1. Therapeutic Potential of Extracellular Vesicles in Hypertension-Associated Kidney Disease.
- Author
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Martinez-Arroyo O, Ortega A, Redon J, and Cortes R
- Subjects
- Biomarkers, Drug Delivery Systems, Exosomes, Humans, Hypertension, Renal etiology, Mesenchymal Stem Cells ultrastructure, MicroRNAs physiology, Nephritis etiology, Extracellular Vesicles physiology, Hypertension, Renal therapy, Nephritis therapy
- Abstract
Hypertension-mediated organ damage frequently includes renal function decline in which several mechanisms are involved. The present review outlines the state of the art on extracellular vesicles in hypertension and hypertension-related renal damage. Emerging evidence indicates that extracellular vesicles, small vesicles secreted by most cell types and body fluids, are involved in cell-to-cell communication and are key players mediating biological processes such as inflammation, endothelial dysfunction or fibrosis, mechanisms present the onset and progression of hypertension-associated kidney disease. We address the potential use of extracellular vesicles as markers of hypertension-mediated kidney damage severity and their application as therapeutic agents in hypertension-associated renal damage. The capacity of exosomes to deliver a wide variety of cargos to the target cell efficiently makes them a potential drug delivery system for treatment of renal diseases.
- Published
- 2021
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