1. Effectiveness of Algan Hemostatic Agent in Bleeding Control: An Experimental Kidney Incision Model.
- Author
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Midi, Ahmet, Kumandaş, Ali, Ekici, Hüsamettin, Kılıç, Yusuf, and Özgöçmen, Ruchan
- Subjects
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ANIMAL experimentation , *BIOLOGICAL models , *BLOOD platelet activation , *COMPARATIVE studies , *DRUG efficacy , *HEMORRHAGE , *HEMOSTASIS , *SURGICAL hemostasis , *HEMOSTATICS , *HEPARIN , *MEDICINAL plants , *RATS , *STATISTICAL sampling , *PLANT extracts , *DESCRIPTIVE statistics , *PHARMACODYNAMICS - Abstract
Aim: The purpose of this study is to evaluate the hemostatic efficacy of a novel plant originated blood stopper which is called Algan Hemostatic Agent (AHA) in uncontrolled kidney incision bleeding model. Methods: The study was conducted with thirty-two rats 5-7 weeks old. The rats were randomly divided into 4 groups, each consisting of eight rats (Group 1: heparinized saline, 2: heparinized AHA, 3: non-heparinized saline, 4: non-heparinized AHA). Experimental kidney incision was made, and saline soaked sponge was applied to the control group and AHA to the study group. Results: The duration of bleeding was significantly shorter in the AHA group compared to the control group. The AHA has controlled the bleeding in the heparinized and non-heparinized groups 5±1.19 and 3±0.91 seconds respectively (p<0.001). In the control group, hemorrhage was controlled in the heparinized and non-heparinized group 180.6±25.4 and 125.4±21 seconds respectively. Conclusion: This study demonstrated that the AHA is useful in controlling bleeding in the Rat kidney incision model. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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