Trifa, Adrian P., Bănescu, Claudia, Dima, Delia, Bojan, Anca S., Tevet, Mihaela, Moldovan, Valeriu G., Vesa, Ștefan C., Murat, Meilin, Pop, Ioan V., Skrypnyk, Cristina, and Popp, Radu A.
Objectives: To analyze the relationship between six polymorphisms in genes related to oxidative stress, namelyCAT-262 C>T,MnSODAla16Val,GPX1Pro198Leu,GSTM1andGSTT1null genotypes, andGSTP1Ile105Val, and the occurrence ofBCR-ABLnegative myeloproliferative neoplasms (polycythemia vera, essential thrombocythemia, and primary myelofibrosis). Methods: We genotyped for these polymorphisms 328 patients with a known mutation status forJAK2V617F,MPLandCALR, and 363 controls, using molecular genetics assays. Results: TheCAT-262 C>T andGPX1Pro198Leu polymorphisms were seen significantly less frequently, while theGSTP1IleVal105 polymorphism was seen significantly more frequently in patients withBCR-ABLnegative myeloproliferative neoplasms, regardless of the molecular sub-type (e.g.JAK2V617F orCALRmutated). Discussion and conclusion: Our study provides evidence that variation in genes related to oxidative stress might modulate the risk of developingBCR-ABLnegative myeloproliferative neoplasms. [ABSTRACT FROM AUTHOR]