21 results on '"Patel, Zara M."'
Search Results
2. Assessment of Opioid Use and Analgesic Requirements After Endoscopic Sinus Surgery: A Randomized Clinical Trial.
- Author
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Ayoub NF, Choby G, Turner JH, Abuzeid WM, Raviv JR, Thamboo A, Ma Y, Chandra RK, Chowdhury NI, Stokken JK, O'Brien EK, Shah S, Akbar N, Roozdar P, Nayak JV, Patel ZM, and Hwang PH
- Subjects
- Acetaminophen administration & dosage, Acetaminophen therapeutic use, Adolescent, Adult, Aged, Aged, 80 and over, Analgesics, Non-Narcotic therapeutic use, Analgesics, Opioid therapeutic use, Drug Therapy, Combination, Female, Humans, Ibuprofen administration & dosage, Ibuprofen therapeutic use, Male, Middle Aged, Oxycodone administration & dosage, Oxycodone therapeutic use, Pain Measurement, Pain, Postoperative diagnosis, Prospective Studies, Treatment Outcome, Young Adult, Analgesics, Non-Narcotic administration & dosage, Analgesics, Opioid administration & dosage, Endoscopy, Pain, Postoperative drug therapy, Rhinitis surgery, Rhinoplasty methods, Sinusitis surgery
- Abstract
Importance: The opioid epidemic has generated interest in optimizing opioid prescribing after common surgeries. Recent studies have shown a broad range of analgesic prescription patterns following endoscopic sinus surgery (ESS)., Objective: To compare the efficacy of different analgesic regimens after ESS., Design, Setting, and Participants: This multi-institutional, nonblinded randomized clinical trial was conducted at 6 tertiary centers across the US and Canada and included participants who underwent ESS for acute or chronic rhinosinusitis. The study was conducted from March 2019 to March 2020, and the data were analyzed in November to December 2020., Interventions: All participants received acetaminophen, 650 mg, as the first-line analgesic. From there, patients were randomized to either oxycodone rescue (oxycodone, 5 mg, as second-line therapy) or ibuprofen rescue (ibuprofen, 600 mg, as second-line therapy, with oxycodone, 5 mg, reserved for breakthrough pain)., Main Outcomes and Measures: Baseline characteristics and disease severity were collected at enrollment. Medication logs, pain scores, and epistaxis measures were collected until postoperative day 7. The primary outcome was the postoperative visual analog scale score for pain. Brief Pain Inventory Pain Severity and Pain Interference Scores were also collected., Results: A total of 118 patients were randomized (62 [52.5%] oxycodone rescue, 56 [47.5%] ibuprofen rescue; mean [SD] age, 46.7 [16.3] years; 44 women [44.0%]; 83 White [83.0%], 7 Black [7.0%], and 7 Asian individuals [7.0%]). After exclusions for loss to follow-up and noncompliance, 51 remained in the oxycodone rescue group and 49 in the ibuprofen rescue group. The groups had similar demographic characteristics and disease severity. Thirty-two (63%) in the oxycodone rescue group had adequate pain management with acetaminophen only, while 19 (37%) consumed at least 1 oxycodone dose. In the ibuprofen rescue group, 18 (16%) required only acetaminophen, 28 (57%) used only acetaminophen and ibuprofen, and the remaining 13 (26%) consumed 1 or more oxycodone doses. The groups had similar average acetaminophen (9.69 vs 7.96 doses; difference, 1.73; 95% CI, -1.37 to 4.83) and oxycodone (1.89 vs 0.77 doses; difference, 1.13; 95% CI, -0.11 to 2.36) use. Both groups had similar postoperative visual analog scale scores. A subanalysis that compared opioids users with nonusers showed clinically significant lower pain scores in nonusers at multiple postoperative points., Conclusions and Relevance: In this randomized clinical trial, most patients who underwent ESS could be treated postoperatively using a nonopioid regimen of either acetaminophen alone or acetaminophen and ibuprofen. Ibuprofen as a second-line therapy did not reduce overall narcotic consumption, but the overall narcotic use was low in both groups., Trial Registration: ClinicalTrials.gov Identifier: NCT03783702.
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- 2021
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3. The Effect of Endoscopic Sinus Surgery on Eustachian Tube Dysfunction Symptoms.
- Author
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Chang MT, Hosseini DK, Song SH, Nayak JV, Patel ZM, Lee JY, and Hwang PH
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- Adult, Aged, Chronic Disease, Ear Diseases diagnosis, Ear Diseases epidemiology, Female, Humans, Male, Middle Aged, Nasal Polyps complications, Nasal Polyps surgery, Prevalence, Retrospective Studies, Rhinitis complications, Sinusitis complications, Surveys and Questionnaires, Symptom Assessment, Treatment Outcome, Ear Diseases complications, Endoscopy, Eustachian Tube physiopathology, Rhinitis surgery, Sinusitis surgery
- Abstract
Objective: We assessed how eustachian tube dysfunction (ETD) changed with endoscopic sinus surgery (ESS) and identified factors associated with improvement., Study Design: Retrospective chart review., Setting: Academic center., Subjects and Methods: Patients undergoing ESS for chronic rhinosinusitis with and without nasal polyposis (CRSwNP, CRSsNP) or recurrent acute rhinosinusitis (RARS) completed the Eustachian Tube Dysfunction Questionnaire 7 (ETDQ-7) preoperatively and postoperatively at 2 weeks, 6 weeks, 3 months, and 6 months. Included in analyses were demographics, comorbidities, Sinonasal Outcome Test 22 (SNOT-22), radiographic score, endoscopy score, procedure, and medication use. Regression analysis identified factors associated with improvement, defined as ΔETDQ-7 >3.5., Results: In total, 302 patients were studied. ETD prevalence was 68% in CRSsNP, 48% in CRSwNP, and 88% in RARS. Patients with ETD had a mean baseline ETDQ-7 of 25.8 ± 8.0 and improved postoperatively at 2 weeks (19.9 ± 8.1, P < .001), 6 weeks (17.8 ± 9.3, P < .001), 3 months (16.8 ± 8.5, P < .001), and 6 months (16.4 ± 7.9, P < .001). At 6 months, ETD improved in 89% of patients with CRSsNP, 68% with CRSwNP, and 78% with RARS. On multivariate analysis, ETD improvement was associated with higher preoperative ETDQ-7 score (adjusted odds ratio [aOR], 1.12; 95% confidence interval [CI], 1.04-1.22; P = .030), higher preoperative SNOT-22 score (aOR, 1.02; 95% CI, 1.02-1.08; P = .001), higher preoperative SNOT-22 ear subscore (aOR, 1.27; 95% CI, 1.02-1.65; P = .034), posterior ethmoidectomy (aOR, 1.59; 95% CI, 1.22-4.92; P = .025), and postoperative corticosteroid spray use (aOR, 1.57; 95% CI, 1.17-1.66; P = .008)., Conclusion: ETD symptoms often improve following ESS. Factors associated with improvement include higher preoperative disease burden, posterior ethmoidectomy, and postoperative corticosteroid spray., Level of Evidence: 4.
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- 2020
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4. In Reply: Precautions for Endoscopic Transnasal Skull Base Surgery During the COVID-19 Pandemic.
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Patel ZM, Fernandez-Miranda J, Hwang PH, Nayak JV, Dodd RL, Sajjadi H, and Jackler RK
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- Betacoronavirus, COVID-19, Humans, SARS-CoV-2, Skull Base, Coronavirus Infections, Endoscopy, Neurosurgical Procedures, Pandemics, Pneumonia, Viral
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- 2020
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5. Indications and Outcomes for Patients With Limited Symptoms Undergoing Endoscopic Sinus Surgery.
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Rahman AS, Hwang PH, Alapati R, Lin Y, Nayak JV, Patel ZM, and Yan CH
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- Adult, Asymptomatic Diseases, Chronic Disease, Clinical Decision-Making, Female, Humans, Male, Middle Aged, Nasal Polyps diagnosis, Quality of Life, Rhinitis diagnosis, Sino-Nasal Outcome Test, Sinusitis diagnosis, Treatment Outcome, Endoscopy, Nasal Polyps surgery, Paranasal Sinuses surgery, Rhinitis surgery, Sinusitis surgery
- Abstract
Background: Previous research have suggested that chronic rhinosinusitis (CRS) patients with lower symptomatic scores, demonstrated by a 22-item Sinonasal Outcome Test (SNOT-22) score <20, may not achieve meaningful quality of life improvement following endoscopic sinus surgery (ESS). However, indications for ESS are continuing to be defined and many low SNOT-22 scoring patients still undergo elective surgery for CRS and other benign sinonasal pathologies. The outcomes for these patients have not been previously studied., Objectives: We sought to evaluate surgical indications and outcomes for those patients with limited symptoms undergoing ESS., Methods: We screened 2829 ESS procedures from 2010-2018 to identify patients with a preoperative SNOT-22 score <20. We reviewed disease characteristics, preoperative Lund-Mackay (LM) scores, and pre- and postoperative SNOT-22 scores in patients with at least 3 months' follow-up., Results: Of all surgical ESS patients screened, 114 had low preoperative SNOT-22 scores (4.0%). Indications for these surgeries included CRS (50.0%), odontogenic sinus disease (11.4%), mucocele (10.5%), recurrent acute sinusitis (7.0%), fungal ball (5.3%), and silent sinus syndrome (4.4%). Specifically, among CRS patients, 45.6% had pulmonary comorbidities and/or systemic immunodeficiencies. Moreover, 100% of CRS patients with nasal polyps and 73.1% of CRS without polyps had LM scores >5. Patients with preoperative SNOT-22 scores between 15 and 19 achieved an average 6.5 point reduction ( P < .001) postoperatively, whereas those with scores between 10 and 14 had a 5.4 point reduction ( P < .001), and preoperative scores <9 resulted in no significant decrease in postoperative symptom scores ( P = .98). Overall, there was a 3.3 point SNOT-22 reduction among all patients at 3 months postoperatively ( P < .001)., Conclusion: Patients with limited sinonasal symptoms may benefit from surgical treatment despite asymptomatic clinical presentations. A case-by-case analysis of comorbidities or unique clinical features should inform surgical decision-making for patients with lower SNOT-22 scores.
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- 2020
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6. The effect of topical epinephrine 1:1000 with and without infiltration of 1% lidocaine with epinephrine 1:100,000 on endoscopic surgical field visualization: a double-blind randomized controlled study.
- Author
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Tangbumrungtham N, Hwang PH, Maul X, Borchard NA, Dholakia SS, Patel ZM, Nayak JV, and Choby G
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- Administration, Topical, Adult, Aged, Chronic Disease, Double-Blind Method, Female, Humans, Male, Middle Aged, Nasal Polyps surgery, Rhinitis surgery, Sinusitis surgery, Anesthetics, Local administration & dosage, Blood Loss, Surgical prevention & control, Endoscopy, Epinephrine administration & dosage, Lidocaine administration & dosage, Paranasal Sinuses surgery, Vasoconstrictor Agents administration & dosage
- Abstract
Background: The objective of this study is to determine whether the infiltration of 1% lidocaine with 1:100,000 epinephrine in addition to topical application of 1:1000 epinephrine significantly improves surgical field grading scale score over topical 1:1000 epinephrine alone., Methods: A prospective, double-blind, randomized, controlled study was performed of 40 patients undergoing bilateral endoscopic sinus surgery (ESS) for chronic rhinosinusitis (CRS). Patients were enrolled and randomly assigned to receive infiltration with 1% lidocaine with 1:100,000 epinephrine on 1 side of the nasal cavity vs plain saline on the other side in preparation for ESS. Both groups received topical application of 1:1000 epinephrine. Surgical videos were recorded and Wormald surgical field grading scale was assigned by 2 blinded reviewers. The number of extra 1:1000 epinephrine pledgets used during the surgery, estimated blood loss, and surgical duration were also recorded., Results: There were no statistically significant differences in Wormald surgical field grading scale, number of extra pledgets used, or estimated blood loss between the nasal cavity side infiltrated with 1% lidocaine with 1:100,000 epinephrine in comparison to infiltration with saline. The side infiltrated with 1% lidocaine with 1:100,000 epinephrine had a reduced operative time compared to the side infiltrated with saline (p = 0.002). There were no differences in postoperative bleeding from questionnaire completed by patient at the first postoperative visit., Conclusion: Addition of infiltration of 1% lidocaine with epinephrine 1:100,000 to topical application of epinephrine 1:1000 for preparation of ESS does not significantly improve surgical field of view compared to topical epinephrine alone., (© 2019 ARS-AAOA, LLC.)
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- 2020
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7. The Horizon Sign and Frontal Bar: Two Topographic Landmarks to Confirm Endoscopic Frontal Sinusotomy.
- Author
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Walgama ES, Thamboo A, Tangbumrungtham N, Ayoub N, Patel ZM, and Nayak JV
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- Adult, Cadaver, Chronic Disease, Humans, Rhinitis surgery, Sensitivity and Specificity, Sinusitis surgery, Tomography, X-Ray Computed, Dissection, Endoscopy, Frontal Sinus diagnostic imaging, Frontal Sinus surgery, Rhinitis diagnostic imaging, Sinusitis diagnostic imaging
- Abstract
Confirming a thorough dissection of the frontal sinus during endoscopic sinus surgery can be challenging, and some surgeons would benefit from reliable topographic landmark identification to ensure completion of this sinus dissection. We defined (1) the "horizon sign" as the curvilinear shadow of the posterior table cast superiorly upon the anterior table of the frontal sinus at the acute angle of their meeting point and (2) the "frontal bar" as a sagittal septation at the union of the anterior/posterior tables. A cadaveric study, followed by an intraoperative consecutive case series, was performed to evaluate these 2 landmarks as indicators of complete dissection. The horizon sign was extremely reliable, identified in 100% of cadaveric frontal sinuses and intraoperative frontal sinuses. The frontal bar was present in only 67% of frontal sinuses by computed tomography. In live patients, the sensitivity and specificity of the frontal bar were 62% and 95%, respectively.
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- 2019
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8. Transoral Endoscopic Resection of High Cervical Osteophytes with Long-Term Symptom Resolution: Case Series, Imaging, and Literature Review.
- Author
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Jabarkheel R, Chen YR, Xu L, Yan CH, Patel ZM, and Desai AM
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- Cervical Vertebrae diagnostic imaging, Deglutition Disorders diagnostic imaging, Deglutition Disorders etiology, Deglutition Disorders surgery, Female, Follow-Up Studies, Humans, Interdisciplinary Communication, Intersectoral Collaboration, Magnetic Resonance Imaging, Middle Aged, Oropharynx diagnostic imaging, Oropharynx surgery, Postoperative Complications diagnostic imaging, Postoperative Complications surgery, Spinal Fusion, Tomography, X-Ray Computed, Cervical Vertebrae surgery, Endoscopy methods, Spinal Osteophytosis diagnostic imaging, Spinal Osteophytosis surgery
- Abstract
Background: Anterior cervical osteophytes (ACOs) are a common radiologic finding in the elderly; rarely, they can cause dysphagia, dysphonia, and dyspnea. Symptomatic ACOs are most commonly found between C4 and C7 and much less commonly at higher cervical levels. Here, we present a case series, with an example case of a 57-year-old woman with high cervical osteophytes at C1-C2 causing globus sensation, dysphagia, and dysphonia. Additionally, we provide a literature review regarding the causes, diagnosis, and treatment of ACOs, with a focus on management of high ACOs., Case Description: A 57-year-old smoker with a history of chronic neck pain and previous cervical spinal instrumentation presented with several months of globus sensation, dysphagia, and dysphonia. Imaging revealed 2 large anterior osteophytes at C1-C2. She underwent endoscopic transoral osteophytectomy, with resolution of symptoms. Five other patients are also presented who underwent similar procedures., Conclusions: ACOs are a potential cause of dysphagia, and their diagnosis is best made with computed tomographic imaging and oropharyngeal swallow study. Although high ACOs at C1-C2 are a rare finding, here we show with an exemplary case and small case series that they can be effectively treated with transoral endoscopic osteophytectomy., (Copyright © 2018 Elsevier Inc. All rights reserved.)
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- 2018
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9. Precision medicine: why surgeons deviate from "appropriateness criteria" in the management of chronic rhinosinusitis and effects on outcomes.
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Thamboo A, Rathor A, Borchard NA, Nayak JV, Hwang PH, and Patel ZM
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- Adult, Aged, Chronic Disease, Decision Making, Female, Humans, Male, Middle Aged, Nasal Polyps epidemiology, Practice Guidelines as Topic, Precision Medicine, Rhinitis epidemiology, Sinusitis epidemiology, Surgeons, Treatment Outcome, United States epidemiology, Endoscopy, Nasal Polyps surgery, Paranasal Sinuses surgery, Rhinitis surgery, Sinusitis surgery
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Background: In uncomplicated chronic rhinosinusitis (CRS), a consensus regarding appropriate medical therapy (AMT) before surgical intervention has been published in the form of "appropriateness criteria" for endoscopic sinus surgery (ESS). We sought to determine why tertiary surgeons may deviate from the suggested criteria and evaluated whether those deviations result in change in outcomes., Methods: Patients with uncomplicated CRS were prospectively enrolled over the course of 1 year. The 22-item Sino-Nasal Outcomes Test (SNOT-22), a general health outcome out of 100, and a physician form, indicating management pathway and decision making, was completed at each visit over a 6-month follow-up period. A descriptive analysis was used to quantify reasons for veering from the "appropriateness criteria," and repeated linear regression modeling was used to measure whether compliance impacted SNOT-22, general health, and Lund-Kennedy (LK) scores over the period of study., Results: One hundred fifty-five patients were enrolled. Sixty-eight percent followed the appropriate management pathway based on their presentation and the suggested criteria. Disparate reasons were documented for deviation in the other 32%, and, despite establishing several predictive categories, "other" was the most common reason, with various explanations well documented. SNOT-22, general health, and LK scores were not statistically impacted by compliancy status (p > 0.05)., Conclusion: The suggested "appropriateness criteria" predict a management pathway for the majority of CRS patients. However, in a tertiary sinus center, surgeons may deviate from that model with a significant minority of their patients, for multiple reasons, without causing a change in outcomes., (© 2018 ARS-AAOA, LLC.)
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- 2018
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10. Nose blowing after endoscopic sinus surgery does not adversely affect outcomes.
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Ayoub N, Chitsuthipakorn W, Nayak JV, Patel ZM, and Hwang PH
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- Adult, Female, Humans, Male, Middle Aged, Nose, Postoperative Complications etiology, Postoperative Period, Quality of Life, Rhinitis surgery, Endoscopy adverse effects, Epistaxis etiology, Paranasal Sinuses surgery, Postoperative Complications prevention & control, Sinusitis surgery
- Abstract
Objective: Patients frequently are advised to abstain from nose blowing following endoscopic sinus surgery (ESS), despite a lack of evidence supporting this recommendation. This randomized study assessed whether nose blowing in the first postoperative week affects subjective and objective clinical outcomes., Methods: Forty patients undergoing ESS were randomized into an interventional arm in which patients blew their nose at least twice daily for the first 7 postoperative days, or a control arm in which patients refrained from nose blowing. All patients were allowed to blow their nose after 7 days. The frequency and degree of epistaxis was documented by daily diary and visual analog scale (VAS). At 1 and 4 weeks postoperatively, Nasal Obstruction Symptom Evaluation (NOSE) and Sino-Nasal Outcome Test-22 (SNOT-22) were collected, and endoscopies were recorded for blinded Lund-Kennedy scale scoring., Results: There were no differences between the two groups in terms of frequency and duration of bleeding events, VAS epistaxis scores, SNOT-22 scores, and NOSE scores at every postoperative timepoint. Lund-Kennedy scores also were similar at the 1-week (P = 0.0762) and 4-week (P = 0.2340) postoperative visits, but the nose-blowing group had improved nasal discharge subscores at the first (P = 0.0075) and second (P = 0.0298) postoperative visits., Conclusion: Nose blowing after ESS does not appear to measurably improve symptoms of nasal congestion or general sinonasal quality of life, nor does it seem to adversely affect the frequency or severity of postoperative epistaxis during the first postoperative week. Judicious nose blowing may be permissible immediately after uncomplicated ESS., Level of Evidence: 1b. Laryngoscope, 128:1268-1273, 2018., (© 2017 The American Laryngological, Rhinological and Otological Society, Inc.)
- Published
- 2018
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11. Risk Stratification for Postoperative Venous Thromboembolism after Endoscopic Sinus Surgery.
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Beswick DM, Vaezeafshar R, Ma Y, Hwang PH, Nayak JV, and Patel ZM
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- Adolescent, Adult, Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged, Postoperative Complications epidemiology, Retrospective Studies, Risk Assessment, Risk Factors, Venous Thromboembolism epidemiology, Endoscopy, Paranasal Sinus Diseases surgery, Postoperative Complications etiology, Venous Thromboembolism etiology
- Abstract
Objectives Venous thromboembolism (VTE) contributes to significant patient morbidity, yet the incidence of VTE following endoscopic sinus surgery (ESS) is unknown. Quality improvement criteria are prompting increased standardization of perioperative VTE prophylaxis. Risk stratification for VTE may better define best practice measures to balance limiting VTE development with avoiding unnecessary chemoprophylaxis. Study Design Retrospective cohort study. Setting Tertiary institution. Subjects and Methods Adult patients who underwent ESS without perioperative chemoprophylaxis from 2008 to 2016 were evaluated. Identification of VTE was performed via screening diagnosis and procedure codes and clinical records, with subsequent confirmation of true-positive VTE. Data for individual Caprini scores were abstracted from electronic medical records. The primary outcome was development of VTE within 30 days following ESS relative to the Caprini score. Results A total of 2369 ESS cases were evaluated. While initial screening identified multiple potential VTE events, in-depth medical record review confirmed only 4 true VTE (0.17%). The VTE rate among cases with a Caprini score of <8 (0.09%, 2/2278) was significantly less ( P = .008) than the rate with a score of ≥8 (2.2%, 2/91). Beyond overall score, specific risk factors associated with development of postoperative VTE included stroke, central venous access, sepsis, and inpatient status (all P < .025), while prior VTE and hypercoagulability were not associated with postoperative VTE (all P > .5). Conclusions In the absence of perioperative chemoprophylaxis, postoperative VTE following ESS is extremely rare, particularly for patients carrying low-to-moderate Caprini scores. Risk stratification based on these data can assist in the design of VTE prophylaxis guidelines for ESS patients.
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- 2018
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12. Equivalence in outcomes between Draf 2B vs Draf 3 frontal sinusotomy for refractory chronic frontal rhinosinusitis.
- Author
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Patel VS, Choby G, Shih LC, Patel ZM, Nayak JV, and Hwang PH
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- Chronic Disease, Female, Humans, Male, Middle Aged, Retrospective Studies, Severity of Illness Index, Endoscopy methods, Frontal Sinus surgery, Nasal Surgical Procedures methods, Rhinitis surgery, Sinusitis surgery
- Abstract
Background: Endoscopic Draf 2B and Draf 3 frontal sinusotomies are frequently performed for chronic refractory frontal rhinosinusitis. The purpose of this study was to compare outcomes between Draf 2B and Draf 3 procedures., Methods: A retrospective cohort study was conducted comparing patients undergoing bilateral Draf 2B vs Draf 3 procedures from 2000 to 2016. Patients with neoplasia, dysplasia, mucocele, cystic fibrosis, or ciliary dyskinesia were excluded. Preoperative disease parameters included number of prior surgeries, presence of polyps, preoperative 22-item Sino-Nasal Outcome Test (SNOT-22) score, frontal Lund-Mackay score, anterior-posterior diameter of the frontal ostium, and Global Osteitis Scoring Scale (GOSS). Postoperative outcomes included SNOT-22 score, neo-ostium patency, surgical revision rates, and complications., Results: A total of 21 patients with bilateral Draf 2B and 17 patients with Draf 3 surgeries were compared. Mean follow-up time was 15.6 months. No significant differences were seen between groups for any preoperative disease parameter. Both cohorts showed statistically significant (p = 0.0001 [Draf 2B]; p = 0.0001 [Draf 3]) and clinically meaningful (Δ = 24.1; Δ = 24.9) improvements in SNOT-22 at last follow-up vs preoperatively. The Draf 2B group had greater improvement in SNOT-22 score than the Draf 3 group at 1 to 3 months (p = 0.003), but the magnitude of improvement equalized at 5 to 9 months (p = 0.66) and last follow-up (p = 0.90). No significant differences were noted between groups regarding patency, revision rates, or complications., Conclusion: Both Draf 2B and Draf 3 procedures offer durable symptomatic improvement for patients with refractory frontal CRS. The Draf 2B is associated with earlier postoperative symptom improvement and overall shows comparable long-term outcomes to the Draf 3 sinusotomy., (© 2017 ARS-AAOA, LLC.)
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- 2018
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13. Successful repair of intraoperative cerebrospinal fluid leaks improves outcomes in endoscopic skull base surgery.
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Shahangian A, Soler ZM, Baker A, Wise SK, Rereddy SK, Patel ZM, Oyesiku NM, DelGaudio JM, Hadjipanayis CG, Woodworth BA, Riley KO, Lee J, Cusimano MD, Govindaraj S, Khan MN, Psaltis A, Wormald PJ, Santoreneos S, Sindwani R, Trosman S, Stokken JK, Woodard TD, Recinos PF, Vandergrift WA 3rd, Boling C, and Schlosser RJ
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- Adolescent, Adult, Aged, Aged, 80 and over, Brain Neoplasms surgery, Child, Child, Preschool, Chordoma surgery, Encephalocele surgery, Female, Head and Neck Neoplasms surgery, Humans, Infant, Length of Stay, Male, Middle Aged, Patient Readmission, Pneumocephalus etiology, Postoperative Complications etiology, Reoperation, Treatment Outcome, Young Adult, Cerebrospinal Fluid Leak surgery, Endoscopy adverse effects, Postoperative Complications surgery, Plastic Surgery Procedures adverse effects, Skull Base surgery
- Abstract
Background: The impact of failed cerebrospinal fluid leak (CSF) leak repair in endoscopic skull base surgery has not been adequately studied., Methods: In this investigation we reviewed patients who had undergone endoscopic skull base surgery between 2002 and 2014 at 7 international centers. Demographic variables, comorbidities, tumor characteristics, and repair techniques were evaluated to determine association with successful repair of CSF leak. Postoperative complications and length of stay were compared among groups., Results: Data were collected on 2097 patients who were divided into 3 groups: (1) those with no intraoperative leak (n = 1533); (2) those with successful repair of their intraoperative leak (n = 452); and (3) those with failed repair (n = 112). Compared with successful repair, failed repair was associated with an increased risk of intracranial infection (odds ratio [OR], 5.6; 95% confidence interval [CI], 5.3-13.15), pneumocephalus (OR, 16; 95% CI, 5.8-44.4), 30-day readmission (OR, 8.4; 95% CI, 5.3-13.5), reoperation (OR, 115.4; 95% CI, 56.3-236.8), and prolonged hospital stay (14.9 vs 7.0 days, p < 0.01). Outcomes in patients who had successful repairs of intraoperative leaks were similar to those who never had leakage. Intraoperative use of pedicled nasoseptal flaps was associated with successful repair (OR, 0.60; 95% CI, 0.34-0.92)., Conclusion: Intraoperative CSF leaks are a frequent and expected occurrence during endoscopic skull base surgery. Failed CSF leak repair has a significant impact on patient outcomes, with increased rates of postoperative pneumocephalus, intracranial infections, reoperation, deep vein thrombosis, readmission, and prolonged hospital stay. Recognition and repair of intraoperative CSF leaks reduces postoperative complications. Use of pedicled nasoseptal flaps improves outcomes in reconstructing defects at higher risk for postoperative leak., (© 2016 ARS-AAOA, LLC.)
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- 2017
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14. Factors impacting cerebrospinal fluid leak rates in endoscopic sellar surgery.
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Karnezis TT, Baker AB, Soler ZM, Wise SK, Rereddy SK, Patel ZM, Oyesiku NM, DelGaudio JM, Hadjipanayis CG, Woodworth BA, Riley KO, Lee J, Cusimano MD, Govindaraj S, Psaltis A, Wormald PJ, Santoreneos S, Sindwani R, Trosman S, Stokken JK, Woodard TD, Recinos PF, Vandergrift WA 3rd, and Schlosser RJ
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- Adult, Aged, Cerebrospinal Fluid Leak, Craniopharyngioma epidemiology, Female, Humans, Male, Middle Aged, Odds Ratio, Pituitary Neoplasms epidemiology, Retrospective Studies, Craniopharyngioma surgery, Endoscopy adverse effects, Intraoperative Complications, Pituitary Neoplasms surgery, Postoperative Complications
- Abstract
Background: In patients undergoing transnasal endoscopic sellar surgery, an analysis of risk factors and predictors of intraoperative and postoperative cerebrospinal fluid leak (CSF) would provide important prognostic information., Methods: A retrospective review of patients undergoing endoscopic sellar surgery for pituitary adenomas or craniopharyngiomas between 2002 and 2014 at 7 international centers was performed. Demographic, comorbidity, and tumor characteristics were evaluated to determine the associations between intraoperative and postoperative CSF leaks. Correlations between reconstructive and CSF diversion techniques were associated with postoperative CSF leak rates. Odds ratios (OR) were identified using a multivariate logistic regression model., Results: Data were collected on 1108 pituitary adenomas and 53 craniopharyngiomas. Overall, 30.1% of patients had an intraoperative leak and 5.9% had a postoperative leak. Preoperative factors associated with increased intraoperative leaks were mild liver disease, craniopharyngioma, and extension into the anterior cranial fossa. In patients with intraoperative CSF leaks, postoperative leaks occurred in 10.3%, with a higher postoperative leak rate in craniopharyngiomas (20.8% vs 5.1% in pituitary adenomas). Once an intraoperative leak occurred, craniopharyngioma (OR = 4.255, p = 0.010) and higher body mass index (BMI) predicted postoperative leak (OR = 1.055, p = 0.010). In patients with an intraoperative leak, the use of septal flaps reduced the occurrence of postoperative leak (OR = 0.431, p = 0.027). Rigid reconstruction and CSF diversion techniques did not impact postoperative leak rates., Conclusion: Intraoperative CSF leaks can occur during endoscopic sellar surgery, especially in larger tumors or craniopharyngiomas. Once an intraoperative leak occurs, risk factors for postoperative leaks include craniopharyngiomas and higher BMI. Use of septal flaps decreases this risk., (© 2016 ARS-AAOA, LLC.)
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- 2016
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15. Olfaction following endoscopic skull base surgery.
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Patel ZM and DelGaudio JM
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- Humans, Quality of Life, Risk Factors, Endoscopy methods, Olfaction Disorders etiology, Paranasal Sinus Diseases surgery, Postoperative Complications etiology, Skull Base surgery
- Abstract
Purpose of Review: As endoscopic skull base surgery advances and becomes more common, recognizing and understanding all possible risks and complications of these procedures is a significant responsibility of the operating surgeon. Olfaction is a deficit often ignored or trivialized by the treating physician, in spite of its loss causing major impacts on our patients' quality of life., Recent Findings: Olfactory dysfunction after endoscopic skull base surgery is still being debated in the literature, with evidence supporting both sides. With some studies denying any loss, others suggesting temporary deficits, and still others showing long-term damage, standardization of testing and high levels of awareness of this possible complication should be the prevailing practice., Summary: Future goals of any endoscopic skull base surgeon should be to use objective olfactory testing before and after surgery, collect information on rates of dysfunction in their patients, and offer treatment options as necessary while tracking the efficacy of those options in this patient population.
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- 2016
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16. The nasal floor pedicled flap: a novel technique for use in skull base reconstruction.
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Daraei P, Oyesiku NM, and Patel ZM
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- Adult, Aged, Female, Humans, Male, Middle Aged, Nasal Surgical Procedures methods, Retrospective Studies, Cerebrospinal Fluid Leak surgery, Endoscopy methods, Head and Neck Neoplasms surgery, Nasal Septum transplantation, Skull Base surgery, Surgical Flaps
- Abstract
Background: Skull base reconstruction can be accomplished using various donor sites. Vascularized tissue, commonly the nasoseptal flap, is the most effective option for large defects or high flow leaks. In cases where the septum cannot be used, a mucoperiosteal flap from the nasal floor, pedicled from the sphenopalatine artery, is a viable option without reported outcomes. The aim of this work was to describe this flap and to report successful outcomes in a cohort of patients., Methods: Retrospective chart review of patients seen by the senior author from 2011 to 2013 requiring skull base reconstruction for defects with cerebrospinal fluid leak., Results: A total of 108 patients underwent endoscopic skull base reconstruction. Ten patients had reconstruction with use of a pedicled nasal floor flap. Mean age was 53.3 years. Defects involved the ethmoid roof in 5 patients, sellar floor in 2, clivus in 2, and planum sphenoidale in 1. Reasons why the septal flap could not be used were intentional sacrifice due to disease involvement, sacrifice for proper exposure, or previous septal perforation. Mean length of follow-up was 10.2 (range, 4 to 25) months. No patient developed cerebrospinal fluid leaks postoperatively., Conclusion: Nasal floor pedicled flaps are an effective alternative to nasoseptal flaps for reconstruction of the skull base, and have not been previously described in the literature. Outcomes are promising in our small cohort of patients. If the septum must be sacrificed, attention should be paid to the nasal floor, which provides a large mucoperiosteal flap that can be consistently exposed and elevated by the experienced surgeon., (© 2014 ARS-AAOA, LLC.)
- Published
- 2014
- Full Text
- View/download PDF
17. Comparing use of the Sonopet(®) ultrasonic bone aspirator to traditional instrumentation during the endoscopic transsphenoidal approach in pituitary tumor resection.
- Author
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Baddour HM, Lupa MD, and Patel ZM
- Subjects
- Female, Humans, Male, Middle Aged, Suction instrumentation, Endoscopy methods, Pituitary Neoplasms surgery, Ultrasonic Surgical Procedures instrumentation
- Abstract
Background: The Sonopet(®) ultrasonic bone aspirator (Stryker(®) , Kalamazoo, MI) has been used within neurosurgery, otolaryngology and in other fields, but to our knowledge has not been reported in the literature for use in endoscopic transsphenoidal approaches (TSAs) to the skull base. The study objective was to compare use of the ultrasonic bone aspirator (UBA) vs traditional cold steel instrumentation during TSA in terms of operative time and blood loss., Methods: The study design was a prospective, randomized, single-blinded controlled clinical trial. The population included patients who presented to a tertiary care skull base center with pituitary tumors amenable to endoscopic resection. Participants were randomized to either an endoscopic approach using the ultrasonic bone aspirator (n = 66) or traditional steel instrumentation (n = 64). Outcomes measured were operative time and blood loss for the approach and exposure portion of the procedure., Results: The use of the UBA resulted in a significant reduction in both operative time (31.92 ± 3.04 minutes vs 41.32 ± 2.75 minutes, p < 0.0001) and blood loss (16.5 ± 5.37 milliliters vs 22.57 ± 3.09 milliliters, p < 0.0001) compared to traditional steel instrumentation., Conclusion: This study is, to our knowledge, the first prospective, randomized, controlled clinical trial comparatively demonstrating the speed, safety and efficacy of the ultrasonic bone aspirator for endoscopic TSA to the skull base. Although the UBA offers surgical benefits, the cost of disposables may limit its usefulness to use in tertiary care institutions where operative cost can be shared across departments and with the hospital., (© 2013 ARS-AAOA, LLC.)
- Published
- 2013
- Full Text
- View/download PDF
18. Concurrent functional endoscopic sinus surgery and septorhinoplasty: using evidence to make clinical decisions.
- Author
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Patel ZM, Setzen M, Sclafani AP, and Del Gaudio JM
- Subjects
- Decision Making, Humans, Rhinoplasty methods, Risk Assessment, Treatment Outcome, Endoscopy methods, Evidence-Based Medicine, Nasal Septum surgery, Nasal Surgical Procedures methods, Paranasal Sinuses surgery
- Abstract
Background: Concurrent septorhinoplasty (SRP) and functional endoscopic sinus surgery (FESS) has been a controversial topic in the literature over the last decade. Warnings and admonitions about the risks of performing these procedures together in a single surgery are both published and voiced at national meetings. Although pros and cons have been discussed in the literature, there have been no guidelines published based solely on a review of the level of evidence., Methods: A systematic review of the literature was performed and the Clinical Practice Guideline Manual, Conference on Guideline Standardization (COGS), and the Appraisal of Guidelines and Research Evaluation (AGREE) instrument recommendations were followed. Study inclusion criteria were an adult population >18 years old, description or implication of study design available, concurrent FESS and SRP performed without additional procedures, and report of complications included in the study., Results: We identified and evaluated the literature meeting those criteria: 11 retrospective studies. The literature was reviewed for both quality of research design as well as benefit and harm of the proposed interventions., Conclusion: If a patient is in need of FESS and SRP, either for functional or cosmetic reasons, and is found on the risk matrix to either have low or moderate risk, that patient is a good candidate for a concurrent procedure. If the patient is found to have higher risk, it is not an absolute contraindication, but the surgeon must use best clinical judgment when deciding to move forward and must counsel the patient preoperatively about possible increased risks., (© 2013 ARS-AAOA, LLC.)
- Published
- 2013
- Full Text
- View/download PDF
19. The prevention and management of complications in ethmoid sinus surgery.
- Author
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Patel ZM and Govindaraj S
- Subjects
- Debridement, Ethmoid Sinus anatomy & histology, Ethmoid Sinus diagnostic imaging, Humans, Intraoperative Complications prevention & control, Otorhinolaryngologic Surgical Procedures adverse effects, Postoperative Care, Postoperative Complications prevention & control, Skull Base anatomy & histology, Tomography, X-Ray Computed, Endoscopy adverse effects, Ethmoid Sinus surgery
- Abstract
Prevention of complications during ethmoid sinus surgery begins with sound knowledge of the relevant anatomy, preoperative planning with use of radiologic imaging, and careful, thoughtful dissection intraoperatively. Despite these measures, however, complications may occur. This article highlights potential complications and treatment techniques to salvage good outcomes following endoscopic ethmoidectomy.
- Published
- 2010
- Full Text
- View/download PDF
20. Transnasal approaches to the sellar and parasellar region: Open and endoscopic.
- Author
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Nduom, Edjah K., Barrow, Emily M., Patel, Zara M., and Oyesiku, Nelson M.
- Abstract
Since the 19th century, many different approaches to sellar and parasellar pathology have been advocated and mastered by neurosurgeons and otolaryngologists. Today, with significant advances in operative technology, both open and endoscopic approaches to the sella have gained wide acceptance. Here, we discuss our open and endoscopic approaches to sellar and parasellar lesions. [Copyright &y& Elsevier]
- Published
- 2013
- Full Text
- View/download PDF
21. Rates of symptomatology are lower in recurrent sinonasal malignancy than in other recurrent cancers of the head and neck: a multi‐institutional study.
- Author
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Workman, Alan D., Velasquez, Nathalia, Khan, Nayel I., Borchard, Nicole A., Kuan, Edward C., Palmer, James N., Wang, Eric W., Patel, Zara M., and Adappa, Nithin D.
- Subjects
- *
HEAD & neck cancer , *SYMPTOMS , *CANCER relapse , *THERAPEUTICS , *SKULL base - Abstract
Background: Sinonasal malignancies are a rare subset of head and neck tumors, and surveillance strategies after definitive tumor treatment are often generalized from those for overall head and neck cancer outcomes data. However, recent literature suggests that the posttreatment period in sinonasal cancer is fundamentally different and a more tailored surveillance approach may be beneficial. Although rates of symptomatology are high in head and neck cancer recurrence and patient‐driven follow‐up is common, rates of symptomatology are unknown in sinonasal cancer specifically. Methods: Patients with recurrence of sinonasal malignancy were identified at 3 academic rhinology and skull base surgery centers. Demographic, tumor, and treatment data were collected. Rates of symptomatology at presentation were tabulated and examined in the context of several other variables. Results: Fifty‐five patients had recurrence of sinonasal malignancy after definitive treatment. Fifty‐one percent of patients had no suspicious symptoms at the time of tumor recurrence, with an average time to recurrence of 33 months. Male patients and patients with stage IVA or lower disease were significantly more likely to be asymptomatic at the time of recurrence (p < 0.05). Conclusion: Patients with sinonasal malignancy have a much lower rate of symptomatology during tumor recurrence than that observed in head and neck cancer overall. Furthermore, time to recurrence is substantially longer, as a majority of head and neck cancer recurrences occur in the first 12 months after treatment. These differences highlight the need for more tailored surveillance paradigms in asymptomatic patients with a history of a definitively treated sinonasal neoplasm. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF
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