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2. 2023 ESH Guidelines for the management of arterial hypertension The Task Force for the management of arterial hypertension of the European Society of Hypertension: Endorsed by the International Society of Hypertension (ISH) and the European Renal Association (ERA)

Author

Mancia, G, Kreutz, R, Brunström, M, Burnier, M, Grassi, G, Januszewicz, A, Muiesan, M, Tsioufis, K, Agabiti-Rosei, E, Algharably, E, Azizi, M, Benetos, A, Borghi, C, Hitij, J, Cifkova, R, Coca, A, Cornelissen, V, Cruickshank, J, Cunha, P, Danser, A, Pinho, R, Delles, C, Dominiczak, A, Dorobantu, M, Doumas, M, Fernández-Alfonso, M, Halimi, J, Járai, Z, Jelaković, B, Jordan, J, Kuznetsova, T, Laurent, S, Lovic, D, Lurbe, E, Mahfoud, F, Manolis, A, Miglinas, M, Narkiewicz, K, Niiranen, T, Palatini, P, Parati, G, Pathak, A, Persu, A, Polonia, J, Redon, J, Sarafidis, P, Schmieder, R, Spronck, B, Stabouli, S, Stergiou, G, Taddei, S, Thomopoulos, C, Tomaszewski, M, Van de Borne, P, Wanner, C, Weber, T, Williams, B, Zhang, Z, Kjeldsen, S, Mancia, Giuseppe, Kreutz, Reinhold, Brunström, Mattias, Burnier, Michel, Grassi, Guido, Januszewicz, Andrzej, Muiesan, Maria Lorenza, Tsioufis, Konstantinos, Agabiti-Rosei, Enrico, Algharably, Engi Abd Elhady, Azizi, Michel, Benetos, Athanase, Borghi, Claudio, Hitij, Jana Brguljan, Cifkova, Renata, Coca, Antonio, Cornelissen, Veronique, Cruickshank, J Kennedy, Cunha, Pedro G, Danser, A H Jan, Pinho, Rosa Maria de, Delles, Christian, Dominiczak, Anna F, Dorobantu, Maria, Doumas, Michalis, Fernández-Alfonso, María S, Halimi, Jean-Michel, Járai, Zoltán, Jelaković, Bojan, Jordan, Jens, Kuznetsova, Tatiana, Laurent, Stephane, Lovic, Dragan, Lurbe, Empar, Mahfoud, Felix, Manolis, Athanasios, Miglinas, Marius, Narkiewicz, Krzystof, Niiranen, Teemu, Palatini, Paolo, Parati, Gianfranco, Pathak, Atul, Persu, Alexandre, Polonia, Jorge, Redon, Josep, Sarafidis, Pantelis, Schmieder, Roland, Spronck, Bart, Stabouli, Stella, Stergiou, George, Taddei, Stefano, Thomopoulos, Costas, Tomaszewski, Maciej, Van de Borne, Philippe, Wanner, Christoph, Weber, Thomas, Williams, Bryan, Zhang, Zhen-Yu, Kjeldsen, Sverre E, Mancia, G, Kreutz, R, Brunström, M, Burnier, M, Grassi, G, Januszewicz, A, Muiesan, M, Tsioufis, K, Agabiti-Rosei, E, Algharably, E, Azizi, M, Benetos, A, Borghi, C, Hitij, J, Cifkova, R, Coca, A, Cornelissen, V, Cruickshank, J, Cunha, P, Danser, A, Pinho, R, Delles, C, Dominiczak, A, Dorobantu, M, Doumas, M, Fernández-Alfonso, M, Halimi, J, Járai, Z, Jelaković, B, Jordan, J, Kuznetsova, T, Laurent, S, Lovic, D, Lurbe, E, Mahfoud, F, Manolis, A, Miglinas, M, Narkiewicz, K, Niiranen, T, Palatini, P, Parati, G, Pathak, A, Persu, A, Polonia, J, Redon, J, Sarafidis, P, Schmieder, R, Spronck, B, Stabouli, S, Stergiou, G, Taddei, S, Thomopoulos, C, Tomaszewski, M, Van de Borne, P, Wanner, C, Weber, T, Williams, B, Zhang, Z, Kjeldsen, S, Mancia, Giuseppe, Kreutz, Reinhold, Brunström, Mattias, Burnier, Michel, Grassi, Guido, Januszewicz, Andrzej, Muiesan, Maria Lorenza, Tsioufis, Konstantinos, Agabiti-Rosei, Enrico, Algharably, Engi Abd Elhady, Azizi, Michel, Benetos, Athanase, Borghi, Claudio, Hitij, Jana Brguljan, Cifkova, Renata, Coca, Antonio, Cornelissen, Veronique, Cruickshank, J Kennedy, Cunha, Pedro G, Danser, A H Jan, Pinho, Rosa Maria de, Delles, Christian, Dominiczak, Anna F, Dorobantu, Maria, Doumas, Michalis, Fernández-Alfonso, María S, Halimi, Jean-Michel, Járai, Zoltán, Jelaković, Bojan, Jordan, Jens, Kuznetsova, Tatiana, Laurent, Stephane, Lovic, Dragan, Lurbe, Empar, Mahfoud, Felix, Manolis, Athanasios, Miglinas, Marius, Narkiewicz, Krzystof, Niiranen, Teemu, Palatini, Paolo, Parati, Gianfranco, Pathak, Atul, Persu, Alexandre, Polonia, Jorge, Redon, Josep, Sarafidis, Pantelis, Schmieder, Roland, Spronck, Bart, Stabouli, Stella, Stergiou, George, Taddei, Stefano, Thomopoulos, Costas, Tomaszewski, Maciej, Van de Borne, Philippe, Wanner, Christoph, Weber, Thomas, Williams, Bryan, Zhang, Zhen-Yu, and Kjeldsen, Sverre E

Abstract

Luis Alcocer (Mexico), Christina Antza (Greece), Mustafa Arici (Turkey), Eduardo Barbosa (Brazil), Adel Berbari (Lebanon), Luís Bronze (Portugal), John Chalmers (Australia), Tine De Backer (Belgium), Alejandro de la Sierra (Spain), Kyriakos Dimitriadis (Greece), Dorota Drozdz (Poland), Béatrice Duly-Bouhanick (France), Brent M. Egan (USA), Serap Erdine (Turkey), Claudio Ferri (Italy), Slavomira Filipova (Slovak Republic), Anthony Heagerty (UK), Michael Hecht Olsen (Denmark), Dagmara Hering (Poland), Sang Hyun Ihm (South Korea), Uday Jadhav (India), Manolis Kallistratos (Greece), Kazuomi Kario (Japan), Vasilios Kotsis (Greece), Adi Leiba (Israel), Patricio López-Jaramillo (Colombia), Hans-Peter Marti (Norway), Terry McCormack (UK), Paolo Mulatero (Italy), Dike B. Ojji (Nigeria), Sungha Park (South Korea), Priit Pauklin (Estonia), Sabine Perl (Austria), Arman Postadzhian (Bulgaria), Aleksander Prejbisz (Poland), Venkata Ram (India), Ramiro Sanchez (Argentina), Markus Schlaich (Australia), Alta Schutte (Australia), Cristina Sierra (Spain), Sekib Sokolovic (Bosnia and Herzegovina), Jonas Spaak (Sweden), Dimitrios Terentes-Printzios (Greece), Bruno Trimarco (Italy), Thomas Unger (The Netherlands), Bert-Jan van den Born (The Netherlands), Anna Vachulova (Slovak Republic), Agostino Virdis (Italy), Jiguang Wang (China), Ulrich Wenzel (Germany), Paul Whelton (USA), Jiri Widimsky (Czech Republic), Jacek Wolf (Poland), Grégoire Wuerzner (Switzerland), Eugene Yang (USA), Yuqing Zhang (China).

Published
2023

3. The Results of the URRAH (Uric Acid Right for Heart Health) Project: A Focus on Hyperuricemia in Relation to Cardiovascular and Kidney Disease and its Role in Metabolic Dysregulation

Author

Maloberti, A, Mengozzi, A, Russo, E, Cicero, A, Angeli, F, Agabiti Rosei, E, Barbagallo, C, Bernardino, B, Bombelli, M, Cappelli, F, Casiglia, E, Cianci, R, Ciccarelli, M, Cirillo, M, Cirillo, P, Desideri, G, D'Elia, L, Dell'Oro, R, Facchetti, R, Ferri, C, Galletti, F, Giannattasio, C, Gesualdo, L, Iaccarino, G, Lippa, L, Mallamaci, F, Masi, S, Masulli, M, Mazza, A, Muiesan, M, Nazzaro, P, Parati, G, Palatini, P, Pauletto, P, Pontremoli, R, Pugliese, N, Quarti-Trevano, F, Rattazzi, M, Reboldi, G, Rivasi, G, Salvetti, M, Tikhonoff, V, Tocci, G, Ungar, A, Verdecchia, P, Viazzi, F, Volpe, M, Virdis, A, Grassi, G, Borghi, C, Maloberti, Alessandro, Mengozzi, Alessandro, Russo, Elisa, Cicero, Arrigo Francesco Giuseppe, Angeli, Fabio, Agabiti Rosei, Enrico, Barbagallo, Carlo Maria, Bernardino, Bruno, Bombelli, Michele, Cappelli, Federica, Casiglia, Edoardo, Cianci, Rosario, Ciccarelli, Michele, Cirillo, Massimo, Cirillo, Pietro, Desideri, Giovambattista, D'Elia, Lanfranco, Dell'Oro, Raffaella, Facchetti, Rita, Ferri, Claudio, Galletti, Ferruccio, Giannattasio, Cristina, Gesualdo, Loreto, Iaccarino, Guido, Lippa, Luciano, Mallamaci, Francesca, Masi, Stefano, Masulli, Maria, Mazza, Alberto, Muiesan, Maria Lorenza, Nazzaro, Pietro, Parati, Gianfranco, Palatini, Paolo, Pauletto, Paolo, Pontremoli, Roberto, Pugliese, Nicola Riccardo, Quarti-Trevano, Fosca, Rattazzi, Marcello, Reboldi, Gianpaolo, Rivasi, Giulia, Salvetti, Massimo, Tikhonoff, Valerie, Tocci, Giuliano, Ungar, Andrea, Verdecchia, Paolo, Viazzi, Francesca, Volpe, Massimo, Virdis, Agostino, Grassi, Guido, Borghi, Claudio, Maloberti, A, Mengozzi, A, Russo, E, Cicero, A, Angeli, F, Agabiti Rosei, E, Barbagallo, C, Bernardino, B, Bombelli, M, Cappelli, F, Casiglia, E, Cianci, R, Ciccarelli, M, Cirillo, M, Cirillo, P, Desideri, G, D'Elia, L, Dell'Oro, R, Facchetti, R, Ferri, C, Galletti, F, Giannattasio, C, Gesualdo, L, Iaccarino, G, Lippa, L, Mallamaci, F, Masi, S, Masulli, M, Mazza, A, Muiesan, M, Nazzaro, P, Parati, G, Palatini, P, Pauletto, P, Pontremoli, R, Pugliese, N, Quarti-Trevano, F, Rattazzi, M, Reboldi, G, Rivasi, G, Salvetti, M, Tikhonoff, V, Tocci, G, Ungar, A, Verdecchia, P, Viazzi, F, Volpe, M, Virdis, A, Grassi, G, Borghi, C, Maloberti, Alessandro, Mengozzi, Alessandro, Russo, Elisa, Cicero, Arrigo Francesco Giuseppe, Angeli, Fabio, Agabiti Rosei, Enrico, Barbagallo, Carlo Maria, Bernardino, Bruno, Bombelli, Michele, Cappelli, Federica, Casiglia, Edoardo, Cianci, Rosario, Ciccarelli, Michele, Cirillo, Massimo, Cirillo, Pietro, Desideri, Giovambattista, D'Elia, Lanfranco, Dell'Oro, Raffaella, Facchetti, Rita, Ferri, Claudio, Galletti, Ferruccio, Giannattasio, Cristina, Gesualdo, Loreto, Iaccarino, Guido, Lippa, Luciano, Mallamaci, Francesca, Masi, Stefano, Masulli, Maria, Mazza, Alberto, Muiesan, Maria Lorenza, Nazzaro, Pietro, Parati, Gianfranco, Palatini, Paolo, Pauletto, Paolo, Pontremoli, Roberto, Pugliese, Nicola Riccardo, Quarti-Trevano, Fosca, Rattazzi, Marcello, Reboldi, Gianpaolo, Rivasi, Giulia, Salvetti, Massimo, Tikhonoff, Valerie, Tocci, Giuliano, Ungar, Andrea, Verdecchia, Paolo, Viazzi, Francesca, Volpe, Massimo, Virdis, Agostino, Grassi, Guido, and Borghi, Claudio

Abstract

The relationship between Serum Uric Acid (UA) and Cardiovascular (CV) diseases has already been extensively evaluated, and it was found to be an independent predictor of all-cause and cardiovascular mortality but also acute coronary syndrome, stroke and heart failure. Similarly, also many papers have been published on the association between UA and kidney function, while less is known on the role of UA in metabolic derangement and, particularly, in metabolic syndrome. Despite the substantial number of publications on the topic, there are still some elements of doubt: (1) the better cut-off to be used to refine CV risk (also called CV cut-off); (2) the needing for a correction of UA values for kidney function; and (3) the better definition of its role in metabolic syndrome: is UA simply a marker, a bystander or a key pathological element of metabolic dysregulation?. The Uric acid Right for heArt Health (URRAH) project was designed by the Working Group on uric acid and CV risk of the Italian Society of Hypertension to answer the first question. After the first papers that individuates specific cut-off for different CV disease, subsequent articles have been published responding to the other relevant questions. This review will summarise most of the results obtained so far from the URRAH research project.

Published
2023

7. Hyperuricaemia and gout in cardiovascular, metabolic and kidney disease

Author

Borghi, C, Agabiti-Rosei, E, Johnson, R, Kielstein, J, Lurbe, E, Mancia, G, Redon, J, Stack, A, Tsioufis, K, Borghi C., Agabiti-Rosei E., Johnson R. J., Kielstein J. T., Lurbe E., Mancia G., Redon J., Stack A. G., Tsioufis K. P., Borghi, C, Agabiti-Rosei, E, Johnson, R, Kielstein, J, Lurbe, E, Mancia, G, Redon, J, Stack, A, Tsioufis, K, Borghi C., Agabiti-Rosei E., Johnson R. J., Kielstein J. T., Lurbe E., Mancia G., Redon J., Stack A. G., and Tsioufis K. P.

Abstract

During the last century, there has been an increasing prevalence of hyperuricaemia noted in many populations. While uric acid is usually discussed in the context of gout, hyperuricaemia is also associated with hypertension, chronic kidney disease, hypertriglyceridaemia, obesity, atherosclerotic heart disease, metabolic syndrome, and type 2 diabetes. Here we review the connection between hyperuricaemia and cardiovascular, kidney and metabolic diseases. Contrary to the popular view that uric acid is an inert metabolite of purine metabolism, recent studies suggest serum uric acid may have a variety of pro-inflammatory, pro-oxidative and vasoconstrictive actions that may contribute to cardiometabolic diseases. Hyperuricaemia is a predictive factor for the development of hypertension, metabolic syndrome, type 2 diabetes, coronary artery disease, left ventricular hypertrophy, atrial fibrillation, myocardial infarction, stroke, heart failure and chronic kidney disease. Treatment with uric acid-lowering therapies has also been found to improve outcomes in patients with hypertension and kidney disease, in some but not all studies. In conclusion, uric acid is emerging as a potentially treatable risk factor for cardiometabolic diseases, and more clinical trials investigating the potential benefit of lowering serum uric acid are recommended in individuals with hyperuricaemia with and without deposition and concomitant hypertension, metabolic syndrome or chronic kidney disease.

Published
2020

8. Nutraceuticals and blood pressure control: A European Society of Hypertension position document

Author

Borghi, C, Tsioufis, K, Agabiti-Rosei, E, Burnier, M, Cicero, A, Clement, D, Coca, A, Desideri, G, Grassi, G, Lovic, D, Lurbe, E, Kahan, T, Kreutz, R, Jelakovic, B, Polonia, J, Redon, J, Van De Borne, P, Mancia, G, Borghi C., Tsioufis K., Agabiti-Rosei E., Burnier M., Cicero A. F. G., Clement D., Coca A., Desideri G., Grassi G., Lovic D., Lurbe E., Kahan T., Kreutz R., Jelakovic B., Polonia J., Redon J., Van De Borne P., Mancia G., Borghi, C, Tsioufis, K, Agabiti-Rosei, E, Burnier, M, Cicero, A, Clement, D, Coca, A, Desideri, G, Grassi, G, Lovic, D, Lurbe, E, Kahan, T, Kreutz, R, Jelakovic, B, Polonia, J, Redon, J, Van De Borne, P, Mancia, G, Borghi C., Tsioufis K., Agabiti-Rosei E., Burnier M., Cicero A. F. G., Clement D., Coca A., Desideri G., Grassi G., Lovic D., Lurbe E., Kahan T., Kreutz R., Jelakovic B., Polonia J., Redon J., Van De Borne P., and Mancia G.

Abstract

High-normal blood pressure (BP) is associated with an increased risk of cardiovascular disease, however the cost-benefit ratio of the use of antihypertensive treatment in these patients is not yet clear. Some dietary components and natural products seems to be able to significantly lower BP without significant side effects. The aim of this position document is to highlight which of these products have the most clinically significant antihypertensive action and wheter they could be suggested to patients with high-normal BP. Among foods, beetroot juice has the most covincing evidence of antihypertensive effect. Antioxidant-rich beverages (teas, coffee) could be considered. Among nutrients, magnesium, potassium and vitamin C supplements could improve BP. Among nonnutrient-nutraceuticals, soy isoflavones could be suggested in perimenopausal women, resveratrol in insulin-resistant patients, melatonin in study participants with night hypertension. In any case, the nutracutical approach has never to substitute the drug treatment, when needed.

Published
2020

9. Cardiac Phenotypes in Secondary Hypertension: JACC State-of-the-Art Review

Author

Januszewicz, A., Mulatero, P., Dobrowolski, P., Monticone, S., Niepen, P. Van der, Sarafidis, P., Reincke, M., Rexhaj, E., Eisenhofer, G., Januszewicz, M., Kasiakogias, A., Kreutz, R., Lenders, J.W.M., Muiesan, M.L., Persu, A., Agabiti-Rosei, E., Soria, R., Śpiewak, M., Prejbisz, A., Messerli, F.H., Januszewicz, A., Mulatero, P., Dobrowolski, P., Monticone, S., Niepen, P. Van der, Sarafidis, P., Reincke, M., Rexhaj, E., Eisenhofer, G., Januszewicz, M., Kasiakogias, A., Kreutz, R., Lenders, J.W.M., Muiesan, M.L., Persu, A., Agabiti-Rosei, E., Soria, R., Śpiewak, M., Prejbisz, A., and Messerli, F.H.

Abstract

Item does not contain fulltext, Several forms of secondary hypertension carry a high risk of cardiac morbidity and mortality. Evaluation of cardiac phenotypes in secondary hypertension provides a unique opportunity to study underlying hormonal and biochemical mechanisms affecting the heart. We review the characteristics of cardiac dysfunction in different forms of secondary hypertension and clarify the mechanisms behind the higher prevalence of heart damage in these patients than in those with primary hypertension. Attention to the specific clinical/biochemical phenotypes of these conditions may assist clinicians to screen for and confirm secondary forms of hypertension. Thereby, early signs of heart damage can be recognized and monitored, allowing individualized treatment to delay or prevent evolution toward more advanced disease.

Published
2022

10. Relationship between salt consumption and iodine intake in a pediatric population

Author

Iacone, R., Iaccarino Idelson, P., Campanozzi, A., Rutigliano, I., Russo, O., Formisano, P., Galeone, D., Macchia, P. E., Strazzullo, P., Agabiti-Rosei, E., Carcea, M., Donfrancesco, C., Galletti, F., Giampaoli, S., Iacoviello, L., Scalfi, L., Siani, A., De Filippo, G., Malamisura, B., Cecere, G., Micillo, M., D'Angelo, E., Maschione, R., De Marco, G., D'Angelo, G., Cosenza, C., Gualano, R., Borsetti, R., Cela, G., Francavilla, R., Tetro, A., Pensabene, L., Talarico, V., Graziano, F., Palermo, B. V. E., Lombardi, G., Illiceto, M. T., Tonelli, L., Catassi, C., Tonelli, G., Castellucci, G., Ferraro, L., Cozzali, R., Di Biase, R., Cipolli, S., Lezo, A., Santini, B., Salvatore, S., Morando, L., Paoletti, S., Gallese, A., Mazzone, T., Iacone, Roberto, IACCARINO IDELSON, Paola, Campanozzi, Angelo, Rutigliano, Irene, Russo, Ornella, Formisano, Pietro, Galeone, Daniela, Macchia, PAOLO EMIDIO, and Strazzullo, Pasquale

Subjects
Adolescent, Endocrinology, Diabetes and Metabolism, Salt (chemistry), Nutritional Status, Medicine (miscellaneous), Context (language use), Sodium Chloride, World health, Animal science, 24 h urinary excretion, Environmental health, salt, Humans, Medicine, Sodium Chloride, Dietary, Salt intake, Child, Iodine intake, chemistry.chemical_classification, Thyroid, Consumption (economics), Nutrition and Dietetics, iodine prophylaxi, business.industry, Salt reduction, Iodine deficiency disorders, Original Contribution, Iodised salt, pediatric, chemistry, Italy, iodine deficiency disorder, Salt restriction, Hypertension, Iodine prophylaxis, Cardiology and Cardiovascular Medicine, business, Pediatric age, Iodine, Pediatric population
Abstract

Purpose The World Health Organization recommends reduction of salt intake to Methods The study population was made of 1270 children and adolescents. Estimates of salt consumption and iodine intake were obtained by measuring 24 h urinary sodium and iodine excretion. Results The iodine intake increased gradually across quartiles of salt consumption independently of sex, age and body weight (p 10.2 g/day). We estimated that approximately 65–73% of the total iodine intake was derived from food and 27–35% from iodized salt and that iodized salt made actually only 20% of the total salt intake. Conclusion In this pediatric population, in face of an elevated average salt consumption, the use of iodized salt was still insufficient to ensure an adequate iodine intake, in particular among teenagers. In the perspective of a progressive reduction of total salt intake, the health institutions should continue to support iodoprophylaxis, in the context of the national strategies for salt reduction. In order for these policies to be successful, in addition to educational campaigns, it is needed that the prescriptions contained in the current legislation on iodoprophylaxis are made compelling through specific enforcement measures for all the involved stakeholders.

Published
2020

11. Cardiac Damage from Left Ventricular Hypertrophy to Heart Failure

Author

Mancia, G, Grassi, G, Tsioufis, K, Dominiczak, A, Agabiti Rosei, E, Muiesan, M, Cuspidi, C, Agabiti Rosei , E, Muiesan, ML, Mancia, G, Grassi, G, Tsioufis, K, Dominiczak, A, Agabiti Rosei, E, Muiesan, M, Cuspidi, C, Agabiti Rosei , E, and Muiesan, ML

Published
2019

12. Validation of an easy questionnaire on the assessment of salt habit: the MINISAL-SIIA Study Program

Author

D'Elia, L, Manfredi, M, Strazzullo, P, Galletti, F, Agabiti-Rosei, E, Arcangeli, E, Artom, A, Barbato, A, Barbiero, M, Belfiore, A, Bernini, G, Boero, R, Berra, E, Biggi, A, Borgheresi, P, Borghi, C, Bosio, A, Caiazza, A, Caielli, P, Calo, L, Castellano, M, Catena, C, Cerrato, F, Cilia, C, Cipollini, F, Crippa, M, Cuspidi, C, D'Avino, M, De Giorgi, G, De Luca, N, De Pergola, G, Del Giudice, A, Desideri, G, Fallo, F, Ferri, C, Galeone, D, Garavelli, G, Gaudio, G, Giacchetti, G, Gidaro, B, Giovannetti, R, Grandi, A, Guglielmi, M, Iacoviello, L, Leonardis, D, Lonati, C, Lonati, L, Malatino, L, Mallamaci, F, Maresca, A, Marzano, L, Massara, C, Merletti, L, Meschi, M, Modesti, S, Montanari, A, Morganti, A, Musiari, L, Musso, N, Nardecchia, A, Nazzaro, P, Pallisco, O, Panichi, V, Parati, G, Pascale, C, Pini, C, Pirola, I, Pucci, G, Rabbia, F, Rescaldani, M, Ronchi, E, Rossi, E, Rossi, G, Sala, C, Sarzani, R, Sechi, L, Silvestris, F, Stancanelli, B, Trimarco, B, Ungar, A, Veglio, F, Veronesi, M, Vinella, L, D'Elia L., Manfredi M., Strazzullo P., Galletti F., Agabiti-Rosei E., Arcangeli E., Artom A., Barbato A., Barbiero M., Belfiore A., Bernini G., Boero R., Berra E., Biggi A., Borgheresi P., Borghi C., Bosio A., Caiazza A., Caielli P., Calo L. A., Castellano M., Catena C., Cerrato F., Cilia C., Cipollini F., Crippa M., Cuspidi C., D'Avino M., De Giorgi G. A., De Luca N., De Pergola G., Del Giudice A., Desideri G., Fallo F., Ferri C., Galeone D., Garavelli G., Gaudio G., Giacchetti G., Gidaro B., Giovannetti R., Grandi A., Guglielmi M., Iacoviello L., Leonardis D., Lonati C., Lonati L. M., Malatino L., Mallamaci F., Maresca A. M., Marzano L., Massara C., Merletti L., Meschi M., Modesti S., Montanari A., Morganti A., Musiari L., Musso N., Nardecchia A., Nazzaro P., Pallisco O., Panichi V., Parati G., Pascale C., Pini C., Pirola I., Pucci G., Rabbia F., Rescaldani M., Ronchi E., Rossi E., Rossi G., Sala C., Sarzani R., Sechi L. A., Silvestris F., Stancanelli B., Trimarco B., Ungar A., Veglio F., Veronesi M., Vinella L., D'Elia, L, Manfredi, M, Strazzullo, P, Galletti, F, Agabiti-Rosei, E, Arcangeli, E, Artom, A, Barbato, A, Barbiero, M, Belfiore, A, Bernini, G, Boero, R, Berra, E, Biggi, A, Borgheresi, P, Borghi, C, Bosio, A, Caiazza, A, Caielli, P, Calo, L, Castellano, M, Catena, C, Cerrato, F, Cilia, C, Cipollini, F, Crippa, M, Cuspidi, C, D'Avino, M, De Giorgi, G, De Luca, N, De Pergola, G, Del Giudice, A, Desideri, G, Fallo, F, Ferri, C, Galeone, D, Garavelli, G, Gaudio, G, Giacchetti, G, Gidaro, B, Giovannetti, R, Grandi, A, Guglielmi, M, Iacoviello, L, Leonardis, D, Lonati, C, Lonati, L, Malatino, L, Mallamaci, F, Maresca, A, Marzano, L, Massara, C, Merletti, L, Meschi, M, Modesti, S, Montanari, A, Morganti, A, Musiari, L, Musso, N, Nardecchia, A, Nazzaro, P, Pallisco, O, Panichi, V, Parati, G, Pascale, C, Pini, C, Pirola, I, Pucci, G, Rabbia, F, Rescaldani, M, Ronchi, E, Rossi, E, Rossi, G, Sala, C, Sarzani, R, Sechi, L, Silvestris, F, Stancanelli, B, Trimarco, B, Ungar, A, Veglio, F, Veronesi, M, Vinella, L, D'Elia L., Manfredi M., Strazzullo P., Galletti F., Agabiti-Rosei E., Arcangeli E., Artom A., Barbato A., Barbiero M., Belfiore A., Bernini G., Boero R., Berra E., Biggi A., Borgheresi P., Borghi C., Bosio A., Caiazza A., Caielli P., Calo L. A., Castellano M., Catena C., Cerrato F., Cilia C., Cipollini F., Crippa M., Cuspidi C., D'Avino M., De Giorgi G. A., De Luca N., De Pergola G., Del Giudice A., Desideri G., Fallo F., Ferri C., Galeone D., Garavelli G., Gaudio G., Giacchetti G., Gidaro B., Giovannetti R., Grandi A., Guglielmi M., Iacoviello L., Leonardis D., Lonati C., Lonati L. M., Malatino L., Mallamaci F., Maresca A. M., Marzano L., Massara C., Merletti L., Meschi M., Modesti S., Montanari A., Morganti A., Musiari L., Musso N., Nardecchia A., Nazzaro P., Pallisco O., Panichi V., Parati G., Pascale C., Pini C., Pirola I., Pucci G., Rabbia F., Rescaldani M., Ronchi E., Rossi E., Rossi G., Sala C., Sarzani R., Sechi L. A., Silvestris F., Stancanelli B., Trimarco B., Ungar A., Veglio F., Veronesi M., and Vinella L.

Abstract

Background/objectives: The aim of the present study was to validate a short questionnaire on habitual dietary salt intake, to quickly and easily identify individuals whose salt consumption exceeds recommended levels. Subjects/methods: A total of 1131 hypertensive subjects participating in the MINISAL-SIIA study were included in the analysis. Anthropometric indexes, blood pressure, and 24-h urinary sodium excretion (NaU) were measured. A fixed-sequence questionnaire on dietary salt intake was administered. Results: NaU was significantly associated with scores, with a linear association across categories (p for trend <0.0001). In addition, participants who achieved a total score above the median value (eight points) had significantly higher NaU than those whose score was below median (p < 0.0001). In the total sample, the prevalence of “high NaU” (NaU > 85 mmol/day) and “very high NaU” (NaU > 170 mmol/day) was 86 and 35%, respectively. The score of the questionnaire had a significant ability to detect both “high NaU”—with a specificity of 95% at the score of 10 points—and “very high NaU”—with a specificity of 99.6% at score of 13 points. Conclusions: The main results of the study indicates that a higher score of this short questionnaire is distinctive of habitual high salt consumption in hypertensive patients.

Published
2019

14. STUDY OF THE EUROPEAN SOCIETY OF HYPERTENSION ON BLOOD PRESSURE CONTROL IN ESH EXCELLENCE CENTERS (BP CON ESH) - THE FIRST PRELIMINARY REPORT

Author

Jelakovic, B, Triantafyllou, A, Doumas, M, Kalaitzidis, R, Protogerou, A, Kallistratos, E, Stergiou, G, Moloberti, A, Giannattasio, C, Marketou, M, Papadakis, I, Papadopoulos, D, Pengo, M, Parati, G, Sarafidis, P, Stojanov, V, Triantafyllidi, E, Manta, E, Tsioufis, K, Agabiti-Rosei, E, Kreutz, R, Polonia, J, Januszewicz, A, Mancia, G, Jelakovic, B, Triantafyllou, A, Doumas, M, Kalaitzidis, R, Protogerou, A, Kallistratos, E, Stergiou, G, Moloberti, A, Giannattasio, C, Marketou, M, Papadakis, I, Papadopoulos, D, Pengo, M, Parati, G, Sarafidis, P, Stojanov, V, Triantafyllidi, E, Manta, E, Tsioufis, K, Agabiti-Rosei, E, Kreutz, R, Polonia, J, Januszewicz, A, and Mancia, G

Published
2021

17. Validation of an easy questionnaire on the assessment of salt habit: the MINISAL-SIIA Study Program

Author

D’Elia, L., Manfredi, M., Strazzullo, P., Galletti, F., Agabiti-Rosei, E., Arcangeli, E., Artom, A., Barbato, A., Barbiero, M., Belfiore, A., Bernini, G., Boero, R., Berra, E., Biggi, A., Borgheresi, P., Borghi, C., Bosio, A., Caiazza, A., Caielli, P., Caló, L. A., Castellano, M., Catena, C., Cerrato, F., Cilia, C., Cipollini, F., Crippa, M., Cuspidi, C., D’Avino, M., De Giorgi, G. A., De Luca, N., De Pergola, G., Del Giudice, A., Desideri, G., Fallo, F., Ferri, C., Galeone, D., Garavelli, G., Gaudio, G., Giacchetti, G., Gidaro, B., Giovannetti, R., Grandi, A., Guglielmi, M., Iacoviello, L., Leonardis, D., Lonati, C., Lonati, L. M., Malatino, L., Mallamaci, F., Maresca, A. M., Marzano, L., Massara, C., Merletti, L., Meschi, M., Modesti, S., Montanari, A., Morganti, A., Musiari, L., Musso, N., Nardecchia, A., Nazzaro, P., Pallisco, O., Panichi, V., Parati, G., Pascale, C., Pini, C., Pirola, I., Pucci, G., Rabbia, F., Rescaldani, M., Ronchi, E., Rossi, E., Rossi, G., Sala, C., Sarzani, R., Sechi, L. A., Silvestris, F., Stancanelli, B., Trimarco, B., Ungar, A., Veglio, F., Veronesi, M., Vinella, L., D'Elia, L, Manfredi, M, Strazzullo, P, Galletti, F, Agabiti-Rosei, E, Arcangeli, E, Artom, A, Barbato, A, Barbiero, M, Belfiore, A, Bernini, G, Boero, R, Berra, E, Biggi, A, Borgheresi, P, Borghi, C, Bosio, A, Caiazza, A, Caielli, P, Calo, L, Castellano, M, Catena, C, Cerrato, F, Cilia, C, Cipollini, F, Crippa, M, Cuspidi, C, D'Avino, M, De Giorgi, G, De Luca, N, De Pergola, G, Del Giudice, A, Desideri, G, Fallo, F, Ferri, C, Galeone, D, Garavelli, G, Gaudio, G, Giacchetti, G, Gidaro, B, Giovannetti, R, Grandi, A, Guglielmi, M, Iacoviello, L, Leonardis, D, Lonati, C, Lonati, L, Malatino, L, Mallamaci, F, Maresca, A, Marzano, L, Massara, C, Merletti, L, Meschi, M, Modesti, S, Montanari, A, Morganti, A, Musiari, L, Musso, N, Nardecchia, A, Nazzaro, P, Pallisco, O, Panichi, V, Parati, G, Pascale, C, Pini, C, Pirola, I, Pucci, G, Rabbia, F, Rescaldani, M, Ronchi, E, Rossi, E, Rossi, G, Sala, C, Sarzani, R, Sechi, L, Silvestris, F, Stancanelli, B, Trimarco, B, Ungar, A, Veglio, F, Veronesi, M, Vinella, L, L. D’Elia, M. Manfredi, P. Strazzullo, F. Galletti, E. Agabiti-Rosei, E. Arcangeli, A. Artom, A. Barbato, M. Barbiero, A. Belfiore, G. Bernini, R. Boero, E. Berra, A. Biggi, P. Borgheresi, C. Borghi, A. Bosio, A. Caiazza, P. Caielli, L. A. Caló, M. Castellano, C. Catena, F. Cerrato, C. Cilia, F. Cipollini, M. Crippa, C. Cuspidi, M. D’Avino, G. A. De Giorgi, N. De Luca, G. De Pergola, A. Del Giudice, G. Desideri, F. Fallo, C. Ferri, D. Galeone, G. Garavelli, G. Gaudio, G. Giacchetti, B. Gidaro, R. Giovannetti, A. Grandi, M. Guglielmi, L. Iacoviello, D. Leonardi, C. Lonati, L. M. Lonati, L. Malatino, F. Mallamaci, A. M. Maresca, L. Marzano, C. Massara, L. Merletti, M. Meschi, S. Modesti, A. Montanari, A. Morganti, L. Musiari, N. Musso, A. Nardecchia, P. Nazzaro, O. Pallisco, V. Panichi, G. Parati, C. Pascale, C. Pini, I. Pirola, G. Pucci, F. Rabbia, M. Rescaldani, E. Ronchi, E. Rossi, G. Rossi, C. Sala, R. Sarzani, L. A. Sechi, F. Silvestri, B. Stancanelli, B. Trimarco, A. Ungar, F. Veglio, M. Veronesi, and L. Vinella

Subjects
Male, 0301 basic medicine, Validation study, medicine.medical_specialty, media_common.quotation_subject, Medicine (miscellaneous), 030209 endocrinology & metabolism, Nutrition and Dietetic, hypertension, sodium intake, 03 medical and health sciences, 0302 clinical medicine, Surveys and Questionnaires, Internal medicine, Nutrition and Dietetic, medicine, Humans, MINISAL-SIIA, Sodium Chloride, Dietary, Nutrition, media_common, 030109 nutrition & dietetics, Nutrition and Dietetics, Urinary sodium, business.industry, MINISAL-SIIA Study Program, Reproducibility of Results, Middle Aged, Anthropometry, Blood pressure, Italy, Hypertension, Dietary salt intake, Female, Habit, dietary salt intake, business, Dietetic, sodium intake
Abstract

Background/objectives: The aim of the present study was to validate a short questionnaire on habitual dietary salt intake, to quickly and easily identify individuals whose salt consumption exceeds recommended levels. Subjects/methods: A total of 1131 hypertensive subjects participating in the MINISAL-SIIA study were included in the analysis. Anthropometric indexes, blood pressure, and 24-h urinary sodium excretion (NaU) were measured. A fixed-sequence questionnaire on dietary salt intake was administered. Results: NaU was significantly associated with scores, with a linear association across categories (p for trend 85 mmol/day) and “very high NaU” (NaU > 170 mmol/day) was 86 and 35%, respectively. The score of the questionnaire had a significant ability to detect both “high NaU”—with a specificity of 95% at the score of 10 points—and “very high NaU”—with a specificity of 99.6% at score of 13 points. Conclusions: The main results of the study indicates that a higher score of this short questionnaire is distinctive of habitual high salt consumption in hypertensive patients.

Published
2019

20. 2018 Practice guidelines for the management of arterial hypertension of the European Society of Hypertension (ESH) and the European Society of Cardiology (ESC)

Author

Williams, B, Mancia, G, Spiering, W, Agabiti Rosei, E, Azizi, M, Burnier, M, Clement, D, Coca, A, De Simone, G, Dominiczak, A, Kahan, T, Mahfoud, F, Redon, J, Ruilope, L, Zanchetti, A, Kerins, M, Kjeldsen, S, Kreutz, R, Laurent, S, Lip, G, Mcmanus, R, Narkiewicz, K, Ruschitzka, F, Schmieder, R, Shlyakhto, E, Tsioufis, K, Aboyans, V, Desormais, I, Williams B., Mancia G., Spiering W., Agabiti Rosei E., Azizi M., Burnier M., Clement D., Coca A., De Simone G., Dominiczak A., Kahan T., Mahfoud F., Redon J., Ruilope L., Zanchetti A., Kerins M., Kjeldsen S., Kreutz R., Laurent S., Lip G. Y. H., McManus R., Narkiewicz K., Ruschitzka F., Schmieder R., Shlyakhto E., Tsioufis K., Aboyans V., Desormais I., Williams, B, Mancia, G, Spiering, W, Agabiti Rosei, E, Azizi, M, Burnier, M, Clement, D, Coca, A, De Simone, G, Dominiczak, A, Kahan, T, Mahfoud, F, Redon, J, Ruilope, L, Zanchetti, A, Kerins, M, Kjeldsen, S, Kreutz, R, Laurent, S, Lip, G, Mcmanus, R, Narkiewicz, K, Ruschitzka, F, Schmieder, R, Shlyakhto, E, Tsioufis, K, Aboyans, V, Desormais, I, Williams B., Mancia G., Spiering W., Agabiti Rosei E., Azizi M., Burnier M., Clement D., Coca A., De Simone G., Dominiczak A., Kahan T., Mahfoud F., Redon J., Ruilope L., Zanchetti A., Kerins M., Kjeldsen S., Kreutz R., Laurent S., Lip G. Y. H., McManus R., Narkiewicz K., Ruschitzka F., Schmieder R., Shlyakhto E., Tsioufis K., Aboyans V., and Desormais I.

Abstract

These practice guidelines on the management of arterial hypertension are a concise summary of the more extensive ones prepared by the Task Force jointly appointed by the European Society of Hypertension and the European Society of Cardiology. These guidelines have been prepared on the basis of the best available evidence on all issues deserving recommendations; their role must be educational and not prescriptive or coercive for the management of individual subjects who may differ widely in their personal, medical and cultural characteristics. The members of the Task Force have participated independently in the preparation of these guidelines, drawing on their academic and clinical experience and by objective examination and interpretation of all available literature.

Published
2018

21. Exploration into Uric and Cardiovascular Disease: Uric Acid Right for heArt Health (URRAH) Project, A Study Protocol for a Retrospective Observational Study

Author

644 Desideri, G, Virdis, A, Casiglia, E, Borghi, C, Cicero, A, Muiesan, M, Agabiti-Rosei, E, Salvetti, M, Ungar, A, Rivasi, G, Pontremoli, R, Viazzi, Grassi, G, Bombelli, M, Facchetti, R, Ferri, C, Bernardino, B, Galetti, F, D’Elia, L, Palatini, P, Tickhonoff, V, Barbagallo, C, Verdecchia, P, Masi, S, Mallamaci, F, Cirillo, M, Gesualdo, L, Mazza, A, Giannattasio, C, Maloberti, A, Ratazzi, M, Pauletto, P, Volpe, M, Tocci, G, Iaccarino, G, Nazzaro, P, 644 Desideri G, Virdis A, Casiglia E, Borghi C, Cicero A, Muiesan ML, Agabiti-Rosei E, Salvetti M, Ungar A, Rivasi G, Pontremoli R, GRASSI G, Bombelli M, Facchetti R, Ferri C, Bernardino B, Galetti F, D’Elia L, Palatini P, Tickhonoff V, Barbagallo CM, Verdecchia P, Masi S, Mallamaci F, Cirillo M, Gesualdo L, Mazza A, giannattasio C, Maloberti A, Ratazzi M, Pauletto P, Volpe M, Tocci G, Iaccarino G, Nazzaro P, 644 Desideri, G, Virdis, A, Casiglia, E, Borghi, C, Cicero, A, Muiesan, M, Agabiti-Rosei, E, Salvetti, M, Ungar, A, Rivasi, G, Pontremoli, R, Viazzi, Grassi, G, Bombelli, M, Facchetti, R, Ferri, C, Bernardino, B, Galetti, F, D’Elia, L, Palatini, P, Tickhonoff, V, Barbagallo, C, Verdecchia, P, Masi, S, Mallamaci, F, Cirillo, M, Gesualdo, L, Mazza, A, Giannattasio, C, Maloberti, A, Ratazzi, M, Pauletto, P, Volpe, M, Tocci, G, Iaccarino, G, Nazzaro, P, 644 Desideri G, Virdis A, Casiglia E, Borghi C, Cicero A, Muiesan ML, Agabiti-Rosei E, Salvetti M, Ungar A, Rivasi G, Pontremoli R, GRASSI G, Bombelli M, Facchetti R, Ferri C, Bernardino B, Galetti F, D’Elia L, Palatini P, Tickhonoff V, Barbagallo CM, Verdecchia P, Masi S, Mallamaci F, Cirillo M, Gesualdo L, Mazza A, giannattasio C, Maloberti A, Ratazzi M, Pauletto P, Volpe M, Tocci G, Iaccarino G, and Nazzaro P

Abstract

The relevance of cardiovascular role played by levels of serum uric acid is dramatically growing, especially as cardiovascular risk factor potentially able to exert either a direct deleterious impact or a synergic effect with other cardiovascular risk factors. At the present time, it still remains undefined the threshold level of serum uric acid able to contribute to the cardiovascular risk. Indeed, the available epidemiological case studies are not homogeneous, and some preliminary data suggest that the so-called “cardiovascular threshold limit” may substantially differ from that identified as a cut-off able to trigger the acute gout attack. In such scenario, there is the necessity to clarify and quantify this threshold value, to insert it in the stratification of risk algorithm scores and, in turn, to adopt proper prevention and correction strategies. The clarification of the relationship between circulating levels of uric acid and cardio-nephro-metabolic disorders in a broad sample representative of general population is critical to identify the threshold value of serum uric acid better discriminating the increased risk associated with uric acid. The Uric acid Right for heArt Health (URRAH) project has been designed to define, as primary objective, the level of uricemia above which the independent risk of cardiovascular disease may increase in a significantly manner in a general Italian population.

Published
2018

22. Hyperuricaemia and gout in cardiovascular, metabolic and kidney disease

Author

Borghi C, Agabiti-Rosei E, Johnson R, Kielstein J, Lurbe E, Mancia G, Redon J, Stack A, and Tsioufis K

Subjects
nutritional and metabolic diseases, urologic and male genital diseases
Abstract

During the last century, there has been an increasing prevalence of hyperuricaemia noted in many populations. While uric acid is usually discussed in the context of gout, hyperuricaemia is also associated with hypertension, chronic kidney disease, hypertriglyceridaemia, obesity, atherosclerotic heart disease, metabolic syndrome, and type 2 diabetes. Here we review the connection between hyperuricaemia and cardiovascular, kidney and metabolic diseases. Contrary to the popular view that uric acid is an inert metabolite of purine metabolism, recent studies suggest serum uric acid may have a variety of pro-inflammatory, pro-oxidative and vasoconstrictive actions that may contribute to cardiometabolic diseases. Hyperuricaemia is a predictive factor for the development of hypertension, metabolic syndrome, type 2 diabetes, coronary artery disease, left ventricular hypertrophy, atrial fibrillation, myocardial infarction, stroke, heart failure and chronic kidney disease. Treatment with uric acid-lowering therapies has also been found to improve outcomes in patients with hypertension and kidney disease, in some but not all studies. In conclusion, uric acid is emerging as a potentially treatable risk factor for cardiometabolic diseases, and more clinical trials investigating the potential benefit of lowering serum uric acid are recommended in individuals with hyperuricaemia with and without deposition and concomitant hypertension, metabolic syndrome or chronic kidney disease. Copyright © 2020 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved.

Published
2020

23. Hyperuricaemia and gout in cardiovascular, metabolic and kidney disease

Author

Borghi, C. Agabiti-Rosei, E. Johnson, R.J. Kielstein, J.T. Lurbe, E. Mancia, G. Redon, J. Stack, A.G. Tsioufis, K.P.

Subjects
nutritional and metabolic diseases, urologic and male genital diseases
Abstract

During the last century, there has been an increasing prevalence of hyperuricaemia noted in many populations. While uric acid is usually discussed in the context of gout, hyperuricaemia is also associated with hypertension, chronic kidney disease, hypertriglyceridaemia, obesity, atherosclerotic heart disease, metabolic syndrome, and type 2 diabetes. Here we review the connection between hyperuricaemia and cardiovascular, kidney and metabolic diseases. Contrary to the popular view that uric acid is an inert metabolite of purine metabolism, recent studies suggest serum uric acid may have a variety of pro-inflammatory, pro-oxidative and vasoconstrictive actions that may contribute to cardiometabolic diseases. Hyperuricaemia is a predictive factor for the development of hypertension, metabolic syndrome, type 2 diabetes, coronary artery disease, left ventricular hypertrophy, atrial fibrillation, myocardial infarction, stroke, heart failure and chronic kidney disease. Treatment with uric acid-lowering therapies has also been found to improve outcomes in patients with hypertension and kidney disease, in some but not all studies. In conclusion, uric acid is emerging as a potentially treatable risk factor for cardiometabolic diseases, and more clinical trials investigating the potential benefit of lowering serum uric acid are recommended in individuals with hyperuricaemia with and without deposition and concomitant hypertension, metabolic syndrome or chronic kidney disease. © 2020 European Federation of Internal Medicine

Published
2020

24. Nutraceuticals and blood pressure control: A European Society of Hypertension position document

Author

Borghi, C., Prof. Tsioufis, K. Agabiti-Rosei, E. Burnier, M. Cicero, A.F.G. Clement, D. Coca, A. Desideri, G. Grassi, G. Lovic, D. Lurbe, E. Kahan, T. Kreutz, R. Jelakovic, B. Polonia, J. Redon, J. Van De Borne, P. Mancia, G.

Abstract

High-normal blood pressure (BP) is associated with an increased risk of cardiovascular disease, however the cost-benefit ratio of the use of antihypertensive treatment in these patients is not yet clear. Some dietary components and natural products seems to be able to significantly lower BP without significant side effects. The aim of this position document is to highlight which of these products have the most clinically significant antihypertensive action and wheter they could be suggested to patients with high-normal BP. Among foods, beetroot juice has the most covincing evidence of antihypertensive effect. Antioxidant-rich beverages (teas, coffee) could be considered. Among nutrients, magnesium, potassium and vitamin C supplements could improve BP. Among nonnutrient-nutraceuticals, soy isoflavones could be suggested in perimenopausal women, resveratrol in insulin-resistant patients, melatonin in study participants with night hypertension. In any case, the nutracutical approach has never to substitute the drug treatment, when needed. © 2020 Lippincott Williams and Wilkins. All rights reserved.

Published
2020

30. The polypill in cardiovascular prevention: Evidence, limitations and perspective-position paper of the European Society of Hypertension

Author

Coca, A, Agabiti-Rosei, E, Cifkova, R, Manolis, A, Redon, J, Mancia, G, Coca A., Agabiti-Rosei E., Cifkova R., Manolis A. J., Redon J., Mancia G., Coca, A, Agabiti-Rosei, E, Cifkova, R, Manolis, A, Redon, J, Mancia, G, Coca A., Agabiti-Rosei E., Cifkova R., Manolis A. J., Redon J., and Mancia G.

Abstract

Antihypertensive, lipid lowering, antidiabetic and antiplatelet treatments all substantially reduce the risk of cardiovascular morbid and fatal events. In real life, however, effective implementation of these treatments is rare, and thus their contribution to cardiovascular prevention is much less than it could be, based on research data. This article reviews the pros and cons of cardiovascular prevention by the polypill approach. It is argued that the high prevalence of individuals with a multifactorial risk profile provides a strong rationale for a therapeutic strategy based on the combination in a single tablet of drugs against different risk factors. It is further argued that other important favourable arguments exist. First, in real-life adherence to all above treatments is very low, leading to a major increase in the incidence and risk of cardiovascular outcomes. Second, although a large number of factors are involved, adherence is adversely affected by the complexity of the prescribed treatment regimen and can be considerably improved by treatment simplification. Third, recent studies in patients with a history of manifest cardiovascular disease have documented that different cardiovascular drugs can be combined in a single tablet with no loss of their individual efficacy or unexpected inconveniences and this does favour adherence to treatment and multiple risk factor control, supporting use of the polypill in secondary cardiovascular prevention. It is finally also mentioned, however, that the polypill may have some drawbacks and that at present no evidence is available that this approach reduces cardiovascular outcome to a greater degree than standard treatment strategies. Trials are under way to provide an answer to this question and thus allow the therapeutic value of this approach to be known.

Published
2017

31. Non-invasive cardiovascular imaging for evaluating subclinical target organ damage in hypertensive patients: A consensus paper from the European Association of Cardiovascular Imaging (EACVI), the European Society of Cardiology Council on Hypertension, and the European Society of Hypertension (ESH)

Author

Perrone Filardi, P, Coca, A, Galderisi, M, Paolillo, S, Alpendurada, F, De Simone, G, Donal, E, Kahan, T, Mancia, G, Redon, J, Schmieder, R, Williams, B, Agabiti Rosei, E, Agabiti Rosei, E., MANCIA, GIUSEPPE, Perrone Filardi, P, Coca, A, Galderisi, M, Paolillo, S, Alpendurada, F, De Simone, G, Donal, E, Kahan, T, Mancia, G, Redon, J, Schmieder, R, Williams, B, Agabiti Rosei, E, Agabiti Rosei, E., and MANCIA, GIUSEPPE

Abstract

Arterial hypertension (HTN) accounts for the largest amount of attributable cardiovascular (CV) mortality worldwide, and risk stratification in hypertensive patients is of crucial importance to manage treatment and prevent adverse events. Asymptomatic involvement of different organs in patients affected by HTN represents an independent determinant of CV risk and the identification of target organ damage (TOD) is recommended to further reclassify patients' risk. Non-invasive CV imaging is progressively being used and continues to provide new technological opportunities to TOD evaluation at early stage. The aim of this article is to provide the community of cardiology with an update on appropriate and justified use of non-invasive imaging tests in the growing population of hypertensive patients.

Published
2017

37. 2018 Practice Guidelines for the management of arterial hypertension of the European Society of Hypertension and the European Society of Cardiology: ESH/ESC Task Force for the Management of Arterial Hypertension

Author

Williams, B, Mancia, G, Spiering, W, Agabiti Rosei, E, Azizi, M, Burnier, M, Clement, D, Coca, A, De Simone, G, Dominiczak, A, Kahan, T, Mahfoud, F, Redon, J, Ruilope, L, Zanchetti, A, Kerins, M, Kjeldsen, S, Kreutz, R, Laurent, S, Lip, G, McManus, R, Narkiewicz, K, Ruschitzka, F, Schmieder, R, Shlyakhto, E, Tsioufis, K, Aboyans, V, Desormais, I, and Members, L

Published
2018

42. Autonomic dysfunction

Author

Mancia, G, Grassi, G, Tsioufis, KP, Dominiczak, AF, Agabiti Rosei, E, Seravalle, G, Mancia, G, Grassi, G, Tsioufis, KP, Dominiczak, AF, Agabiti Rosei, E, and Seravalle, G

Published
2019

43. Introduction

Author

Mancia, G, Grassi, G, Tsioufis, KP, Dominiczak, AF, Agabiti Rosei, E, Tsioufis, K, Dominiczak, A, Agabiti Rsei, E, Mancia, G, Grassi, G, Tsioufis, KP, Dominiczak, AF, Agabiti Rosei, E, Tsioufis, K, Dominiczak, A, and Agabiti Rsei, E

Published
2019

44. Non-invasive cardiovascular imaging for evaluating subclinical target organ damage in hypertensive patients: A consensus paper from the European Association of Cardiovascular Imaging (EACVI), the European Society of Cardiology Council on Hypertension, and the European Society of Hypertension (ESH)

Author

Perrone-Filardi P, Coca A, Galderisi M, Paolillo S, Alpendurada F, de Simone G, Donal E, Kahan T, Mancia G, Redon J, Schmieder R, Williams B, Agabiti-Rosei E, Perrone Filardi, P, Coca, A, Galderisi, M, Paolillo, S, Alpendurada, F, De Simone, G, Donal, E, Kahan, T, Mancia, G, Redon, J, Schmieder, R, Williams, B, and Agabiti Rosei, E

Subjects
cardiovascular risk, Male, arterial hypertension, Consensus, Cardiology, Risk Assessment, Europe, Cardiac Imaging Techniques, Cardiovascular Diseases, target organ damage, Asymptomatic Diseases, Hypertension, Practice Guidelines as Topic, Humans, Female, non-invasive cardiovascular imaging, prognosi, Societies, Medical
Abstract

Arterial hypertension (HTN) accounts for the largest amount of attributable cardiovascular (CV) mortality worldwide, and risk stratification in hypertensive patients is of crucial importance to manage treatment and prevent adverse events. Asymptomatic involvement of different organs in patients affected by HTN represents an independent determinant of CV risk and the identification of target organ damage (TOD) is recommended to further reclassify patients' risk. Non-invasive CV imaging is progressively being used and continues to provide new technological opportunities to TOD evaluation at early stage. The aim of this article is to provide the community of cardiology with an update on appropriate and justified use of non-invasive imaging tests in the growing population of hypertensive patients.

Published
2017

46. Treatment of high blood pressure in elderly and octogenarians: European Society of Hypertension statement on blood pressure targets

Author

Kjeldsen, S, Stenehjem, A, Os, I, Van de Borne, P, Burnier, M, Narkiewicz, K, Redon, J, Agabiti Rosei, E, Mancia, G, Kjeldsen S. E., Stenehjem A., Os I., Van de Borne P., Burnier M., Narkiewicz K., Redon J., Agabiti Rosei E., Mancia G., Kjeldsen, S, Stenehjem, A, Os, I, Van de Borne, P, Burnier, M, Narkiewicz, K, Redon, J, Agabiti Rosei, E, Mancia, G, Kjeldsen S. E., Stenehjem A., Os I., Van de Borne P., Burnier M., Narkiewicz K., Redon J., Agabiti Rosei E., and Mancia G.

Abstract

The European Society of Hypertension recommend the following main rules for treatment of hypertension in elderly and octogenarians: 1) In elderly hypertensives with SBP ≥ 160 mmHg there is solid evidence to recommend reducing SBP to between 140 mmHg and 150 mmHg. 2) In fit elderly patients less than 80 years old treatment may be considered at SBP ≥ 140 mmHg with a target SBP < 140 mmHg if treatment is well tolerated. 3) In fit individuals older than 80 years with an initial SBP ≥ 160 mmHg it is recommended to reduce SBP to between 150 mmHg and 140 mmHg. 4) In frail elderly patients, it is recommended to base treatment decisions on comorbidity and carefully monitor the effects of treatment. 5) Continuation of well-tolerated antihypertensive treatment should be considered when a treated individual becomes octogenarian. 6) All hypertensive agents are recommended and can be used in the elderly, although diuretics and calcium antagonists may be preferred in isolated systolic hypertension.

Published
2016

47. Impact of substitution among generic drugs on persistence and adherence: A retrospective claims data study from 2 Local Healthcare Units in the Lombardy Region of Italy

Author

Colombo, G, Agabiti-Rosei, E, Margonato, A, Mencacci, C, Montecucco, C, Trevisan, R, Catapano, A, Colombo GL, Agabiti-Rosei E, Margonato A, Mencacci C, Montecucco CM, Trevisan R, Catapano AL, Colombo, G, Agabiti-Rosei, E, Margonato, A, Mencacci, C, Montecucco, C, Trevisan, R, Catapano, A, Colombo GL, Agabiti-Rosei E, Margonato A, Mencacci C, Montecucco CM, Trevisan R, and Catapano AL

Abstract

Background The use of generics, equivalent but less expensive drugs, is an important opportunity to reduce healthcare expenditure. Methods The purpose of this study was to investigate the effect of substitution between unbranded generics on persistence and adherence to therapy in two Italian Local Health Units (ASL) in real-world clinical practice in 5 therapeutic areas using tracing drugs. Substitution of generic drugs is any change in the name of the manufacturer of the generic drug. The therapeutic areas were: diabetes (metformin); hypertension (amlodipine); dyslipidemia (simvastatin); psychiatry (sertraline); cardiology (propafenone); osteoporosis (alendronate). The retrospective analysis was carried out on the administrative databases of two Local Healthcare Units (ASL – Azienda sanitaria locale Bergamo (BG) and Pavia (PV)) in the Lombardy Region of Italy. The correlation between persistence and adherence with the different cohorts of generic substitution frequency within each therapeutic area was then calculated. Results According to the inclusion criteria, 23,773 patients were evaluated. Patients were observed for a period of 36 months starting from the first drug delivery (index date). The median age of the overall population was above 61 years in all therapeutic areas. The generic drug substitution occurred in 61.5% of patients (BG: 57.6% and PV: 65.4% respectively); Hypertension was the therapeutic area with the highest percentage of patients with substitutions. Patients' adherence, evaluated by the Medical Possession Rate (MPR) and persistence to the treatment decreases with the increase in the frequency of generic substitutions. This observation was confirmed by a statistically significant negative correlation (p-value of <0.001) between the adherence and persistence and the number of generic substitutions in each therapeutic area and Local Healthcare Units (ASL). Discussion Adherence is one of the pillars of the patient's health management in the con

Published
2016

48. MASked-unconTrolled hypERtension management based on office BP or on ambulatory blood pressure measurement (MASTER) Study: A randomised controlled trial protocol

Author

Parati, G. Agabiti-Rosei, E. Bakris, G.L. Bilo, G. Branzi, G. Cecchi, F. Chrostowska, M. De La Sierra, A. Domenech, M. Dorobantu, M. Faria, T. Huo, Y. Jelaković, B. Kahan, T. Konradi, A. Laurent, S. Li, N. Madan, K. Mancia, G. McManus, R.J. Modesti, P.A. Ochoa, J.E. Octavio, J.A. Omboni, S. Palatini, P. Park, J.B. Pellegrini, D. Perl, S. Podoleanu, C. Pucci, G. Redon, J. Renna, N. Rhee, M.Y. Rodilla Sala, E. Sanchez, R. Schmieder, R. Soranna, D. Stergiou, G. Stojanovic, M. Tsioufis, K. Valsecchi, M.G. Veglio, F. Waisman, G.D. Wang, J.G. Wijnmaalen, P. Zambon, A. Zanchetti, A. Zhang, Y.

Abstract

Introduction Masked uncontrolled hypertension (MUCH) carries an increased risk of cardiovascular (CV) complications and can be identified through combined use of office (O) and ambulatory (A) blood pressure (BP) monitoring (M) in treated patients. However, it is still debated whether the information carried by ABPM should be considered for MUCH management. Aim of the MASked-unconTrolled hypERtension management based on OBP or on ambulatory blood pressure measurement (MASTER) Study is to assess the impact on outcome of MUCH management based on OBPM or ABPM. Methods and analysis MASTER is a 4-year prospective, randomised, open-label, blinded-endpoint investigation. A total of 1240 treated hypertensive patients from about 40 secondary care clinical centres worldwide will be included -upon confirming presence of MUCH (repeated on treatment OBP

Published
2018

49. Should renal color Doppler ultrasonography be a routine test in newly diagnosed hypertensive patient?

Author

Tsioufis, C. Andrikou, I. Pruijm, M. Ponte, B. Sarafidis, P. Koureas, A. Tousoulis, D. Agabiti-Rosei, E. Mancia, G. Burnier, M.

Abstract

European Society of Hypertension/European Society of Cardiology guidelines recommend calculation of estimated glomerular filtration rate and evaluation of urinary albumin excretion rate as routine tests in the initial evaluation and during the follow-up of all hypertensive patients. However, from a clinical point of view, renal ultrasound-a noninvasive, readily available and cheap imaging modality-could contribute to the better evaluation of a hypertensive patient by identifying common causes of secondary hypertension (HTN) originating from the kidney and more recently by detecting renal injury in severe or long-standing essential HTN by measuring renal resistive indexes. The purpose of this review is to summarize the actual evidence which could support a larger use of renal ultrasound in the work-up of patients with newly diagnosed HTN. Copyright © 2017 Wolters Kluwer Health, Inc. All rights reserved.

Published
2018

50. 2018 Practice guidelines for the management of arterial hypertension of the European Society of Hypertension (ESH) and the European Society of Cardiology (ESC)

Author

Williams, B. Mancia, G. Spiering, W. Agabiti Rosei, E. Azizi, M. Burnier, M. Clement, D. Coca, A. De Simone, G. Dominiczak, A. Kahan, T. Mahfoud, F. Redon, J. Ruilope, L. Zanchetti, A. Kerins, M. Kjeldsen, S. Kreutz, R. Laurent, S. Lip, G.Y.H. McManus, R. Narkiewicz, K. Ruschitzka, F. Schmieder, R. Shlyakhto, E. Tsioufis, K. Aboyans, V. Desormais, I.

Abstract

These practice guidelines on the management of arterial hypertension are a concise summary of the more extensive ones prepared by the Task Force jointly appointed by the European Society of Hypertension and the European Society of Cardiology. These guidelines have been prepared on the basis of the best available evidence on all issues deserving recommendations; their role must be educational and not prescriptive or coercive for the management of individual subjects who may differ widely in their personal, medical and cultural characteristics. The members of the Task Force have participated independently in the preparation of these guidelines, drawing on their academic and clinical experience and by objective examination and interpretation of all available literature. © 2018, © 2018 Informa UK Limited, trading as Taylor & Francis Group.

Published
2018

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