1. Association of the IFNG +874T/A Polymorphism with Symptomatic COVID-19 Susceptibility.
- Author
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Sarges KML, Póvoa da Costa F, Santos EFD, Cantanhede MHD, da Silva R, Veríssimo AOL, Viana MNDSA, Rodrigues FBB, Leite MM, Torres MKDS, Bentes da Silva C, Brito MTFM, Silva ALSD, Henriques DF, Vallinoto IMVC, Viana GMR, Queiroz MAF, Vallinoto ACR, and Santos EJMD
- Subjects
- Female, Humans, Male, Alleles, Cytokine Release Syndrome genetics, Gene Frequency, Polymorphism, Single Nucleotide, Tumor Necrosis Factor-alpha genetics, COVID-19 genetics, COVID-19 virology, Genetic Predisposition to Disease, Genotype, Interferon-gamma genetics, SARS-CoV-2 pathogenicity
- Abstract
Tumor necrosis factor (TNF) and interferon-gamma (IFNγ) are important inflammatory mediators in the development of cytokine storm syndrome (CSS). Single nucleotide polymorphisms (SNPs) regulate the expression of these cytokines, making host genetics a key factor in the prognosis of COVID-19. In this study, we investigated the associations of the TNF -308G/A and IFNG +874T/A polymorphisms with COVID-19. We analyzed the frequencies of the two polymorphisms in the control groups (CG: TNF -308G/A, n = 497; IFNG +874T/A, n = 397), a group of patients with COVID-19 (CoV, n = 222) and among the subgroups of patients with nonsevere ( n = 150) and severe ( n = 72) COVID-19. We found no significant difference between the genotypic and allelic frequencies of TNF -308G/A in the groups analyzed; however, both the frequencies of the high expression genotype (TT) (CoV: 13.51% vs. CG: 6.30%; p = 0.003) and the *T allele (CoV: 33.56% vs. CG: 24. 81%; p = 0.001) of the IFNG +874T/A polymorphism were higher in the COVID-19 group than in the control group, with no differences between the subgroups of patients with nonsevere and severe COVID-19. The *T allele of IFNG +874T/A (rs2430561) is associated with susceptibility to symptomatic COVID-19. These SNPs provided valuables clues about the potential mechanism involved in the susceptibility to developing symptomatic COVID-19.
- Published
- 2024
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