuzzi, Lawrence A., Yeh, Po-Ting, Yonekawa, Yoshihiro, Yoon, Young Hee, Yu, Hyeong Gon, Zarbin, Marco A., Zhang, Kang, Zhu, Jie, and Zinkernagel, Martin

Published
2018
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39. Tuberculous Uveitis

Author

Cunningham, Emmett T., primary, Rathinam, Sivakumar R., additional, Albini, Thomas A., additional, Chee, Soon-Phaik, additional, and Zierhut, Manfred, additional

Published
2015
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40. A shared HLA-DRB1 epitope in the DR beta first domain is associated with Vogt-Koyanagi-Harada syndrome in Indian patients

Author

Tiercy, Jean-Marie, Rathinam, Sivakumar R., Gex-Fabry, Marianne, and Baglivo, Edoardo

Subjects
Adult, Male, Epitopes/*chemistry/genetics/*immunology, Genotype, Molecular Sequence Data, India, Epitopes, ddc:616.89, Gene Frequency, Humans, Genetic Predisposition to Disease, Amino Acid Sequence, Complementarity Determining Regions/chemistry, Alleles, ddc:616, HLA-DR Antigens/*chemistry/genetics/*immunology, Uveomeningoencephalitic Syndrome/*genetics/*immunology, HLA-DR Antigens, Middle Aged, Complementarity Determining Regions, eye diseases, Protein Structure, Tertiary, Gene Frequency/genetics, Case-Control Studies, Female, Uveomeningoencephalitic Syndrome, Research Article, HLA-DRB1 Chains
Abstract

PURPOSE: Vogt-Koyanagi-Harada (VKH) disease and sympathetic ophthalmia (SO) are two distinct entities that share common clinical and histopathological features; however, it remains unknown whether they have a common genetic susceptibility. Several studies have shown an association of human leukocyte antigen (HLA)-DR4 with VKH disease in patients of different ethnic backgrounds. We present in this paper the HLA-DRB1 genotyping analysis of a large cohort of VKH patients from southern India and compare these patients to patients with SO and to healthy individuals from the same geographic area. METHODS: VKH patients were diagnosed according to the revised criteria of the International Committee on VKH disease. Patients with granulomatous uveitis after ocular trauma or multiple eye surgeries were diagnosed as having SO. Genomic DNA was extracted from all patients and controls. Samples were analyzed for HLA-DRB1 alleles by reverse polymerase chain reaction (PCR) sequence-specific oligonucleotide (SSO) hybridization on microbeads, using the Luminex technology, and by PCR sequence-specific primers (SSP) typing for DRB1*04 allele determination. Strength of associations was estimated by odds ratios (OR) and 95% confidence intervals (CI) and frequencies were compared using the Fisher's exact test. RESULTS: HLA-DRB1 alleles were determined in 94 VKH patients, 39 SO patients, and 112 healthy controls. HLA-DRB1*04 frequency was higher in VKH patients (20.2% versus 10.3% in controls; OR=2.2, p=0.005, pc=0.067). This association was lower than the association of HLA-DRB1*04 frequency in cohorts of patients from different origins. No significant DR4 association with SO was detected. HLA-DRB1*0405 and HLA-DRB1*0410 alleles were significantly increased in VKH patients (8.5% versus 0.9% in controls; OR=10.3, 95% CI=2.34-45.5, p

Published
2010

42. Vogt-Koyanagi-Harada Disease

Author

Cunningham, Emmett T., primary, Rathinam, Sivakumar R., additional, Tugal-Tutkun, Ilknur, additional, Muccioli, Cristina, additional, and Zierhut, Manfred, additional

Published
2014
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50. HIV/AIDS in the Developing World

Author

London, Nikolas J.S., primary, Shukla, Dhananjay, additional, Heiden, David, additional, Rathinam, Sivakumar R., additional, Arevalo, J. Fernando, additional, and Cunningham, Emmett T., additional

Published
2010
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