1. Tin(IV) Complexes With 2‐Formylpyridine Thiosemicarbazones: Structural and Cytotoxic Activity Studies on Bacterial, Fungal, and Cancer Cells.
- Author
-
Ibrahim, Ahmed B. M., Cordes, David B., Slawin, Alexandra M. Z., and Abbas, S. M.
- Subjects
- *
ESCHERICHIA coli , *LIGANDS (Biochemistry) , *SPACE groups , *FUNGAL cultures , *THIOSEMICARBAZONES - Abstract
ABSTRACT Tin complexes,
Sn(IV)‐TSC 1·MeOH andSn(IV)‐TSC 2 , with thiosemicarbazones possessing an N2S ligation system [TSC 1 = 4‐(4‐nitrophenyl)‐1‐((pyridin‐2‐yl)methylene)thiosemicarbazide andTSC 2 = 4‐(2‐methoxyphenyl)‐1‐((pyridin‐2‐yl)methylene)thiosemicarbazide] were prepared and structurally characterized. These complexes are found in the space groupsP 1¯$$ \overline{1} $$ andP 21/n , respectively, with their tin atoms in octahedral environments established by three chlorine atoms and an anionic thiosemicarbazone ligand. All compounds (20 mg/mL in DMSO) were tested for their antibacterial [against Bacillus subtilis, Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa] and antifungal [againstAspergillus flavus and Candida albicans] properties. The ligandTSC 2 displayed inhibitions in the S. aureus and E. coli cultures (with zones of 11 and 10 mm, respectively), whereasSn(IV)‐TSC 1·MeOH andSn(IV)‐TSC 2 inhibited all bacteria with 11–15 and 14–16 mm, respectively. In the fungal cultures, onlySn(IV)‐TSC 1·MeOH (10 mm) showed an inhibition zone against A. flavus. The ligands' antiproliferative activities were determined against human cancer cells of the lung, breast, liver, and colon, and both ligands afforded the highest activity against the breast MCF‐7 cells. The complexation enhanced the ligands' activities asTSC 1 ,TSC 2 ,Sn(IV)‐TSC 1·MeOH , andSn(IV)‐TSC 2 afforded respective IC50 values of 52.4, 153.7, 18.3, and 63.9 μM. However, against normal baby hamster kidney (BHK) cells, these compounds showed IC50 data of 54.8, 82.7, 16.1, and 15.3 μM, respectively. [ABSTRACT FROM AUTHOR]- Published
- 2024
- Full Text
- View/download PDF