1. Long-term risk of stroke and its predictors in transient ischaemic attack patients in Germany
- Author
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Karel Kostev, Louis Jacob, Christian Tanislav, Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), and The authors have received no financial support for the research, authorship and/or publication of this paper.
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Male ,associated predictors ,Cohort Studies ,0302 clinical medicine ,general practices ,Germany ,Atrial Fibrillation ,030212 general & internal medicine ,Stroke ,Aged, 80 and over ,Incidence ,Hazard ratio ,Age Factors ,Atrial fibrillation ,Middle Aged ,stroke ,3. Good health ,Neurology ,Ischemic Attack, Transient ,Hypertension ,Cohort ,Platelet aggregation inhibitor ,Female ,[SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] ,Risk ,medicine.medical_specialty ,transient ischaemic attack ,03 medical and health sciences ,Sex Factors ,Diabetes mellitus ,Internal medicine ,parasitic diseases ,medicine ,Humans ,long-term risk ,In patient ,cardiovascular diseases ,Aged ,Ischemic Stroke ,business.industry ,Anticoagulants ,Protective Factors ,medicine.disease ,nervous system diseases ,Long term risk ,Neurology (clinical) ,business ,Platelet Aggregation Inhibitors ,030217 neurology & neurosurgery - Abstract
International audience; Background and purpose: Little is known about the long-term association between transient ischaemic attack (TIA) and stroke. Therefore, the goal of this study was to analyze the long-term risk of stroke and associated predictors in a large cohort of TIA patients followed in general practices in Germany. Methods: This study included patients with an initial TIA diagnosis and subsequently followed up in one of 1262 general practices in Germany between January 2007 and December 2016 (N = 19 824 patients). The primary outcome of the study was the risk of ischaemic stroke within 10 years of the initial diagnosis of TIA. The secondary outcome was the identification of demographic, clinical and pharmaceutical variables significantly associated with stroke in TIA patients. Results: Within 10 years of the initial TIA diagnosis, 18.3% of individuals were diagnosed with stroke. Age was positively associated with stroke, with hazard ratios ranging from 1.88 in patients aged 51–60 years to 4.00 in those aged >80 years (reference group: patients aged ≤50 years). Furthermore, male sex, hypertension, diabetes mellitus, atrial fibrillation and ischaemic heart diseases had an additional impact on the risk of stroke. Finally, new oral anticoagulants, heparins, diuretics, angiotensin II receptor blockers and platelet aggregation inhibitors were identified as protective factors. Conclusions: In a cohort of almost 20 000 TIA patients, 18.3% were diagnosed with stroke within 10 years after the TIA index event. Several demographic, clinical and pharmaceutical variables significantly predicted the long-term risk of stroke in TIA patients.
- Published
- 2020
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