1. The human herpesvirus 6 U21-U24 gene cluster is dispensable for virus growth.
- Author
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Jasirwan, Chyntia, Tang, Huamin, Kawabata, Akiko, and Mori, Yasuko
- Subjects
HERPESVIRUSES ,BACTERIAL artificial chromosomes ,VIRAL genes ,VIRAL genomes ,DNA analysis - Abstract
ABSTRACT Human herpesvirus 6 (HHV-6) is a T-lymphotrophic virus belongs to the genus Roseolovirus within the beta herpesvirus subfamily. The U20-U24 gene cluster is unique to Roseoloviruses; however, both their function and whether they are essential for virus growth is unknown. Recently, bacterial artificial chromosome (BAC) techniques have been used to investigate HHV-6A. This study describes generation of a virus genome lacking U21-U24 (HHV-6ABACΔU21-24) and shows that infectious virus particles can be reconstituted from this BAC DNA. Our data indicate that the HHV-6 U21-U24 gene cluster is dispensable for virus propagation. [ABSTRACT FROM AUTHOR]
- Published
- 2015
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