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3. The WARP Reactor Concept

Author

Anderson, Michael G., Walters, James K., Anaya, Enrique M., Max, Don A., Stygar, William A., and Link, Anthony J.

Subjects
Physics - Plasma Physics, High Energy Physics - Experiment, Physics - Accelerator Physics
Abstract

The WARP Reactor Concept promises orders of magnitude increase of intense ion beam energies and respective radiation yields at a fraction of the size and cost over existing z-pinch class accelerators allowing the economically viable study of new Relativistic High Energy Density Physics regimes for probing the intersection between General Relativity and Quantum Field Theory along with game-changing direct applications from rep-rated Magnetized Liner Inertial Fusion devices for energy production and advanced propulsion to multi-pulse compact flash x-ray/neutron radiography sources for assessing nuclear weapons stockpile. An overview of the WARP Reactor Concept is presented., Comment: 12 pages, 26 figures, 9 tables. Submitting to Physical Review Accelerators and Beams

Published
2023

6. Consensus Recommendation for Mouse Models of Ocular Hypertension to Study Aqueous Humor Outflow and Its Mechanisms.

Author

McDowell, Colleen M, Kizhatil, Krishnakumar, Elliott, Michael H, Overby, Darryl R, van Batenburg-Sherwood, Joseph, Millar, J Cameron, Kuehn, Markus H, Zode, Gulab, Acott, Ted S, Anderson, Michael G, Bhattacharya, Sanjoy K, Bertrand, Jacques A, Borras, Terete, Bovenkamp, Diane E, Cheng, Lin, Danias, John, De Ieso, Michael Lucio, Du, Yiqin, Faralli, Jennifer A, Fuchshofer, Rudolf, Ganapathy, Preethi S, Gong, Haiyan, Herberg, Samuel, Hernandez, Humberto, Humphries, Peter, John, Simon WM, Kaufman, Paul L, Keller, Kate E, Kelley, Mary J, Kelly, Ruth A, Krizaj, David, Kumar, Ajay, Leonard, Brian C, Lieberman, Raquel L, Liton, Paloma, Liu, Yutao, Liu, Katy C, Lopez, Navita N, Mao, Weiming, Mavlyutov, Timur, McDonnell, Fiona, McLellan, Gillian J, Mzyk, Philip, Nartey, Andrews, Pasquale, Louis R, Patel, Gaurang C, Pattabiraman, Padmanabhan P, Peters, Donna M, Raghunathan, Vijaykrishna, Rao, Ponugoti Vasantha, Rayana, Naga, Raychaudhuri, Urmimala, Reina-Torres, Ester, Ren, Ruiyi, Rhee, Douglas, Chowdhury, Uttio Roy, Samples, John R, Samples, E Griffen, Sharif, Najam, Schuman, Joel S, Sheffield, Val C, Stevenson, Cooper H, Soundararajan, Avinash, Subramanian, Preeti, Sugali, Chenna Kesavulu, Sun, Yang, Toris, Carol B, Torrejon, Karen Y, Vahabikashi, Amir, Vranka, Janice A, Wang, Ting, Willoughby, Colin E, Xin, Chen, Yun, Hongmin, Zhang, Hao F, Fautsch, Michael P, Tamm, Ernst R, Clark, Abbot F, Ethier, C Ross, and Stamer, W Daniel

Subjects
Biomedical and Clinical Sciences, Ophthalmology and Optometry, Eye Disease and Disorders of Vision, Cardiovascular, Aging, Hypertension, Neurosciences, 2.1 Biological and endogenous factors, Aetiology, Animals, Aqueous Humor, Consensus, Disease Models, Animal, Glaucoma, Intraocular Pressure, Mice, Ocular Hypertension, Tonometry, Ocular, Trabecular Meshwork, mouse model, conventional outflow, glaucoma, intraocular pressure, ocular hypertension, outflow facility, Biological Sciences, Medical and Health Sciences, Ophthalmology & Optometry, Ophthalmology and optometry
Abstract

Due to their similarities in anatomy, physiology, and pharmacology to humans, mice are a valuable model system to study the generation and mechanisms modulating conventional outflow resistance and thus intraocular pressure. In addition, mouse models are critical for understanding the complex nature of conventional outflow homeostasis and dysfunction that results in ocular hypertension. In this review, we describe a set of minimum acceptable standards for developing, characterizing, and utilizing mouse models of open-angle ocular hypertension. We expect that this set of standard practices will increase scientific rigor when using mouse models and will better enable researchers to replicate and build upon previous findings.

Published
2022

7. Utilizing Meta Pseudo Labels for Semantic Segmentation of Targeted Optic Nerve Features

Author

Mann, Ashelyn, Hedberg-Buenz, Adam, Anderson, Michael G., Garvin, Mona K., Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Antony, Bhavna, editor, Chen, Hao, editor, Fang, Huihui, editor, Fu, Huazhu, editor, Lee, Cecilia S., editor, and Zheng, Yalin, editor

Published
2023
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8. Decided among the Cities: The Past, Present, and Future of War in Urban Environments

Author

Anderson, Michael G.

Subjects
United States. Marine Corps, United States. Army. War College, United States. Army, Cities and towns -- Military aspects, General interest, Military and naval science
Abstract

Cities not only possess cultural and psychological value for combatants, but they are also sociologically and geographically anchored to multiple aspects of military key terrain. Cities sit astride, near, or [...]

Published
2023

9. Flipping the Large-Enrollment Introductory Physics Classroom

Author

Kishimoto, Chad T., Anderson, Michael G., and Salamon, Joe P.

Subjects
Physics - Physics Education
Abstract

Most STEM students experience the introductory physics sequence in large-enrollment (N $\gtrsim$ 100 students) classrooms, led by one lecturer and supported by a few teaching assistants. This work describes methods and principles we used to create an effective "flipped classroom" in large- enrollment introductory physics courses by replacing a majority of traditional lecture time with in-class student-driven activity worksheets. In this work, we compare student learning in courses taught by the authors with the flipped classroom pedagogy versus a more traditional pedagogy. By comparing identical questions on exams, we find significant learning gains for students in the student-centered flipped classroom compared to students in the lecturer-centered traditional classroom. Furthermore, we find that the gender gap typically seen in the introductory physics sequence is significantly reduced in the flipped classroom., Comment: 12 pages, 3 figures

Published
2018

11. Association of Genetic Variants With Primary Open-Angle Glaucoma Among Individuals With African Ancestry

Author

Consortium, The Genetics of Glaucoma in People of African Descent, Hauser, Michael A, Allingham, R Rand, Aung, Tin, Van Der Heide, Carly J, Taylor, Kent D, Rotter, Jerome I, Wang, Shih-Hsiu J, Bonnemaijer, Pieter WM, Williams, Susan E, Abdullahi, Sadiq M, Abu-Amero, Khaled K, Anderson, Michael G, Akafo, Stephen, Alhassan, Mahmoud B, Asimadu, Ifeoma, Ayyagari, Radha, Bakayoko, Saydou, Nyamsi, Prisca Biangoup, Bowden, Donald W, Bromley, William C, Budenz, Donald L, Carmichael, Trevor R, Challa, Pratap, Chen, Yii-Der Ida, Chuka-Okosa, Chimdi M, Bailey, Jessica N Cooke, Costa, Vital Paulino, Cruz, Dianne A, DuBiner, Harvey, Ervin, John F, Feldman, Robert M, Flamme-Wiese, Miles, Gaasterland, Douglas E, Garnai, Sarah J, Girkin, Christopher A, Guirou, Nouhoum, Guo, Xiuqing, Haines, Jonathan L, Hammond, Christopher J, Herndon, Leon, Hoffmann, Thomas J, Hulette, Christine M, Hydara, Abba, Igo, Robert P, Jorgenson, Eric, Kabwe, Joyce, Kilangalanga, Ngoy Janvier, Kizor-Akaraiwe, Nkiru, Kuchtey, Rachel W, Lamari, Hasnaa, Li, Zheng, Liebmann, Jeffrey M, Liu, Yutao, Loos, Ruth JF, Melo, Monica B, Moroi, Sayoko E, Msosa, Joseph M, Mullins, Robert F, Nadkarni, Girish, Napo, Abdoulaye, Ng, Maggie CY, Nunes, Hugo Freire, Obeng-Nyarkoh, Ebenezer, Okeke, Anthony, Okeke, Suhanya, Olaniyi, Olusegun, Olawoye, Olusola, Oliveira, Mariana Borges, Pasquale, Louise R, Perez-Grossmann, Rodolfo A, Pericak-Vance, Margaret A, Qin, Xue, Ramsay, Michele, Resnikoff, Serge, Richards, Julia E, Schimiti, Rui Barroso, Sim, Kar Seng, Sponsel, William E, Svidnicki, Paulo Vinicius, Thiadens, Alberta AHJ, Uche, Nkechinyere J, van Duijn, Cornelia M, de Vasconcellos, José Paulo Cabral, Wiggs, Janey L, Zangwill, Linda M, Risch, Neil, Milea, Dan, Ashaye, Adeyinka, Klaver, Caroline CW, Weinreb, Robert N, Koch, Allison E Ashley, Fingert, John H, and Khor, Chiea Chuen

Subjects
Biomedical and Clinical Sciences, Ophthalmology and Optometry, Genetics, Neurodegenerative, Clinical Research, Neurosciences, Human Genome, Eye Disease and Disorders of Vision, Aging, 2.1 Biological and endogenous factors, 2.4 Surveillance and distribution, Eye, Adaptor Proteins, Signal Transducing, Aged, Amyloid beta-Peptides, Black People, Case-Control Studies, Female, Genetic Predisposition to Disease, Genome-Wide Association Study, Genotype, Glaucoma, Open-Angle, Humans, Immunohistochemistry, Male, Meta-Analysis as Topic, Middle Aged, Polymorphism, Single Nucleotide, Risk Factors, Genetics of Glaucoma in People of African Descent (GGLAD) Consortium, Medical and Health Sciences, General & Internal Medicine, Biomedical and clinical sciences, Health sciences
Abstract

ImportancePrimary open-angle glaucoma presents with increased prevalence and a higher degree of clinical severity in populations of African ancestry compared with European or Asian ancestry. Despite this, individuals of African ancestry remain understudied in genomic research for blinding disorders.ObjectivesTo perform a genome-wide association study (GWAS) of African ancestry populations and evaluate potential mechanisms of pathogenesis for loci associated with primary open-angle glaucoma.Design, settings, and participantsA 2-stage GWAS with a discovery data set of 2320 individuals with primary open-angle glaucoma and 2121 control individuals without primary open-angle glaucoma. The validation stage included an additional 6937 affected individuals and 14 917 unaffected individuals using multicenter clinic- and population-based participant recruitment approaches. Study participants were recruited from Ghana, Nigeria, South Africa, the United States, Tanzania, Britain, Cameroon, Saudi Arabia, Brazil, the Democratic Republic of the Congo, Morocco, Peru, and Mali from 2003 to 2018. Individuals with primary open-angle glaucoma had open iridocorneal angles and displayed glaucomatous optic neuropathy with visual field defects. Elevated intraocular pressure was not included in the case definition. Control individuals had no elevated intraocular pressure and no signs of glaucoma.ExposuresGenetic variants associated with primary open-angle glaucoma.Main outcomes and measuresPresence of primary open-angle glaucoma. Genome-wide significance was defined as P C) with primary open-angle glaucoma (odds ratio [OR], 1.32 [95% CI, 1.20-1.46]; P = 2 × 10-8). The association was validated in an analysis of an additional 6937 affected individuals and 14 917 unaffected individuals (OR, 1.15 [95% CI, 1.09-1.21]; P

Published
2019

12. Association of Genetic Variants With Primary Open-Angle Glaucoma Among Individuals With African Ancestry.

Author

Genetics of Glaucoma in People of African Descent (GGLAD) Consortium, Hauser, Michael A, Allingham, R Rand, Aung, Tin, Van Der Heide, Carly J, Taylor, Kent D, Rotter, Jerome I, Wang, Shih-Hsiu J, Bonnemaijer, Pieter WM, Williams, Susan E, Abdullahi, Sadiq M, Abu-Amero, Khaled K, Anderson, Michael G, Akafo, Stephen, Alhassan, Mahmoud B, Asimadu, Ifeoma, Ayyagari, Radha, Bakayoko, Saydou, Nyamsi, Prisca Biangoup, Bowden, Donald W, Bromley, William C, Budenz, Donald L, Carmichael, Trevor R, Challa, Pratap, Chen, Yii-Der Ida, Chuka-Okosa, Chimdi M, Cooke Bailey, Jessica N, Costa, Vital Paulino, Cruz, Dianne A, DuBiner, Harvey, Ervin, John F, Feldman, Robert M, Flamme-Wiese, Miles, Gaasterland, Douglas E, Garnai, Sarah J, Girkin, Christopher A, Guirou, Nouhoum, Guo, Xiuqing, Haines, Jonathan L, Hammond, Christopher J, Herndon, Leon, Hoffmann, Thomas J, Hulette, Christine M, Hydara, Abba, Igo, Robert P, Jorgenson, Eric, Kabwe, Joyce, Kilangalanga, Ngoy Janvier, Kizor-Akaraiwe, Nkiru, Kuchtey, Rachel W, Lamari, Hasnaa, Li, Zheng, Liebmann, Jeffrey M, Liu, Yutao, Loos, Ruth JF, Melo, Monica B, Moroi, Sayoko E, Msosa, Joseph M, Mullins, Robert F, Nadkarni, Girish, Napo, Abdoulaye, Ng, Maggie CY, Nunes, Hugo Freire, Obeng-Nyarkoh, Ebenezer, Okeke, Anthony, Okeke, Suhanya, Olaniyi, Olusegun, Olawoye, Olusola, Oliveira, Mariana Borges, Pasquale, Louise R, Perez-Grossmann, Rodolfo A, Pericak-Vance, Margaret A, Qin, Xue, Ramsay, Michele, Resnikoff, Serge, Richards, Julia E, Schimiti, Rui Barroso, Sim, Kar Seng, Sponsel, William E, Svidnicki, Paulo Vinicius, Thiadens, Alberta AHJ, Uche, Nkechinyere J, van Duijn, Cornelia M, de Vasconcellos, José Paulo Cabral, Wiggs, Janey L, Zangwill, Linda M, Risch, Neil, Milea, Dan, Ashaye, Adeyinka, Klaver, Caroline CW, Weinreb, Robert N, Ashley Koch, Allison E, Fingert, John H, and Khor, Chiea Chuen

Subjects
Genetics of Glaucoma in People of African Descent (GGLAD) Consortium, Humans, Glaucoma, Open-Angle, Genetic Predisposition to Disease, Adaptor Proteins, Signal Transducing, Immunohistochemistry, Risk Factors, Case-Control Studies, Genotype, Polymorphism, Single Nucleotide, Aged, Middle Aged, African Continental Ancestry Group, Female, Male, Meta-Analysis as Topic, Genome-Wide Association Study, Amyloid beta-Peptides, Eye Disease and Disorders of Vision, Clinical Research, Human Genome, Aging, Neurodegenerative, Genetics, Neurosciences, 2.1 Biological and endogenous factors, General & Internal Medicine, Medical and Health Sciences
Abstract

Importance:Primary open-angle glaucoma presents with increased prevalence and a higher degree of clinical severity in populations of African ancestry compared with European or Asian ancestry. Despite this, individuals of African ancestry remain understudied in genomic research for blinding disorders. Objectives:To perform a genome-wide association study (GWAS) of African ancestry populations and evaluate potential mechanisms of pathogenesis for loci associated with primary open-angle glaucoma. Design, Settings, and Participants:A 2-stage GWAS with a discovery data set of 2320 individuals with primary open-angle glaucoma and 2121 control individuals without primary open-angle glaucoma. The validation stage included an additional 6937 affected individuals and 14 917 unaffected individuals using multicenter clinic- and population-based participant recruitment approaches. Study participants were recruited from Ghana, Nigeria, South Africa, the United States, Tanzania, Britain, Cameroon, Saudi Arabia, Brazil, the Democratic Republic of the Congo, Morocco, Peru, and Mali from 2003 to 2018. Individuals with primary open-angle glaucoma had open iridocorneal angles and displayed glaucomatous optic neuropathy with visual field defects. Elevated intraocular pressure was not included in the case definition. Control individuals had no elevated intraocular pressure and no signs of glaucoma. Exposures:Genetic variants associated with primary open-angle glaucoma. Main Outcomes and Measures:Presence of primary open-angle glaucoma. Genome-wide significance was defined as P C) with primary open-angle glaucoma (odds ratio [OR], 1.32 [95% CI, 1.20-1.46]; P = 2 × 10-8). The association was validated in an analysis of an additional 6937 affected individuals and 14 917 unaffected individuals (OR, 1.15 [95% CI, 1.09-1.21]; P

Published
2019

13. ESSENTIAL TRAINING: Sustainers Must Prepare for High-Intensity Conflict

Author

Anderson, Michael G. and Wood, Megan J.

Subjects
United States. Army -- Training, General interest, Military and naval science
Abstract

The Army's small unit tactical sustainers are ill-prepared to conduct required forward supply operations and survive in high-intensity, fast-paced, long-distance large-scale combat operations (LSCO) that could typify future great power [...]

Published
2023

19. Star Maps and Travelling to Ceremonies -- the Euahlayi People and Their Use of the Night Sky

Author

Fuller, Robert S., Trudgett, Michelle, Norris, Ray P., and Anderson, Michael G.

Subjects
Physics - History and Philosophy of Physics
Abstract

The Euahlayi people are an Australian Aboriginal language group located in north-central New South Wales and south-central Queensland. They have a rich culture of astronomy, and use of the night sky in resource management. Like several other Aboriginal peoples, they did not travel extensively at night, and so were assumed not to use the night sky for navigation. This study has confirmed that they, like most other Aboriginal groups, travelled extensively outside their own country for purposes of trade and ceremonies. We also found that, previously unknown, they used star maps in the night sky for learning and remembering waypoints along their routes of travel, but not for actual navigation. Further research may find that this was common to many Aboriginal groups in Australia., Comment: 17 pages, 8 figures

Published
2014

20. TECHNOLOGY TRUST: SYSTEM INFORMATION IMPACT ON AUTONOMOUS SYSTEMS ADOPTION IN HIGH-RISK APPLICATIONS

Author

Anderson, Michael G. and Mun, Johnathan C.

Subjects
United States. Department of Defense -- Technology application, Technological innovations -- Military aspects, Technology application, Military and naval science
Abstract

The use of technology by the Department of Defense (DoD) depends on its ability to perform a desired task. Many issues associated with trust in technology are increasing in importance [...]

Published
2021
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21. Using genetic mouse models to gain insight into glaucoma: Past results and future possibilities

Author

Fernandes, Kimberly A, Harder, Jeffrey M, Williams, Pete A, Rausch, Rebecca L, Kiernan, Amy E, Nair, K Saidas, Anderson, Michael G, John, Simon WM, Howell, Gareth R, and Libby, Richard T

Subjects
Biomedical and Clinical Sciences, Ophthalmology and Optometry, Human Genome, Eye Disease and Disorders of Vision, Aging, Neurosciences, Neurodegenerative, Genetics, 2.6 Resources and infrastructure (aetiology), Aetiology, Eye, Animals, Disease Models, Animal, Glaucoma, Humans, Intraocular Pressure, Mice, Retinal Ganglion Cells, Neuroinflammation, IOP, Axonal degeneration, Trabecular meshwork, Mouse genetics, Genomics, Neurodegeneration, DBA/2J, Medical Biochemistry and Metabolomics, Opthalmology and Optometry, Ophthalmology & Optometry, Ophthalmology and optometry
Abstract

While all forms of glaucoma are characterized by a specific pattern of retinal ganglion cell death, they are clinically divided into several distinct subclasses, including normal tension glaucoma, primary open angle glaucoma, congenital glaucoma, and secondary glaucoma. For each type of glaucoma there are likely numerous molecular pathways that control susceptibility to the disease. Given this complexity, a single animal model will never precisely model all aspects of all the different types of human glaucoma. Therefore, multiple animal models have been utilized to study glaucoma but more are needed. Because of the powerful genetic tools available to use in the laboratory mouse, it has proven to be a highly useful mammalian system for studying the pathophysiology of human disease. The similarity between human and mouse eyes coupled with the ability to use a combination of advanced cell biological and genetic tools in mice have led to a large increase in the number of studies using mice to model specific glaucoma phenotypes. Over the last decade, numerous new mouse models and genetic tools have emerged, providing important insight into the cell biology and genetics of glaucoma. In this review, we describe available mouse genetic models that can be used to study glaucoma-relevant disease/pathobiology. Furthermore, we discuss how these models have been used to gain insights into ocular hypertension (a major risk factor for glaucoma) and glaucomatous retinal ganglion cell death. Finally, the potential for developing new mouse models and using advanced genetic tools and resources for studying glaucoma are discussed.

Published
2015

22. Exome-based investigation of the genetic basis of human pigmentary glaucoma

Author

van der Heide, Carly, Goar, Wes, Meyer, Kacie J., Alward, Wallace L. M., Boese, Erin A., Sears, Nathan C., Roos, Ben R., Kwon, Young H., DeLuca, Adam P., Siggs, Owen M., Gonzaga-Jauregui, Claudia, Sheffield, Val C., Wang, Kai, Stone, Edwin M., Mullins, Robert F., Anderson, Michael G., Fan, Bao Jian, Ritch, Robert, Craig, Jamie E., Wiggs, Janey L., Scheetz, Todd E., and Fingert, John H.

Published
2021
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26. The Migratory Bird Treaty and a Century of Waterfowl Conservation

Author

ANDERSON, MICHAEL G., ALISAUSKAS, RAY T., BATT, BRUCE D. J., BLOHM, ROBERT J., HIGGINS, KENNETH F., PERRY, MATTHEW C., RINGELMAN, JAMES K., SEDINGER, JAMES S., SERIE, JEROME R., SHARP, DAVID E., TRAUGER, DAVID L., and WILLIAMS, CHRISTOPHER K.

Published
2018

44. Sirius I Prototype: A Prime-Power Source for Future 1 – 10 GJ Fusion-Yield Experiments

Author

Anderson, Michael G., primary, LeChien, Keith R., additional, Stygar, William A., additional, Max, Don. A., additional, Anaya, Enrique M., additional, Beatty, Cuyler B., additional, White, Adam D., additional, Trueblood, Jacob J., additional, Benson, Andrew M., additional, Beverly, Robert E., additional, Chaffee, Ronald S., additional, Cortes, John E., additional, Drews, William A., additional, Hicks, Randy K., additional, Howland, Fred A., additional, Norton, David B., additional, and Speer, Ronald D., additional

Published
2023
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45. The WARP Reactor Concept

Author

Anderson, Michael G., primary, Walters, James K., additional, Anaya, Enrique M., additional, Max, Don. A., additional, Stygar, William A., additional, and Link, Anthony J., additional

Published
2023
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