95,434 results on '"Arthur P"'
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2. Sitting foot: posture dependent changes of volume, edema and perfusion of the foot. A prospective interventional study with 27 volunteers
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Wolfgang Freund, Peter Wikstroem, Arthur P. Wunderlich, Uwe Schuetz, and Meinrad Beer
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Posture ,Sedentary lifestyle ,Edema ,Perfusion ,Osteochondritis ,Diseases of the musculoskeletal system ,RC925-935 - Abstract
Abstract Background Sitting is known to be bad for your cardiovascular health. We furthermore hypothesized that sitting posture will reduce perfusion of the foot and increase edema, possibly predisposing to disease like osteochondritis. Methods We included 27 healthy volunteers and performed MRI measurements including arterial spin labelling (ASL) and intravoxel incoherent motion (IVIM) perfusion as well as short tau inversion recovery (STIR) edema measurement and 3D volumetry. After randomization, the elevation of one foot during the day was used as an intervention. Results Intra- and interrater variability was 1–6%. ASL perfusion measurement was hindered by artifacts. IVIM perfusion showed no significant changes during supine measurements. Volumetry could demonstrate a highly significant (p = 0.00005) volume increase, while the intervention led to a significant (p = 0.0076) volume decrease during the day. However, the water content in STIR remained unchanged and the normalized (quotient bone/muscle) edema was reduced on the control side (p = 0.006) and increased on the intervention side (p = 0.01). Conclusions Sitting all day leads to swelling of the healthy foot. Compensation in healthy subjects seems to prevent lasting perfusion changes or edema evolution in the bone despite an increase of muscle signal and volume increase. Thus, the etiology of osteochondritis needs further studies.
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- 2024
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3. Deposition temperature-mediated growth of helically shaped polymers and chevron-type graphene nanoribbons from a fluorinated precursor
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Jacob D. Teeter, Mamun Sarker, Wenchang Lu, Chenggang Tao, Arthur P. Baddorf, Jingsong Huang, Kunlun Hong, Jerry Bernholc, Alexander Sinitskii, and An-Ping Li
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Chemistry ,QD1-999 - Abstract
Abstract Graphene nanoribbons (GNRs) of precise size and shape, critical for controlling electronic properties and future device applications, can be realized via precision synthesis on surfaces using rationally designed molecular precursors. Fluorine-bearing precursors have the potential to form GNRs on nonmetallic substrates suitable for device fabrication. Here, we investigate the deposition temperature-mediated growth of a new fluorine-bearing precursor, 6,11-diiodo-1,4-bis(2-fluorophenyl)-2,3-diphenyltriphenylene (C42H24F2I2), into helically shaped polymer intermediates and chevron-type GNRs on Au(111) by combining scanning tunneling microscopy, X-ray photoelectron spectroscopy, and density functional theory simulations. The fluorinated precursors do not adsorb on the Au(111) surface at lower temperatures, necessitating an optimum substrate temperature to achieve maximum polymer and GNR lengths. We compare the adsorption behavior with that of pristine chevron precursors and discuss the effects of C-H and C-F bonds. The results elucidate the growth mechanism of GNRs with fluorine-bearing precursors and establish a foundation for future synthesis of GNRs on nonmetallic substrates.
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- 2024
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4. Biodistribution of intravenously delivered PEGylated carbon nanotubes to the rat brain cortex
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Gisele Eva Bruch, Lidiane Dal Bosco, Arthur P. Cordeiro, Marcos F. Cordeiro, Sangram K. Sahoo, Carolina Peixoto, Marta C. Klosterhoff, Luis Alberto Romano, Cristiano Fantini, Adelina P. Santos, and Daniela M. Barros
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nanomedicine ,carbon nanotubes ,polyethylene glycol ,biodistribution ,Raman spectroscopy ,Technology - Abstract
Polyethylene glycol-functionalized single-walled carbon nanotubes (SWCNT-PEG) have been studied for many biomedical applications because of their unique physicochemical properties. Due to their reduced size and high stability in physiological media, SWCNT-PEG are candidates for crossing the blood–brain barrier (BBB), with potential use in treating central nervous system diseases that are currently unresponsive to pharmacological interventions because of the tightly regulated permeability of the BBB. In this study, we investigated the biodistribution of intravenously delivered SWCNT-PEG using Raman spectroscopy, as well as possible toxicological outcomes using morphological, histological, biochemical, and behavioral analyses. SWCNT-PEG were identified in the brain cortex, blood, spleen, and liver of rats. Biochemical and histological analyses did not reveal toxic effects in rats 24 h after SWCNT-PEG injection. Additionally, no behavioral impairments were observed in treated animals subjected to the Morris water maze task. Our preliminary experimental results clearly indicate that SWCNT-PEG were able to cross biological membranes and reach the rat brain cortex parenchyma (but not other brain structures) after systemic administration without the presence of acute toxic effects. The biodistribution of SWCNT-PEG in a specific region of the brain tissue encourages further studies regarding the application of SWCNTs in neuroscience.
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- 2025
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5. Sex-dependent interactions between prodromal intestinal inflammation and LRRK2 G2019S in mice promote endophenotypes of Parkinson’s disease
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Ping Fang, Lewis W. Yu, Hannah Espey, Gulistan Agirman, Sabeen A. Kazmi, Kai Li, Yongning Deng, Jamie Lee, Haley Hrncir, Arlene Romero-Lopez, Arthur P. Arnold, and Elaine Y. Hsiao
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Biology (General) ,QH301-705.5 - Abstract
Abstract Gastrointestinal (GI) disruptions and inflammatory bowel disease (IBD) are commonly associated with Parkinson’s disease (PD), but how they may impact risk for PD remains poorly understood. Herein, we provide evidence that prodromal intestinal inflammation expedites and exacerbates PD endophenotypes in rodent carriers of the human PD risk allele LRRK2 G2019S in a sex-dependent manner. Chronic intestinal damage in genetically predisposed male mice promotes α-synuclein aggregation in the substantia nigra, loss of dopaminergic neurons and motor impairment. This male bias is preserved in gonadectomized males, and similarly conferred by sex chromosomal complement in gonadal females expressing human LRRK2 G2019S. The early onset and heightened severity of neuropathological and behavioral outcomes in male LRRK2 G2019S mice is preceded by increases in α-synuclein in the colon, α-synuclein-positive macrophages in the colonic lamina propria, and loads of phosphorylated α-synuclein within microglia in the substantia nigra. Taken together, these data reveal that prodromal intestinal inflammation promotes the pathogenesis of PD endophenotypes in male carriers of LRRK2 G2019S, through mechanisms that depend on genotypic sex and involve early accumulation of α-synuclein in myeloid cells within the gut.
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- 2024
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6. Using training impulse and monotony methods to monitor aerobic training load in rats
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ARTHUR P. DA SILVA, MACÁRIO A. REBELO, RICARDO AUGUSTO BARBIERI, CARLOS D. DE CARVALHO, and CAMILA DE MORAES
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Training protocol ,Training monitoring ,Interval training ,Animal model research ,Science - Abstract
Abstract This study is the first to apply training impulse (TRIMP) and Training Monotony (TM) methodologies, within the realm of sport science, in animal model studies. Rats were divided into Sedentary (SED, n=10) and Training (TR, n=13). TR performed a four-week moderate-intensity interval training with load progression. Lactate kinetics, lactate training impulse (TRIMPLac), maximal speed training impulse (TRIMPSmax) and TM were utilized to develop and monitor training protocol. TR showed an 11.9% increase in time to exhaustion at the second maximum incremental test and a 17.5% increase at the third test. External work was increased by 17.8% at the second test and 30.3% at the third. There was a 10.6% increase in external work at the third test compared to the second for TR. No difference in TRIMPLac between the 1st week (94±9 A.U) and 3rdweek (83±10 A.U) were seen. TRIMPSmax was 2400 A.U. in the 1st week, 2760 A.U. in the 2nd and 3rd weeks, and 3120 A.U. in the 4th week. The TM remained at 1.24 A.U throughout the protocol and there was no dropouts. TRIMPLac and TRIMPSmax contributed to the development and monitoring loads, demonstrating their potential to improve the accuracy of training protocols in animal model research.
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- 2024
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7. Comment on 'Tunneling-tip-induced collapse of the charge gap in the excitonic insulator Ta_{2}NiSe_{5}'
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Dowook Kim, So Young Kim, Jun Sung Kim, Arthur P. Baddorf, An-Ping Li, and Tae-Hwan Kim
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Physics ,QC1-999 - Abstract
In this study, we investigate the discrepancy between the estimate of Q. He et al. [Phys. Rev. Res. 3, L032074 (2021)2643-156410.1103/PhysRevResearch.3.L032074], who observed a remarkable collapse of the exciton gap in Ta_{2}NiSe_{5} due to the electrostatic field between the scanning tunneling microscope (STM) tip and the sample, and that of a recent angle-resolved photoemission spectroscopy investigation [C. Chen et al., Phys. Rev. Res. 5, 043089 (2023)2643-156410.1103/PhysRevResearch.5.043089]. It is proposed that a critical factor contributing to this discrepancy is due to He et al.'s assumption of a constant work function of the STM tip. This assumption led to an underestimation of the tip-induced electric field. Using a literature value for the sample work function, a more substantial electric field strength is obtained, which resolves the apparent conflict between the doping estimates of these two techniques. Furthermore, our findings highlight the importance of the STM tip condition, which can significantly impact the tip work function and, consequently, influence the doping estimation in experiments involving tip-induced electric fields.
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- 2024
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8. Supply Rate and Equilibrium Inventory of Air Force Enlisted Personnel: A Simultaneous Model of the Accession and Retention Markets Incorporating Force Level Constraints. Final Report for Period July 1969-June 1976.
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Resources Research Corp., College Station, TX. and DeVany, Arthur S.
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This research was designed to develop and test a model of the Air Force manpower market. The study indicates that previous manpower supply studies failed to account for simultaneous determination of enlistments and retentions and misinterpreted regressions as supply equations. They are, instead, reduced form equations resulting from joint interaction of Air Force demand and enlistment supply activity. A stochastic process model is used to represent the Air Force manpower market. Variables determining manpower inventory levels, personnel turnover, and new enlistment flows are the mandated force level requirement, Air Force and civilian wages, the unemployment rate, and perceived civilian returns to Air Force-provided training. In the model it is possible to trace the impact of changes in the determining variables upon retention and enlistments. The empirical work supports the simultaneous demand and supply approach developed in the study. The results indicate that (1) changes in force level account for most enlistment rate changes during the all-volunteer force period, (2) higher Air Force wages have improved retention and reduce demand for new enlistments, (3) accessions show lower Air Force Qualifications Test scores, and (4) previous estimates of military manpower supply elasticities are biased downward from true elasticity. (Author/CSS)
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- 2024
9. Cerebellar growth, volume and diffusivity in children cooled for neonatal encephalopathy without cerebral palsy
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Chelsea Q. Wu, Frances M. Cowan, Sally Jary, Marianne Thoresen, Ela Chakkarapani, and Arthur P. C. Spencer
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Medicine ,Science - Abstract
Abstract Children cooled for HIE and who did not develop cerebral palsy (CP) still underperform at early school age in motor and cognitive domains and have altered supra-tentorial brain volumes and white matter connectivity. We obtained T1-weighted and diffusion-weighted MRI, motor (MABC-2) and cognitive (WISC-IV) scores from children aged 6–8 years who were cooled for HIE secondary to perinatal asphyxia without CP (cases), and controls matched for age, sex, and socioeconomic status. In 35 case children, we measured cerebellar growth from infancy (age 4–15 days after birth) to childhood. In childhood, cerebellar volumes were measured in 26 cases and 23 controls. Diffusion properties (mean diffusivity, MD and fractional anisotropy, FA) were calculated in 24 cases and 19 controls, in 9 cerebellar regions. Cases with FSIQ ≤ 85 had reduced growth of cerebellar width compared to those with FSIQ > 85 (p = 0.0005). Regional cerebellar volumes were smaller in cases compared to controls (p
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- 2023
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10. Identifying the secondary electron cutoff in ultraviolet photoemission spectra for work function measurements of non-ideal surfaces
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Arthur P. Baddorf
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Medicine ,Science - Abstract
Abstract Absolute values of work functions can be determined in ultraviolet photoemission spectroscopy (UPS) by measuring the minimum kinetic energy of secondary electrons generated by a known photon energy. However, some samples can produce spectra that are difficult to interpret due to additional intensity below the true secondary electron cutoff. Disordered absorbates on elemental metals add small intensity below the onset for the transition metal surfaces studied, which can be attributed to energy losses after photoelectrons are generated. In contrast, spectra from WO3−x films can produce multiple onsets with comparable intensity which do not fit this model. False onsets (in the context of work function measurements) can be minimized by optimizing experimental detection parameters including limiting analyzer acceptance angles and pass energy. True work functions can be identified by examining the onsets as the sample bias is varied.
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- 2023
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11. Modelling the impact of forest management and CO2-fertilisation on growth and demography in a Sitka spruce plantation
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Arthur P. K. Argles, Eddy Robertson, Anna B. Harper, James I. L. Morison, Georgios Xenakis, Astley Hastings, Jon Mccalmont, Jon R. Moore, Ian J. Bateman, Kate Gannon, Richard A. Betts, Stephen Bathgate, Justin Thomas, Matthew Heard, and Peter M. Cox
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Medicine ,Science - Abstract
Abstract Afforestation and reforestation to meet ‘Net Zero’ emissions targets are considered a necessary policy by many countries. Their potential benefits are usually assessed through forest carbon and growth models. The implementation of vegetation demography gives scope to represent forest management and other size-dependent processes within land surface models (LSMs). In this paper, we evaluate the impact of including management within an LSM that represents demography, using both in-situ and reanalysis climate drivers at a mature, upland Sitka spruce plantation in Northumberland, UK. We compare historical simulations with fixed and variable CO2 concentrations, and with and without tree thinning implemented. Simulations are evaluated against the observed vegetation structure and carbon fluxes. Including thinning and the impact of increasing CO2 concentration (‘CO2 fertilisation’) gave more realistic estimates of stand-structure and physical characteristics. Historical CO2 fertilisation had a noticeable effect on the Gross Primary Productivity seasonal–diurnal cycle and contributed to approximately 7% higher stand biomass by 2018. The net effect of both processes resulted in a decrease of tree density and biomass, but an increase in tree height and leaf area index.
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- 2023
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12. Mechanisms of antiviral action and toxicities of ipecac alkaloids: Emetine and dehydroemetine exhibit anti-coronaviral activities at non-cardiotoxic concentrations
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Viktoriya S. Sidorenko, Ira Cohen, Kunchok Dorjee, Conceição A. Minetti, David P. Remeta, Junyuan Gao, Irina Potapova, Hong Zhan Wang, Janet Hearing, Wan-Yi Yen, Hwan Keun Kim, Keiji Hashimoto, Masaaki Moriya, Kathleen G. Dickman, Xingyu Yin, Miguel Garcia-Diaz, Rajesh Chennamshetti, Radha Bonala, Francis Johnson, Amanda L. Waldeck, Ramesh Gupta, Chaoping Li, Kenneth J. Breslauer, Arthur P. Grollman, and Thomas A. Rosenquist
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Emetine ,Dehydroemetine ,SARS-CoV-2 ,Coronoviruses ,Antiviral ,Microbiology ,QR1-502 ,Infectious and parasitic diseases ,RC109-216 - Abstract
The emergence of highly infectious pathogens with their potential for triggering global pandemics necessitate the development of effective treatment strategies, including broad-spectrum antiviral therapies to safeguard human health. This study investigates the antiviral activity of emetine, dehydroemetine (DHE), and congeneric compounds against SARS-CoV-2 and HCoV-OC43, and evaluates their impact on the host cell. Concurrently, we assess the potential cardiotoxicity of these ipecac alkaloids. Significantly, our data reveal that emetine and the (-)-R,S isomer of 2,3-dehydroemetine (designated in this paper as DHE4) reduce viral growth at nanomolar concentrations (i.e., IC50 ∼ 50–100 nM), paralleling those required for inhibition of protein synthesis, while calcium channel blocking activity occurs at elevated concentrations (i.e., IC50 ∼ 40–60 µM). Our findings suggest that the antiviral mechanisms primarily involve disruption of host cell protein synthesis and is demonstrably stereoisomer specific. The prospect of a therapeutic window in which emetine or DHE4 inhibit viral propagation without cardiotoxicity renders these alkaloids viable candidates in strategies worthy of clinical investigation.
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- 2024
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13. Edaphic mesofauna responses to land use change for sugarcane cultivation: insights from contrasting soil textures
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Beatriz S. Vanolli, Nariane de Andrade, Lucas Pecci Canisares, André. L. C. Franco, Arthur P. A. Pereira, and Maurício R. Cherubin
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bioenergy ,soil biodiversity ,soil fauna ,soil health ,TSBF ,Evolution ,QH359-425 ,Ecology ,QH540-549.5 - Abstract
Land use change (LUC), specifically the cultivation of monoculture sugarcane, can negatively impact soil biodiversity, leading to a decline in soil health and ecosystem functioning. However, while studies focusing on macrofauna and microorganisms are more frequent in the literature, the impacts of LUC on mesofauna are still little known. Therefore, this study aimed to investigate the impacts of the predominant LUC for sugarcane production in Brazil on the diversity of edaphic mesofauna in soils with contrasting textures. In addition, we assessed correlations between biodiversity and soil properties chemical, biological, and physical attributes. We took samples from two sites (clayey and sandy soils) in southeastern Brazil. The sequence of LUC included i) native vegetation (NV), ii) pasture (PA), iii) sugarcane (SC), and iv) sugarcane ratoon (SCr). In the rainy season, monoliths (25 x 25 x 10 cm), soil samples were collected at 0-10, 10-20, and 20-30 cm to assess soil mesofauna, soil chemical (pH, soil organic matter, phosphorus, sulfur, potassium, calcium, magnesium, potential acidity, cation exchange capacity), physical (soil porosity) and biological (microbial biomass carbon and nitrogen) properties. The mesofauna taxonomic groups were quantified after the classification. Briefly, a total of 22 taxonomic groups were classified. The most predominant groups were non-oribatid mites, oribatid mites, and Collembola. Richness and abundance were lower in the three land uses studied (PA, SCr, SC) compared to the intercept (NV). In clayey soil, diversity decreased from NV to PA (-0.68 ± 0.27) and SC (-0.55 ± 0.27) but not to SCr. In sandy soil, land use significantly impacted the mesofauna diversity and evenness index, significantly reducing these indexes in SCr in relation to NV. Although land use change towards more intensified systems resulted in a loss of richness and abundance of soil mesofauna, sugarcane cultivation over the years can recover the diversity of mesofauna in clay-textured soils. These results provide a scientific background to better understand the LUC effects on sugarcane cultivation and support the establishment of sustainable practices that enhance soil health and biodiversity in different soil textures. This study highlights the need for tailored land management considering soil texture and biodiversity for improved ecosystem services.
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- 2024
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14. Development of the corpus callosum and cognition after neonatal encephalopathy
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Hollie Byrne, Arthur P. C. Spencer, Georgia Geary, Sally Jary, Marianne Thoresen, Frances M. Cowan, Jonathan C. W. Brooks, and Elavazhagan Chakkarapani
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Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
Abstract Objective Neonatal imaging studies report corpus callosum abnormalities after neonatal hypoxic–ischaemic encephalopathy (HIE), but corpus callosum development and relation to cognition in childhood are unknown. Using magnetic resonance imaging (MRI), we examined the relationship between corpus callosum size, microstructure and cognitive and motor outcomes at early school‐age children cooled for HIE (cases) without cerebral palsy compared to healthy, matched controls. A secondary aim was to examine the impact of HIE‐related neonatal brain injury on corpus callosum size, microstructure and growth. Methods Participants aged 6–8 years underwent MRI, the Movement Assessment Battery for Children Second Edition and Wechsler Intelligence Scale for Children Fourth Edition. Cross‐sectional area, volume, fractional anisotropy and radial diffusivity of the corpus callosum and five subdivisions were measured. Multivariable regression was used to assess associations between total motor score, full‐scale IQ (FSIQ) and imaging metrics. Results Adjusting for age, sex and intracranial volume, cases (N = 40) compared to controls (N = 39) demonstrated reduced whole corpus callosum area (β = −26.9, 95% confidence interval [CI] = −53.17, −0.58), volume (β = −138.5, 95% CI = −267.54, −9.56), fractional anisotropy and increased radial diffusivity (P
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- 2023
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15. Governing sustainability in the Thai palm oil-supply chain: the role of private actors
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Somjai Nupueng, Peter Oosterveer, and Arthur P. J. Mol
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palm oil ,roundtable on sustainhable palm oil (rspo) certification ,value chain ,governance ,sustainability ,private actors ,Social sciences (General) ,H1-99 - Abstract
Private actors are essential partners in the sustainability governance of commodity-supply chains such as palm oil. However, their actual contribution to promoting sustainability is also contested. This article assesses the role of private actors in the governance of the palm oil-supply chain in Thailand by comparing supply-chain actors that are certified with the Roundtable on Sustainable Palm Oil (RSPO) standards and non-certified supply-chain actors. The comparison entails input supply and production, collection and sales, processing and storage, and distribution. Building on the concept of (global) value chains, we examine the following governance dimensions in our comparison: the management of contracts and agreements, the role of trust in transactions, the relative power of various actors, and the control over smallholder farmers’ access to the market. Primary data were collected in the Surat Thani and Krabi Provinces in southern Thailand. We found that the RSPO-certified palm-oil chain was shorter, more transparent, and that farmers received higher prices than the non-RSPO-certified chains.
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- 2022
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16. Author Correction: Cerebellar growth, volume and diffusivity in children cooled for neonatal encephalopathy without cerebral palsy
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Chelsea Q. Wu, Frances M. Cowan, Sally Jary, Marianne Thoresen, Ela Chakkarapani, and Arthur P. C. Spencer
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Medicine ,Science - Published
- 2023
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17. Communication skills in children aged 6–8 years, without cerebral palsy cooled for neonatal hypoxic-ischemic encephalopathy
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Thomas J. Robb, James Tonks, Arthur P. C. Spencer, Sally Jary, Charlotte K. Whitfield, Marianne Thoresen, Frances M. Cowan, and Ela Chakkarapani
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Medicine ,Science - Abstract
Abstract We assessed communication skills of 48 children without cerebral palsy (CP) treated with therapeutic hypothermia (TH) for neonatal hypoxic-ischemic encephalopathy (HIE) (cases) compared to 42 controls at early school-age and examined their association with white matter diffusion properties in both groups and 18-month Bayley-III developmental assessments in cases. Parents completed a Children’s Communication Checklist (CCC-2) yielding a General Communication Composite (GCC), structural and pragmatic language scores and autistic-type behavior score. GCC ≤ 54 and thresholds of structural and pragmatic language score differences defined language impairment. Using tract-based spatial statistics (TBSS), fractional anisotropy (FA) was compared between 31 cases and 35 controls. Compared to controls, cases had lower GCC (p = 0.02), structural (p = 0.03) and pragmatic language score (p = 0.04) and higher language impairments (p = 0.03). GCC correlated with FA in the mid-body of the corpus callosum, the cingulum and the superior longitudinal fasciculus (p
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- 2022
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18. Genome Organization of Four Brazilian Xanthomonas albilineans Strains Does Not Correlate with Aggressiveness
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Raquel P. Miranda, Paula C. G. Turrini, Dora T. Bonadio, Marcelo M. Zerillo, Arthur P. Berselli, Silvana Creste, and Marie-Anne Van Sluys
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comparative genomics ,in vitro transcriptome ,mobile genetic elements ,SPI-1 T3SS ,pangenome ,whole-genome SNP ,Microbiology ,QR1-502 - Abstract
ABSTRACT An integrative approach combining genomics, transcriptomics, and cell biology is presented to address leaf scald disease, a major problem for the sugarcane industry. To gain insight into the biology of the causal agent, the complete genome sequences of four Brazilian Xanthomonas albilineans strains with differing virulence capabilities are presented and compared to the GPEPC73 reference strain and FJ1. Based on the aggressiveness index, different strains were compared: Xa04 and Xa11 are highly aggressive, Xa26 is intermediate, and Xa21 is the least, while, based on genome structure, Xa04 shares most of its genomic features with Xa26, and Xa11 share most of its genomic features with Xa21. In addition to presenting more clustered regularly interspaced short palindromic repeats (CRISPR) clusters, four more novel prophage insertions are present than the previously sequenced GPEPC73 and FJ1 strains. Incorporating the aggressiveness index and in vitro cell biology into these genome features indicates that disease establishment is not a result of a single determinant factor, as in most other Xanthomonas species. The Brazilian strains lack the previously described plasmids but present more prophage regions. In pairs, the most virulent and the least virulent share unique prophages. In vitro transcriptomics shed light on the 54 most highly expressed genes among the 4 strains compared to ribosomal proteins (RPs), of these, 3 outer membrane proteins. Finally, comparative albicidin inhibition rings and in vitro growth curves of the four strains also do not correlate with pathogenicity. In conclusion, the results disclose that leaf scald disease is not associated with a single shared characteristic between the most or the least pathogenic strains. IMPORTANCE An integrative approach is presented which combines genomics, transcriptomics, and cell biology to address leaf scald disease. The results presented here disclose that the disease is not associated with a single shared characteristic between the most pathogenic strains or a unique genomic pattern. Sequence data from four Brazilian strains are presented that differ in pathogenicity index: Xa04 and Xa11 are highly virulent, Xa26 is intermediate, and Xa21 is the least pathogenic strain, while, based on genome structure, Xa04 shares with Xa26, and Xa11 shares with X21 most of the genome features. Other than presenting more CRISPR clusters and prophages than the previously sequenced strains, the integration of aggressiveness and cell biology points out that disease establishment is not a result of a single determinant factor as in other xanthomonads.
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- 2023
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19. State and Federal Legislators’ Responses on Social Media to the Mental Health and Burnout of Health Care Workers Throughout the COVID-19 Pandemic: Natural Language Processing and Sentiment Analysis
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Matthew P Abrams, Arthur P Pelullo, Zachary F Meisel, Raina M Merchant, Jonathan Purtle, and Anish K Agarwal
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Computer applications to medicine. Medical informatics ,R858-859.7 - Abstract
BackgroundBurnout and the mental health burden of the COVID-19 pandemic have disproportionately impacted health care workers. The links between state policies, federal regulations, COVID-19 case counts, strains on health care systems, and the mental health of health care workers continue to evolve. The language used by state and federal legislators in public-facing venues such as social media is important, as it impacts public opinion and behavior, and it also reflects current policy-leader opinions and planned legislation. ObjectiveThe objective of this study was to examine legislators’ social media content on Twitter and Facebook throughout the COVID-19 pandemic to thematically characterize policy makers’ attitudes and perspectives related to mental health and burnout in the health care workforce. MethodsLegislators’ social media posts about mental health and burnout in the health care workforce were collected from January 2020 to November 2021 using Quorum, a digital database of policy-related documents. The total number of relevant social media posts per state legislator per calendar month was calculated and compared with COVID-19 case volume. Differences between themes expressed in Democratic and Republican posts were estimated using the Pearson chi-square test. Words within social media posts most associated with each political party were determined. Machine-learning was used to evaluate naturally occurring themes in the burnout- and mental health–related social media posts. ResultsA total of 4165 social media posts (1400 tweets and 2765 Facebook posts) were generated by 2047 unique state and federal legislators and 38 government entities. The majority of posts (n=2319, 55.68%) were generated by Democrats, followed by Republicans (n=1600, 40.34%). Among both parties, the volume of burnout-related posts was greatest during the initial COVID-19 surge. However, there was significant variation in the themes expressed by the 2 major political parties. Themes most correlated with Democratic posts were (1) frontline care and burnout, (2) vaccines, (3) COVID-19 outbreaks, and (4) mental health services. Themes most correlated with Republican social media posts were (1) legislation, (2) call for local action, (3) government support, and (4) health care worker testing and mental health. ConclusionsState and federal legislators use social media to share opinions and thoughts on key topics, including burnout and mental health strain among health care workers. Variations in the volume of posts indicated that a focus on burnout and the mental health of the health care workforce existed early in the pandemic but has waned. Significant differences emerged in the content posted by the 2 major US political parties, underscoring how each prioritized different aspects of the crisis.
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- 2023
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20. A Brain Age Residual Biomarker (BARB): Leveraging MRI-Based Models to Detect Latent Health Conditions in U.S. Veterans
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Bousquet, Arthur, Banerji, Sugata, Conneely, Mark F., and Jamshidi, Shahrzad
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Computer Science - Machine Learning - Abstract
Age prediction using brain imaging, such as MRIs, has achieved promising results, with several studies identifying the model's residual as a potential biomarker for chronic disease states. In this study, we developed a brain age predictive model using a dataset of 1,220 U.S. veterans (18--80 years) and convolutional neural networks (CNNs) trained on two-dimensional slices of axial T2-weighted fast spin-echo and T2-weighted fluid attenuated inversion recovery MRI images. The model, incorporating a degree-3 polynomial ensemble, achieved an $R^{2}$ of 0.816 on the testing set. Images were acquired at the level of the anterior commissure and the frontal horns of the lateral ventricles. Residual analysis was performed to assess its potential as a biomarker for five ICD-coded conditions: hypertension (HTN), diabetes mellitus (DM), mild traumatic brain injury (mTBI), illicit substance abuse/dependence (SAD), and alcohol abuse/dependence (AAD). Residuals grouped by the number of ICD-coded conditions demonstrated different trends that were statistically significant ($p = 0.002$), suggesting a relationship between disease states and predicted brain age. This association was particularly pronounced in patients over 49 years, where negative residuals (indicating advanced brain aging) correlated with the presence of multiple ICD codes. These findings support the potential of residuals as biomarkers for detecting latent health conditions.
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- 2025
21. Modeling User Preference in Single-Finger Grasping Interactions
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Caetano, Arthur, Luo, Yunhao, and Sra, Misha
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Computer Science - Human-Computer Interaction - Abstract
Grasp User Interfaces (GPUIs) are well-suited for dual-tasking between virtual and physical tasks. These interfaces do not require users to release handheld objects, supporting microinteractions that happen in short bursts and cause minimal interruption on the physical task. Design approaches for these interfaces include user elicitation studies and expert-based strategies, which can be combined with computational techniques for quicker and more cost-effective iterations. Current computational tools for designing GPUIs utilize simulations based on kinematic, geometric, and biomechanical parameters. However, the relationship between these low-level factors and higher-level user preferences remains underexplored. In this study, we gathered user preferences using a two-alternative forced choice paradigm with single-finger reach tasks performed while holding objects representative of real-world activities with different grasp types. We present a quantitative analysis of how various low-level factors influence user preference in grasp interactions, identifying the most significant ones. Leveraging this analysis, we developed a predictive model to estimate user preference and integrated it into an existing simulation tool for GPUI design. In addition to enhancing the understanding of design factors in grasp interactions, our predictive model provides a spatial utility metric based on user preferences, paving the way for adaptive GPUI and mixed-initiative systems for better dual-tasking between virtual and physical environments.
- Published
- 2025
22. Accelerated Diffusion Models via Speculative Sampling
- Author
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De Bortoli, Valentin, Galashov, Alexandre, Gretton, Arthur, and Doucet, Arnaud
- Subjects
Computer Science - Machine Learning ,Statistics - Machine Learning - Abstract
Speculative sampling is a popular technique for accelerating inference in Large Language Models by generating candidate tokens using a fast draft model and accepting or rejecting them based on the target model's distribution. While speculative sampling was previously limited to discrete sequences, we extend it to diffusion models, which generate samples via continuous, vector-valued Markov chains. In this context, the target model is a high-quality but computationally expensive diffusion model. We propose various drafting strategies, including a simple and effective approach that does not require training a draft model and is applicable out of the box to any diffusion model. Our experiments demonstrate significant generation speedup on various diffusion models, halving the number of function evaluations, while generating exact samples from the target model.
- Published
- 2025
23. Optimality and Adaptivity of Deep Neural Features for Instrumental Variable Regression
- Author
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Kim, Juno, Meunier, Dimitri, Gretton, Arthur, Suzuki, Taiji, and Li, Zhu
- Subjects
Statistics - Machine Learning ,Computer Science - Machine Learning - Abstract
We provide a convergence analysis of deep feature instrumental variable (DFIV) regression (Xu et al., 2021), a nonparametric approach to IV regression using data-adaptive features learned by deep neural networks in two stages. We prove that the DFIV algorithm achieves the minimax optimal learning rate when the target structural function lies in a Besov space. This is shown under standard nonparametric IV assumptions, and an additional smoothness assumption on the regularity of the conditional distribution of the covariate given the instrument, which controls the difficulty of Stage 1. We further demonstrate that DFIV, as a data-adaptive algorithm, is superior to fixed-feature (kernel or sieve) IV methods in two ways. First, when the target function possesses low spatial homogeneity (i.e., it has both smooth and spiky/discontinuous regions), DFIV still achieves the optimal rate, while fixed-feature methods are shown to be strictly suboptimal. Second, comparing with kernel-based two-stage regression estimators, DFIV is provably more data efficient in the Stage 1 samples., Comment: 46 pages, 1 figure, 2 tables
- Published
- 2025
24. State-dependent preconditioning for the inner-loop in Variational Data Assimilation using Machine Learning
- Author
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Trappler, Victor and Vidard, Arthur
- Subjects
Mathematics - Optimization and Control - Abstract
Data Assimilation is the process in which we improve the representation of the state of a physical system by combining information coming from a numerical model, real-world observations, and some prior modelling. It is widely used to model and to improve forecast systems in Earth science fields such as meteorology, oceanography and environmental sciences. One key aspect of Data assimilation is the analysis step, where the output of the numerical model is adjusted in order to account for the observational data. In Variational Data Assimilation and under Gaussian assumptions, the analysis step comes down to solving a high-dimensional non-linear least-square problem. In practice, this minimization involves successive inversions of large, and possibly ill-conditioned matrices constructed using linearizations of the forward model. In order to improve the convergence rate of these methods, and thus reduce the computational burden, preconditioning techniques are often used to get better-conditioned matrices, but require either the sparsity pattern of the matrix to inverse, or some spectral information. We propose to use Deep Neural Networks in order to construct a preconditioner. This surrogate is trained using some properties of the singular value decomposition, and is based on a dataset which can be constructed online to reduce the storage requirements.
- Published
- 2025
25. Mixing by Internal Gravity Waves in Stars: Assessing Numerical Simulations Against Theory
- Author
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Morton, Jack, Guillet, Thomas, Baraffe, Isabelle, Morison, Adrien, Saux, Arthur Le, Vlaykov, Dimitar, Goffrey, Tom, and Pratt, Jane
- Subjects
Astrophysics - Solar and Stellar Astrophysics - Abstract
Here we present a study of radial chemical mixing in non-rotating massive main-sequence stars driven by internal gravity waves (IGWs), based on multi-dimensional hydrodynamical simulations with the fully compressible code MUSIC. We examine two proposed mechanisms of material mixing in stars by IGWs that are commonly quoted, relating to thermal diffusion and sub-wavelength shearing. Thermal diffusion provides a non-restorative effect to the waves, leaving material displaced from its previous equilibrium, while shearing arising within the waves drives weak localised flows, mixing the fluid there. Using IGW spectra from the simulations, we evaluate theoretical predictions of mixing rates due to these mechanisms. We show, for $20M_\odot$ main-sequence stars, that neither of these mechanisms are likely to create mixing sufficient to correct inaccuracies in current stellar evolution models. Furthermore, we compare these predictions to results obtained from Lagrangian tracer particles, following a method recently used for global simulations of stellar interiors to measure mixing by IGWs in their radiative zones. We demonstrate that tracer particle methods face significant numerical challenges in measuring the small diffusion coefficients predicted by the aforementioned theories, for which they are prone to yielding artificially enhanced coefficients. Diffusion coefficients based on such methods are currently used with stellar evolution codes for asteroseismic studies, but should be viewed with caution. Finally, in a case where tracer particles do not suffer from numerical artefacts, we suggest that a diffusion model is not suitable for timescales typically considered by two-dimensional numerical simulations., Comment: 18 pages, 13 figures; to be published in MNRAS
- Published
- 2025
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- View/download PDF
26. A symmetric function approach to log-concavity of independence polynomials
- Author
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Li, Ethan Y. H., Li, Grace M. X., Yang, Arthur L. B., and Zhang, Zhong-Xue
- Subjects
Mathematics - Combinatorics ,05C69, 05E05, 05C05, 05C15 - Abstract
As introduced by Gutman and Harary, the independence polynomial of a graph serves as the generating polynomial of its independent sets. In 1987, Alavi, Malde, Schwenk and Erd\H{o}s conjectured that the independence polynomials of all trees are unimodal. In this paper we come up with a new way for proving log-concavity of independence polynomials of graphs by means of their chromatic symmetric functions, which is inspired by a result of Stanley connecting properties of polynomials to positivity of symmetric functions. This method turns out to be more suitable for treating trees with irregular structures, and as a simple application we show that all spiders have log-concave independence polynomials, which provides more evidence for the above conjecture. Moreover, we present two symmetric function analogues of a basic recurrence formula for independence polynomials, and show that all pineapple graphs also have log-concave independence polynomials., Comment: 19 pages, 5 figures
- Published
- 2025
27. Fundamentals of Antenna Bandwidth and Quality Factor
- Author
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Yaghjian, Arthur D.
- Subjects
Physics - Classical Physics - Abstract
After a brief history of the development of quality factor, useful expressions are derived for the robust Qz(w) quality factor that accurately determines the VSWR input-impedance fractional bandwidth of antennas for isolated resonances and a small enough bandwidth power drop. For closely spaced multiple resonances/antiresonances, a definitive formula is given for the increase in fractional bandwidth enabled by Bode-Fano matching. Methods are given for determining the conventional and complex-energy quality factors of antennas from RLC circuit models. New field-based quality factors Q(w) are derived for antennas with known fields produced by an input current I. These Q(w) are remarkably robust because they equal Qz(w) when the input impedance is available. Like Qz(w), the field-based Q(w) is independent of the choice of origin of the antenna fields and is impervious to extra lengths of transmission lines and surplus reactances. These robust field-based quality factors are used to derive new lower bounds on the quality factors (upper bounds on the bandwidths) of spherical-mode antennas that improve upon the previous Chu/Collin-Rothschild lower bounds for spherical modes. A criterion for antenna supergain is found by combining the Harrington maximum gain formula with the recently derived formula for the reactive power boundaries of antennas. Maximum gain versus minimum quality factor for spherical antennas are determined using the improved lower bounds on quality factor for different values of electrical size ka. Lastly, reduced antenna quality factors allowed by dispersive tuning overcome the traditional Chu lower bounds for lower radiation efficiencies and small enough bandwidth power drops., Comment: 15 pages, 8 figures
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- 2025
28. Human Gaze Boosts Object-Centered Representation Learning
- Author
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Schaumlöffel, Timothy, Aubret, Arthur, Roig, Gemma, and Triesch, Jochen
- Subjects
Computer Science - Computer Vision and Pattern Recognition ,Computer Science - Machine Learning - Abstract
Recent self-supervised learning (SSL) models trained on human-like egocentric visual inputs substantially underperform on image recognition tasks compared to humans. These models train on raw, uniform visual inputs collected from head-mounted cameras. This is different from humans, as the anatomical structure of the retina and visual cortex relatively amplifies the central visual information, i.e. around humans' gaze location. This selective amplification in humans likely aids in forming object-centered visual representations. Here, we investigate whether focusing on central visual information boosts egocentric visual object learning. We simulate 5-months of egocentric visual experience using the large-scale Ego4D dataset and generate gaze locations with a human gaze prediction model. To account for the importance of central vision in humans, we crop the visual area around the gaze location. Finally, we train a time-based SSL model on these modified inputs. Our experiments demonstrate that focusing on central vision leads to better object-centered representations. Our analysis shows that the SSL model leverages the temporal dynamics of the gaze movements to build stronger visual representations. Overall, our work marks a significant step toward bio-inspired learning of visual representations., Comment: 13 pages
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- 2025
29. Seeing the Whole in the Parts in Self-Supervised Representation Learning
- Author
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Aubret, Arthur, Teulière, Céline, and Triesch, Jochen
- Subjects
Computer Science - Machine Learning ,Computer Science - Computer Vision and Pattern Recognition - Abstract
Recent successes in self-supervised learning (SSL) model spatial co-occurrences of visual features either by masking portions of an image or by aggressively cropping it. Here, we propose a new way to model spatial co-occurrences by aligning local representations (before pooling) with a global image representation. We present CO-SSL, a family of instance discrimination methods and show that it outperforms previous methods on several datasets, including ImageNet-1K where it achieves 71.5% of Top-1 accuracy with 100 pre-training epochs. CO-SSL is also more robust to noise corruption, internal corruption, small adversarial attacks, and large training crop sizes. Our analysis further indicates that CO-SSL learns highly redundant local representations, which offers an explanation for its robustness. Overall, our work suggests that aligning local and global representations may be a powerful principle of unsupervised category learning., Comment: 20 pages
- Published
- 2025
30. Fundamental polytope for the isometry group of an alcove
- Author
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Seco, Lucas, Garnier, Arthur, and Neeb, Karl-Hermann
- Subjects
Mathematics - Combinatorics ,Mathematics - Group Theory ,Primary 17B22, 51F15, 20F55, Secondary 57R91, 57Q15 - Abstract
A fundamental alcove $\mathcal{A}$ is a tile in a paving of a vector space $V$ by an affine reflection group $W_{\mathrm{aff}}$. Its geometry encodes essential features of $W_{\mathrm{aff}}$, such as its affine Dynkin diagram $\widetilde{D}$ and fundamental group $\Omega$. In this article we investigate its full isometry group $\mathrm{Aut}(\mathcal{A})$. It is well known that the isometry group of a regular polyhedron is generated by hyperplane reflections on its faces. Being a simplex, an alcove $\mathcal{A}$ is the simplest of polyhedra, nevertheless it is seldom a regular one. In our first main result we show that $\mathrm{Aut}(\mathcal{A})$ is isomorphic to $\mathrm{Aut}(\widetilde{D})$. Building on this connection, we establish that $\mathrm{Aut}(\mathcal{A})$ is an abstract Coxeter group, with generators given by affine isometric involutions of the ambient space. Although these involutions are seldom reflections, our second main result leverages them to construct, by slicing the Komrakov--Premet fundamental polytope $\mathcal{K}$ for the action of $\Omega$, a family of fundamental polytopes for the action of $\mathrm{Aut}(\mathcal{A})$ on $\mathcal{A}$, whose vertices are contained in the vertices of $\mathcal{K}$ and whose faces are parametrized by the so-called balanced minuscule roots, which we introduce here. In an appendix, we discuss some related negative results on stratified centralizers and equivariant triangulations., Comment: 6 Figures, 3 Tables
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- 2025
31. Dynamic realization of emergent high-dimensional optical vortices
- Author
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Kim, Dongha, Park, Geonhyeong, Choi, Yun-Seok, Baucour, Arthur, Hwang, Jisung, Park, Sanghyeok, Yun, Hee Seong, Shin, Jonghwa, Wang, Haiwen, Fan, Shanhui, Yoon, Dong Ki, and Seo, Min-Kyo
- Subjects
Physics - Optics ,Condensed Matter - Mesoscale and Nanoscale Physics - Abstract
The dimensionality of vortical structures has recently been extended beyond two dimensions, providing higher-order topological characteristics and robustness for high-capacity information processing and turbulence control. The generation of high-dimensional vortical structures has mostly been demonstrated in classical systems through the complex interference of fluidic, acoustic, or electromagnetic waves. However, natural materials rarely support three- or higher-dimensional vortical structures and their physical interactions. Here, we present a high-dimensional gradient thickness optical cavity (GTOC) in which the optical coupling of planar metal-dielectric multilayers implements topological interactions across multiple dimensions. Topological interactions in high-dimensional GTOC construct non-trivial topological phases, which induce high-dimensional vortical structures in generalized parameter space in three, four dimensions, and beyond. These emergent high-dimensional vortical structures are observed under electro-optic tomography as optical vortex dynamics in two-dimensional real-space, employing the optical thicknesses of the dielectric layers as synthetic dimensions. We experimentally demonstrate emergent vortical structures, optical vortex lines and vortex rings, in a three-dimensional generalized parameter space and their topological transitions. Furthermore, we explore four-dimensional vortical structures, termed optical vortex sheets, which provide the programmability of real-space optical vortex dynamics. Our findings hold significant promise for emulating high-dimensional physics and developing active topological photonic devices., Comment: 21 pages,5 figures
- Published
- 2025
32. Universal Embedding spaces for $G$-manifolds
- Author
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Wasserman, Arthur G.
- Subjects
Mathematics - Algebraic Topology ,57S15(primary), 57R91(secondary) - Abstract
For any compact Lie group $G$ and any $n$ we construct a smooth $G$-manifold $U_n(G)$ such that any smooth $n$-dimensional $G$-manifold can be embedded in $U_n(G)$ with a trivial normal bundle. Furthermore, we show that such embeddings are unique up to equivariant isotopy It is shown that the (inverse limit) of the cohomology of such spaces gives rise to natural classes which are the analogue for $G$-manifolds of characteristic classes for ordinary manifolds. The cohomotopy groups of $U_n(G)$ are shown to be equal to equivariant bordism groups.
- Published
- 2024
33. A 6-functor formalism for solid quasi-coherent sheaves on the Fargues-Fontaine curve
- Author
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Anschütz, Johannes, Bras, Arthur-César Le, and Mann, Lucas
- Subjects
Mathematics - Algebraic Geometry ,Mathematics - Number Theory - Abstract
We develop a 6-functor formalism $\mathcal{D}_{[0,\infty)}(-)$ with $\mathbb{Z}_p$-linear coefficients on small v-stacks, and discuss consequences for duality and finiteness for pro-\'etale cohomology of rigid-analytic varieties of general pro-\'etale $\mathbb{Q}_p$-local systems as well as first examples motivated by a potential $p$-adic analog of Fargues-Scholze's geometrization program of the local Langlands correspondence., Comment: 85 pages. Comments welcome!
- Published
- 2024
34. A phase transition for the biased tree-builder random walk
- Author
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Blanc-Renaudie, Arthur, Cazaux, Camille, Conchon-Kerjan, Guillaume, Lions, Tanguy, and Singh, Arvind
- Subjects
Mathematics - Probability ,60K35 - Abstract
We consider a recent model of random walk that recursively grows the network on which it evolves, namely the Tree Builder Random Walk (TBRW). We introduce a bias $\rho \in (0,\infty)$ towards the root, and exhibit a phase transition for transience/recurrence at a critical threshold $\rho_c =1+2\overline{\nu}$, where $\overline{\nu}$ is the (possibly infinite) expected number of new leaves attached to the walker's position at each step. This generalizes previously known results, which focused on the unbiased case $\rho=1$. The proofs rely on a recursive analysis of the local times of the walk at each vertex of the tree, after a given number of returns to the root. We moreover characterize the strength of the transience (law of large numbers and central limit theorem with positive speed) via standard arguments, establish recurrence at $\rho_c$, and show a condensation phenomenon in the non-critical recurrent case.
- Published
- 2024
35. Habitability in 4-D: Predicting the Climates of Earth Analogs across Rotation and Orbital Configurations
- Author
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Adams, Arthur D., Colose, Christopher, Merrelli, Aronne, Turnbull, Margaret, and Kane, Stephen R.
- Subjects
Astrophysics - Earth and Planetary Astrophysics - Abstract
Earth-like planets in the circumstellar habitable zone (HZ) may have dramatically different climate outcomes depending on their spin-orbit parameters, altering their habitability for life as we know it. We present a suite of 93 ROCKE-3D general circulation models (GCMs) for planets with the same surface conditions and average annual insolation as Earth, but with a wide range of rotation periods, obliquities, orbital eccentricities, and longitudes of periastra. Our habitability metric $f_\mathrm{HZ}$ is calculated based on the temperature and precipitation in each model across grid cells over land. Latin Hypercube Sampling (LHS) aids in sampling all 4 of the spin-orbit parameters with a computationally feasible number of GCM runs. Statistical emulation then allows us to model $f_\mathrm{HZ}$ as a smooth function with built-in estimates of statistical uncertainty. We fit our emulator to an initial set of 46 training runs, then test with an additional 46 runs at different spin-orbit values. Our emulator predicts the directly GCM-modeled habitability values for the test runs at the appropriate level of accuracy and precision. For orbital eccentricities up to 0.225, rotation period remains the primary driver of the fraction of land that remains above freezing and with precipitation above a threshold value. For rotation periods greater than $\sim 20$ days, habitability drops significantly (from $\sim 70$% to $\sim 20$%), driven primarily by cooler land temperatures. Obliquity is a significant secondary factor for rotation periods less than $\sim 20$ Earth days, with a factor of two impact on habitability that is maximized at intermediate obliquity., Comment: Accepted for publication in the Astrophysical Journal
- Published
- 2024
36. Towards structure-preserving quantum encodings
- Author
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Parzygnat, Arthur J., Bradley, Tai-Danae, Vlasic, Andrew, and Pham, Anh
- Subjects
Quantum Physics ,Computer Science - Machine Learning ,Mathematics - Category Theory - Abstract
Harnessing the potential computational advantage of quantum computers for machine learning tasks relies on the uploading of classical data onto quantum computers through what are commonly referred to as quantum encodings. The choice of such encodings may vary substantially from one task to another, and there exist only a few cases where structure has provided insight into their design and implementation, such as symmetry in geometric quantum learning. Here, we propose the perspective that category theory offers a natural mathematical framework for analyzing encodings that respect structure inherent in datasets and learning tasks. We illustrate this with pedagogical examples, which include geometric quantum machine learning, quantum metric learning, topological data analysis, and more. Moreover, our perspective provides a language in which to ask meaningful and mathematically precise questions for the design of quantum encodings and circuits for quantum machine learning tasks., Comment: 17 pages body, 10 pages back matter; Comments welcome!
- Published
- 2024
37. Deliberation in Latent Space via Differentiable Cache Augmentation
- Author
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Liu, Luyang, Pfeiffer, Jonas, Wu, Jiaxing, Xie, Jun, and Szlam, Arthur
- Subjects
Computer Science - Computation and Language ,Computer Science - Artificial Intelligence ,Computer Science - Machine Learning - Abstract
Techniques enabling large language models (LLMs) to "think more" by generating and attending to intermediate reasoning steps have shown promise in solving complex problems. However, the standard approaches generate sequences of discrete tokens immediately before responding, and so they can incur significant latency costs and be challenging to optimize. In this work, we demonstrate that a frozen LLM can be augmented with an offline coprocessor that operates on the model's key-value (kv) cache. This coprocessor augments the cache with a set of latent embeddings designed to improve the fidelity of subsequent decoding. We train this coprocessor using the language modeling loss from the decoder on standard pretraining data, while keeping the decoder itself frozen. This approach enables the model to learn, in an end-to-end differentiable fashion, how to distill additional computation into its kv-cache. Because the decoder remains unchanged, the coprocessor can operate offline and asynchronously, and the language model can function normally if the coprocessor is unavailable or if a given cache is deemed not to require extra computation. We show experimentally that when a cache is augmented, the decoder achieves lower perplexity on numerous subsequent tokens. Furthermore, even without any task-specific training, our experiments demonstrate that cache augmentation consistently reduces perplexity and improves performance across a range of reasoning-intensive tasks.
- Published
- 2024
38. Editing Implicit and Explicit Representations of Radiance Fields: A Survey
- Author
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Hubert, Arthur, Elghazaly, Gamal, and Frank, Raphael
- Subjects
Computer Science - Computer Vision and Pattern Recognition - Abstract
Neural Radiance Fields (NeRF) revolutionized novel view synthesis in recent years by offering a new volumetric representation, which is compact and provides high-quality image rendering. However, the methods to edit those radiance fields developed slower than the many improvements to other aspects of NeRF. With the recent development of alternative radiance field-based representations inspired by NeRF as well as the worldwide rise in popularity of text-to-image models, many new opportunities and strategies have emerged to provide radiance field editing. In this paper, we deliver a comprehensive survey of the different editing methods present in the literature for NeRF and other similar radiance field representations. We propose a new taxonomy for classifying existing works based on their editing methodologies, review pioneering models, reflect on current and potential new applications of radiance field editing, and compare state-of-the-art approaches in terms of editing options and performance.
- Published
- 2024
39. An Interaction Design Toolkit for Physical Task Guidance with Artificial Intelligence and Mixed Reality
- Author
-
Caetano, Arthur, Aponte, Alejandro, and Sra, Misha
- Subjects
Computer Science - Human-Computer Interaction ,H.5 - Abstract
Physical skill acquisition, from sports techniques to surgical procedures, requires instruction and feedback. In the absence of a human expert, Physical Task Guidance (PTG) systems can offer a promising alternative. These systems integrate Artificial Intelligence (AI) and Mixed Reality (MR) to provide realtime feedback and guidance as users practice and learn skills using physical tools and objects. However, designing PTG systems presents challenges beyond engineering complexities. The intricate interplay between users, AI, MR interfaces, and the physical environment creates unique interaction design hurdles. To address these challenges, we present an interaction design toolkit derived from our analysis of PTG prototypes developed by eight student teams during a 10-week-long graduate course. The toolkit comprises Design Considerations, Design Patterns, and an Interaction Canvas. Our evaluation suggests that the toolkit can serve as a valuable resource for practitioners designing PTG systems and researchers developing new tools for human-AI interaction design.
- Published
- 2024
40. Bi-normal trajectories in the Circular Restricted Three-Body Problem
- Author
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Moreno, Agustin and Limoge, Arthur
- Subjects
Mathematics - Symplectic Geometry - Abstract
In this note, we show there exist infinitely many trajectories which are bi-normal (i.e. normal at initial and final times) to the xz-plane, in the Spatial Circular Restricted Three-Body Problem, for energies below or slightly above the first critical value and near the primaries, under the assumption of the twist condition as defined by Moreno-van-Koert in arXiv:2011.06562. This is an application of the relative Poincar\'e-Birkhoff theorem for Lagrangians in Liouville domains, as proven by the authors in arXiv:2408.06919.
- Published
- 2024
41. Strongly interacting matter in extreme magnetic fields
- Author
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Adhikari, Prabal, Ammon, Martin, Avancini, Sidney S., Ayala, Alejandro, Bandyopadhyay, Aritra, Blaschke, David, Braghin, Fabio L., Buividovich, Pavel, Cardoso, Rafael P., Cartwright, Casey, Castaño-Yepes, Jorge David, Chernodub, Maxim, Coppola, M., Das, Mayusree, Dutra, Mariana, Endrődi, Gergely, Fang, Jianjun, Farias, Ricardo L. S., Fraga, Eduardo S., Frazon, Arthur, Fukushima, Kenji, García-Muñoz, Juan D., Garnacho-Velasco, Eduardo, Dumm, D. Gomez, Grieninger, Sebastian, Gulminelli, Francesca, Hernandez, Juan, Islam, Chowdhury Aminul, Kaminski, Matthias, Kotov, Andrey, Krein, Gastão, Li, Jing, Lo, Pok Man, Loewe, Marcelo, Lourenço, Odilon, Markó, Gergely, Marquez, Kau D., Mizher, Ana, Mukhopadhyay, Banibrata, Muñoz, Enrique, Noguera, S., Nunes, Rodrigo M., Pais, Helena, Palhares, Letícia F., Providência, Constança, Raya, Alfredo, Restrepo, Tulio, Rojas, Juan Cristóbal, Scoccola, N. N., Scurto, Luigi, Sedrakian, Armen, Smith, Dominik, Tavares, William Rafael, Tejeda-Yeomans, Maria E., Timóteo, Varese S., Tolos, Laura, Villavicencio, Cristian, Weber, Fridolin, Yasui, Shigehiro, Zamora, Renato, and Zuraiq, Zenia
- Subjects
Nuclear Theory - Abstract
Magnetic fields are ubiquitous across different physical systems of current interest; from the early Universe, compact astrophysical objects and heavy-ion collisions to condensed matter systems. A proper treatment of the effects produced by magnetic fields during the dynamical evolution of these systems, can help to understand observables that otherwise show a puzzling behavior. Furthermore, when these fields are comparable to or stronger than \Lambda_QCD, they serve as excellent probes to help elucidate the physics of strongly interacting matter under extreme conditions of temperature and density. In this work we provide a comprehensive review of recent developments on the description of QED and QCD systems where magnetic field driven effects are important. These include the modification of meson static properties such as masses and form factors, the chiral magnetic effect, the description of anomalous transport coefficients, superconductivity in extreme magnetic fields, the properties of neutron stars, the evolution of heavy-ion collisions, as well as effects on the QCD phase diagram. We describe recent theory and phenomenological developments using effective models as well as LQCD methods. The work represents a state-of-the-art review of the field, motivated by presentations and discussions during the "Workshop on Strongly Interacting Matter in Strong Electromagnetic Fields" that took place in the European Centre for Theoretical Studies in Nuclear Physics and Related Areas (ECT*) in the city of Trento, Italy, September 25-29, 2023., Comment: 325 pages-long review of recent topics of interest in the field of magnetic field effects on QED and QCD matter. To be susbmitted to PNPP
- Published
- 2024
42. Pure connection formalism and Plebanski's second heavenly equation
- Author
-
Krasnov, Kirill and Lipstein, Arthur
- Subjects
High Energy Physics - Theory ,General Relativity and Quantum Cosmology - Abstract
Plebanski's second heavenly equation reduces the problem of finding a self-dual Einstein metric to solving a non-linear second-order PDE for a single function. Plebanski's original equation is for self-dual metrics obtained as perturbations of the flat metric. Recently, a version of this equation was discovered for self-dual metrics arising as perturbations around a constant curvature background. We provide a new simple derivation of both versions of the Plebanski second heavenly equation. Our derivation relies on the `pure connection' description of self-dual gravity. Our results also suggest a new interpretation to the kinematic algebra of self-dual Yang-Mills theory, as the Lie algebra of (0,1) vector fields on a R4 endowed with a complex structure., Comment: 12 pages, no figures
- Published
- 2024
43. Existence of normal elements with prescribed norms
- Author
-
Fernandes, Arthur, Panario, Daniel, and Reis, Lucas
- Subjects
Mathematics - Number Theory ,11T30 and 11T24 - Abstract
For each positive integer $n$, let $\mathbb F_{q^n}$ be the unique $n$-degree extension of the finite field $\mathbb F_q$ with $q$ elements, where $q$ is a prime power. It is known that for arbitrary $q$ and $n$, there exists an element $\beta\in \mathbb F_{q^n}$ such that its Galois conjugates $\beta, \beta^q, \ldots, \beta^{q^{n-1}}$ form a basis for $\mathbb F_{q^n}$ as an $\mathbb F_q$-vector space. These elements are called normal and they work as additive generators of finite fields. On the other hand, the multiplicative group $\mathbb F_{q^n}^*$ is cyclic and any generator of this group is a primitive element. Many past works have dealt with the existence of primitive and normal elements with specified properties, including the existence of primitive elements whose traces over intermediate extensions are prescribed. Inspired by the latter, in this paper we explore the existence of normal elements whose norms over intermediate extensions are prescribed. We combine combinatorial and number-theoretic ideas and obtain both asymptotic and concrete results. In particular, we completely solve the problem in the case where only one intermediate extension is considered.
- Published
- 2024
44. Towards Provable Security in Industrial Control Systems Via Dynamic Protocol Attestation
- Author
-
Amorim, Arthur, Kann, Trevor, Taylor, Max, and Joneckis, Lance
- Subjects
Computer Science - Cryptography and Security ,Computer Science - Formal Languages and Automata Theory ,Computer Science - Logic in Computer Science ,Computer Science - Programming Languages - Abstract
Industrial control systems (ICSs) increasingly rely on digital technologies vulnerable to cyber attacks. Cyber attackers can infiltrate ICSs and execute malicious actions. Individually, each action seems innocuous. But taken together, they cause the system to enter an unsafe state. These attacks have resulted in dramatic consequences such as physical damage, economic loss, and environmental catastrophes. This paper introduces a methodology that restricts actions using protocols. These protocols only allow safe actions to execute. Protocols are written in a domain specific language we have embedded in an interactive theorem prover (ITP). The ITP enables formal, machine-checked proofs to ensure protocols maintain safety properties. We use dynamic attestation to ensure ICSs conform to their protocol even if an adversary compromises a component. Since protocol conformance prevents unsafe actions, the previously mentioned cyber attacks become impossible. We demonstrate the effectiveness of our methodology using an example from the Fischertechnik Industry 4.0 platform. We measure dynamic attestation's impact on latency and throughput. Our approach is a starting point for studying how to combine formal methods and protocol design to thwart attacks intended to cripple ICSs., Comment: This paper was accepted into the ICSS'24 workshop
- Published
- 2024
45. SEREP: Semantic Facial Expression Representation for Robust In-the-Wild Capture and Retargeting
- Author
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Josi, Arthur, Hafemann, Luiz Gustavo, Dib, Abdallah, Got, Emeline, Cruz, Rafael M. O., and Carbonneau, Marc-Andre
- Subjects
Computer Science - Computer Vision and Pattern Recognition ,Computer Science - Graphics ,Computer Science - Machine Learning - Abstract
Monocular facial performance capture in-the-wild is challenging due to varied capture conditions, face shapes, and expressions. Most current methods rely on linear 3D Morphable Models, which represent facial expressions independently of identity at the vertex displacement level. We propose SEREP (Semantic Expression Representation), a model that disentangles expression from identity at the semantic level. It first learns an expression representation from unpaired 3D facial expressions using a cycle consistency loss. Then we train a model to predict expression from monocular images using a novel semi-supervised scheme that relies on domain adaptation. In addition, we introduce MultiREX, a benchmark addressing the lack of evaluation resources for the expression capture task. Our experiments show that SEREP outperforms state-of-the-art methods, capturing challenging expressions and transferring them to novel identities., Comment: For our project page, see https://ubisoft-laforge.github.io/character/serep/
- Published
- 2024
46. Prompting Strategies for Enabling Large Language Models to Infer Causation from Correlation
- Author
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Sgouritsa, Eleni, Aglietti, Virginia, Teh, Yee Whye, Doucet, Arnaud, Gretton, Arthur, and Chiappa, Silvia
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Computer Science - Computation and Language ,Computer Science - Artificial Intelligence ,Computer Science - Machine Learning - Abstract
The reasoning abilities of Large Language Models (LLMs) are attracting increasing attention. In this work, we focus on causal reasoning and address the task of establishing causal relationships based on correlation information, a highly challenging problem on which several LLMs have shown poor performance. We introduce a prompting strategy for this problem that breaks the original task into fixed subquestions, with each subquestion corresponding to one step of a formal causal discovery algorithm, the PC algorithm. The proposed prompting strategy, PC-SubQ, guides the LLM to follow these algorithmic steps, by sequentially prompting it with one subquestion at a time, augmenting the next subquestion's prompt with the answer to the previous one(s). We evaluate our approach on an existing causal benchmark, Corr2Cause: our experiments indicate a performance improvement across five LLMs when comparing PC-SubQ to baseline prompting strategies. Results are robust to causal query perturbations, when modifying the variable names or paraphrasing the expressions.
- Published
- 2024
47. Development of self-modulation as a function of plasma length
- Author
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Clairembaud, Arthur, Turner, Marlene, and Muggli, Patric
- Subjects
Physics - Plasma Physics ,Physics - Accelerator Physics - Abstract
We use numerical simulations to determine whether the saturation length of the self-modulation (SM) instability of a long proton bunch in plasma could be determined by measuring the radius of the bunch halo SM produces. Results show that defocused protons acquire their maximum transverse momentum and exit the wakefields at a distance approximately equal to the saturation length of the wakefields. This suggests that measuring the radius of the halo as a function of plasma length in the AWAKE experiment would yield a very good estimate for the saturation length of SM., Comment: 13 pages, 2 tables, 4 figures, AAC2024 Proceedings
- Published
- 2024
48. The Role of Natural Language Processing Tasks in Automatic Literary Character Network Construction
- Author
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Amalvy, Arthur, Labatut, Vincent, and Dufour, Richard
- Subjects
Computer Science - Computation and Language - Abstract
The automatic extraction of character networks from literary texts is generally carried out using natural language processing (NLP) cascading pipelines. While this approach is widespread, no study exists on the impact of low-level NLP tasks on their performance. In this article, we conduct such a study on a literary dataset, focusing on the role of named entity recognition (NER) and coreference resolution when extracting co-occurrence networks. To highlight the impact of these tasks' performance, we start with gold-standard annotations, progressively add uniformly distributed errors, and observe their impact in terms of character network quality. We demonstrate that NER performance depends on the tested novel and strongly affects character detection. We also show that NER-detected mentions alone miss a lot of character co-occurrences, and that coreference resolution is needed to prevent this. Finally, we present comparison points with 2 methods based on large language models (LLMs), including a fully end-to-end one, and show that these models are outperformed by traditional NLP pipelines in terms of recall.
- Published
- 2024
49. What if we had built a prediction model with a survival super learner instead of a Cox model 10 years ago?
- Author
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Chatton, Arthur, Pilote, Émilie, Feugo, Kevin Assob, Cardinal, Héloïse, Platt, Robert W., and Schnitzer, Mireille E
- Subjects
Statistics - Methodology ,Statistics - Applications - Abstract
Objective: This study sought to compare the drop in predictive performance over time according to the modeling approach (regression versus machine learning) used to build a kidney transplant failure prediction model with a time-to-event outcome. Study Design and Setting: The Kidney Transplant Failure Score (KTFS) was used as a benchmark. We reused the data from which it was developed (DIVAT cohort, n=2,169) to build another prediction algorithm using a survival super learner combining (semi-)parametric and non-parametric methods. Performance in DIVAT was estimated for the two prediction models using internal validation. Then, the drop in predictive performance was evaluated in the same geographical population approximately ten years later (EKiTE cohort, n=2,329). Results: In DIVAT, the super learner achieved better discrimination than the KTFS, with a tAUROC of 0.83 (0.79-0.87) compared to 0.76 (0.70-0.82). While the discrimination remained stable for the KTFS, it was not the case for the super learner, with a drop to 0.80 (0.76-0.83). Regarding calibration, the survival SL overestimated graft survival at development, while the KTFS underestimated graft survival ten years later. Brier score values were similar regardless of the approach and the timing. Conclusion: The more flexible SL provided superior discrimination on the population used to fit it compared to a Cox model and similar discrimination when applied to a future dataset of the same population. Both methods are subject to calibration drift over time. However, weak calibration on the population used to develop the prediction model was correct only for the Cox model, and recalibration should be considered in the future to correct the calibration drift., Comment: 10 pages, 2 Tables, 3 Figures, Submitted
- Published
- 2024
50. Regression trees for nonparametric diagnostics of sequential positivity violations in longitudinal causal inference
- Author
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Chatton, Arthur, Schomaker, Michael, Luque-Fernandez, Miguel-Angel, Platt, Robert W., and Schnitzer, Mireille E.
- Subjects
Statistics - Methodology - Abstract
Sequential positivity is often a necessary assumption for drawing causal inferences, such as through marginal structural modeling. Unfortunately, verification of this assumption can be challenging because it usually relies on multiple parametric propensity score models, unlikely all correctly specified. Therefore, we propose a new algorithm, called "sequential Positivity Regression Tree" (sPoRT), to check this assumption with greater ease under either static or dynamic treatment strategies. This algorithm also identifies the subgroups found to be violating this assumption, allowing for insights about the nature of the violations and potential solutions. We first present different versions of sPoRT based on either stratifying or pooling over time. Finally, we illustrate its use in a real-life application of HIV-positive children in Southern Africa with and without pooling over time. An R notebook showing how to use sPoRT is available at github.com/ArthurChatton/sPoRT-notebook., Comment: 10 pages, 4 Tables, 2 Figures. Submitted
- Published
- 2024
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