1. Prognostic significance of preoperative serum triglycerides and high-density lipoproteins cholesterol in patients with non-small cell lung cancer: a retrospective study
- Author
-
Cong Ma, Jingjing Guo, Ping Liu, and Xiaoyan Wang
- Subjects
Male ,medicine.medical_specialty ,RC620-627 ,Endocrinology, Diabetes and Metabolism ,Clinical Biochemistry ,Blood lipids ,Clinical nutrition ,Gastroenterology ,Endocrinology ,Non-small cell lung cancer ,High-density lipoprotein cholesterol ,Carcinoma, Non-Small-Cell Lung ,Internal medicine ,medicine ,Humans ,Lung cancer ,Nutritional diseases. Deficiency diseases ,Survival analysis ,Triglycerides ,Aged ,Proportional Hazards Models ,Retrospective Studies ,Proportional hazards model ,business.industry ,Research ,Cholesterol, HDL ,Biochemistry (medical) ,Cancer ,Retrospective cohort study ,Middle Aged ,medicine.disease ,Prognosis ,Survival Analysis ,ROC Curve ,Female ,lipids (amino acids, peptides, and proteins) ,business ,Lipidology - Abstract
Background Abnormalities in serum lipids and lipoproteins have been documented to link to the risk of cancers in recent years, but its prognostic value for cancer is not known. This study retrospectively evaluated the significance of preoperative serum lipids and lipoproteins for NSCLC’s prognosis. Methods A retrospective review was implemented of 551 patients succumbed to NSCLC. A ROC curve was utilized to determine the best cut-off value and area under the ROC curve. Kaplan-Meier and a Cox proportional hazards model were utilized to perform survival analysis. Results With a median follow-up of 42 months, the NSCLC patients in the high TG (> 1.21 mmol/L) and low HDL-C (≤ 1.26 mmol/L) two groups exhibited shorter OS and DFS. In multivariable analysis, preoperative HDL-C and TG can work as independent prognosis factors for OS (PP Conclusion Abnormalities of serum lipids and lipoproteins metabolism linked to the survival outcomes of NSCLC. Preoperative serum HDL-C and TG may be promising biomarkers to predict the NSCLC patients’ prognosis.
- Published
- 2021