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The microorganism resistance to antibiotics has become one of the most worrying issues for science due to the difficulties related to clinical treatment and the rapid spread of diseases. Efflux pumps are classified into six groups of carrier proteins that are part of the different types of mechanisms that contribute to resistance in microorganisms, allowing their survival. The present study aimed to carry out a bibliographic review on the superfamilies of carriers in order to understand their compositions, expressions, substrates, and role in intrinsic resistance. At first, a search for manuscripts was carried out in the databases Medline, Pubmed, ScienceDirect, and Scielo, using as descriptors: efflux pump, expression, pump inhibitors and efflux superfamily. For article selection, two criteria were taken into account: for inclusion, those published between 2000 and 2020, including textbooks, and for exclusion, duplicates and academic collections. In this research, 139,615 published articles were obtained, with 312 selected articles and 7 book chapters that best met the aim. From the comprehensive analysis, it was possible to consider that the chromosomes and genetic elements can contain genes encoding efflux pumps and are responsible for multidrug resistance. Even though this is a well-explored topic in the scientific community, understanding the behavior of antibiotics as substrates that increase the expression of pump-encoding genes has challenged medicine. This review study succinctly summarizes the most relevant features of these systems, as well as their contribution to multidrug resistance.

Tetranychus evansi Baker & Pritchard and Tetranychus urticae Koch (Acari: Tetranychiade) are important mites for the economy of many countries. Populations from these species have presented resistance to acaricides of different chemical groups, thus demanding new products with an acaricidal effect. Essential oils have been investigated. The chemical composition and acaricidal effect of the Eugenia uniflora L. (Myrtaceae) essential oil were investigated. The essential oil was extracted by hydro-distillation and the chemical composition was identified by Gas Chromatography coupled to Mass Spectrometry (GC/MS). Repellence, fumigation and residual effect tests were performed. The essential oil presented the sesquiterpenes selin-1,3,7(11)-trien-8-one and selin-1,3,7(11)-trien-8-one epoxide. Repellence occurred against T. urticae and T. evansi . Oil vapors provoked 100% T. evansi mortality at all concentrations and time intervals tested with significant mortalities being observed against T. urticae after 48 h. Tetranychus evansi mortalities greater than 80% due to a residual effect were recorded after 24 h, whereas no significant mortality was observed for T. urticae .