1. The polymorphisms in cGAS-STING pathway are associated with mitochondrial DNA copy number in coke oven workers.
- Author
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Liu, Xiaohua, Li, Xinling, Wei, Wan, Fan, Yahui, Guo, Zhifeng, Duan, Xiaoran, Zhou, Xiaoshan, Yang, Yongli, and Wang, Wei
- Subjects
POLYCYCLIC aromatic hydrocarbons ,MITOCHONDRIAL DNA ,GENETIC polymorphisms ,CELLULAR signal transduction ,RESEARCH funding ,MASS spectrometry ,POLYMERASE chain reaction - Abstract
To evaluate the interaction effects of Polycyclic aromatic hydrocarbons (PAHs) exposure and variants in cGAS-STING genes on mitochondrial DNA copy number (mtDNAcn) in workers. The mtDNAcn was determined by real-time quantitative polymerase-chain reaction in 544 PAHs-exposed workers and 238 office workers. The polymorphisms were detected by flight mass spectrometry. The mtDNAcn in PAHs exposure group was significantly lower than non-occupational exposure population (P < 0.00). The cGAS rs610913 CA+AA had significant interaction effects with STING rs11554776 GG+GA (P = 0.035), rs7380824 CC+CT (P = 0.026), and rs78233829 GC+CC (P = 0.034) on mtDNAcn. The generalized linear model results showed that the influencing factors of mtDNAcn include PAHs exposure (P < 0.001) and the interaction of PAHs exposure and cGAS rs 311678 AA+AG (P = 0.047). The influencing factors of mtDNAcn include PAHs exposure and the interaction of PAHs exposure and cGAS rs 311678 AA+AG. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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