1. Stereocontrolled total synthesis of leukotriene B4
- Author
-
Avignon-Tropis, M., Berjeaud, J.M., Pougny, J.R., Frechard-Ortuno, I., Guillerm, D., and Linstrumelle, G.
- Subjects
Leukotrienes -- Synthesis ,Enantiomers -- Research ,Oxidation-reduction reaction -- Research ,Biological sciences ,Chemistry - Abstract
The reduction of D-mannitol and 2-deoxy-D-ribose with (E)-dichloroethylene resulted in the stereocontrolled synthesis of leukotriene B. The process involved palladium-copper catalysts to provide sequential substitution of dichloroethylenes E and Z. The selective reduction, prior to the coupling of the chiral building blocks, also produced other stereoisomers of leukotriene B aside from the desired chiral structures.
- Published
- 1992