1. Syndecan-1 and stromal heparan sulfate proteoglycans: key moderators of plasma cell biology and myeloma pathogenesis.
- Author
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Ren Z, Spaargaren M, and Pals ST
- Subjects
- Animals, Bone Marrow metabolism, Bone Marrow pathology, Humans, Multiple Myeloma metabolism, Plasma Cells metabolism, Tumor Microenvironment, Heparitin Sulfate metabolism, Multiple Myeloma pathology, Plasma Cells pathology, Proteoglycans metabolism, Syndecan-1 metabolism
- Abstract
Plasma cells no longer express a B-cell antigen receptor and are hence deprived of signals crucial for survival throughout B-cell development. Instead, normal plasma cells, as well as their malignant myeloma counterparts, heavily rely on communication with the bone marrow (BM) microenvironment for survival. The plasma cell heparan sulfate proteoglycan (HSPG) syndecan-1 (CD138) and HSPGs in the BM microenvironment act as master regulators of this communication by co-opting specific growth and survival factors from the BM niche. This designates syndecan-1/HSPGs and their synthesis machinery as potential treatment targets in multiple myeloma., (© 2021 by The American Society of Hematology.)
- Published
- 2021
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