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Dojran Lake is the smallest natural lake in Macedonia, but is very important water resource for population in the region. Main economy in the region is tourism and fishery. Dojran Lake with its hydrological basin is a closed hydrological system with natural inflow of water to the lake, but no natural outflow. Recharge of the lake is from direct surface and underground inflow. In the period 1988-2000, the water level in the lake continuously was declining. Water level declination caused ecological catastrophe for the flora and fauna in the lake and lake's basin. In 2002, the Republic of Macedonia finished a project to build a system for bringing water from Gjavato wells near Vardar River with capacity of 1 m /s. The water level in the lake has recently increased. The reasons for changing the water level in the lake are not clearly identified, and they are located in hydrological conditions or uncontrolled usage the water from the lake. In order to define the causes of changes in the lake requires detailed hydrological and meteorological analysis. This paper will present the results of mathematical-statistical analysis on the basis of historical data of measured water level, precipitation, and air temperature from hydro-meteorological stationNew Dojran for the period 1961-2008. [ABSTRACT FROM AUTHOR]