1. Derivation of Patient-Defined Adverse Cardiovascular and Noncardiovascular Events Through a Modified Delphi Process
- Author
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Jillian Rodger, Douglas S. Lee, Fraser D. Rubens, E. MacPhee, Aun-Yeong Chong, Jean Bilodeau, Louise Y. Sun, Sean van Diepen, Lisa Duffett, Thierry G. Mesana, Ann-Marie Julien, Heather Tulloch, Andrew M. Crean, Marc Ruel, and Rob S. Beanlands
- Subjects
Adult ,Male ,Canada ,medicine.medical_specialty ,Consensus ,Delphi Technique ,medicine.medical_treatment ,Delphi method ,Disease ,Computer-assisted web interviewing ,Renal Dialysis ,Physicians ,medicine ,Humans ,Patient Reported Outcome Measures ,Qualitative Research ,Dialysis ,Original Investigation ,Pace ,Heart Failure ,Rehabilitation ,business.industry ,Research ,General Medicine ,Respiration, Artificial ,Nursing Homes ,Hospitalization ,Stroke ,Online Only ,Caregivers ,Cardiovascular Diseases ,Emergency medicine ,Surgery ,Female ,Hemodialysis ,business ,Qualitative research - Abstract
Key Points Question Which adverse cardiovascular and noncardiovascular events are most relevant to patients? Findings In this qualitative study of patients with advanced cardiovascular diseases and their caregivers and clinicians, a consensus-based definition of patient-defined adverse cardiovascular and noncardiovascular events (PACE) was reached using a modified Delphi process; the definition included severe stroke necessitating hospitalization for 14 days or more or inpatient rehabilitation, ventilator dependence, new onset or worsening heart failure, nursing home admission, and new onset dialysis. Meaning Given the paucity of patient-centered outcomes in cardiovascular research, the concept of PACE may be applied in future epidemiological and intervention studies to ensure that management of cardiovascular disease is founded on outcomes that are important and relevant to patients, caregivers, and clinicians., This qualitative study attempts to derive patient-defined adverse cardiovascular and noncardiovascular events through a modified Delphi consensus-based process involving panel discussions with patients and their caregivers and clinicians., Importance There is little evidence to support patient-centered outcomes in patients with cardiovascular disease. Objective To derive patient-defined adverse cardiovascular and noncardiovascular events (PACE) through a consensus-based process. Design, Setting, and Participants This pan-Canadian, consensus-based, qualitative study used an iterative Delphi method to achieve consensus within a 35-member panel consisting of patients with cardiovascular diseases and their caregivers and clinicians. The process included 4 rounds of online questionnaires, followed by an in-person final consensus meeting. Data analysis was performed in September 2019. Main Outcomes and Measures Defining PACE as a 5-item composite outcome. Results Thirty-five potential panelists consented to participate, including 11 clinicians (8 men [73%]) and 24 patients and caregivers (13 men [54%]). Twenty-nine (83%), 28 (80%), 26 (74%), and 23 (66%) of the panelists participated in each of respective the online rounds. A shortlist of 11 patient-defined items was further refined at the in-person meeting, which 20 of the panelists attended. The PACE definition that was decided through the consensus process was a composite of severe stroke necessitating hospitalization for 14 days or longer or inpatient rehabilitation, ventilator dependence, new onset or worsening heart failure, nursing home admission, or new onset dialysis. Conclusions and Relevance This study defined PACE as a versatile, patient-centered outcome through a consensus process with input from patients, caregivers, and clinicians. Given the paucity of patient-centered outcomes in cardiovascular research, PACE may be considered as a potential outcome after methodological evaluation of its reliability.
- Published
- 2021